Cepheid limb darkening, angular diameter corrections, and projection factor from static spherical model stellar atmospheres

Context. One challenge for measuring the Hubble constant using Classical Cepheids is the calibration of the Leavitt Law or period-luminosity relationship. The Baade-Wesselink method for distance determination to Cepheids relies on the ratio of the measured radial velocity and pulsation velocity, the so-called projection factor and the ability to measure the stellar angular diameters. Aims. We use spherically-symmetric model stellar atmospheres to explore the dependence of the p-factor and angular diameter corrections as a function of pulsation period. Methods. Intensity profiles are computed from a grid of plane-parallel and spherically-symmetric model stellar atmospheres using the SAtlas code. Projection factors and angular diameter corrections are determined from these intensity profiles and compared to previous results. Results. Our predicted geometric period-projection factor relation including previously published state-of-the-art hydrodynamical predictions is not with recent observational constraints. We suggest a number of potential resolutions to this discrepancy. The model atmosphere geometry also affects predictions for angular diameter corrections used to interpret interferometric observations, suggesting corrections used in the past underestimated Cepheid angular diameters by 3 - 5%. Conclusions. While spherically-symmetric hydrostatic model atmospheres cannot resolve differences between projection factors from theory and observations, they do help constrain underlying physics that must be included, including chromospheres and mass loss. The models also predict more physically-based limb-darkening corrections for interferometric observations.Comment: 8 pages, 6 figures, 2 tables, accepted for publication in A&

A Multi-Moded RF Delay Line Distribution System for the Next Linear Collider

The Delay Line Distribution System (DLDS) is an alternative to conventional pulse compression, which enhances the peak power of rf sources while matching the long pulse of those sources to the shorter filling time of accelerator structures. We present an implementation of this scheme that combines pairs of parallel delay lines of the system into single lines. The power of several sources is combined into a single waveguide delay line using a multi-mode launcher. The output mode of the launcher is determined by the phase coding of the input signals. The combined power is extracted from the delay line using mode-selective extractors, each of which extracts a single mode. Hence, the phase coding of the sources controls the output port of the combined power. The power is then fed to the local accelerator structures. We present a detailed design of such a system, including several implementation methods for the launchers, extractors, and ancillary high power rf components. The system is designed so that it can handle the 600 MW peak power required by the NLC design while maintaining high efficiency.Comment: 25 pages, 11 figure

Medicines adherence: Involving patients in decisions about prescribed medicines and supporting adherence

It is thought that between a third and a half of all medicines1 There are many causes of non-adherence but they fall into two overlapping categories: intentional and unintentional. Unintentional non-adherence occurs when the patient wants to follow the agreed treatment but is prevented from doing so by barriers that are beyond their control. Examples include poor recall or difficulties in understanding the instructions, problems with using the treatment, inability to pay for the treatment, or simply forgetting to take it. prescribed for long-term conditions are not taken as recommended. If the prescription is appropriate, then this may represent a loss to patients, the healthcare system and society. The costs are both personal and economic. Adherence presumes an agreement between prescriber and patient about the prescriber’s recommendations. Adherence to medicines is defined as the extent to which the patient’s action matches the agreed recommendations. Non-adherence may limit the benefits of medicines, resulting in lack of improvement, or deterioration, in health. The economic costs are not limited to wasted medicines but also include the knock-on costs arising from increased demands for healthcare if health deteriorates. Non-adherence should not be seen as the patient’s problem. It represents a fundamental limitation in the delivery of healthcare, often because of a failure to fully agree the prescription in the first place or to identify and provide the support that patients need later on. Addressing non-adherence is not about getting patients to take more medicines per se. Rather, it starts with an exploration of patients’ perspectives of medicines and the reasons why they may not want or are unable to use them. Healthcare professionals have a duty to help patients make informed decisions about treatment and use appropriately prescribed medicines to best effec

Many-body correlations probed by plasmon-enhanced drag measurements in double quantum well structures

Electron drag measurements of electron-electron scattering rates performed close to the Fermi temperature are reported. While evidence of an enhancement due to plasmons, as was recently predicted [K. Flensberg and B. Y.-K. Hu, Phys. Rev. Lett. 73, 3572 (1994)], is found, important differences with the random-phase approximation based calculations are observed. Although static correlation effects likely account for part of this difference, it is argued that correlation-induced multiparticle excitations must be included to account for the magnitude of the rates and observed density dependences.Comment: 4 pages, 3 figures, revtex Accepted in Phys. Rev.

Superconductivity in correlated disordered two-dimensional electron gas

We calculate the dynamic effective electron-electron interaction potential for a low density disordered two-dimensional electron gas. The disordered response function is used to calculate the effective potential where the scattering rate is taken from typical mobilities from recent experiments. We investigate the development of an effective attractive pair potential for both disordered and disorder free systems with correlations determined from existing numerical simulation data. The effect of disorder and correlations on the superconducting critical temperature Tc is discussed.Comment: 4 pages, RevTeX + epsf, 4 figure

Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour

The mechanism of eukaryotic chemotaxis remains unclear despite intensive study. The most frequently described mechanism acts through attractants causing actin polymerization, in turn leading to pseudopod formation and cell movement. We recently proposed an alternative mechanism, supported by several lines of data, in which pseudopods are made by a self-generated cycle. If chemoattractants are present, they modulate the cycle rather than directly causing actin polymerization. The aim of this work is to test the explanatory and predictive powers of such pseudopod-based models to predict the complex behaviour of cells in chemotaxis. We have now tested the effectiveness of this mechanism using a computational model of cell movement and chemotaxis based on pseudopod autocatalysis. The model reproduces a surprisingly wide range of existing data about cell movement and chemotaxis. It simulates cell polarization and persistence without stimuli and selection of accurate pseudopods when chemoattractant gradients are present. It predicts both bias of pseudopod position in low chemoattractant gradients and-unexpectedly-lateral pseudopod initiation in high gradients. To test the predictive ability of the model, we looked for untested and novel predictions. One prediction from the model is that the angle between successive pseudopods at the front of the cell will increase in proportion to the difference between the cell's direction and the direction of the gradient. We measured the angles between pseudopods in chemotaxing Dictyostelium cells under different conditions and found the results agreed with the model extremely well. Our model and data together suggest that in rapidly moving cells like Dictyostelium and neutrophils an intrinsic pseudopod cycle lies at the heart of cell motility. This implies that the mechanism behind chemotaxis relies on modification of intrinsic pseudopod behaviour, more than generation of new pseudopods or actin polymerization by chemoattractant

Mean angular diameters, distances and pulsation modes of the classical Cepheids FF Aql and T Vul - CHARA/FLUOR near-infrared interferometric observations

We report the first angular diameter measurements of two classical Cepheids, FF Aql and T Vul, that we have obtained with the FLUOR instrument installed at the CHARA interferometric array. We obtain average limb-darkened angular diameters of \theta_LD = 0.878 +/- 0.013 mas and \theta_LD = 0.629 +/- 0.013 mas, respectively for FF Aql and T Vul. Combining these angular diameters with the HST-FGS trigonometric parallaxes leads to linear radii R = 33.6 +/- 2.2 Rsol and R = 35.6 +/- 4.4 Rsol, respectively. The comparison with empirical and theoretical Period-Radius relations leads to the conclusion that these Cepheids are pulsating in their fundamental mode. The knowledge of the pulsation mode is of prime importance to calibrate the Period-Luminosity relation with a uniform sample of fundamental mode Cepheids

Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The miRNA machinery interacts with fragile X mental retardation protein (FMRP), which functions as translational repressor. We show that miR-125b and miR-132, as well as several other miRNAs, are associated with FMRP in mouse brain. miR-125b and miR-132 had largely opposing effects on dendritic spine morphology and synaptic physiology in hippocampal neurons. FMRP knockdown ameliorates the effect of miRNA overexpression on spine morphology. We identified NMDA receptor subunit NR2A as a target of miR-125b and show that NR2A mRNA is specifically associated with FMRP in brain. In hippocampal neurons, NR2A expression is negatively regulated through its 3′ UTR by FMRP, miR-125b, and Argonaute 1. Regulation of NR2A 3′UTR by FMRP depends in part on miR-125b. Because NMDA receptor subunit composition profoundly affects synaptic plasticity, these observations have implications for the pathophysiology of fragile X syndrome, in which plasticity is altered.Deutsche Forschungsgemeinschaft (ED157/1, postdoctoral fellowship)National Cancer Institute (U.S.) (NCI PO1-CA42063)National Cancer Institute (U.S.) (NCI P30-CA14051)National Cancer Institute (U.S.) (Cancer Center Support (Core) Grant)National Cancer Institute (U.S.) (NCI K99-CA131474)Howard Hughes Medical Institute (Investigator