Trace elements disturbance and Liver toxicity in Sudanese Fuel Stations Workers

Abstract: Workers in benzene stations are more susceptible to hepatotoxicity. This study was aimed to assess serum levels of trace elements and liver enzymes activity as indicator of hepatotoxicity in benzene station workers. In a matched case control study conducted in Khartoum State -Sudan during the period from October 2015 to January 2016. After signing written informed consent blood specimen was collected from 50 individual working in petrol station as case group and 20 healthy individuals not working in petrol station as control group aged from (20-50) years and serum levels of AST,ALT.GGT activity and Copper and Zink was measured using spectrophotometrical and atomic absorption methods. Data were collected using structural questionnaire. Data analysis was carried out by means of statistical package for social science (SPSS version 16). The mean level of Copper and Zinc was significantly decreased in comparison with control group (p < .05). There was no significant correlation of serum level of trace elements zinc and copper with duration, BMI, AST, ALT, and GGT activities. Working in petrol station is associated with decreased level of copper and Zink however the disturbance in these trace elements dose not correlated with abnormalities in liver enzymes

Assessment of the Role of the Anti-Mullerian Hormone, Luteinizing Hormone/Follicle Stimulating Hormone Ratio in the Diagnosis of Polycystic Ovary Syndrome in Sudanese Women

BACKGROUND: The diagnosis of polycystic ovary syndrome (PCOS) is not an easy procedure, as the signs and symptoms are heterogeneous and of undefined aetiology.AIM: This study is aimed to evaluate serum anti-Mullerian hormone (AMH) level and luteinizing hormone (LH)/folic stimulating hormone (FSH) ratio in women with PCOS in Sudan and to assess the diagnostic efficiency for the diagnosis of PCOS.METHODS: In a case-control study, Serum AMH, LH, FSH was measured in the early follicular phase from Sudanese patients (N = 230) with PCOS and100 controls. The LH/FSH ratio was calculated, and its diagnostic power was evaluated by receiver operating characteristic curves.RESULTS: The means of serum AMH, serum LH level and LH/FSH ratio of the test, were significantly increased in the test group compared to the control group (P-value < 0.000). The AMH sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) were found to be 83%, 99%, 99%, and 72% respectively. Serum AMH was considered adequate measures for the diagnosis of PCOS; its level showed an area under the ROC curve of 0.98 (95% confidence, P-value < 0.000). The best compromise between 98% specificity and 90% sensitivity was obtained with a cut-off value of 3.3 ng/mL for PCOS diagnosis. There was no correlation between age, body mass index (BMI) and AMH level in the test group.CONCLUSIONS: The Serum AMH level and LH/FSH ratio were higher in patients than in control. However AMH level has better discriminative power and good diagnostic potency for the diagnosis of the PCOS among Sudanese women

Assessment of Iron Overload and its Effect on Liver Function Tests (ALT, AST) in Multiple Blood Transfusion Sudanese Pediatrics Patients

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Effect of Anti-Psychotic Drugs on Lipid and Prolactin Level among Sudanese patients

A psychiatric medication is a licensed psychoactive drug taken to exert an effect on the chemical makeup of the brain and nervous system. Thus, these medications are used to treat mental disorders. The aim of the current study was to determine the effect of anti-Psychotic drugs on lipid and prolactin level among Sudanese psychotic patients. This cross-sectiona