Pathos degree prime graph of a tree

Let T be a tree of order n (n ≥ 2). A pathos degree prime graph of T, written PDP(T), is a graph whose vertices are the vertices and paths of a pathos of T, with two vertices of PDP(T) adjacent whenever the degree of the corresponding vertices of T are unequal and relatively prime; or the corresponding paths Pʹᵢ and Pʹᵢ (i ≠ j) of a pathos of T have a vertex in common; or one corresponds to the path Pʹ and the other to a vertex v and Pʹ begins (or ends) at v such that v is a pendant vertex in T. We look at some properties of this graph operator. For this class of graphs we discuss the planarity; outerplanarity; maximal outerplanarity; minimally nonouterplanarity; Eulerian; and Hamiltonian properties these graphs.Publisher's Versio

Development and validation of UV spectrophotometric method for simultaneous estimation of propranolol hydrochloride and rosuvastatin calcium in bulk drug and pharmaceutical dosage form

A new, simple and sensitive UV spectrophotometric method has been developed for simultaneous quantitative determination of propranolol hydrochloride and rosuvastatin calcium in bulk and pharmaceutical dosage form. This is achieved by simultaneous equation (Vierodts method) and absorbance ratio (Q- point) method. Propranolol hydrochloride and rosuvastatin calcium exhibits maximum absorbance at 289 nm and 243 nm respectively in methanol as solvent. Beers law was found to be obeyed in the concentration range 2-40 g/ml for propranolol hydrochloride and 2-42 g/ml or rosuvastatin calcium. Method were validated for linearity, accuracy, precision, LOD, LOQ as per ICH guidelines

A randomized prospective comparative study of efficacy of asenapine, iloperidone and zotepine in patients with psychosis

Background: Antipsychotic drugs constitute the mainstay in the treatment of schizophrenia and other psychotic disorders. For these medications to be maximally beneficial, they must be efficacious, with an acceptable side effect profile and be taken as prescribed. The objective of the study was to compare the efficacy of iloperidone, asenapine and zotepinein subjects with psychotic disorders.Methods: Randomized prospective study was conducted in the Department of Psychiatry of a tertiary care hospital, at Mysore, India. Sixty Patients who met the criteria for acute psychosis and schizophrenia according to ICD 10 were recruited. Atypical antipsychotics-asenapine, iloperidone and zotepine were administered and their efficacy was monitored by brief psychiatric rating scale (BPRS), which was administered on day one, week 1, week 3 and week 6.Results: Out of 60 recruited subjects 31 (51.7%) completed all four visits of the study. Iloperidone and asenapine showed significant improvement in efficacy than zotepine at week 6. Among the total dropouts 55.2% subjects didn’t come for follow-up and 44.8% were dropped due to development of side effects.Conclusions: In patients with acute psychosis and schizophrenia, iloperidone appears more effective and tolerated than the other two. Asenapine was effective but less tolerated and zotepine was less efficacious and produced poor response. Asenapine and zotepine have more dropouts and showed few uncommon extrapyramidal side effects

A randomized open label comparative study to determine the various side effects and patient satisfaction of low dose continuous versus low dose intermittent oral isotretinoin therapy in moderate to severe acne vulgaris

Background: Acne Vulgaris is chronic inflammatory disease of pilosebaceous units. Oral isotretinoin is recommended for moderate to severe acne vulgaris who are not responding satisfactorily to conventional therapies. Recent reports indicate that acne patients have been benefiting from the low dose treatment protocols. However, long term daily use of this drug results in frequent side effects such mucocutaneous and systemic side effects. Our aim was to assess and compare the various side effects and patient satisfaction of oral isotretinoin in low dose continuous and intermittent treatment of moderate to severe acne vulgaris.Methods: This was a prospective randomized open labeled comparative study carried out at outpatient department in the Department of Dermatology in Mandya Institute of Medical sciences, Mandya. Patients with moderate to severe acne were assigned equally (50 subjects each) to one of the two treatment regimens by using block randomization technique, Group A was given low dose continuous regimen-20 mg oral isotretinoin once daily for 4 months and Group B was given low dose intermittent regimen-20 mg oral isotretinoin once daily for 1 week out of every 4 weeks. The patients were followed up every 4th week during the treatment period. The patients were examined and side effects were noted in each visit. A six month follow-up evaluation was done to analyze patient satisfaction.Results: Muco-cutaneous dryness was most common adverse effect noted in both the groups A and B. Itching (42%), Alopecia (44%), Myalgia (36%) were seen most commonly in group A and Acne flaring (47%) was most common with group B. With regard to patient satisfaction, in group A 42% were satisfied and 20% were very satisfied, in group B 36% were satisfied and 14% were very satisfied.Conclusions: Study suggests that, Muco-cutaneous dryness was most common side effect in both treatment regimens. Side effects were more frequent with low dose continuous than low dose intermittent isotretinoin regimen. Patient satisfaction was better in continuous regimen

Long-term survival in permanent middle cerebral artery occlusion:a model of malignant stroke in rats

Occlusion of the middle cerebral artery (MCA) by an intraluminal filament is widely used to study focal brain ischemia in male Sprague-Dawley rats. However, permanent occlusion goes along with a high fatality. To overcome this drawback we designed a new filament carrying a bowling pin-shaped tip (BP-tip) and compared this with three conventionally tipped filaments. Follow-up periods were 24 h ( all groups) and 72 and 120 h in BP-tip group. Ischemic damage and swelling were quantified using silver nitrate staining. Collateral flow via the posterior cerebral artery (PCA) was assessed using selective dye perfusion of the internal carotid artery. Despite a comparable decrease of brain perfusion in all groups, ischemic damage was significantly smaller in BP-tips (p &lt;0.05). Moreover, BP-tip significantly reduced mortality from 60% to 12.5% and widely spared the occipital region and hypothalamus from ischemic damage. Conventional but not BP-tip filaments induced vascular distortion, measured as gross displacement of the MCA origin, which correlated with occipital infarction size. Accordingly, BP-tip occluded rats showed a significantly better collateral filling of the PCA territory. Ischemic volume significantly increased in BP-tip occlusion at 72 h follow-up. BP-tip filaments offer superior survival in permanent MCA occlusion, while mimicking the course of a malignant stroke in patients.</p

An assessment on the relation between Prakruti and Amavata disease

Prakruti is said to be the basic component of a human being. It has been explained in classics that Prakruti provides susceptibility for certain diseases based on Dosha. It is the time of the hour to explore and prove the concept clinically. A total of 362 diagnosed cases of Amavata were taken for the study and were assessed for the Prakruti dominant among them. Sampling was cross sectional simple random method. The observation made during were recorded and analyzed. It was also observed about predominant Rasas consumed as well as the dominant Guna they consumed. Analyzing Rasa and Guna added more value to the study. The observations were applied with descriptive as well as inferential statistics. Dominance of Vata-Pitta Prakruti was found with 42% of cases and Pitta Prakruti alone stood last with only 5% cases developing Amavata

Evaluation of wound healing activity of ethanolic extract of Azadirachta Indica leaves on incision and excision wound models in Wister albino rats

Background: Wound healing is complex cellular and biochemical cascade that lead to restitution of integrity and function. Recently, the traditional use of plants for wound healing has received attention by the scientific community, as traditional medicine is a source of less expensive, comprehensive medical care, especially in developing countries. Azadirachta indica (Neem) is well-known in India, as one of the most versatile medicinal plants having a wide spectrum of biological activity. Hence, this study was undertaken to evaluate the wound healing activity of the ethanolic extract of A. indica leaf in the experimentally-induced wound in rats.Methods: The healing effect produced by A. indica extract was assessed by the rate of wound contraction histopathology and skin breaking strength by using excision wound model and incision wound model in Wister albino rats. This was compared with control (soft white paraffin) and standard (1% w/w framycetin sulfate ointment). The results have been analyzed by calculating the mean values, standard deviation and compared by using student t-test.Results: The ethanol extract of leaves of A. indica significantly promoted the wound healing activity in both excision and incision wound models.Conclusion: The study revealed promising wound healing activity of ethanolic extract of A. indica and provides a scientific rationale for the traditional use in the management of wounds

Emulated reactance and resistance by a SSSC incorporating energy storage device

Static Synchronous series compensator without energy storage device can exchange only reactive power with the network and can operate in limited operating range in two quadrants only. When energy storage device is connected at the DC bus of SSSC (SSSC – ES), it can also exchange real power with the network. Operating range of SSSC will be much broader and it covers all the four quadrants. However, emulated reactance and resistance by SSSC – ES is likely to affect the performance of a distance protection system. This paper presents a detailed model of an SMIB system with SSSC – ES. Injected voltage by SSSC – ES in all the four quadrants of operation is presented. Impact of operation of SSSC _ ES in different quadrants and various control strategies for SSSC – ES on impedance emulated by SSSC – ES during steady state condition and transient system disturbance is discussed.

Physician and Patient Moves in the Hospital Do Not Move Patient Satisfaction: A Single-Center Retrospective Analysis

Background. Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) is a standardized survey for measuring patient\u27s experiences at US hospitals. There is a shift towards geographically assigning patients and physicians. However, its impact on patient satisfaction scores has not been studied. Objective: Examine the correlation between patient experience and overall hospital rating with the number of physicians seen and the number of times the patient was moved during a hospitalization. Methods: A retrospective observational study was performed using select HCAHPS & Press Ganey survey questions to assess physician satisfaction scores and overall hospital rating and recommendation scores. Results: There was no significant difference across the select survey questions based on the number of times a patient was moved or the hospitalists seen during a hospitalization on most questions. A higher case mix index was associated with an increased likelihood of receiving the highest rating for the hospital (OR 1.39,95% CI 1.03-1.88), p 0.03), and two other physician communication questions. An increase in the length of stay was associated with a lower likelihood of receiving the highest rating for similar physician communication questions (OR 0.91, 95% CI 0.83 to 0.99,p 0.04) Conclusions: The number of hospitalists seen by the patient and the number of times a patient is moved during a hospitalization is not associated with physicians related patient satisfaction scores, overall care received in the hospital, or if the patient would recommend the hospital to others

Load Balancing in Cloud Computing: A Survey on Popular Techniques and Comparative Analysis

Cloud Computing is universally accepted as the most intensifying field in web technologies today. With the increasing popularity of the cloud, popular website2019;s servers are getting overloaded with high request load by users. One of the main challenges in cloud computing is Load Balancing on servers. Load balancing is the procedure of sharing the load between multiple processors in a distributed environment to minimize the turnaround time taken by the servers to cater service requests and make better utilization of the available resources. It greatly helps in scenarios where there is misbalance of workload on the servers as some machines may get heavily loaded while others remain under-loaded or idle. Load balancing methods make sure that every VM or server in the network holds workload equilibrium and load as per their capacity at any instance of time. Static and Dynamic load balancing are main techniques for balancing load on servers. This paper presents a brief discussion on different load balancing schemes and comparison between prime techniques