Adaptación de asignaturas seleccionadas de la titulación de Logopedia a créditos ETCS. Implicaciones del alumnado

Producción CientíficaSe presenta una primera experiencia práctica en el marco del proceso de Convergencia Europea de la enseñanza. El proyecto nace con el objetivo de adaptar asignaturas seleccionadas del actual plan de estudios de la Titulación (Diplomatura) de Logopedia al reciente “Sistema de Transferencia de Créditos Europeos” (créditos ECTS o European Credit Transfer System). Con este fin se crea una red de carácter nacional en la que participan la Universidad de Valladolid, Salamanca y Castilla-La Mancha. En la presente comunicación se explican de forma exhaustiva diversos aspectos relacionados con la elaboración del proyecto: selección de asignaturas, implicación de profesorado y alumnado, así como la programación de actividades y acciones que se están llevando a cabo actualmente

Prognosis assessment of early-stage chronic lymphocytic leukemia: Are we ready to predict clinical evolution without a crystal ball?

On behalf ofGrupo Español de Leucemia Linfática Crónica and Grupo Cooperativo Español de Citogenética Hematológica.[Background]: The discovery of new biologic variables with high prognostic effect has been accompanied by the emergence of different prognostic indexes (PIs) to assess the time to first treatment in patients with early-stage (Binet A) chronic lymphocytic leukemia (CLL). The present study compared the prognostic value of 5 PIs: CLL international prognostic index (CLL-IPI), Barcelona-Brno, international prognostic score-A (IPS-A), CLL-01, and a tailored approach.[Patients and Methods]: We applied the 5 PIs to a cohort of 428 unselected patients with Binet A CLL from a multicenter Spanish database with clinical and biologic information available. The predictive value of the scores was assessed using Harrell’s concordance index (C index) and area under the receiver operating characteristic curve (AUC).[Results]: We found a significant association between time to first treatment and risk subgroups for all 5 PIs used. The most accurate PI was the IPS-A (C-index, 0.72; AUC, 0.76), closely followed by CLL-01 (C-index, 0.69; AUC, 0.70), CLL-IPI (C-index, 0.69; AUC, 0.69), Barcelona-Brno (C-index, 0.67; AUC, 0.69), and the tailored approach (C-index, 0.61 and 0.58; AUC, 0.58 and 0.54).[Conclusions]: The concordance between the PIs was low (44%), suggesting that although all these PIs improve clinical staging and help physicians in routine clinical practice, it will be necessary to harmonize larger cohorts of patients to define the best PI for treatment decision-making in the real world.The present study was supported by the Spanish Fondo de Investigaciones Sanitarias (grants PI15/01471 and PI18/01500), Instituto de Salud Carlos III, European Regional Development Fund (Una manera de hacer Europa), Consejería de Educación, Junta de Castilla y León (grant SA271P18), Proyectos de Investigación del SACYL (grants GRS1847/A/18 and GRS1653/A17), Fundación Memoria Don Samuel Solórzano Barruso (grant FS/23-2018), Red Temática de Investigación Cooperativa en Cáncer (grant RD12/0036/0069), Centro de Investigación Biomédica en Red de Cáncer (grant CIBERONC CB16/12/00233), and Synthetic Lethality for Personalized Therapy-based Stratification in Acute Leukemia (grant ERAPERMED2018-275); and Instituto de Salud Carlos III (grant AC18/00093). M.H.S. holds a Sara Borrell postdoctoral contract (CD19/00222) from the Spanish Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, European Regional Development Fund (El Fondo Social Europeo invierte en tu future). A.E.R.V. is supported by a research grant from the Fundación Española de Hematología y Hemoterapia. M.Q.Á. is fully supported by the Ayuda predoctoral de la Junta de Castilla y León from the Fondo Social Europeo (PhD scholarship JCYL EDU/529/2017). C.P.C. is a recipient of a PFIS grant (FI19/00191) from Instituto de Salud Carlos III, cofounded by Fondo Social Europeo (El Fondo Social Europeo invierte en tu future).Peer reviewe

Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia

[EN]Background: In B-cell precursor acute lymphoblastic leukaemia (B-ALL), the identification of additional genetic alterations associated with poor prognosis is still of importance. We determined the frequency and prognostic impact of somatic mutations in children and adult cases with B-ALL treated with Spanish PETHEMA and SEHOP protocols. Methods: Mutational status of hotspot regions of TP53, JAK2, PAX5, LEF1, CRLF2 and IL7R genes was determined by next-generation deep sequencing in 340 B-ALL patients (211 children and 129 adults). The associations between mutation status and clinicopathological features at the time of diagnosis, treatment outcome and survival were assessed. Univariate and multivariate survival analyses were performed to identify independent prognostic factors associated with overall survival (OS), event-free survival (EFS) and relapse rate (RR). Results: A mutation rate of 12.4% was identified. The frequency of adult mutations was higher (20.2% vs 7.6%, P=0.001). TP53 was the most frequently mutated gene (4.1%), followed by JAK2 (3.8%), CRLF2 (2.9%), PAX5 (2.4%), LEF1 (0.6%) and IL7R (0.3%). All mutations were observed in B-ALL without ETV6-RUNX1 (P=0.047) or BCR-ABL1 fusions (P<0.0001). In children, TP53mut was associated with lower OS (5-year OS: 50% vs 86%, P=0.002) and EFS rates (5-year EFS: 50% vs 78.3%, P=0.009) and higher RR (5-year RR: 33.3% vs 18.6% P=0.037), and was independently associated with higher RR (hazard ratio (HR)=4.5; P=0.04). In adults, TP53mut was associated with a lower OS (5-year OS: 0% vs 43.3%, P=0.019) and a higher RR (5-year RR: 100% vs 61.4%, P=0.029), whereas JAK2mut was associated with a lower EFS (5-year EFS: 0% vs 30.6%, P=0.035) and a higher RR (5-year RR: 100% vs 60.4%, P=0.002). TP53mut was an independent risk factor for shorter OS (HR=2.3; P=0.035) and, together with JAK2mut, also were independent markers of poor prognosis for RR (TP53mut: HR=5.9; P=0.027 and JAK2mut: HR=5.6; P=0.036). Conclusions: TP53mut and JAK2mut are potential biomarkers associated with poor prognosis in B-ALL patients.European Commision (EC). Funding FP7/SP1/HEALTH. Project Code: 30624

Genome-wide DNA copy number analysis of acute lymphoblastic leukemia identifies new genetic markers associated with clinical outcome

Altres ajuts: FUCALHH 2013; HUS272U13; GRS 994/A/14, BIO/SA10/14, BIO/SA31/13; Fundación Española de Hematología y Hemoterapia (FEHH), Universidad Pedagógica y Tecnológica de Colombia 223-2011Identifying additional genetic alterations associated with poor prognosis in acute lymphoblastic leukemia (ALL) is still a challenge. Aims: To characterize the presence of additional DNA copy number alterations (CNAs) in children and adults with ALL by whole-genome oligonucleotide array (aCGH) analysis, and to identify their associations with clinical features and outcome. Array-CGH was carried out in 265 newly diagnosed ALLs (142 children and 123 adults). The NimbleGen CGH 12x135K array (Roche) was used to analyze genetic gains and losses. CNAs were analyzed with GISTIC and aCGHweb software. Clinical and biological variables were analyzed. Three of the patients showed chromothripsis (cth6, cth14q and cth15q). CNAs were associated with age, phenotype, genetic subtype and overall survival (OS). In the whole cohort of children, the losses on 14q32.33 (p = 0.019) and 15q13.2 (p = 0.04) were related to shorter OS. In the group of children without good- or poor-risk cytogenetics, the gain on 1p36.11 was a prognostic marker independently associated with shorter OS. In adults, the gains on 19q13.2 (p = 0.001) and Xp21.1 (p = 0.029), and the loss of 17p (p = 0.014) were independent markers of poor prognosis with respect to OS. In summary, CNAs are frequent in ALL and are associated with clinical parameters and survival. Genome-wide DNA copy number analysis allows the identification of genetic markers that predict clinical outcome, suggesting that detection of these genetic lesions will be useful in the management of patients newly diagnosed with ALL

Supression of inflammatory responses by labdane-type diterpenoids

A series of 11 labdane-type diterpenoids (1-11) with various patterns of substitution were tested for potential anti-inflammatory activity. Of these compounds, 4 and 11 were selected to evaluate their influence on targets relevant to the regulation of the inflammatory response. These diterpenoids reduced the production of nitric oxide (NO), prostaglandin E2, and tumor necrosis factor-α in LPS-activated RAW 264.7 macrophages, with IC50 in the range 1-10 μM. Inhibition of these inflammatory mediators was related to inhibition of the expression of nitric oxide synthase-2 (NOS-2) and cyclooxygenase-2 (COX-2) at the transcriptional level, as determined by western-blot and RT-PCR. Examination of the effects of these diterpenoids on nuclear factor κB signaling showed that both compounds inhibit the phosphorylation of IκBα and IκBβ, preventing their degradation and the nuclear translocation of the NF-κB p65 subunit. Inhibition of IKK activity was also observed. These derivatives displayed significant anti-inflammatory activity in vivo, suppressing mouse ear edema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and inhibiting myeloperoxidase activity, an index of neutrophil infiltration. The anti-inflammatory effects of these labdane diterpenoids, together with their low cell toxicity, suggest potential therapeutic applications in the regulation of the inflammatory response. © 2007 Elsevier Inc. All rights reserved.Peer Reviewe

Aged Garlic Extract Improves Adiponectin Levels in Subjects with Metabolic Syndrome: A Double-Blind, Placebo-Controlled, Randomized, Crossover Study

Background. Garlic (Allium sativum) has been shown to have important benefits in individuals at high cardiovascular risk. The aim of the present study was to evaluate the effects of the administration of aged garlic extract (AGE) on the risk factors that constitute the cluster of metabolic syndrome (MS). Methods and Design. Double-blind, crossover, randomized, placebo-controlled clinical trial to assess the effect of 1.2 g/day of AGE (Kyolic), for 24 weeks of treatment (12 weeks of AGE and 12 weeks of placebo), on subjects with MS. Results. The administration of AGE increased the plasma levels of adiponectin (). No serious side effects associated with the intervention were reported. Conclusion. The present results have shown for the first time that the administration of AGE for 12 weeks increased plasma adiponectin levels in patients with MS. This suggests that AGE might be a useful, novel, nonpharmacological therapeutic intervention to increase adiponectin and to prevent cardiovascular (CV) complications in individuals with MS

Documentación presentada al premio de innovación docente del Consejo Social de la Universidad de Valladolid, convocatoria de 2014-15

Se describe el proyecto de innovación docente Logopedia Prolingua, realizado durante los cursos académicos 2013-14 y 2014-15, que ha obtenido el accésit en la convocatoria de 2014-15 de los premios de innovación docente del Consejo Social de la Universidad de Valladolid. Se trata de un proyecto carácter multidisciplinar e interuniversitario (Universidades de Valladolid, Castilla-La Mancha y Granada), que tiene como objetivo principal la promoción, innovación e internacionalización de la logopedia. Se articula en 3 etapas (inicial, media y final) y 5 paquetes de trabajo (coordinación, idiomas, movilidad, institucional y publicaciones). El documento muestra los resultados obtenidos hasta la fecha en las distintas actividades realizadas. Las conclusiones son: 1. Las tecnologías de información y comunicación han favorecido la coordinación y resultados del proyecto. 2. Se está fomentando el uso de la terminología profesional en inglés y español entre los estudiantes de logopedia. 3. La participación de estudiantes y profesores de logopedia en programas de movilidad internacional es reducida, y puede estimularse con proyectos como Logopedia Prolingua. 4. La colaboración interuniversitaria resulta beneficiosa para la optimización de los recursos disponibles y el establecimiento de una línea de investigación en innovación docente en logopedia. 5. La proyección internacional de las universidades precisa un plan de colaboración con otras instituciones públicas o privadas.Titulación de LogopediaVéanse también las memorias de seguimiento y finales de dicho proyecto (cursos 2013-14 y 2014-15)

Adaptación de asignaturas seleccionadas de la titulación de Logopedia a Créditos ECTS : implicaciones del alumnado

Se presenta una experiencia práctica en el marco del proceso de convergencia europea de la enseñanza. El proyecto nace con el objetivo de adaptar algunas asignaturas del plan de estudios de la Titulación de Logopedia al reciente Sistema de Transferencia Créditos Europeos. Se crea una red interuniversiatria nacional formada por miembros de la Universidad de Valladolid que dirige y coordina el proyecto, la Universidad Pontificia de Salamanca y la Universidad de Castilla La Mancha. Se desarrollan reuniones informativas con los alumnos, a los que se les realizan encuestas para delimitar los contenidos y competencias de las asignaturas. Se realizan intercambios de experiencias docentes entre los docentes de las diferentes Universidades participantes. Se fomenta la cooperación entre el profesorado y el alumnado, arrojando resultados positivos su interacción.Castilla y LeónConsejería de Educación. Dirección General de Universidades e Investigación; Monasterio de Nuestra Señora de Prado, Autovía Puente Colgante s. n.; 47071 Valladolid; +34983411881; +34983411939;ES

Red interuniversitaria de diplomaturas de Logopedia: experiencia y resultados durante dos cursos académicos

Producción CientíficaA partir de la experiencia del trabajo común en el Libro Blanco del Título de Grado en Logopedia (2004), se constituye en julio de 2004 la red interuniversitaria de profesoras de las Diplomaturas de Logopedia de las Universidades de Valladolid (UVa), Pontificia de Salamanca (UPS) y Castilla-La Mancha (UCLM), integrada en el curso 2004/2005 por 8 miembros y en 2005/2006 por 11. Durante ambos cursos académicos, la red lleva a cabo el proyecto: Adaptación de asignaturas seleccionadas de la titulación de Logopedia a créditos ECTS. Implicaciones del alumnado. [Texto extraído del artículo de María de las Nieves Mendizábal de la Cruz]