Management of Online Tutorials: A Model for a Step-by-Step Approach

Online tutorials have great potential to reach a large population and to accommodate multiple learning styles anytime and anywhere. This paper describes the management of online tutorials and related concepts in detail. The review of literature method is used to study the variables. The variables under study include the mission, objectives, funding, manpower, in-house creation, outsourcing, incorporation in curriculum, content, type, technology, metadata, discovery services, script design, standards, assessment, professional training, marketing techniques and future goals for creation and management of online tutorials in libraries. A practical model based on literature study and the authors\u27 experience with online tutorials is designed and recommended for libraries for a step-by-step approach to planning and designing online tutorials for their library user population

The Evaluation of Use of Electronic Resources and Services in Academic Libraries: A Study of E-metrics and Related Methods for Measurement and Assessment

This paper presents a review of literature for the evaluation of use of electronic resources and services in Academic libraries. E-metrics and similar methods for evaluation are discussed in detail. The paper highlights how some libraries approached e-metrics to start useful evaluations and dealt with technicalities to achieve better decision making for e-collection, services and infrastructure for their library users. The evaluation of use of e-resources and services is discussed in five parts explaining application of e-metrics, different methods to capture usage data in different settings, types of data requirement by libraries, complexities and technicalities involved in measurement of usage statistics and why such evaluation is significant for libraries. A model is designed and highlighted and recommendations are given to initiate an evaluation and assessment plan which will lead to evidenced based and better decision making concerning electronic resources and service

Making Electronic Databases Functional on the Library Website: a Practical Approach

This paper presents a process on making electronic databases functional on the library website for on and off campus access for optimum use. It covers the steps after the price, license terms and conditions are finalized between library and vendor and the decision is made by library and subject experts to subscribe or purchase the database. The operational workflow steps can be challenging for new professionals when implementing it for the first time. The step by step approach provided in this paper is meant to help new professionals in strategic planning, organizing the structure and management of library databases provision, along with providing an operational workflow for successfully mounting electronic databases and open access electronic resources on the library website. The operational steps include gathering necessary access information from vendor, local branding, creating metadata, enhancing discovery and access points, setting up access authentication, updating link resolver service and journal portal, testing, anticipated maintenance and delivery of subscribed electronic database and open access electronic resources on the library website

Implementing excellence in diversity, equity, and inclusion in the library workforce: Tips to overcome challenges

Diversifying the library workforce is challenging, with the graduation data of library and information science degrees not representing equity in demographics for diverse populations. Is this the reason for the lack of diversity among library staff or are recruitment practices not based on measurable performance standards? Both questions call upon the library and information science (LIS) profession to address diverse staffing issues to remedy these challenges

Organic Learning in Undergraduate Library Instruction

Organic learning engages undergraduates in discovering new knowledge based on prior learning through variety of guided activities that stimulate inquiry-based learning and critical thinking in the research process. Some activities include searching, browsing, accessing, gathering, evaluating, assessing, reflecting, organizing, linking, and synthesizing.  Learning how to access information by using a variety of search strategies as well as delivery platforms such as Google, discovery, individual databases, and the internet can be overwhelming and challenging.  When students discover how to search and access desired sources through a variety of explicitly designed information literacy instructions with clearly defined learning outcomes, they take ownership of developing their learning and research skills. Through organic learning, they experience lightbulb moments, asking questions, discussing topics, and then searching again for more information.  Organic learning unconsciously involves students in self-education, engaging them in the research process without pressuring them to practice redundant, rote exercises. Often undergraduates encounter difficulty in conceptualizing the research process as complex and multi-faceted. The authors argue that organic learning strategies to activate prior learning that builds advanced searching skills and increase new scholarly knowledge.

Academic librarians serving diverse populations of multilingual students

A group of academic librarians working in community and four-year colleges, graduate programs and other settings present strategies and approaches for serving diverse multilingual populations. Multilingual students improve their awareness and understanding of United States academic libraries and higher education when librarians are cognizant of their needs. Encounters can occur at the research desk, in classroom instruction, and during research consultations. Also included are tips on how academic librarians can assist multilingual and international students, including how to improve communication. Based on an ACRL 2019 panel discussion of the same title

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease