431 research outputs found

    A novel ratiometric fluorescent approach for the modulation of the dynamic range of lateral flow immunoassays

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    The majority of lateral flow assays (LFAs) use single-color optical labels to provide a qualitative naked-eye detection, however this detection method displays two important limitations. First, the use of a single-color label makes the LFA prone to results misinterpretation. Second, it does not allow the precise modulation of the sensitivity and dynamic range of the test. To overcome these limitations, a ratiometric approach is developed. In particular, using anti-HIgG functionalized red-fluorescent quantum dots on the conjugate pad (as target dependent labels) and blue-fluorescent nanoparticles fixed on the test line (as target independent reporters), it is possible to generate a wide color palette (blue, purple, pink, red) on the test line. It is believed that this strategy will facilitate the development of LFAs by easily adjusting their analytical properties to the needs required by the specific application

    Information Retrieval on the World Wide Web and Active Logic: A Survey and Problem Definition

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    As more information becomes available on the World Wide Web (there are currently over 4 billion pages covering most areas of human endeavor), it becomes more difficult to provide effective search tools for information access. Today, people access web information through two main kinds of search interfaces: Browsers (clicking and following hyperlinks) and Query Engines (queries in the form of a set of keywords showing the topic of interest). The first process is tentative and time consuming and the second may not satisfy the user because of many inaccurate and irrelevant results. Better support is needed for expressing one's information need and returning high quality search results by web search tools. There appears to be a need for systems that do reasoning under uncertainty and are flexible enough to recover from the contradictions, inconsistencies, and irregularities that such reasoning involves. Active Logic is a formalism that has been developed with real-world applications and their challenges in mind. Motivating its design is the thought that one of the factors that supports the flexibility of human reasoning is that it takes place step-wise, in time. Active Logic is one of a family of inference engines (step-logics) that explicitly reason in time, and incorporate a history of their reasoning as they run. This characteristic makes Active Logic systems more flexible than traditional AI systems and therefore more suitable for commonsense, real-world reasoning. In this report we mainly will survey recent advances in machine learning and crawling problems related to the web. We will review the continuum of supervised to semi-supervised to unsupervised learning problems, highlight the specific challenges which distinguish information retrieval in the hypertext domain and will summarize the key areas of recent and ongoing research. We will concentrate on topic-specific search engines, focused crawling, and finally will propose an Information Integration Environment, based on the Active Logic framework. Keywords: Web Information Retrieval, Web Crawling, Focused Crawling, Machine Learning, Active Logic (Also UMIACS-TR-2001-69

    Analysis and Verification of Service Interaction Protocols - A Brief Survey

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    Modeling and analysis of interactions among services is a crucial issue in Service-Oriented Computing. Composing Web services is a complicated task which requires techniques and tools to verify that the new system will behave correctly. In this paper, we first overview some formal models proposed in the literature to describe services. Second, we give a brief survey of verification techniques that can be used to analyse services and their interaction. Last, we focus on the realizability and conformance of choreographies.Comment: In Proceedings TAV-WEB 2010, arXiv:1009.330

    Room temperature plasmon laser by total internal reflection

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    Plasmon lasers create and sustain intense and coherent optical fields below light's diffraction limit with the unique ability to drastically enhance light-matter interactions bringing fundamentally new capabilities to bio-sensing, data storage, photolithography and optical communications. However, these important applications require room temperature operation, which remains a major hurdle. Here, we report a room temperature semiconductor plasmon laser with both strong cavity feedback and optical confinement to 1/20th of the wavelength. The strong feedback arises from total internal reflection of surface plasmons, while the confinement enhances the spontaneous emission rate by up to 20 times.Comment: 8 Page, 2 Figure

    Superheated Microdrops as Cold Dark Matter Detectors

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    It is shown that under realistic background considerations, an improvement in Cold Dark Matter sensitivity of several orders of magnitude is expected from a detector based on superheated liquid droplets. Such devices are totally insensitive to minimum ionizing radiation while responsive to nuclear recoils of energies ~ few keV. They operate on the same principle as the bubble chamber, but offer unattended, continuous, and safe operation at room temperature and atmospheric pressure.Comment: 15 pgs, 4 figures include

    Advances in small lasers

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    M.T.H was supported by an Australian Research council Future Fellowship research grant for this work. M.C.G. is grateful to the Scottish Funding Council (via SUPA) for financial support.Small lasers have dimensions or modes sizes close to or smaller than the wavelength of emitted light. In recent years there has been significant progress towards reducing the size and improving the characteristics of these devices. This work has been led primarily by the innovative use of new materials and cavity designs. This Review summarizes some of the latest developments, particularly in metallic and plasmonic lasers, improvements in small dielectric lasers, and the emerging area of small bio-compatible or bio-derived lasers. We examine the different approaches employed to reduce size and how they result in significant differences in the final device, particularly between metal- and dielectric-cavity lasers. We also present potential applications for the various forms of small lasers, and indicate where further developments are required.PostprintPeer reviewe
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