129 research outputs found
Is arrhythmogenic right ventricular cardiomyopathy a paediatric problem too?
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease
that is often familial, characterized by arrhythmias of right ventricular origin, due to
transmural fatty or fibrofatty replacement of atrophic myocardium. ARVC is usually
diagnosed in the clinical setting between 20 and 40 years of age. The disease is
seldom recognised in infancy or under the age of 10, probably because the clinical
expression of the disease is normally postponed to youth and adulthood. This review
focuses its attention to the pediatric age, defined as the period of life raging from birth
to 18 years. During this span of life, ARVC is not so rare as previously supposed and
can be identified by applying the same diagnostic criteria proposed for the adult.
Ventricular arrhythmias range from isolated ventricular arrhythmias to sustained
ventricular tachycardia and fibrillation. Children and adolescents with ARVC must be
carefully evaluated and followed-up especially when a family positive history is
present, taking into account the high probability during this life-period that
asymptomatic affected patients become symptomatic or that arrhythmias worsen
during follow-up. The recent identification of the first defective gene opens new
avenues for the early identification of affected subjects even when asymptomatic.peer-reviewe
Online Interval Type-2 Fuzzy Extreme Learning Machine Applied to 3D Path Following for Remotely Operated Underwater Vehicles
In marine missions that involve 3D path following tasks, the overall goal of Underwater Vehicles (UVs) is the successful completion of a path previously specified by the operator. This implies that the path must be followed by the UV as closely as possible and arrive at a location for collection by a vessel. In this paper, an Online Interval Type-2 Fuzzy Extreme Learning Machine (OIT2-FELM) is suggested to achieve a robust following behaviour along a predefined 3D path using a Remotely Operated Underwater Vehicle (ROV). The proposed machine is a fast sequential learning scheme to the training of a more generalised model of TSK Interval Type-2 Fuzzy Inference Systems (TSK IT2 FISs) equivalent to Single Layer Feedforward Neural Networks (SLFNs). Learning new input data in the OIT2-FELM can be done one-by-one or chunk-by-chunk with a fixed or varying size. The OIT2-FELM is implemented in a hierarchical navigation strategy (HNS) as the main guidance mechanism to infer local control motions and to provide the ROV with the necessary autonomy to complete a predefined 3D path. For local path-planning, the OIT2-FELM performs signal classification for obstacle avoidance and target detection based on data collected by an on-board scan sonar. To evaluate the performance of the proposed OIT2-FELM, two different experiments are suggested. First, a number of benchmark problems in the field of non-linear system identification, regression and classification problems are used. Secondly, a number of experiments to the completion of a predefined 3D path using an ROV is implemented. Compared to other fuzzy strategies, the OIT2-FELM offered two significant capabilities. On the one hand, the OIT2-FELM provides a better treatment of uncertainty and noisy signals in underwater environments while improving the ROV's performance. Secondly, online learning in OIT2-FELM allows continuous knowledge discovery from survey data to infer the surroundings of the ROV. Experiment results to the completion of 3D paths show the effectiveness of the proposed approach to handle uncertainty and produce reasonable classification predictions (∼90.5% accuracy in testing data).</p
Quality and reporting of clinical guidelines for breast cancer treatment: A systematic review
Background: High-quality, well-reported clinical practice guidelines (CPGs) and consensus statements
(CSs) underpinned by systematic reviews are needed. We appraised the quality and reporting of CPGs
and CSs for breast cancer (BC) treatment.
Methods: Following protocol registration (Prospero no: CRD42020164801), CPGs and CSs on BC treatment
were identified, without language restrictions, through a systematic search of bibliographic databases
(MEDLINE, EMBASE, Web of Science, Scopus, CDSR) and online sources (12 guideline databases
and 51 professional society websites) from January 2017 to June 2020. Data were extracted in duplicate
assessing overall quality using AGREE II (% of maximum score) and reporting compliance using RIGHT (%
of total 35 items); reviewer agreement was 98% and 96% respectively.
Results: There were 59 relevant guidance documents (43 CPGs, 16 CSs), of which 20 used systematic
reviews for evidence synthesis. The median overall quality was 54.0% (IQR 35.9e74.3) and the median
overall reporting compliance was 60.9% (IQR 44.5e84.4). The correlation between quality and reporting
was 0.9. Compared to CSs, CPGs had better quality (55.4% vs 44.2%; p ¼ 0.032) and reporting (67.18% vs
44.5%; p ¼ 0.005). Compared to subjective methods of evidence analysis, guidance documents that used
systematic reviews had better quality (76.3% vs 51.4%; p ¼ 0.001) and reporting (87.1% vs 59.4%;
p ¼ 0.001).
Conclusion: The quality and reporting of CPGs and CSs in BC treatment were moderately strong. Systematic
reviews should be used to improve the quality and reporting of CPGs and CSs.Beatriz Galindo (senor modality) Program by the Ministry of Science, Innovation, and Universities of the Spanish Governmen
Low dose rate brachytherapy (LDR-BT) as monotherapy for early stage prostate cancer in Italy: practice and outcome analysis in a series of 2237 patients from 11 institutions
OBJECTIVE:
Low-dose-rate brachytherapy (LDR-BT) in localized prostate cancer is available since 15 years in Italy. We realized the first national multicentre and multidisciplinary data collection to evaluate LDR-BT practice, given as monotherapy, and outcome in terms of biochemical failure.
METHODS:
Between May 1998 and December 2011, 2237 patients with early-stage prostate cancer from 11 Italian community and academic hospitals were treated with iodine-125 ((125)I) or palladium-103 LDR-BT as monotherapy and followed up for at least 2 years. (125)I seeds were implanted in 97.7% of the patients: the mean dose received by 90% of target volume was 145 Gy; the mean target volume receiving 100% of prescribed dose (V100) was 91.1%. Biochemical failure-free survival (BFFS), disease-specific survival (DSS) and overall survival (OS) were estimated using Kaplan-Meier method. Log-rank test and multivariable Cox regression were used to evaluate the relationship of covariates with outcomes.
RESULTS:
Median follow-up time was 65 months. 5- and 7-year DSS, OS and BFFS were 99 and 98%, 94 and 89%, and 92 and 88%, respectively. At multivariate analysis, the National Comprehensive Cancer Network score (p < 0.0001) and V100 (p = 0.09) were correlated with BFFS, with V100 effect significantly different between patients at low risk and those at intermediate/high risk (p = 0.04). Short follow-up and lack of toxicity data represent the main limitations for a global evaluation of LDR-BT.
CONCLUSION:
This first multicentre Italian report confirms LDR-BT as an excellent curative modality for low-/intermediate-risk prostate cancer.
ADVANCES IN KNOWLEDGE:
Multidisciplinary teams may help to select adequately patients to be treated with brachytherapy, with a direct impact on the implant quality and, possibly, on outcome
Intronic ATTTC repeat expansions in STARD7 in familial adult myoclonic epilepsy linked to chromosome 2
Familial Adult Myoclonic Epilepsy (FAME) is characterised by cortical myoclonic tremor
usually from the second decade of life and overt myoclonic or generalised tonic-clonic seizures.
Four independent loci have been implicated in FAME on chromosomes (chr) 2, 3, 5
and 8. Using whole genome sequencing and repeat primed PCR, we provide evidence that
chr2-linked FAME (FAME2) is caused by an expansion of an ATTTC pentamer within the first
intron of STARD7. The ATTTC expansions segregate in 158/158 individuals typically affected
by FAME from 22 pedigrees including 16 previously reported families recruited worldwide.
RNA sequencing from patient derived fibroblasts shows no accumulation of the AUUUU or
AUUUC repeat sequences and STARD7 gene expression is not affected. These data, in
combination with other genes bearing similar mutations that have been implicated in FAME,
suggest ATTTC expansions may cause this disorder, irrespective of the genomic locus
involvedSupplementary Information:
Supplementary Data 1;
Supplementary Data 2;
Reporting Summary.NHMRC;
Women’s and Children’s Hospital Research Foundation;
Muir Maxwell Trust;
Epilepsy Society;
The European Fund for Regional Development;
The province of Friesland, Dystonia Medical Research Foundation;
Stichting Wetenschapsfonds Dystonie Vereniging;
Fonds Psychische Gezondheid;
Phelps Stichting;
The Italian Ministry of Health;
Istituto Superiore di Sanità, Italy;
Undiagnosed Disease Network Italy;
The Fondation maladies rares, University Hospital Essen and
UK Department of Health’s NIHR.https://www.nature.com/ncommspm2020Neurolog
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Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
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Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
The original version of this article unfortunately contained a mistake
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