A Review on Niosomes - A novel approach for drug targeting

This is a general review on niosome as drug carrier, which improves the bioavailability of drugs, increases penetration through skin, releases drug in a controlled or sustained manner, and used for targeting of drugs to specic sites in the body.Niosomal drug delivery system can be considered as an emerging novel drug delivery system, which consists of microscopic non-ionic vesicles composed of non-ionic surfactants. These are biodegradable, relatively nontoxic, more stable and inexpensive, and an alternative to liposomes. Methods of preparation, characterisation and application of niosomes have been reviewed. Niosome has potential to reduce the side effects of drugs and increase therapeutic effectiveness in various diseases. It can also be used as a carrier to deliver drugs topically. This review presents an overview of the types of niosomes, techniques of preparation of niosome characterisation and their applications

Simultaneous estimation of aspirin and omeprazole in laboratory sample by different UV spectrophotometric techniques

The aim of the present work is to develop simple, precise and economic UV- spectrophotometric methods for the simultaneous estimation of aspirin and omeprazole laboratory sample. The absorbance maxima (?max) for detection of aspirin and omeprazole were selected as 274 nm and 302 nm respectively for simultaneous equation method while wavelength range for detection of aspirin and omeprazole were selected as 270 nm - 276 nm and 300 nm - 305 nm respectively for area under curve method. Absorbance ratio method uses the ratio of absorbances at two selected wavelengths, one which is an isoabsorptive point and other being the ? max of one of the two components. From the overlay spectra of two drugs, it is evident that aspirin and omeprazole show an isoabsorptive point at 238.6 nm. Zero crossing first derivative spectrophotometry, where Aspirin showed zero crossing point at 301nm and Omeprazole showed zero crossing point at 274nm. Linearity for Aspirin was between 25- 125 ?g/mL and Omeprazole was 3-15 ?g/mL. These methods were successfully applied for estimation of Aspirin and Omeprazole in laboratory sample

Formulation, development, and evaluation of Silymarin loaded topical gel for fungal infection

The objective of work was the formulation of Silymarin Loaded Topical gel obtained from the seeds of plant Silybum Marianum (L). Silymarin is a composition of flavolignan. It includes Silibinin, Silydianin, Silychristin, and isosilybinin. silymarin is used as Hepatoprotective, Antioxidant, Anticancer, Anti-Inflammatory, Anti-fibrotic, Immunomodulatory a Liver Regenerating action. It also used in viral hepatitis neuroprotective and Neurotropic action. The different type of formulation available in tablet, capsule, syrup, suspension, nanoparticles in the market. The aim of the study was to formulate and develop silymarin Loaded gel and to check its Antipsoriasis activity, with the use of Methanol as co-solvent the HPMC as Gel forming Agent and Methyl paraben and propyl paraben as Preservative. The glycerin acts as Humectant and Tween 80 used as a surfactant. The Characterization of gel such as pH, Drug content, spreadability, viscosity, in-vitro drug release was carried out in pH 6, Primary skin irritation test and antifungal activity were checked. The drug content was found to be 95.8%. Spreadability of the gel was found to be 20.66gm cm/sec. The pH of silymarin loaded gel was found to be 6.9. The silymarin loaded gel shows the pseudoplastic flow from the rheogram. It shows Drug release 96.08% over a period of 3h. There was no acute skin irritancy found

Formulation and Characterization of Zingiberol Loaded Microsphere for Motion Sickness

The present research work involve the development of Zingiberol as the treatment of motion sickness. The Zingiberol microsphere was formulated by Ionotropic gelation method using different polymers in different ratio depending on RSM method. The prepared formulations were optimized on the basis of dependent variables like particle size (mg), entrapment efficiency etc. The SEM photographs of Zingiberol microsphere before dissolution shows the spherical and smooth surface whereas after dissolution the pores and crevices were shown which is indicating that the microsphere are showing drug release by diffusion mechanism. The microsphere formulations were able to sustain the release of drug both in vitro and in vivo. In the stability studies no significant change in drug entrapment release characteristics of the microspheres

Formulation and evaluation of herbal face pack for glowing skin

The aim of this work is to formulate and evaluate an herbal face pack for glowing skin by using natural herbal ingredients. The natural herbal ingredients such as multani mitti, turmeric, sandalwood, saffron, milk powder, rice flour, orange peel were purchased from local market in the form of dried powder. The powder of banana peel was prepared by shade drying commercially, all powdered natural ingredients were sieved using #120 mesh, weighed accurately and mixed geometrically for uniform formulation and then evaluated for parameters including morphological, physicochemical, physical, phytochemical, irritancy along with stability examination. Thus, in the present work, we formulated a herbal face pack which can be easily made with the easily available ingredients. After evaluation, we found good properties for the face packs, free from skin irritation and maintained its consistency even after stability storage conditions. Results of the study scientifically verified that herbal face pack having enough potential to give efficient glowing effect on skin. The overall study is useful to substantiate product claims due its useful benefits on the human beings

A review on recent advancement in liquisolid techology

Liquisolid technique is a novel process in which a liquid can be converted into a material that flows freely, is readily compressible. The carrier material in liquisolid compact comprises the liquid part, which is the liquid drug or a drug solution in liquid vehicles that are non-volatile. Solubility is the main parameter in the circulation of blood to achieve the whole concentration of the drug for pharmacological action. The rate of dissolution of drugs enhances in liquisolid technology. This in turn increases absorption and bioavailability subsequently. This review discusses the different advances and changes to improve liquisolid technology formulations and enhancement of dissolution rate of poorly soluble drugs. Most of the new chemical entities have high lipophilicity and poor water solubility, resulting in poor bioavailability. The release rate of these drugs should be increased in order to improve bioavailability. The technique is based on dissolving the insoluble drug in the solution loaded with non-volatile solvent. Then the dissolution rate of drug which is poorly soluble will rise. The enhanced bioavailability is due to the increased surface area of drug for release, increased drug aqueous solubility or improved wetting capacity

Inclusion of Hydrophilic-Lipophilic Balance (HLB) in the treatment of Psoriasis- A new approach

The present study highlights the importance of Hydrophillic-Lipophilic value of the base cream for the dermatological purposes beyond formulation stability. Hydrophilic- Lipophilic Balance (HLB) is largely considered for attaining stability of the base cream by the chosen emulsifier/ surfactants. However the base formulation (cream or ointment) also must act as an emulsifier to balance the hydrophilic- lipophilic ecosystem of the skin besides the formulation acts as the drug dispensing mechanism. Psorolin ointment for the treatment of psoriasis is being formulated with due diligence to HLB value due to the skin conditions of psoriasis. Details are presented in the paper

A General Review on Vitamin world

Vitamins, are any of the normal blends required by the body in little wholes for absorption, to guarantee prosperity, and for honest to goodness advancement in kids. Vitamins also help the course of action of hormones, platelets, tactile framework chemicals, and innate material. The distinctive vitamins are not artificially related, and most fluctuate in their physiological exercises. They generally go about as stimuli, joining with proteins to make metabolically powerful intensifies that in this way convey numerous essential mixture reactions all through the body. Without vitamins, an expansive number of these reactions would back off or stop. The multifaceted behaviour by which vitamins follow up on the body, however, are as yet far from clear

Estimation of Valsartan in Pharmaceutical Formulation by Area under Curve Spectrophotometric Method

For estimation of Valsartan in pharmaceutical dosage form, a simple, accurate and precise area under curve spectrophotometric method was developed. The area under two points on the mixture spectra is directly proportional to the concentration of the component of interest is the AUC curve. The area selected for estimation of Valsartan was between 238.20 to 254.40 nm. The method represented regression coefficient (r2 = 0.996) at concentration rang 2-10 μg/ml. Estimation of the drugs was found up to 100 % representing the accuracy of the method. The recovery of the Valsartan was found up to 100 %. Validation of the proposed method was carried out for its accuracy, precision and specificity according to ICH Q2 (R1) guidelines. The developed methods can be successfully applied in routine work for the estimation of Valsartan in its pharmaceutical dosage form

Formulation And Development Of Nanosuspension As An Alternative Approach For Solubility And Dissolution Enhancement Of Aceclofenac

Main objectives to develop Aceclofenac Nanosuspension are to enhance solubility and dissolution rate of poorly soluble Drug (aceclofenac), substantially leading to its bioavailability enhancement and Improvement of aqueous and saturation solubility in turn rapid release of Drug which leads to enhancing therapeutic efficacy. Aceclofenac Nanosuspension was prepared by quasi solvent evaporation method with help of different polymer and concentration. There was changes polymer ratio, volume of organic solvent and stirring speed. Aceclofenac nanosuspension gives immediate release. Aceclofenac nanosuspension were showing highest dissolution rate within 10 minutes comparison with marketed formulations. Aceclofenac Nanosuspension compacts may enhance aqueous solubility and dissolution rate in compare to other solubility enhancement technique hence, this research work may be useful to formulate Aceclofenac Nanosuspension which may give rapid onset of action by rapid absorption, maximize efficacy, dose frequency and hence increase patient Compliance