Has Affirmative Action Reached South African Women?

South Africa has unfortunately inherited a work environment based on an economic system characterised by deprivation, political instability, adversarial labour relations, cheap migrant labour, and massive income and wealth disparities. The world of work is also characterised by an appalling systematic discrimination against Blacks, women, and people with disabilities. Affirmative action has been the only policy instrument used by the Democratic South Africa to redress the past imbalances. In line with the Employment Equity Act No. 55 of 1998, the beneficiaries of this action are mainly African women (Blacks, Coloured, and Indians including disabled people). This has been justified by the fact that they were subjected to innumerable forms of discrimination and bias in the past. The policies of Affirmative Action are a system of political tools used to level the playing field. They focus on policies and strategies needed to redress past racial imbalances in the workplace, education, gender equality, and the like. This paper examines the strategy of Affirmative Action in South Africa harnessed to redress past wrongs and its effectiveness in so doing

Comparative metabolism as a key driver of wildlife species sensitivity to human and veterinary pharmaceuticals

Human and veterinary drug development addresses absorption, distribution, metabolism, elimination and toxicology (ADMET) of the Active Pharmaceutical Ingredient (API) in the target species. Metabolism is an important factor in controlling circulating plasma and target tissue API concentrations and in generating metabolites which are more easily eliminated in bile, faeces and urine. The essential purpose of xenobiotic metabolism is to convert lipid-soluble, non-polar and non-excretable chemicals into water soluble, polar molecules that are readily excreted. Xenobiotic metabolism is classified into Phase I enzymatic reactions (which add or expose reactive functional groups on xenobiotic molecules), Phase II reactions (resulting in xenobiotic conjugation with large water-soluble, polar molecules) and Phase III cellular efflux transport processes. The human-fish plasma model provides a useful approach to understanding the pharmacokinetics of APIs (e.g. diclofenac, ibuprofen and propranolol) in freshwater fish, where gill and liver metabolism of APIs have been shown to be of importance. By contrast, wildlife species with low metabolic competency may exhibit zero-order metabolic (pharmacokinetic) profiles and thus high API toxicity, as in the case of diclofenac and the dramatic decline of vulture populations across the Indian subcontinent. A similar threat looms for African Cape Griffon vultures exposed to ketoprofen and meloxicam, recent studies indicating toxicity relates to zero-order metabolism (suggesting P450 Phase I enzyme system or Phase II glucuronidation deficiencies). While all aspects of ADMET are important in toxicity evaluations, these observations demonstrate the importance of methods for predicting API comparative metabolism as a central part of environmental risk assessment

Acceleration of Diffusional Jumps of Interstitial Fe with Increasing Ge Concentration in Si1 − x Ge x Alloys Observed by Mössbauer Spectroscopy

Radioactive 57Mn isotopes have been implanted into Si1 − x Ge x crystals (x ≤ 0.1) at elevated temperatures for Mössbauer studies of the diffusion of interstitial 57Fe daughter atoms. The atomic jump frequency is found to increase upon Ge alloying. This is attributed to a lowering of the activation energy, i.e. the saddle point energy at hexagonal interstitial sites with Ge neighbour atom

Service Learning and Community Engagement: A Comparison of Three National Contexts

One of the presumptions of a well-functioning, viable democracy is that citizens participate in the life of their communities and nation. The role of higher education in forming actively engaged citizens has long been the focus of scholarly research, but recently an active debate has emerged concerning the role of service as a third core function of institutions of higher learning. Service learning (SL), a teaching approach that extends student learning beyond the classroom, is increasingly seen as a vehicle to realize this third core function. By aligning educational objectives with community partners’ needs, community service is meant to enhance, among other objectives, reciprocal learning. Although the term and its associated activities originated in the United States (US), theoretical debates linking civic engagement and education extend far beyond the US context. Nevertheless, research on SL as a distinctive pedagogical approach remains a nascent field. A significant gap exists in the literature about what this pedagogical approach seeks to achieve (in nature and in outcomes) and how it is construed in non-western contexts. Using a comparative analysis across three widely different contexts, this article explores the extent to which these differences are merely differences in degree or whether the differences are substantive enough to demand qualitatively different models for strengthening the relationship between higher education and civil society

Safeguarding children in dentistry: 1. Child protection training, experience and practice of dental professionals with an interest in paediatric dentistry

* Few dental professionals with child protection training have experience of making referrals. * There is a wide gap in practice between recognising signs of child abuse and neglect and responding effectively. * This may indicate missed opportunities to save children from continuing abuse. * There is a need for improved child protection information, support and training for dental professionals. Abstract Following several highly publicised inquiries into the deaths of children from abuse and neglect, there has been much recent interest in the role and responsibility of all health professionals to protect children at risk of maltreatment. The findings of a postal questionnaire, sent in March 2005 to 789 dentists and dental care professionals with an interest in paediatric dentistry working in varied settings in the UK, are presented in a two-part report and discussed in the context of current multi-agency good practice in safeguarding and promoting the welfare of children. This first part explores reported child protection training, experience and practice. There was a significant gap between recognising signs of abuse and responding effectively: 67% of respondents had suspected abuse or neglect of a child patient at some time in their career but only 29% had ever made a child protection referral. The dental profession is alerted to the need to ensure necessary appropriate action to safeguard children is always taken when child abuse or neglect are suspected

Promoting the well-being of higher education: Re-engineering of transnational nursing education

Internationalization of nursing education has become a priority of academic institutions’ strategic plans and visions allowing for greater autonomy and inter-connectedness of the nursing profession.  South African universities have, in recent years, engaged in international partnerships, influencing the delivery and facilitation of transnational nursing education (TNE) or cross-border nursing education, involving the steady increase of international student enrolment, particularly from other African nations. Whilst, much has been written about international partnerships relevant to other forms of higher education, minimal research has been done and reported on for cross-border nursing education and partnerships. This provided the rationale for this study to examine and explore TNE challenges by using actual participant examples and experiences. Using a qualitative, multiple case-study approach to sample local, national and international nursing education institutions, academic leaders and nurse graduates, the study attempted to identify challenges and best operating practices in TNE implementation and facilitation. The study aimed to highlight regulatory, administrative and quality assurance factors that challenged TNE’s successful delivery and findings revealed that these programmes are still challenged alluding to it being a ‘for profit’ arrangement. The study, further concluded that, for international students to adapt academically and socially and be in a position to fulfil the requirements of their respective academic programmes, a culturally and socially inclusive teaching and learning environment needed to be provided. This will ensure that the standard of the programme remained consistently high and globally competitive increasing the credibility of the educational institution and the country’s higher education system

Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor

Background: Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited. Methods: We treated glioma cell lines, LN-229 and SW1088, and melanoma cell lines, A375 and WM35, with two endothelin receptor type B (ETRB)-specific antagonists, A-192621 and BQ788, and quantified viable cells by the capacity of their intracellular esterases to convert non-fluorescent calcein AM into green-fluorescent calcein. We assessed cell proliferation by labeling cells with carboxyfluorescein diacetate succinimidyl ester and quantifying the fluorescence by FACS analysis. We also examined the cell cycle status using BrdU/propidium iodide double staining and FACS analysis. We evaluated changes in gene expression by microarray analysis following treatment with A-192621 in glioma cells. We examined the role of ETRB by reducing its expression level using small interfering RNA (siRNA). Results: We report that two ETRB-specific antagonists, A-192621 and BQ788, reduce the number of viable cells in two glioma cell lines in a dose- and time-dependent manner. We describe similar results for two melanoma cell lines. The more potent of the two antagonists, A-192621, decreases the mean number of cell divisions at least in part by inducing a G2/M arrest and apoptosis. Microarray analysis of the effects of A-192621 treatment reveals up-regulation of several DNA damage-inducible genes. These results were confirmed by real-time RT-PCR. Importantly, reducing expression of ETRB with siRNAs does not abrogate the effects of either A-192621 or BQ788 in glioma or melanoma cells. Furthermore, BQ123, an endothelin receptor type A (ETRA)-specific antagonist, has no effect on cell viability in any of these cell lines, indicating that the ETRB-independent effects on cell viability exhibited by A-192621 and BQ788 are not a result of ETRA inhibition. Conclusion: While ETRB antagonists reduce the viability of glioma cells in vitro, it appears unlikely that this effect is mediated by ETRB inhibition or cross-reaction with ETRA. Instead, we present evidence that A-192621 affects glioma and melanoma viability by activating stress/DNA damage response pathways, which leads to cell cycle arrest and apoptosis. This is the first evidence linking ETRB antagonist treatment to enhanced expression of DNA damage-inducible genes

Railton Community Assessment Project

A collaborative project between Railton Foundation and Stellenbosch University.This booklet is about sharing our process with other people so that they may be able to do the same in other communities. We have realised how valuable this kind of research is in the process of community development and we would like to help share our experiences of collaborative and community participative research. We hope that this handbook will serve as a guideline for any community leader, teacher or researcher who would like to undertake similar research projects. We realise that there are other ways of doing this, but you may find it helpful to see how we went about the community assessment process. In this booklet we will be providing background information that will help to create a context for doing this kind of research, and we will be outlining various steps in the process. To help bring life to this research process, we will give real lived experiences and examples from the Railton Community Assessment Project (CAP) team. Please consult the Railton Community Assessment Project Report for a comprehensive description of the research processes and findings referred to in this booklet. We hope this handbook is helpful to you and your community.Stellenbosch UniversityRailton FoundationPublishers' versio