Gravitational potential and X-ray luminosities of early-type galaxies observed with XMM-Newton and Chandra

We study dark matter content in early-type galaxies and investigate whether X-ray luminosities of early-type galaxies are determined by the surrounding gravitational potential. We derived gravitational mass profiles of 22 early-type galaxies observed with XMM-Newton and Chandra. Sixteen galaxies show constant or decreasing radial temperature profiles, and their X-ray luminosities are consistent with kinematical energy input from stellar mass loss. The temperature profiles of the other 6 galaxies increase with radius, and their X-ray luminosities are significantly higher. The integrated mass-to-light ratio of each galaxy is constant at that of stars within 0.5-1 r_e, and increases with radius, where r_e is the effective radius of a galaxy. The scatter of the central mass-to-light ratio of galaxies was less in K-band light. At 3r_e, the integrated mass-to-light ratios of galaxies with flat or decreasing temperature profiles are twice the value at 0.5r_e, where the stellar mass dominates, and at 6r_e, these increase to three times the value at 0.5r_e. This feature should reflect common dark and stellar mass distributions in early-type galaxies: Within 3r_e, the mass of dark matter is similar to the stellar mass, while within 6r_e, the former is larger than the latter by a factor of two. By contrast, X-ray luminous galaxies have higher gravitational mass in the outer regions than X-ray faint galaxies. We describe these X-ray luminous galaxies as the central objects of large potential structures; the presence or absence of this potential is the main source of the large scatter in the X-ray luminosity.Comment: 22 pages, 18 figures, 6 tables, accepted for publication in A&

Quadruple-peaked spectral line profiles as a tool to constrain gravitational potential of shell galaxies

Stellar shells observed in many giant elliptical and lenticular as well as a few spiral and dwarf galaxies, presumably result from galaxy mergers. Line-of-sight velocity distributions of the shells could, in principle, if measured with a sufficiently high S/N, constitute one of methods to constrain the gravitational potential of the host galaxy. Merrifield & Kuijken (1998) predicted a double-peaked line profile for stationary shells resulting from a nearly radial minor merger. In this paper, we aim at extending their analysis to a more realistic case of expanding shells, inherent to the merging process, whereas we assume the same type of merger and the same orbital geometry. We use analytical approach as well as test particle simulations to predict the line-of-sight velocity profile across the shell structure. Simulated line profiles are convolved with spectral PSFs to estimate the peak detectability. The resulting line-of-sight velocity distributions are more complex than previously predicted due to non-zero phase velocity of the shells. In principle, each of the Merrifield & Kuijken (1998) peaks splits into two, giving a quadruple-peaked line profile, which allows more precise determination of the potential of the host galaxy and, moreover, contains additional information. We find simple analytical expressions that connect the positions of the four peaks of the line profile and the mass distribution of the galaxy, namely the circular velocity at the given shell radius and the propagation velocity of the shell. The analytical expressions were applied to a test-particle simulation of a radial minor merger and the potential of the simulated host galaxy was successfully recovered. The shell kinematics can thus become an independent tool to determine the content and distribution of the dark matter in shell galaxies, up to ~100 kpc from the center of the host galaxy.Comment: 15 pages, 16 figures | v2: accepted for publication in A&A, minor language correction

Flowcharts for the diagnosis and treatment of acute cholangitis and cholecystitis: Tokyo Guidelines

Diagnostic and therapeutic strategies for acute biliary inflammation/ infection (acute cholangitis and acute cholecystitis), according to severity grade, have not yet been established in the world. Therefore we formulated flowcharts for the management of acute biliary inflammation/ infection in accordance with severity grade. For mild (grade I) acute cholangitis, medical treatment may be sufficient/appropriate. For moderate (grade II) acute cholangitis, early biliary drainage should be performed. For severe (grade III) acute cholangitis, appropriate organ support such as ventilatory/circulatory management is required. After hemodynamic stabilization is achieved, urgent endoscopic or percutaneous transhepatic biliary drainage should be performed. For patients with acute cholangitis of any grade of severity, treatment for the underlying etiology, including endoscopic, percutaneous, or surgical treatment should be performed after the patient's general condition has improved. For patients with mild (grade I) cholecystitis, early laparoscopic cholecystectomy is the preferred treatment. For patients with moderate (grade II) acute cholecystitis, early laparoscopic or open cholecystectomy is preferred. In patients with extensive local inflammation, elective cholecystectomy is recommended after initial management with percutaneous gallbladder drainage and/or cholecystostomy. For the patient with severe (grade III) acute cholecystitis, multiorgan support is a critical part of management. Biliary peritonitis due to perforation of the gallbladder is an indication for urgent cholecystectomy and/or drainage. Delayed elective cholecystectomy may be performed after initial treatment with gallbladder drainage and improvement of the patient's general medical condition. © Springer-Verlag Tokyo 2007.published_or_final_versio

Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment

The only curative treatment in biliary tract cancer is surgical treatment. Therefore, the suitability of curative resection should be investigated in the first place. In the presence of metastasis to the liver, lung, peritoneum, or distant lymph nodes, curative resection is not suitable. No definite consensus has been reached on local extension factors and curability. Measures of hepatic functional reserve in the jaundiced liver include future liver remnant volume and the indocyanine green (ICG) clearance test. Preoperative portal vein embolization may be considered in patients in whom right hepatectomy or more, or hepatectomy with a resection rate exceeding 50%–60% is planned. Postoperative complications and surgery-related mortality may be reduced with the use of portal vein embolization. Although hepatectomy and/or pancreaticoduodenectomy are preferable for the curative resection of bile duct cancer, extrahepatic bile duct resection alone is also considered in patients for whom it is judged that curative resection would be achieved after a strict diagnosis of its local extension. Also, combined caudate lobe resection is recommended for hilar cholangiocarcinoma. Because the prognosis of patients treated with combined portal vein resection is significantly better than that of unresected patients, combined portal vein resection may be carried out. Prognostic factors after resection for bile duct cancer include positive surgical margins, especially in the ductal stump; lymph node metastasis; perineural invasion; and combined vascular resection due to portal vein and/or hepatic artery invasion. For patients with suspected gallbladder cancer, laparoscopic cholecystectomy is not recommended, and open cholecystectomy should be performed as a rule. When gallbladder cancer invading the subserosal layer or deeper has been detected after simple cholecystectomy, additional resection should be considered. Prognostic factors after resection for gallbladder cancer include the depth of mural invasion; lymph node metastasis; extramural extension, especially into the hepatoduodenal ligament; perineural invasion; and the degree of curability. Pancreaticoduodenectomy is indicated for ampullary carcinoma, and limited operation is also indicated for carcinoma in adenoma. The prognostic factors after resection for ampullary carcinoma include lymph node metastasis, pancreatic invasion, and perineural invasion

Use of Non-Amplified RNA Samples for Microarray Analysis of Gene Expression

Demand for high quality gene expression data has driven the development of revolutionary microarray technologies. The quality of the data is affected by the performance of the microarray platform as well as how the nucleic acid targets are prepared. The most common method for target nucleic acid preparation includes in vitro transcription amplification of the sample RNA. Although this method requires a small amount of starting material and is reported to have high reproducibility, there are also technical disadvantages such as amplification bias and the long, laborious protocol. Using RNA derived from human brain, breast and colon, we demonstrate that a non-amplification method, which was previously shown to be inferior, could be transformed to a highly quantitative method with a dynamic range of five orders of magnitude. Furthermore, the correlation coefficient calculated by comparing microarray assays using non-amplified samples with qRT-PCR assays was approximately 0.9, a value much higher than when samples were prepared using amplification methods. Our results were also compared with data from various microarray platforms studied in the MicroArray Quality Control (MAQC) project. In combination with micro-columnar 3D-Gene™ microarray, this non-amplification method is applicable to a variety of genetic analyses, including biomarker screening and diagnostic tests for cancer

Usefulness of measuring hepatic functional volume using Technetium-99m galactosyl serum albumin scintigraphy in bile duct carcinoma: report of two cases.

We report the usefulness of measuring functional liver volume in two patients undergoing hepatectomy. Case 1 involved a 47-year-old man with hepatitis B virus infection. The indocyanine green test retention rate at 15 min (ICGR15) was 14%. Liver uptake ratio (LHL15) by technetium-99 m galactosyl human serum albumin ((99m)Tc-GSA) liver scintigraphy was 0.91. The patient displayed hilar bile duct carcinoma necessitating right hepatectomy. After preoperative portal vein embolization (PVE), future remnant liver volume became 54% and functional volume by (99m)Tc-GSA became 79%. Although the permitted resected liver volume was lower than the liver volume, scheduled hepatectomy was performed following the results of functional liver volume. Case 2 involved a 75-year-old man with diabetes. ICGR15 was 27.4% and LHL15 was 0.87. The patient displayed bile duct carcinoma located in the upper bile duct with biliary obstruction in the right lateral sector. The right hepatectomy was scheduled. After PVE, future remnant volume became 68% and functional volume became 88%. Although ICGR15 was worse as 31%, planned hepatectomy was performed due to the results of functional volume. In the liver with biliary obstruction or portal embolization, functional liver volume is decreased more than morphological volume. Measurement of functional volume provides useful information for deciding operative indication