Pizzas, pizzen, pizze: frequency, iconicity, cue validity, and productivity in the plural acquisition of German preschoolers

Some factors which influence the choice of plural markers in German are discussed: frequency of nouns and plural allomorphs, iconicity, cue validity, productivity, and gender specific distribution of plural allomorphs. The evidence comes from studies on a language screening conducted in the state of Hesse in Germany in 2007-2010 with three-, four-, and five-year-old monolingual and multilingual children.Some factors which influence the choice of plural markers in German are discussed: frequency of nouns and plural allomorphs, iconicity, cue validity, productivity, and gender specific distribution of plural allomorphs. The evidence comes from studies on a language screening conducted in the state of Hesse in Germany in 2007-2010 with three-, four-, and five-year-old monolingual and multilingual children

Destruction of the Kondo effect by a local measurement

We show that the local spin measurement which decoheres the localized spin in a Kondo system, suppresses the Abrikosov-Suhl resonance and destroys the Kondo effect. This happens due to elimination of the entanglement between the localized spin and the conduction electrons, and differs essentially from smearing of the resonance by dissipation. Considering decoherence by a spin bath, we predict that the Kondo effect disappears when the Kondo temperature becomes smaller than the coupling with a bath. This effect can be detected in experiments on ``quantum corrals'' or quantum dots doped by impurities with internal degrees of freedom.Comment: REVTeX4, 1 figure (EPS

Maxwell equations in matrix form, squaring procedure, separating the variables, and structure of electromagnetic solutions

The Riemann -- Silberstein -- Majorana -- Oppenheimer approach to the Maxwell electrodynamics in vacuum is investigated within the matrix formalism. The matrix form of electrodynamics includes three real 4 \times 4 matrices. Within the squaring procedure we construct four formal solutions of the Maxwell equations on the base of scalar Klein -- Fock -- Gordon solutions. The problem of separating physical electromagnetic waves in the linear space \lambda_{0}\Psi^{0}+\lambda_{1}\Psi^{1}+\lambda_{2}\Psi^{2}+ lambda_{3}\Psi^{3} is investigated, several particular cases, plane waves and cylindrical waves, are considered in detail.Comment: 26 pages 16 International Seminar NCPC, May 19-22, 2009, Minsk, Belaru

Comparing endovenous laser ablation, foam sclerotherapy, and conventional surgery for great saphenous varicose veins

BackgroundMany case series have been published on treatments of varicose veins, but comparative randomized controlled trials remain sparse.ObjectiveTo compare the anatomic success rate, frequency of major complications, and quality-of-life improvement of endovenous laser ablation (EVLA), ultrasound-guided foam sclerotherapy (UGFS), and conventional surgery (CS), after 1-year follow-up.MethodsA total of 240 consecutive patients with primary symptomatic great saphenous vein reflux were randomized to EVLA, UGFS, or CS, consisting of high ligation and short stripping. Primary outcome was anatomic success defined as obliteration or absence of the treated vein on ultrasound examination after 1 year. Secondary outcomes were complications, improvement of the “C” class of the CEAP classification, and improvement of disease-specific (Chronic Venous Insufficiency Quality-of-Life Questionnaire) and general (EuroQol 5) quality-of-life scores.ResultsMore than 80% of the study population was classified as C2 or C3 venous disease. After 1 year, the anatomic success rate was highest after EVLA (88.5%), followed by CS (88.2%) and UGFS (72.2%) (P < .001). The complication rate was low and comparable between treatment groups. All groups showed significant (P < .001) improvement of EuroQol 5 and Chronic Venous Insufficiency Quality-of-Life Questionnaire scores after therapy; 84.3% of all treated patients showed an improvement of the “C” of the CEAP classification.ConclusionsAfter 1-year follow-up, EVLA is as effective as CS and superior to UGFS according to occlusion on ultrasound duplex. Quality of life improves after treatment in all groups significantly

Drug-induced Fanconi syndrome associated with fumaric acid esters treatment for psoriasis: A case series

Background: Fumaric acid esters (FAEs), an oral immunomodulating treatment for psoriasis and multiple sclerosis, have been anecdotally associated with proximal renal tubular dysfunction due to a drug-induced Fanconi syndrome. Few data are available on clinical outcomes of FAE-induced Fanconi syndrome. Methods: Descriptive case series with two cases of Fanconi syndrome associated with FAE treatment diagnosed at two Dutch university nephrology departments, three cases reported at the Dutch and German national pharmacovigilance databases and six previously reported cases. Results: All 11 cases involved female patients with psoriasis. The median age at the time of onset was 38 years [interquartile range (IQR) 37-46]. Patients received long-term FAEs treatment with a median treatment duration of 60 months (IQR 28-111). Laboratory tests were typically significant for low serum levels of phosphate and uric acid, while urinalysis showed glycosuria and proteinuria. Eight (73%) patients had developed a hypophosphataemic osteomalacia and three (27%) had pathological bone fractures. All patients discontinued FAEs, while four (36%) patients were treated with supplementation of phosphate and/or vitamin D. Five (45%) patients had persisting symptoms despite FAEs discontinuation. Conclusions: FAEs treatment can cause drug-induced Fanconi syndrome, but the association has been reported infrequently. Female patients with psoriasis treated long term with FAEs seem to be particularly at risk. Physicians treating patients with FAEs should be vigilant and monitor for the potential occurrence of Fanconi syndrome. Measurement of the urinary albumin:total protein ratio is a suggested screening tool for tubular proteinuria in Fanconi syndrome

Localization dynamics in a binary two-dimensional cellular automaton: the Diffusion Rule

We study a two-dimensional cellular automaton (CA), called Diffusion Rule (DR), which exhibits diffusion-like dynamics of propagating patterns. In computational experiments we discover a wide range of mobile and stationary localizations (gliders, oscillators, glider guns, puffer trains, etc), analyze spatio-temporal dynamics of collisions between localizations, and discuss possible applications in unconventional computing.Comment: Accepted to Journal of Cellular Automat

外国語を教えるということ(SOLAC発足10周年記念特別寄稿エッセー)

Contains fulltext : 153048.pdf (publisher's version ) (Closed access)BACKGROUND: To describe functioning and health of lymphedema patients and to identify their most common problems using the International Classification of Functioning, Disability and Health (ICF) as part of the preparatory studies for the development of ICF Core Sets for lymphedema. METHODS: Cross-sectional study in a population of lymphedema patients (n = 200), undergoing treatment in a Dutch lymphedema-specialized hospital. The second-level categories of the ICF were used to collect information on patients' problems in daily functioning. RESULTS: The mean age of the study group was 56 years (22-84). In total 78.5% of the patients were female. The most frequent mentioned items were: In the Body Functions component: muscle power and mobility of joints, in the Activities and Participation component: doing housework, and changing and maintaining a body position, in the Environmental Factors: Health professionals, who can act as both facilitators and barriers. Interestingly, patients assessed their health more positively than health professionals do. CONCLUSION: By using the ICF, a considerable part of the broad spectrum of problems in functioning of lymphedema patients was reported

Production of Medical Radioisotopes with High Specific Activity in Photonuclear Reactions with γ\gamma Beams of High Intensity and Large Brilliance

We study the production of radioisotopes for nuclear medicine in $(\gamma,x{\rm n}+y{\rm p})$ photonuclear reactions or ($\gamma,\gamma'$) photoexcitation reactions with high flux [($10^{13}-10^{15}$)$\gamma$/s], small diameter $\sim (100 \, \mu$m$)^2$ and small band width ($\Delta E/E \approx 10^{-3}-10^{-4}$) $\gamma$ beams produced by Compton back-scattering of laser light from relativistic brilliant electron beams. We compare them to (ion,$x$n$+ y$p) reactions with (ion=p,d,$\alpha$) from particle accelerators like cyclotrons and (n,$\gamma$) or (n,f) reactions from nuclear reactors. For photonuclear reactions with a narrow $\gamma$ beam the energy deposition in the target can be managed by using a stack of thin target foils or wires, hence avoiding direct stopping of the Compton and pair electrons (positrons). $(\gamma,\gamma')$ isomer production via specially selected $\gamma$ cascades allows to produce high specific activity in multiple excitations, where no back-pumping of the isomer to the ground state occurs. We discuss in detail many specific radioisotopes for diagnostics and therapy applications. Photonuclear reactions with $\gamma$ beams allow to produce certain radioisotopes, e.g. $^{47}$Sc, $^{44}$Ti, $^{67}$Cu, $^{103}$Pd, $^{117m}$Sn, $^{169}$Er, $^{195m}$Pt or $^{225}$Ac, with higher specific activity and/or more economically than with classical methods. This will open the way for completely new clinical applications of radioisotopes. For example $^{195m}$Pt could be used to verify the patient's response to chemotherapy with platinum compounds before a complete treatment is performed. Also innovative isotopes like $^{47}$Sc, $^{67}$Cu and $^{225}$Ac could be produced for the first time in sufficient quantities for large-scale application in targeted radionuclide therapy.Comment: submitted to Appl. Phys.

Weight velocity equations with 14–448 days time separated weights should not be used for infants under 3 years of age

Abnormal growth of infants may indicate disease of the children, thus methods to identify growth disorders are wanted in medicine. We previously showed that two-time-points weight growth velocities at age t, calculated by a commercial software product as [Weight(t)− Weight(t − X)]/X, with X = 448 days, were erroneous due to the long separation of 448 days. We were convinced that shorter X-values would solve this accuracy problem. However, our hypothesis is that: “shorter time separations than 448 days cause a decreased accuracy of numerical weight velocity equations in realistic infant weights until an age of about three years”. Supporting evidence comes from analyzing how shorter X-values will affect the accuracy of two-time-points weight velocity calculations. We systematically varied X between 1 and 448 days of various P50/0SD-related standard weight curves: (a)P50/0SD with the weights separated by 1 day and X = 1,28,224,448 days; (b)P50/0SD with the weights at variable ages and X = 14–448 days; and (c)case (b)and incorporating weight fluctuations typically occurring in infants. Cases (b)and (c)include details observed in a clinical case. Our results show that the combination of weight fluctuations and varying time intervals between consecutive weights make weight velocity predictions worse for shorter X values in children younger than three years. Because these two causes of failure occur naturally in infants whose weight is regularly measured, other weight velocity equations face the same causes for inaccuracy. In conclusion, our hypothesis suggests that any software that predicts weight velocities should be abandoned in infants < 3 years. Practically, it should require that when (commercial)software weight velocity prediction suggests a medical problem, careful clinical checking should be mandatory, e.g. by linking predicted and exact weight velocities at age t (the latter from the mathematical first derivative at age t of standard weight curves)

Is symmetry identity?

Wigner found unreasonable the "effectiveness of mathematics in the natural sciences". But if the mathematics we use to describe nature is simply a coded expression of our experience then its effectiveness is quite reasonable. Its effectiveness is built into its design. We consider group theory, the logic of symmetry. We examine the premise that symmetry is identity; that group theory encodes our experience of identification. To decide whether group theory describes the world in such an elemental way we catalogue the detailed correspondence between elements of the physical world and elements of the formalism. Providing an unequivocal match between concept and mathematical statement completes the case. It makes effectiveness appear reasonable. The case that symmetry is identity is a strong one but it is not complete. The further validation required suggests that unexpected entities might be describable by the irreducible representations of group theory