12,644 research outputs found
State Sentencing Guidelines: Profiles and Continuum
Describes twenty-one state sentencing commissions; highlights key attributes of each state's sentencing guidelines and the composition of each commission; and compares guideline systems along a continuum from "more voluntary" to "more mandatory.
Polarisation structuring of broadband light
Spatial structuring of the intensity, phase and polarisation of light is useful in a wide variety of modern applications, from microscopy to optical communications. This shaping is most commonly achieved using liquid crystal spatial light modulators (LC-SLMs). However, the inherent chromatic dispersion of LC-SLMs when used as diffractive elements presents a challenge to the extension of such techniques from monochromatic to broadband light. In this work we demonstrate a method of generating broadband vector beams with dynamically tunable intensity, phase and polarisation over a bandwidth of 100 nm. We use our system to generate radially and azimuthally polarised vector vortex beams carrying orbital angular momentum, and beams whose polarisation states span the majority of the Poincaré sphere. We characterise these broadband vector beams using spatially and spectrally resolved Stokes measurements, and detail the technical and fundamental limitations of our technique, including beam generation fidelity and efficiency. The broadband vector beam shaper that we demonstrate here may find use in applications such as ultrafast beam shaping and white light microscopy
Polarisation structuring of broadband light
Spatial structuring of the intensity, phase and polarisation of light is useful in a wide variety of modern applications, from microscopy to optical communications. This shaping is most commonly achieved using liquid crystal spatial light modulators (LC-SLMs). However, the inherent chromatic dispersion of LC-SLMs when used as diffractive elements presents a challenge to the extension of such techniques from monochromatic to broadband light. In this work we demonstrate a method of generating broadband vector beams with dynamically tunable intensity, phase and polarisation over a bandwidth of 100 nm. We use our system to generate radially and azimuthally polarised vector vortex beams carrying orbital angular momentum, and beams whose polarisation states span the majority of the Poincaré sphere. We characterise these broadband vector beams using spatially and spectrally resolved Stokes measurements, and detail the technical and fundamental limitations of our technique, including beam generation fidelity and efficiency. The broadband vector beam shaper that we demonstrate here may find use in applications such as ultrafast beam shaping and white light microscopy
Chemoselective Suzuki-Miyaura cross-coupling via kinetic transmetallation
Chemoselective Suzuki-Miyaura cross-coupling generally requires a designed deactivation of one nucleophile towards transmetallation. Here we show that boronic acids can be chemoselectively reacted in the presence of ostensibly equivalently reactive boronic acid pinacol (BPin) esters by kinetic discrimination during transmetallation. Simultaneous electrophile control allows sequential chemoselective cross-couplings in a single operation in the absence of protecting groups
Inferring the Origin Locations of Tweets with Quantitative Confidence
Social Internet content plays an increasingly critical role in many domains,
including public health, disaster management, and politics. However, its
utility is limited by missing geographic information; for example, fewer than
1.6% of Twitter messages (tweets) contain a geotag. We propose a scalable,
content-based approach to estimate the location of tweets using a novel yet
simple variant of gaussian mixture models. Further, because real-world
applications depend on quantified uncertainty for such estimates, we propose
novel metrics of accuracy, precision, and calibration, and we evaluate our
approach accordingly. Experiments on 13 million global, comprehensively
multi-lingual tweets show that our approach yields reliable, well-calibrated
results competitive with previous computationally intensive methods. We also
show that a relatively small number of training data are required for good
estimates (roughly 30,000 tweets) and models are quite time-invariant
(effective on tweets many weeks newer than the training set). Finally, we show
that toponyms and languages with small geographic footprint provide the most
useful location signals.Comment: 14 pages, 6 figures. Version 2: Move mathematics to appendix, 2 new
references, various other presentation improvements. Version 3: Various
presentation improvements, accepted at ACM CSCW 201
Modelling of flood hazard extent in data sparse areas: a case study of the Oti River basin, West Africa
Study region: Terrain and hydrological data are scarce in many African countries. The coarse spatial resolution of freely available Shuttle Radar Topographic Mission elevation data and the absence of flow gauges on flood-prone reaches, such as the Oti River studied here, make flood inundation modelling challenging in West Africa. Study focus: A flood modelling approach is developed here to simulate flood extent in data scarce regions. The methodology is based on a calibrated, distributed hydrological model for the whole basin to simulate the input discharges for a hydraulic model which is used to predict the flood extent for a 140 km reach of the Oti River. New hydrological insight for the region: Good hydrological model calibration (Nash Sutcliffe coefficient: 0.87) and validation (Nash Sutcliffe coefficient: 0.94) results demonstrate that even with coarse scale (5 km) input data, it is possible to simulate the discharge along this region's rivers, and importantly with a distributed model, derive model flows at any ungauged location within basin. With a lack of surveyed channel bathymetry, modelling the flood was only possible with a parametrized sub-grid hydraulic model. Flood model fit results relative to the observed 2007 flood extent and extensive sensitivity testing shows that this fit (64%) is likely to be as good as is possible for this region, given the coarseness of the terrain digital elevation model
Research, Identity, and the Future of UNLV
Messages from the Administration, Innovation Magazine
Horseshoe-based Bayesian nonparametric estimation of effective population size trajectories
Phylodynamics is an area of population genetics that uses genetic sequence
data to estimate past population dynamics. Modern state-of-the-art Bayesian
nonparametric methods for recovering population size trajectories of unknown
form use either change-point models or Gaussian process priors. Change-point
models suffer from computational issues when the number of change-points is
unknown and needs to be estimated. Gaussian process-based methods lack local
adaptivity and cannot accurately recover trajectories that exhibit features
such as abrupt changes in trend or varying levels of smoothness. We propose a
novel, locally-adaptive approach to Bayesian nonparametric phylodynamic
inference that has the flexibility to accommodate a large class of functional
behaviors. Local adaptivity results from modeling the log-transformed effective
population size a priori as a horseshoe Markov random field, a recently
proposed statistical model that blends together the best properties of the
change-point and Gaussian process modeling paradigms. We use simulated data to
assess model performance, and find that our proposed method results in reduced
bias and increased precision when compared to contemporary methods. We also use
our models to reconstruct past changes in genetic diversity of human hepatitis
C virus in Egypt and to estimate population size changes of ancient and modern
steppe bison. These analyses show that our new method captures features of the
population size trajectories that were missed by the state-of-the-art methods.Comment: 36 pages, including supplementary informatio
Slowly cycling Rho kinase-dependent actomyosin cross-bridge slippage explains intrinsic high compliance of detrusor smooth muscle
Biological soft tissues are viscoelastic because they display timeindependent pseudoelasticity and time-dependent viscosity. However, there is evidence that the bladder may also display plasticity, defined as an increase in strain that is unrecoverable unless work is done by the muscle. In the present study, an electronic lever was used to induce controlled changes in stress and strain to determine whether rabbit detrusor smooth muscle (rDSM) is best described as viscoelastic or viscoelastic plastic. Using sequential ramp loading and unloading cycles, stress-strain and stiffness-stress analyses revealed that rDSM displayed reversible viscoelasticity, and that the viscous component was responsible for establishing a high stiffness at low stresses that increased only modestly with increasing stress compared with the large increase produced when the viscosity was absent and only pseudoelasticity governed tissue behavior. The study also revealed that rDSM underwent softening correlating with plastic deformation and creep that was reversed slowly when tissues were incubated in a Ca2+ -containing solution. Together, the data support a model of DSM as a viscoelastic-plastic material, with the plasticity resulting from motor protein activation. This model explains the mechanism of intrinsic bladder compliance as slipping cross bridges, predicts that wall tension is dependent not only on vesicle pressure and radius but also on actomyosin cross-bridge activity, and identifies a novel molecular target for compliance regulation, both physiologically and therapeutically
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