Rapid heuristic projection on simplicial cones

A very fast heuristic iterative method of projection on simplicial cones is presented. It consists in solving two linear systems at each step of the iteration. The extensive experiments indicate that the method furnishes the exact solution in more then 99.7 percent of the cases. The average number of steps is 5.67 (we have not found any examples which required more than 13 steps) and the relative number of steps with respect to the dimension decreases dramatically. Roughly speaking, for high enough dimensions the absolute number of steps is independent of the dimension

Characterisation of the Etching Quality in Micro-Electro-Mechanical Systems by Thermal Transient Methodology

Our paper presents a non-destructive thermal transient measurement method that is able to reveal differences even in the micron size range of MEMS structures. Devices of the same design can have differences in their sacrificial layers as consequence of the differences in their manufacturing processes e.g. different etching times. We have made simulations examining how the etching quality reflects in the thermal behaviour of devices. These simulations predicted change in the thermal behaviour of MEMS structures having differences in their sacrificial layers. The theory was tested with measurements of similar MEMS devices prepared with different etching times. In the measurements we used the T3Ster thermal transient tester equipment. The results show that deviations in the devices, as consequence of the different etching times, result in different temperature elevations and manifest also as shift in time in the relevant temperature transient curves.Comment: Submitted on behalf of TIMA Editions (http://irevues.inist.fr/tima-editions

Merchant Vessel Crew Levels: An American Perspective

This paper, with an emphasis on policies of effective manning, provides a critical appraisal on the issue of crew levels aboard large merchant vessels (those greater than 1,000 gross tons). Non-traditional approaches to crew organization and management are discussed. Special regard is made to addressing the various domestic and international laws, regulations, and conventions that pertain to ships\u27 manning. The relationship between the seafarer and ships\u27 safety is emphasized as it pertains to reduced crew size. It is argued that U.S. manning laws and regulations should be amended to permit not only smaller crews, but organizational changes aboard ship that will permit flexibility, increased efficiency, and ultimately, increased competitiveness. This view is supported with comparisons of present U.S. policy on ships\u27 manning with manning practices in Japan and Germany. Conclusions demonstrate that, although effective manning has the ability to increase a ship operator\u27s competitive posture, the potential for abuse begs that international regulation of manning levels be adopted

Calculation of Weibull strength parameters, Batdorf flaw density constants and related statistical quantities using PC-CARES

This manual describes the operation and theory of the PC-CARES (Personal Computer-Ceramic Analysis and Reliability Evaluation of Structures) computer program for the IBM PC and compatibles running PC-DOS/MS-DOR OR IBM/MS-OS/2 (version 1.1 or higher) operating systems. The primary purpose of this code is to estimate Weibull material strength parameters, the Batdorf crack density coefficient, and other related statistical quantities. Included in the manual is the description of the calculation of shape and scale parameters of the two-parameter Weibull distribution using the least-squares analysis and maximum likelihood methods for volume- and surface-flaw-induced fracture in ceramics with complete and censored samples. The methods for detecting outliers and for calculating the Kolmogorov-Smirnov and the Anderson-Darling goodness-of-fit statistics and 90 percent confidence bands about the Weibull line, as well as the techniques for calculating the Batdorf flaw-density constants are also described

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

Iron overload is the hallmark of hereditary hemochromatosis and a complication of iron-loading anemias such as β-thalassemia. Treatment can be burdensome and have significant side effects, and new therapeutic options are needed. Iron overload in hereditary hemochromatosis and β-thalassemia intermedia is caused by hepcidin deficiency. Although transgenic hepcidin replacement in mouse models of these diseases prevents iron overload or decreases its potential toxicity, natural hepcidin is prohibitively expensive for human application and has unfavorable pharmacologic properties. Here, we report the rational design of hepcidin agonists based on the mutagenesis of hepcidin and the hepcidin-binding region of ferroportin and computer modeling of their docking. We identified specific hydrophobic/aromatic residues required for hepcidin-ferroportin binding and obtained evidence in vitro that a thiol-disulfide interaction between ferroportin C326 and the hepcidin disulfide cage may stabilize binding. Guided by this model, we showed that 7–9 N-terminal amino acids of hepcidin, including a single thiol cysteine, comprised the minimal structure that retained hepcidin activity, as shown by the induction of ferroportin degradation in reporter cells. Further modifications to increase resistance to proteolysis and oral bioavailability yielded minihepcidins that, after parenteral or oral administration to mice, lowered serum iron levels comparably to those after parenteral native hepcidin. Moreover, liver iron concentrations were lower in mice chronically treated with minihepcidins than those in mice treated with solvent alone. Minihepcidins may be useful for the treatment of iron overload disorders

Hot subdwarf stars and their connection to thermonuclear supernovae

Hot subdwarf stars (sdO/Bs) are evolved core helium-burning stars with very thin hydrogen envelopes, which can be formed by common envelope ejection. Close sdB binaries with massive white dwarf (WD) companions are potential progenitors of thermonuclear supernovae type Ia (SN Ia). We discovered such a progenitor candidate as well as a candidate for a surviving companion star, which escapes from the Galaxy. More candidates for both types of objects have been found by crossmatching known sdB stars with proper motion and light curve catalogues. The Gaia mission will provide accurate astrometry and light curves of all the stars in our hot subdwarf sample and will allow us to compile a much larger all-sky catalogue of those stars. In this way we expect to find hundreds of progenitor binaries and ejected companions.Comment: Proceedings of the 11th Pacific Rim Conference on Stellar Astrophysics, Hong Kong 2015, Journal of Physics: Conference Series, in pres

Visions of Childhood, Notions of Rurality, and Anti-bias Education: Emerging Educators Strive for Praxis

The work of anti-bias educators is becoming increasingly important across educational landscapes in the United States. While this work is well-documented within K–12 schools, less known are the efforts of educators working on the front lines of the anti-bias educational agenda within out-of-school time (OST) programs. In an effort to explore how this work happens in OST programs, we partnered with Read, a summer literacy program serving children in grades K–8. Through an engaged research framework, we asked what factors mediated their delivery of an anti-bias education in the Read program. Two significant findings emerged. First, White parents and caregivers in rural settings were a significant force shaping curricular decisions. Second, conceptualizations of childhood influenced teaching and learning. We offer implications for practice and research and conclude by discussing future directions of anti-bias education in these sites of teaching and learning

Revised Coordinates and Proper Motions of the Stars in the Luyten Half-Second Catalogue

We present refined coordinates and proper motion data for the high proper motion (HPM) stars in the Luyten Half-Second (LHS) catalogue. The positional uncertainty in the original Luyten catalogue is typically >10" and is often >30". We have used the digital scans of the Palomar Observatory Sky Survey (POSS) I and POSS II plates to derive more accurate positions and proper motions of the objects. Out of the 4470 candidates in the LHS catalogue, 4323 objects were manually re-identified in the POSS I and POSS II scans. A small fraction of the stars were not found due to the lack of finder charts and digitized POSS II scans. The uncertainties in the revised positions are typically ~2", but can be as high as ~8" in a few cases; this is a large improvement over the original data. Cross-correlation with the Tycho-2 and Hipparcos catalogues yielded 819 candidates (with m_R < 12). For these brighter sources, the position and proper motion data have been replaced with the more accurate Tycho/Hipparcos data. In total, we have revised proper motion measurements and coordinates for 4040 stars and revised coordinates for 4330 stars, which are presented here.Comment: 108 pages. Accepted for Publication in ApJ Suppl. Some errors caused by the transcription errors in the original LHS catalogue have been corrected in this resubmission. The most current version of the catalogue is also available online at http://www.stsci.edu/~ksahu/lh

Cloud Workload Prediction by Means of Simulations

Clouds hide the complexity of maintaining a physical infrastructure with a disadvantage: they also hide their internal workings. Should users need to know about these details e.g., to increase the reliability or performance of their applications, they would need to detect slight behavioural changes in the underlying system. Existing solutions for such purposes offer limited capabilities. This paper proposes a technique for predicting background workload by means of simulations that are providing knowledge of the underlying clouds to support activities like cloud orchestration or workflow enactment. We propose these predictions to select more suitable execution environments for scientific workflows. We validate the proposed prediction approach with a biochemical application