Bioclimatic buildings strategies for the climate of Araras city, São Paulo - Brazil

The concept of bioclimatic architecture or passive solar architecture can be defined as an architecture that includes the climate as an important variable in the design process. Through the use of bioclimatic strategies the environment comfort can be obtained naturally for users of buildings, which depending on the climate, the construction techniques and the type of use. Considering these aspects, the main objective of this work is to identify bioclimatic strategies for buildings for the climate of Araras city, countryside of São Paulo State - Brazil, based on climatic characterization of the city and in the study of design guidelines indicated by the Brazilian Code NBR 15220-3, the Brazilian Bioclimatic Zoning. According to the code, the climate of Araras is inserted in Bioclimatic Zone 4. For this climate the main indicated strategies for winter are the use of solar passive heating and massive internal walls in buildings. For summer, the use of evaporative cooling and ventilation are indicated. Based on this information were established initial guidelines for thermal comfort and energy efficiency for projects of buildings in the climate of Araras-SP

Effect of MK-801 and clozapine on the proteome of cultured human oligodendrocytes

Separate lines of evidence have demonstrated the involvement of N-methyl-D-aspartate (NMDA) receptor and oligodendrocyte dysfunctions in schizophrenia. Here, we have carried out shotgun mass spectrometry proteome analysis of oligodendrocytes treated with the NMDA receptor antagonist MK-801 to gain potential insights into these effects at the molecular level. The MK-801 treatment led to alterations in the levels of 68 proteins, which are associated with seven distinct biological processes. Most of these proteins are involved in energy metabolism and many have been found to be dysregulated in previous proteomic studies of post-mortem brain tissues from schizophrenia patients. Finally, addition of the antipsychotic clozapine to MK-801-treated oligodendrocyte cultures resulted in changes in the levels of 45 proteins and treatment with clozapine alone altered 122 proteins and many of these showed opposite changes to the MK-801 effects. Therefore, these proteins and the associated energy metabolism pathways should be explored as potential biomarkers of antipsychotic efficacy. In conclusion, MK-801 treatment of oligodendrocytes may provide a useful model for testing the efficacy of novel treatment approaches10CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP460289/2014-413/08711-3; 14/21035-0; 14/14881-1; 14/10068-

Information management in the Brazil and Argentina journals: an analysis of the last decade

Percibir cómo la gestión de la información está siendo trabajada por las revistas del área auxilia tanto en el crecimiento de la propia área, así como en la de los profesionales que en ella actúan. El objetivo general de esta comunicación fue realizar un análisis minucioso de los artículos de las revistas con estrato Qualis Capes A1, A2 y B1 del área de Comunicación e información, direccionados para la temática de la Gestión de la Información, de Brasil y de Argentina. Con relación a los objetivos específicos, se buscó identificar cuáles son las revistas que más publicaron artículos en la temática; descubrir en qué año hubo un mayor número de publicaciones; conocer quiénes son los autores más productivos; encasillar las palabras-clave más empleadas en los artículos; averiguar los procedimientos metodológicos utilizados y la manera como los textos recuperados están discutiendo la temática gestión de la información, así como sus modelos en estos contextos. En cuanto a la metodología, el artículo es de naturaleza exploratoria con abordaje tanto cualitativa como cuantitativa, a partir de una revisión bibliográfica sobre los temas información y competitividad; gestión de la información; modelos de gestión de la información y, posteriormente, un estudio bibliométrico realizado en los artículos de revistas brasileñas y argentinas en el período de enero de 2007 a enero de 2017. Como resultado, se demuestra que hay una producción considerable sobre la temática, y que se mantiene con el transcurrir de los años. Se considera que existe un interés de los investigadores en cuanto a la importancia de la gestión de la información para el área disciplinar.Understanding how information management is being handled by the area's journals assists both in the growth of the area itself and in the professionals who work in it. Therefore, the general objective of this communication was to carry out a detailed analysis of the articles of the journals with Qualis Capes A1, A2 and B1 strata of the Communication and Information area, addressed to the Information Management, Brazil and Argentina. With regard to the specific objectives, we tried to identify which are the periodicals that most published articles in the theme; Discover in which year there were more publications; Knowing who are the most productive authors; Listing the most commonly used keywords in the articles; To ascertain the methodological procedures used and the way the recovered texts are discussing the information management theme, as well as their models in these contexts. Regarding the methodology, the article is exploratory with a qualitative-quantitative approach based on a bibliographical review on the topics of information and competitiveness; information management; Information management models and, later, a bibliometric study carried out in the articles of Brazilian and Argentine periodicals from January 2007 to January 2017. As results, they show that there is considerable production on the subject and that it is being. Maintained over the years. it is considered that there is the interest of researchers in the importance of information management for the area.Dossier: Gestión de la información: dilemas y perspectivaFacultad de Humanidades y Ciencias de la Educació

CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis

Myelofibrosis (MF) is characterized by increased circulating hematopoietic progenitor cells (HPCs), abnormal cytokine levels, and the survival advantage of neoplastic progenitors over their normal counterparts, which leads to progressive disappearance of polyclonal hematopoiesis. CD47 is a surface glycoprotein with many functions, such as acting as a phagocytosis inhibitor of the expressing cell, that is increased in normal hematopoietic stem and progenitor cells mobilized into the blood and several human cancer-initiating cells, such as in acute myeloid leukemia. We compared CD47 expression in hematopoietic stem and progenitor cells of patients with MF and controls and found it to be decreased in progenitors of MF. Exposure of control HPCs to the cytokines transforming growth factor β and stromal-derived factor 1, which are important regulators of hematopoietic stem cell cycling and are overexpressed in patients with MF, did not modulate CD47 expression

Hydrogenated fat intake during pregnancy and lactation caused increase in TRAF-6 and reduced AdipoR1 in white adipose tissue, but not in muscle of 21 days old offspring rats

<p>Abstract</p> <p>Background</p> <p>Although lipids transfer through placenta is very limited, modification in dietary fatty acids can lead to implications in fetal and postnatal development. <it>Trans </it>fatty acid (TFA) intake during gestation and lactation have been reported to promote dyslipidemia and increase in pro- inflammatory adipokines in offspring. The aim of this study was to evaluate whether the alterations on pro-inflammatory cytokines and dyslipidemia observed previously in 21-d-old offspring of rats fed a diet containing hydrogenated vegetable fat during gestation and lactation were related to alterations in TLR-4, TRAF-6 and adipo-R1 receptor in white adipose tissue and muscle. On the first day of gestation, rats were randomly divided into two groups: (C) received a control diet, and (T) received a diet enriched with hydrogenated vegetable fat, rich in <it>trans </it>fatty acids. The diets were maintained throughout gestation and lactation. Each mother was given eight male pups. On the 21st day of life the offspring were killed. Blood, soleus and extensor digital longus (EDL) muscles, and retroperitoneal (RET) white adipose tissue were collected.</p> <p>Results</p> <p>21-d-old of T rats had higher serum triacylglycerols, cholesterol, and insulin. The Adipo R1 protein expression was lower in RET and higher in EDL of T group than C. TLR-4 protein content in all studied tissues were similar between groups, the same was verified in TRAF-6 protein expression in soleus and EDL. However, TRAF-6 protein expression in RET was higher in T than C.</p> <p>Conclusion</p> <p>These results demonstrated that maternal ingestion of hydrogenated vegetable fat rich in TFAs during gestation and lactation decrease in Adipo R1 protein expression and increase in TRAF-6 protein expression in retroperitoneal adipose tissue, but not in skeletal muscle, which could contributed for hyperinsulinemia and dyslipidemia observed in their 21-d-old offspring.</p

Dermoscopic and reflectance confocal microscopy findings in extra-genital hpv16-associated pigmented squamous cell carcinoma in situ

Cutaneous Oncology Department AC Camargo Cancer Center, Rua Professor Antonio Prudente, 211, São Paulo, BrazilPathology Department, AC Camargo Cancer Center, Rua Professor Antonio Prudente, 211, São Paulo, BrazilDepartment of Dermatology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelDermatology Department, Federal University of São Paulo, São Paulo, BrazilDermatology Department, Federal University of São Paulo, São Paulo, BrazilWeb of Scienc

Análise proteômica do secretoma obtido a partir do meio da cultura de células de pacientes com esquizofrenia e controle

A esquizofrenia é uma doença psiquiátrica complexa, sendo influenciada por fatores genéticos e ambientais. Sendo que os sintomas podem ser organizados 3 classes principais de sintomas:positivos, negativos e cognitivos. O principal meio de tratamento da esquizofrenia são as drogas antipsicóticas, utilizadas geralmente na fase aguda da doença para aliviar principalmente os sintomas positivos. O proteoma corresponde ao conjunto de proteínas expressas em um indivíduo em determinadas condições fisiológicas, sendo possível através da análise proteômica identificar proteínas e relacioná-las com a vias metabólicas em que elas atuam. Este estudo analisou o proteoma do secretoma obtido a partir do meio de cultura de células progenitoras neurais de pacientes com esquizofrenia, comparando com o controle. A fim de identificar possíveis proteínas diferentemente expressas, bem como vias metabólicas, que possam estar relacionadas com a fisiopatologia da esquizofreniaFil: Gouvêa-Junqueira, Danielle. Universidade Estadual de Campinas (Brasil).Fil: Martins-de-Souza, Daniel . Universidade Estadual de Campinas (Brasil).Fil: Zuccoli, Giuliana S.. Universidade Estadual de Campinas (Brasil).Fil: Nascimento, Juliana M.. Universidade Estadual de Campinas (Brasil)

Extensive Cryptic Diversity Within the Physalaemus cuvieri - Physalaemus ephippifer Species Complex (Amphibia, Anura) Revealed by Cytogenetic, Mitochondrial, and Genomic Markers

Previous cytogenetic and phylogenetic analyses showed a high variability in the frog taxa Physalaemus cuvieri and Physalaemus ephippifer and suggested the presence of undescribed diversity in this species complex. Here, by 1) adding specimens from the Brazilian Amazon region, 2) employing sequence-based species delimitation approaches, and 3) including RADseq-style markers, we demonstrate that the diversity in the P. cuvieri–P. ephippifer species complex is even greater than previously suspected. Specimens from Viruá and Western Pará, located at the Guiana Amazonian area of endemism, were recovered as distinct from all previously identified lineages by the phylogenetic analyses based on mitochondrial DNA and RAD markers, a PCA from RAD data, and cytogenetic analysis. The sequence-based species delimitation analyses supported the recognition of one or two undescribed species among these Amazonian specimens and also supported the recognition of at least three other species in the P. cuvieri–P. ephippifer species complex. These new results reinforce the need for a comprehensive taxonomic revision.Fil: Nascimento, Juliana. Universidade Estadual de Campinas. Instituto de Biología; BrasilFil: Lima, Jucivaldo D.. Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá; BrasilFil: Suarez, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; ArgentinaFil: Baldo, Juan Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; ArgentinaFil: Andrade, Gilda V.. Universidade Federal Do Maranhao.; BrasilFil: Pierson, Todd W.. University of Tennessee; Estados UnidosFil: Fitzpatrick, Benjamin M.. University of Tennessee; Estados UnidosFil: Baptista Haddad, Célio Fernando. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Recco Pimentel, Shirlei M.. Universidade Estadual de Campinas. Instituto de Biología; BrasilFil: Lourenço, Luciana B.. Universidade Estadual de Campinas. Instituto de Biología; Brasi

Access to medicines in the Brazilian Unified Health System's primary health care : assessment of a public policy

In 2008, the Programa Rede Farmácia de Minas (RFM, literally translated: ‘Minas Gerais Pharmacy Network’ program) was created as a strategy to expand access to medicines. Aim: Measure access to medicines in public pharmacies through comparison between municipalities that joined or not the RFM. Materials & methods: Cross-sectional, evaluative study, gathering information from a representative sample of the municipalities in Minas Gerais between July 2014 and May 2015. The Poisson regression results were obtained by calculating the prevalence ratios. Results: Adequate access to medicines in Minas Gerais was 69.9%, being 75.8% in municipalities with and 69.2% without the RFM. The municipalities with the RFM showed statistically higher percentages in the Availability, Adequacy/Accommodation, and Acceptability dimensions. Conclusion: RFM appears an efficient strategy for promoting access to medicines

Strategies to improve the availability of medicines in primary health care in Brazil : findings and implications

Aim: Access to essential medicines is a key component of managing patients in ambulatory care. In 2008, the State of Minas Gerais, Brazil, created the Pharmacy Network of Minas (Rede Farmácia de Minas [RFM]) program to improve access to medicines, increasing availability and restructuring the infrastructures. The aim was to assess the current situation, comparing municipalities with and without RFM. Materials & methods: Descriptive survey study, data collected from 2014 July to May 2015. Availability was verified by stock levels. Results: The drug availability index was 61.0%, higher in municipalities with RFM. Most physicians considered the pharmaceutical services as good/very good. The main reasons for medicines shortage were ‘financial transference problems’, ‘insufficient financial resources’ and ‘budget’. Conclusion: Strategies, such as the RFM can promote improvements in medicine availability