1,671 research outputs found
Impresión 3D para la construcción: un enfoque basado en el procedimiento y los materiales
3D printing for construction is stagnated at an early stage of development, especially regarding material optimization and procedural issues. These limitations are due to the specific knowledge that these technologies imply, the total cost of the machinery involved, and the lack of clear procedural guidelines. This paper presents a methodology that aims at overcoming these limitations through a workflow that allows for the ease of use of 6-axis robotic arms. A technique for the optimization of material usage is presented. A test case that shows the integration the design-to-fabrication process combining Integrated Robotic Systems (IRS) and Additive Layer Manufacturing (ALM) techniques is discussed. A structure-based approach to material optimization and smart infill patterning is introduced. A 0.4 x 0.4 x 1.5 m test part is shown as technological demonstrator.Las aplicaciones de impresión 3D para construcción se encuentran en una fase inicial de desarrollo, tanto en lo referente a materiales y piezas como a procedimientos. Dichas limitaciones se deben a la especificidad del sector, el coste de la maquinaria necesaria y una ausencia de un patrón procedimental característico. El artículo presenta una metodología innovadora para superar estas limitaciones mediante un flujo de trabajo sencillo que permita el uso generalista de brazos robóticos mediante software integrativo y un uso de materiales optimizado. Asimismo se expone la integración de diseño y fabricación combinando Sistemas de Integración Robótica y técnicas de Fabricación por Deposición. Finalmente se muestra un modelo de optimización de material y patrones de relleno inteligentes. Se expone una pieza real de 0,4 x 0,4 x 1,5 metros como demostrador tecnológico de gran escala
Calidad de agua para riego en invernáculos de la región central de la Provincia de La Pampa
En zona aledaña a la ciudad de Santa Rosa, provincia de La Pampa, ha cobrado importancia el cultivo de hortalizas. El agua utilizada para el riego es extra Ida de perforaciones y eventualmente de alguna laguna. Es por ello que en este trabajo se determina la calidad del agua que se utiliza para el riego y se aportan datos concretos y posibles prácticas de manejo. En este trabajo, desarrollado durante los años 1997 y 1998, se determinaron las características químicas Relación de absorción de Sodio, Carbonato de Sodio Residual y concentración de cationes y aniones, y las características físicas pH, sales totales disueltas y conductividad eléctrica del agua de diferentes pozos, para luego clasificarla siguiendo el criterio del Laboratorio de Salinidad de Riverside (USDA) y de la FAO. El pH del agua de los pozos analizados no presentó ninguna restricción en ningún momento, mientras que de las otras características analizadas siempre se presentó alguna restricción en algún pozo. En los pozos muestreados, en general no se detectaron restos de nitritos ni de amonio, a excepción del pozo N° 8 que presentó un contenido de amonio comprendido en el rango de 0 a 10 partes por millón. En el agua de los pozos N° 1, N° 4, N° 5 Y N° 7 se halló que la concentración de arsénico es superior a la tolerancia admitida por la Organización Mundial de la Salud. Los pozos N° 8 Y N° 10 no presentaron ninguna restricción respecto al total de sales disueltas.Director: Ing. Agr. Nilda B. Reinaudi Cátedra de Química. Facultad de Agronomía. Universidad Nacional de La Pampa.Co-Director: Ing. Agr. Horacio C. Gregoire Cátedra de Horticultura, Facultad de Agronomía. Universidad Nacional de La Pampa
Right tail expansion of Tracy-Widom beta laws
Using loop equations, we compute the large deviation function of the maximum
eigenvalue to the right of the spectrum in the Gaussian beta matrix ensembles,
to all orders in 1/N. We then give a physical derivation of the all order
asymptotic expansion of the right tail Tracy-Widom beta laws, for all positive
beta, by studying the double scaling limit.Comment: 23 page
Statistical distribution of quantum entanglement for a random bipartite state
We compute analytically the statistics of the Renyi and von Neumann entropies
(standard measures of entanglement), for a random pure state in a large
bipartite quantum system. The full probability distribution is computed by
first mapping the problem to a random matrix model and then using a Coulomb gas
method. We identify three different regimes in the entropy distribution, which
correspond to two phase transitions in the associated Coulomb gas. The two
critical points correspond to sudden changes in the shape of the Coulomb charge
density: the appearance of an integrable singularity at the origin for the
first critical point, and the detachement of the rightmost charge (largest
eigenvalue) from the sea of the other charges at the second critical point.
Analytical results are verified by Monte Carlo numerical simulations. A short
account of some of these results appeared recently in Phys. Rev. Lett. {\bf
104}, 110501 (2010).Comment: 7 figure
Quasiperiodic Patterns in Boundary-Modulated Excitable Waves
We investigate the impact of the domain shape on wave propagation in
excitable media. Channelled domains with sinusoidal boundaries are considered.
Trains of fronts generated periodically at an extreme of the channel are found
to adopt a quasiperiodic spatial configuration stroboscopically frozen in time.
The phenomenon is studied in a model for the photo-sensitive
Belousov-Zabotinsky reaction, but we give a theoretical derivation of the
spatial return maps prescribing the height and position of the successive
fronts that is valid for arbitrary excitable reaction-diffusion systems.Comment: 4 pages (figures included
Entangled random pure states with orthogonal symmetry: exact results
We compute analytically the density of Schmidt
eigenvalues, distributed according to a fixed-trace Wishart-Laguerre measure,
and the average R\'enyi entropy for reduced
density matrices of entangled random pure states with orthogonal symmetry
. The results are valid for arbitrary dimensions of the
corresponding Hilbert space partitions, and are in excellent agreement with
numerical simulations.Comment: 15 pages, 5 figure
Large deviations of the maximal eigenvalue of random matrices
We present detailed computations of the 'at least finite' terms (three
dominant orders) of the free energy in a one-cut matrix model with a hard edge
a, in beta-ensembles, with any polynomial potential. beta is a positive number,
so not restricted to the standard values beta = 1 (hermitian matrices), beta =
1/2 (symmetric matrices), beta = 2 (quaternionic self-dual matrices). This
model allows to study the statistic of the maximum eigenvalue of random
matrices. We compute the large deviation function to the left of the expected
maximum. We specialize our results to the gaussian beta-ensembles and check
them numerically. Our method is based on general results and procedures already
developed in the literature to solve the Pastur equations (also called "loop
equations"). It allows to compute the left tail of the analog of Tracy-Widom
laws for any beta, including the constant term.Comment: 62 pages, 4 figures, pdflatex ; v2 bibliography corrected ; v3 typos
corrected and preprint added ; v4 few more numbers adde
Intravenous immunoglobulin to prevent myasthenic crisis after thymectomy and other procedures can be omitted in patients with well-controlled myasthenia gravis
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was funded by a Fondo de Investigación Sanitaria (FIS-FEDER) (grants PI16-01673 and PI19/00593) and an Interlaken Research Award Programme (2012-12094537).Background: Myasthenic crisis (MC) is a potentially life-threatening complication of myasthenia gravis. Its precipitating factors include surgical procedures, particularly thymectomy. The role of preoperative intravenous immunoglobulin (IVIg) in preventing MC in patients scheduled for thymectomy and other surgery with general anaesthesia is unknown. Our objective was to test the hypothesis that preoperative IVIg is effective in preventing myasthenic crisis in patients with myasthenia gravis scheduled for surgery under general anaesthesia, including thymectomy. Methods: A prospective, randomized, double-blind, single-centre study was conducted over a 4-year period. The treatment group received IVIg, 0.4 g/kg/day preoperatively for 5 consecutive days, and the placebo group received saline solution under the same conditions. The two groups were age-matched, with similar functional status, and Myasthenia Gravis Foundation of America class. All patients had well-controlled myasthenia gravis with minimal manifestations before surgery. The primary outcome measured was MC. Intubation times, time in the recovery room, number of postoperative complications, and days of hospitalization were the secondary outcomes measured. Results: A total of 47 patients were randomized, 25 to the IVIg group and 22 to placebo. There were 19 men and 28 women, with a mean age of 58.6 years, mean body mass index of 27.8 kg/m, and mean acetylcholine receptor antibodies of 12.9 nmol/l. The mean forced vital capacity was 84.4%. The mean quantitative myasthenia gravis sum score was 6.3. Ten patients (five in each arm) had a history of MC. Thymectomy was performed in 16 patients. Only one patient in the placebo group presented with MC requiring non-invasive ventilation (but no reintubation) for 6 days. Neither differences between groups in the univariate analysis nor risk factors for MC in the multivariate analysis were found. Conclusions: Preoperative IVIg to prevent MC does not appear to be justified in well-controlled myasthenia gravis patients. This study provides class I evidence that preparation with IVIg to prevent MC is not necessary in well-controlled myasthenia gravis patients scheduled for surgery with general anaesthesia
Intravenous immunoglobulin to prevent myasthenic crisis after thymectomy and other procedures can be omitted in patients with well-controlled myasthenia gravis
Immunoglobulin; Myasthenia; ThymectomyInmunoglobulina; Miastenia; TimectomíaImmunoglobulina; Miastènia; TimectomiaBACKGROUND:
Myasthenic crisis (MC) is a potentially life-threatening complication of myasthenia gravis. Its precipitating factors include surgical procedures, particularly thymectomy. The role of preoperative intravenous immunoglobulin (IVIg) in preventing MC in patients scheduled for thymectomy and other surgery with general anaesthesia is unknown. Our objective was to test the hypothesis that preoperative IVIg is effective in preventing myasthenic crisis in patients with myasthenia gravis scheduled for surgery under general anaesthesia, including thymectomy.
METHODS:
A prospective, randomized, double-blind, single-centre study was conducted over a 4-year period. The treatment group received IVIg, 0.4 g/kg/day preoperatively for 5 consecutive days, and the placebo group received saline solution under the same conditions. The two groups were age-matched, with similar functional status, and Myasthenia Gravis Foundation of America class. All patients had well-controlled myasthenia gravis with minimal manifestations before surgery. The primary outcome measured was MC. Intubation times, time in the recovery room, number of postoperative complications, and days of hospitalization were the secondary outcomes measured.
RESULTS:
A total of 47 patients were randomized, 25 to the IVIg group and 22 to placebo. There were 19 men and 28 women, with a mean age of 58.6 years, mean body mass index of 27.8 kg/m2, and mean acetylcholine receptor antibodies of 12.9 nmol/l. The mean forced vital capacity was 84.4%. The mean quantitative myasthenia gravis sum score was 6.3. Ten patients (five in each arm) had a history of MC. Thymectomy was performed in 16 patients. Only one patient in the placebo group presented with MC requiring non-invasive ventilation (but no reintubation) for 6 days. Neither differences between groups in the univariate analysis nor risk factors for MC in the multivariate analysis were found.
CONCLUSIONS:
Preoperative IVIg to prevent MC does not appear to be justified in well-controlled myasthenia gravis patients. This study provides class I evidence that preparation with IVIg to prevent MC is not necessary in well-controlled myasthenia gravis patients scheduled for surgery with general anaesthesia.This work was funded by a Fondo de Investigacion Sanitaria (FIS-FEDER) (grants PI16-01673 and PI19/00593) and an Interlaken Research Award Programme (2012-12094537
Rapid Insulinotropic Action of Low Doses of Bisphenol-A on Mouse and Human Islets of Langerhans: Role of Estrogen Receptor β
Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical (EDC) used as the base compound in the manufacture of polycarbonate plastics. It alters pancreatic β-cell function and can be considered a risk factor for type 2 diabetes in rodents. Here we used ERβ−/− mice to study whether ERβ is involved in the rapid regulation of KATP channel activity, calcium signals and insulin release elicited by environmentally relevant doses of BPA (1 nM). We also investigated these effects of BPA in β-cells and whole islets of Langerhans from humans. 1 nM BPA rapidly decreased KATP channel activity, increased glucose-induced [Ca2+]i signals and insulin release in β-cells from WT mice but not in cells from ERβ−/− mice. The rapid reduction in the KATP channel activity and the insulinotropic effect was seen in human cells and islets. BPA actions were stronger in human islets compared to mouse islets when the same BPA concentration was used. Our findings suggest that BPA behaves as a strong estrogen via nuclear ERβ and indicate that results obtained with BPA in mouse β-cells may be extrapolated to humans. This supports that BPA should be considered as a risk factor for metabolic disorders in humans
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