Problems and Prospects of Internal Diseases Course Teaching in Clinical General Practice Residency

The article studies graduate medical education in clinical general practice residenc

Formation of Millisecond Pulsars in Globular Clusters

In this contribution we discuss how neutron stars are produced and retained in globular clusters, outlining the most important dynamical channels and evolutionary events that affect thepopulation of mass-transferring binaries with neutron stars and result in the formation of recycled pulsars. We confirm the importance of electron-capture supernovae in globular clusters as the major supplier of retained neutron stars.By comparing the observed millisecond pulsar population and the results obtained from simulations, we discuss several constraints on the evolution of mass-transferring systems.In particular, we find that in our cluster model the following mass-gaining events create populations of MSPs that do not match the observations (with respect to binary periods and companion masses or the number of produced systems) and therefore likely do not lead to NSs spun up to millisecond periods: (i) accretion during a common envelope event with a NS formed through accretion-induced collapse, and (ii) mass transfer from a WD donor. By restricting ourselves to the evolutionary and dynamical paths that most likely lead to neutron star recycling, we obtain good agreement between our models and the numbers and characteristics of observed millisecond pulsars in the clusters Terzan 5 and 47 Tuc.Comment: 6 pages, 3 figures, to appear in the proceedings of the 40 Years of Pulsars conference held at McGill University in August 200

Methodological approach as a strategy for professional employees’ training in small and medium sized enterprises in Russia

In the era of rapid development and the emergence of new methods and ideas for the employees’ training in small and medium sized enterprises in Russia, managers need to think about the role that the methodological organization of the educational process, which refers, not only with respect to vocational training, but also in providing the methodological foundation for teaching certain disciplines in small and medium sized enterprises in Russia. The article describes the integrative-praxicological approach in the professional training of employees, it describes the principles and requirements as a methodological basis for the educational process

The main groups of adjuvants and the prospects of their use for the specific prevention of particularly dangerous and other infectious diseases

The purpose of this review is to analyze scientific data on the adjuvant properties of substances of various origin and chemical nature (adjuvants) published in recent decades and to evaluate the effectiveness of their use in the vaccination against various infections, including particularly dangerous ones. The analysis of the literature data available in PubMed, Web of Science, Scopus, eLibrary databases, indicates that the search for new substances and drugs with the ability to enhance the immune response to antigens that are part of antibacterial and antiviral registered vaccines, as well as experimental preventive drugs, is an important and promising direction. The use of various substances and compounds as adjuvants enhances the immunogenic and protective properties of vaccines, reduces the antigenic load on the human body and causes a tense immune response in individuals with reduced functioning of immune system and in the elderly. When choosing an adjuvant, it is necessary to take into account the direction of its action on the formation of both local and systemic specific immune response, depending on the nature of the pathogen

Characterization of Bacillus strains of marine origin

A total of twenty aerobic endospore-forming bacilli, isolated from marine invertebrates and sea water of different areas of the Pacific Ocean, were taxonomically characterized. Most of the bacilli (11 strains) of marine origin belonged to the species Bacillus subtilis, according to their phenotypic characteristics, antibiotic susceptibility profiles, and fatty acids patterns. A group of four alkaliphilic strains formed a separate cluster that was tentatively classified as B. horti. One isolate, KMM 1717, associated with a sponge from the Coral Sea was identified as B. pumilus. Two strains, Bacillus KMM 1916 and KMM 1918, showed antibiotic sensitivity profiles similar to B. licheniformis, but they had a distinct fatty acid composition and peculiar phenotypic traits. The taxonomic affiliation of KMM 1810 and KMM 1763 remained unclear since their fatty acid composition and antibiotic sensitivity patterns were not resembled with none of these obtained for Bacillus strains

Frequency of EGFR mutations in non-small cell lung cancer patients: screening data from West Siberia

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Metatranscriptomic Sequencing of a Cyanobacterial Soil-Surface Consortium with and without a Diverse Underlying Soil Microbiome.

Soil surface consortia are easily observed and sampled, allowing examination of their interactions with soil microbiomes. Here, we present metatranscriptomic sequences from Dark Green 1 (DG1), a cyanobacterium-based soil surface consortium, in the presence and absence of an underlying soil microbiome and/or urea

Синергетичний ефект як базовий елемент ділового адміністрування та результат ефективності персонального менеджменту в управлінні організацією

EN: The article focuses on modern aspects of achieving synergism in business administration and personnel management. The difference, the additional result obtained from such an interaction, is called a synergistic effect. Nowadays there is no a single definition of the phenomenon of synergism, although at the present stage there is a considerable interest in studying synergy and the factors provided. Interest is achieved due to the enterprises and organizations which got an additional result - a synergistic effect. UK: В статті розглянуті сучасні аспекти досягнення синергетизму в діловому адмініструванні та менеджменті персоналу. Розглянуто різновиди прояву синергитичного ефекту. Доведено значення синергитичного ефекту в адмініструванні персоналу підприємств

Dehydroepiandrosterone sulphate as a putative protective factor against tardive dyskinesia

AbstractBackgroundTardive dyskinesia (TD) is a potentially irreversible consequence of long term treatment with antipsychotic drugs which is according to a well-known theory believed to be related to oxidative stress induced neurotoxicity. Dehydroepiandrosterone (DHEA) is an endogenous antioxidant with neuroprotective activity. The biosynthesis of DHEA depends upon the activity of cytochrome P450c17α (CYP17). The gene that encodes for CYP17 has a (T34C) single nucleotide polymorphism which enhances CYP17 transcription and expression.ObjectiveTo test the hypothesis that carriership of a more active CYP17 variant would result in higher DHEA(S) levels and protect against neurotoxicity which results in orofaciolingual TD (TDof), limb-truncal TD (TDlt) or both (TDsum).MethodTardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia.ResultsPatients who are carriers of the Cyp17 genotype CC have less chance of developing TD compared to patients who are carriers of the Cyp17 genotypes TC or TT (p<0.05). However, these carriers have significant lower circulating DHEAS levels compared to carriers of the Cyp17 genotypes TC and TT (p<0.05). Conversely, carriers of the CYP17 T-allele have significant elevated DHEAS levels. After correcting for gender and age no significant relationship between Cyp17 genotype CC, the T-allelle and the C-allele and the DHEAS concentration of patients was observed.ConclusionsAlthough an association between the CYP17 CC genotype and TD is indicated, our findings do not support the hypothesis that this is mediated through increased DHEA(S) levels. We believe that the relationship between this polymorphism and neuroprotective effects of steroids is more complex and cannot be elucidated without taking the posttranslational regulation of the enzyme into account

The Strength of Masonry Based on the Deformation Characteristics of Its Components

The chapter presents a new approach to determining the strength of masonry reinforced with transverse meshes in mortar joints. The method consists of using the values of the modulus of elasticity and limiting deformations of the stone material, mortar for joints, and both steel and composite reinforcements. An analytical notation is proposed that integrally takes into account the characteristics of the initial materials. The results of physical tests of centrally loaded masonry pillars reinforced with steel and composite meshes are given. To test the masonry, widely used materials were used: solid brick and cement-sand mortar. The values of the bearing capacity, deformations, and internal stresses of the masonry are obtained. It is determined that the stresses in the reinforcing bars of the meshes are unevenly distributed in the horizontal plane of the mortar joint and amount to 20–37% of the design resistance of the mesh material. The strength of masonry reinforced with composite meshes is 65–75% of steel of the same cross section. It is shown that there is a good convergence of test results with the presented analytical dependence