13 research outputs found
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Get PDFEpigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike’s information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk
An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients
Get PDF10.1038/ki.2008.202Kidney International744521-527KDYI
Estimated glomerular filtration rate and its association with the retinol-binding protein 4 (RBP4) locus on human chromosome 10q23
No full text10.1093/ndt/gfr442Nephrology Dialysis Transplantation2741511-1515NDTR
Nephrinuria associates with multiple renal traits in type 2 diabetes
No full text10.1093/ndt/gfq738Nephrology Dialysis Transplantation2682508-2514NDTR
Synthesis of Hyperbranched Polymers with Rhenium(I) Bis(Stilbazoylimino)Acephthalene Complexes at the Branching Units
No full textFacile fabrication of epoxy-TiO2 nanocomposites: A critical analysis of TiO2 impact on mechanical properties and toughening mechanisms
No full textInternational Lung Cancer Consortium: Pooled Analysis of Sequence Variants in DNA Repair and Cell Cycle Pathways
Get PDF10.1158/1055-9965.EPI-08-0411Cancer Epidemiology Biomarkers and Prevention17113081-3089CEBP
Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
No full textIn the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML.
The error has now been corrected in the HTML version of the paper
