2,580 research outputs found
Noncommutative Symmetric Functions VII: Free Quasi-Symmetric Functions Revisited
We prove a Cauchy identity for free quasi-symmetric functions and apply it to
the study of various bases. A free Weyl formula and a generalization of the
splitting formula are also discussed.Comment: 21 pages, Latex, 2 figure
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SMEs Inventive Performance and Profitability in the Markets for Technology
This paper studies the inventive performance and profitability of small and medium sized firms (SMEs) that are “technology specialists” compared to the inventive performance and profitability of SMEs that are instead vertically-integrated. In this paper perspective, “technology specialists” are firms that specialize upstream in generating inventions and trade those inventions in disembodied form with other firms, usually through licensing agreements. Instead, vertically-integrated firms are those firms that both generate inventions and commercialize products incorporating those inventions. We argue that technology specialists achieve a higher inventive performance than vertically-integrated firms, since they can accumulate deeper and broader inventive experience, whilst keeping a more flexible organizational structure. These firms display a lower profitability though, due to the imperfections inherent in invention market transactions and the lower bargaining power caused by the lack of commercialization assets. The theoretical framework is tested through a cross-industry investigation on a sample of European SMEs. Implications for the viability of being a technology specialist as a strategy and for the development of markets for technology are discussed
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Specializing in generality: Firm strategies when intermediate markets work
This paper studies the relationship between two decisions shaping the organizational configuration of a firm: whether to make the upstream resources more general and deployable to more markets (vs. keeping them tailored to a few markets), and whether to trade with downstream firms as an upstream supplier of intermediate products and services (vs. directly entering downstream markets). While the literature has looked at these two decisions separately, we argue that they depend on each other. This has the important implication that they can generate organizational complementarities, inducing firms to implement them jointly. We are motivated in particular by the observation that an increasing number of firms invest in general upstream resources and exploit them as upstream suppliers of intermediate services or products— a strategy that we refer to as specialization in generality. Interestingly, the literature following the seminal work by Penrose (1959) and Nelson (1959) has highlighted the use of general upstream resources to enter new downstream markets. We identify the supply and demand conditions under which specialization in generality is instead more likely to emerge: lack of prior downstream assets, on the supply side, and a roughly equal distribution of buyers across intermediate markets (a “broad” demand), on the demand side. We test our predictions using a sample of firms in the U.S. laser industry between 1993 and 2001. A regulatory shock that increases the value of trading relative to downstream entry provides the setting for a quasi-natural experiment, which corroborates our theoretical predictions
Exponential series without denominators
For a commutative algebra which comes from a Zinbiel algebra the exponential
series can be written without denominators. When lifted to dendriform algebras
this new series satisfies a functional equation analogous to the
Baker-Campbell-Hausdorff formula. We make it explicit by showing that the
obstruction series is the sum of the brace products. In the multilinear case we
show that the role the Eulerian idempotent is played by the iterated pre-Lie
product.Comment: 13
Fat inclusion level, NaCl content and lab starter cultures in the manufacturing of Italian-type ostrich Salami: Weight loss and nutritional traits \u2020
The experiment studied the effect of two different fat inclusion levels (30% and 40%), NaCl contents (2.4 and 2.6%) and starter cultures (lactic acid bacteria (LAB) 6: L. curvatus/S. xylosus; LAB 8: L. sakei/S. xylosus) on the weight loss and nutritional composition of Italian-type ostrich salami. With this purpose, 8 batches of 9 salami each (n = 72) were prepared. Salami were ripened for 20 weeks: weight loss was monitored throughout the experiment, while salami nutritional composition was evaluated at 10 and 20 weeks of ripening. The lowest fat and highest salt inclusion levels provided the highest cumulative weight loss throughout the trial. At 10 weeks of ripening, salami with 40% fat were the richest in moisture and fat, whereas the leanest ones had the highest protein, ash and cholesterol contents. LAB 6 provided salami with the highest moisture and protein, while LAB 8 increased fat and cholesterol contents. At 20 weeks of ripening the proximate composition of ostrich salami was solely affected by fat inclusion level, with similar findings to those observed at 10 weeks. Overall, fat inclusion level had a great impact on the weight loss and nutritional composition of Italian-style ostrich salami. Reducing the NaCl inclusion from 2.6% to 2.4%, the weight loss of ostrich salami was retarded by approximately 1 week, without affecting the nutritional composition of the final product. Results of the study suggested that it is feasible to produce salami with lower fat and salt contents, while ensuring satisfactory product quality
Environmental enrichment extends photoreceptor survival and visual function in a mouse model of retinitis pigmentosa
Slow, progressive rod degeneration followed by cone death leading to blindness is the pathological signature of all forms of
human retinitis pigmentosa (RP). Therapeutic schemes based on intraocular delivery of neuroprotective agents prolong the
lifetime of photoreceptors and have reached the stage of clinical trial. The success of these approaches depends upon
optimization of chronic supply and appropriate combination of factors. Environmental enrichment (EE), a novel
neuroprotective strategy based on enhanced motor, sensory and social stimulation, has already been shown to exert
beneficial effects in animal models of various disorders of the CNS, including Alzheimer and Huntington disease. Here we
report the results of prolonged exposure of rd10 mice, a mutant strain undergoing progressive photoreceptor degeneration
mimicking human RP, to such an enriched environment from birth. By means of microscopy of retinal tissue,
electrophysiological recordings, visual behaviour assessment and molecular analysis, we show that EE considerably
preserves retinal morphology and physiology as well as visual perception over time in rd10 mutant mice. We find that
protective effects of EE are accompanied by increased expression of retinal mRNAs for CNTF and mTOR, both factors known
as instrumental to photoreceptor survival. Compared to other rescue approaches used in similar animal models, EE is highly
effective, minimally invasive and results into a long-lasting retinal protection. These results open novel perspectives of
research pointing to environmental strategies as useful tools to extend photoreceptor survival
Osservazioni tecnico-estimative sulla legge dell'equo canone per gli immobili urbani alla luce dei recenti strumenti urbanistici
Vibronic resonances facilitate excited state coherence in light harvesting proteins at room temperature
Until recently it was believed that photosynthesis, a fundamental process for
life on earth, could be fully understood with semi-classical models. However,
puzzling quantum phenomena have been observed in several photosynthetic
pigment-protein complexes, prompting questions regarding the nature and role of
these effects. Recent attention has focused on discrete vibrational modes that
are resonant or quasi-resonant with excitonic energy splittings and strongly
coupled to these excitonic states. Here we unambiguously identify excited state
coherent superpositions in photosynthetic light-harvesting complexes using a
new experimental approach. Decoherence on the timescale of the excited state
lifetime allows low energy (56 cm-1) oscillations on the signal intensity to be
observed. In conjunction with an appropriate model, these oscillations provide
clear and direct experimental evidence that the persistent coherences observed
require strong vibronic mixing among excited states
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Profiting from enabling technologies?
How to profit from innovation has been an important question for both innovation scholars and practitioners over the years. It is certainly a relevant question for all types of technological innovation, including emerging ones. Teece's (1986) profiting from innovation (PFI) framework sets forth a theory of the relevant contingencies. However, Teece's framework focuses on technologies with applications in specific domains. We focus on the question of how to profit from enabling technologies: technologies that are applicable across multiple domains. We argue that capturing value in such circumstances is fundamentally different from profiting from less-enabling technologies and raises new issues with respect to the relevant business models and public policies. This paper's contribution is threefold. It formally revises and extends the original PFI framework to include the case of enabling technologies; it provides empirical evidence to support the distinction between profiting from enabling as compared to profiting from narrower "discrete" technologies; and it generates perspectives on the appropriate business models for these technologies and discusses related public-policy implications, in light of the fact that the share of the benefits the innovator can capture is likely to be even smaller for enabling than for discrete technologies
Loss of expression of ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN
Repair of double strand DNA breaks (DSBs) is pivotal in maintaining normal
cell division and disruption of this system has been shown to be a key factor in
carcinogenesis. Loss of expression of the DSB repair proteins have previously been
shown to be associated with poorer survival in colorectal cancer. We wished to
ascertain the relationship of altered expression of the DSB repair proteins Îł-H2AX
(gamma-H2AX), ATM and Ku70 with biological and clinico-pathological features
of colorectal cancer. 908 tumours from the VICTOR clinical trial of stage II/III
colorectal cancer were analysed for expression of Îł-H2AX, ATM and Ku70 using
immunohistochemistry. Expression levels were correlated with CIN and with diseasefree
survival, correcting for microsatellite instability, BRAF/KRAS mutation status,
Dukes stage, chemo/radiotherapy, age, gender and tumour location. Down-regulated
Ku70 expression was associated with chromosomal instability (p=0.029) in colorectal
cancer. Reduced ATM expression was an independent marker of poor disease-free
survival (HR=1.67, 95% CI 1.11-2.50, p=0.015). For Ku70, further studies are
required to investigate the potential relationship of non-homologous end joining with
chromosomal instability. Loss of ATM expression might serve as a biomarker of poor
prognosis in colorectal cancer
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