Dynamical and Thermodynamic Elements of Modeled Climate Change at the East African Margin of Convection

We propose a dynamical interpretation of model projections for an end-of-century wetting in equatorial East Africa. In the current generation of global climate models, increased atmospheric moisture content associated with warming is not the dominant process explaining the increase in rainfall, as the regional circulation is only weakly convergent even during the rainy seasons. Instead, projected wetter future conditions are generally consistent with the El Niño-like trend in tropical Pacific sea surface temperatures in climate models. In addition, a weakening in moisture convergence over the adjacent Congo Basin and Maritime Continent cores of convection results in the weakening of near-surface winds, which increases moisture advection from the Congo Basin core toward the East African margin. Overall confidence in the projections is limited by the significant biases in simulation of the regional climatology and disagreement between observed and modeled tropical Pacific sea surface temperature trends to date

Editorial review: Male circumcision, gender and HIV prevention in sub-Saharan Africa: a (social science) research agenda

No Abstract.SAHARA J Vol. 4 (3) 2007: pp. 658-66

Report and policy brief: 2nd Annual Conference on Social Aspects of HIV/AIDS Research, Cape Town, 9 - 12 May 2004

This report and policy brief summarises the overarching principles, key findings and suggested policy options that emerged from rapporteur reports of conference proceedings of the 2nd Annual Conference on Social Aspects of HIV/AIDS Research, Cape Town, 9 - 12 May 2004. SAHARA-J (2004) 1(2): 62-77 Keywords: SAHARA Network, Conference proceedings, Policy brief, HIV, AIDS, Sub-Saharan Africa, reseach, Social aspects. RÉSUMÉ Ce dossier de rapport et de politique présente un compte-rendu des principes dominants, des conclusions principales et des options d'une politique proposée qui font partie des communications présentées de la 2è Conférence Annuelle de Recherche sur les Aspects Sociaux du VIH/SIDA, le Cap, 9 - 12 mai 2004. SAHARA-J (2004) 1(2): 62-77 Mots clés: Réseau du SAHARA, démarches de conférence, dossier de politique, HIV/AIDS, Afrique Secondaire-Saharan, reseach, aspects sociaux

A SOM-based analysis of the drivers of the 2015–2017 Western Cape drought in South Africa

The multi-year (2015–2017) drought in the South West of the Western Cape (SWC) caused a severe water shortage in the summer of 2017–2018, with damaging impacts on the local and regional economy, and Cape Town being in the news one of the first major cities to potentially run out of water. Here, we assess the links between the rainfall deficits during the drought and (a) large scale circulation patterns, (b) moisture transport, and (c) convective available potential energy (CAPE). We used self-organising maps (SOM) analysis to classify daily ERA-interim 850 hPa geopotential height for the period 1979–2017 (March–October) into synoptic types. This allowed us to identify the dominant synoptic states over Southern Africa that influence the local climate in the area affected by the drought. The results show that (a) the frequency of nodes with rain-bearing circulation types decreased during the drought; (b) the amount of rain falling on days that did have rain-bearing circulation types was reduced, especially in the shoulder seasons (March–May and August–October); (c) the rainfall reduction was also associated with anomalously low moisture transport, and convective energy (CAPE), over SWC. These results add to the existing knowledge of drivers of the Cape Town drought, providing an understanding of underlying synoptic processes

Clinical and pathological kidney aspects of sickle cell anemia at Dakar: study of 11 cases of renal biopsies

Few studies are devoted to the practice of renal biopsy in sickle cell nephropathy; our objective was to determine the histological and evolutionary patterns of renal lesions in sickle cell patients who underwent renal biopsy in Dakar.Methods:This was a retrospective multicentric study (conducted from December 2009 to August 2011) on renal biopsies performed on sickle cell anaemic patients at the Nephrology Department of Teaching Hospital Aristide Le Dantec and the Albert Royer Childrens Hospital. The histological, therapeutic and evolutionary data were analysed.From the 292 total renal biopsies, 11 (3.80%) were performed on sickle cell patients (6SS, 1SBth + 4 AS) with a mean age of 23.1 [13-51 years]. Nephrotic syndrome was the indication of renal biopsy in all cases. Focal segmental glomerulosclerosis was the most frequent histological finding (five cases), followed by a combination of various specific lesions (hypertrophy of glomerular and peritubular capillaries), minimal glomerular lesions (three cases), membranoproliferative glomerulonephritis (two cases) and extra-membranous glomerulonephritis (one case). Complete remission after treatment was achieved in seven cases and one patient expired. Three patients did not continue with follow-up appointments.Conclusions:Renal biopsy is not very frequent in the course of sickle cell anaemia and in most cases it is performed because of nephrotic syndrome. The histological findings are diverse with a predominance of focal segmental glomerulosclerosis

Culture Matters in Communicating the Global Response to COVID-19.

Current communication messages in the COVID-19 pandemic tend to focus more on individual risks than community risks resulting from existing inequities. Culture is central to an effective community-engaged public health communication to reduce collective risks. In this commentary, we discuss the importance of culture in unpacking messages that may be the same globally (physical/social distancing) yet different across cultures and communities (individualist versus collectivist). Structural inequity continues to fuel the disproportionate impact of COVID-19 on black and brown communities nationally and globally. PEN-3 offers a cultural framework for a community-engaged global communication response to COVID-19

Green manure in coffee systems in the region of Zona da Mata, Minas Gerais: characteristics and kinetics of carbon and nitrogen mineralization.

The use of green manure may contribute to reduce soil erosion and increase the soil organic matter content and N availability in coffee plantations in the Zona da Mata, State of Minas Gerais, in Southeastern Brazil. The potential of four legumes (A. pintoi, C. mucunoides, S. aterrimum and S. guianensis)to produce above-ground biomass, accumulate nutrients and mineralize N was studied in two coffee plantations of subsistence farmers under different climate conditions. The biomass production of C. mucunoides was influenced by the shade of the coffee plantation.C. mucunoides tended to mineralize more N than the other legumes due to the low polyphenol content and polyphenol/N ratio. In the first year, the crop establishment of A. pintoi in the area took longer than of the other legumes, resulting in lower biomass production and N2 fixation. In the long term, cellulose was the main factor controlling N mineralization. The biochemical characteristics, nutrient accumulation and biomass production of the legumes were greatly influenced by the altitude and position of the area relative to the sun

Focus on environmental risks and migration: causes and consequences

Environmental change poses risks to societies, including disrupting social and economic systems such as migration. At the same time, migration is an effective adaptation to environmental and other risks. We review novel science on interactions between migration, environmental risks and climate change. We highlight emergent findings, including how dominant flows of rural to urban migration mean that populations are exposed to new risks within destination areas and the requirement for urban sustainability. We highlight the issue of lack of mobility as a major issue limiting the effectiveness of migration as an adaptation strategy and leading to potentially trapped populations. The paper presents scenarios of future migration that show both displacement and trapped populations over the incoming decades. Papers in the special issue bring new insights from demography, human geography, political science and environmental science to this emerging field

The Plasmodium falciparum STEVOR Multigene Family Mediates Antigenic Variation of the Infected Erythrocyte

Modifications of the Plasmodium falciparum–infected red blood cell (iRBC) surface have been linked to parasite-associated pathology. Such modifications enable the parasite to establish long-lasting chronic infection by evading antibody mediate immune recognition and splenic clearance. With the exception of the well-demonstrated roles of var-encoded PfEMP1 in virulence and immune evasion, the biological significance of other variant surface antigens (rif and stevor) is largely unknown. While PfEMP1 and RIFIN have been located on the iRBC surface, recent studies have located STEVOR at the iRBC membrane where it may be exposed on the erythrocyte surface. To investigate the role of STEVOR in more detail, we have developed antibodies against two putative STEVOR proteins and used a combination of indirect immunofluorescence assays (IFA), live IFA, flow cytometry, as well as agglutination assays, which enable us to demonstrate that STEVOR is clonally variant at the surface of schizont stage parasites. Crucially, expression of different STEVOR on the surface of the iRBC changes the antigenic property of the parasite. Taken together, our data for the first time demonstrate that STEVOR plays a role in creating antigenic diversity of schizont stage parasites, thereby adding additional complexity to the immunogenic properties of the iRBC. Furthermore, it clearly demonstrates that to obtain a complete understanding of how parasite-induced pathology is linked to variation on the surface of the iRBC, focusing the interactions of multiple multigene families needs to be considered