1,737 research outputs found
Doping dependence of superconducting gap in YBa_2Cu_3O_y from universal heat transport
Thermal transport in the T -> 0 limit was measured as a function of doping in
high-quality single crystals of the cuprate superconductor YBa_2Cu_3O_y. The
residual linear term kappa_0/T is found to decrease as one moves from the
overdoped regime towards the Mott insulator region of the phase diagram. The
doping dependence of the low-energy quasiparticle gap extracted from kappa_0/T
is seen to scale closely with that of the pseudogap, arguing against a
non-superconducting origin for the pseudogap. The presence of a linear term for
all dopings is evidence against the existence of a quantum phase transition to
an order parameter with a complex (ix) component.Comment: 2 pages, 2 figures, submitted to M2S-Rio 2003 Proceeding
Estimating the burden of disease attributable to childhood and maternal undernutrition in South Africa in 2000
Objectives. To estimate the disease burden attributable to being
underweight as an indicator of undernutrition in children
under 5 years of age and in pregnant women for the year 2000.
Design. World Health Organization comparative risk
assessment (CRA) methodology was followed. The
1999 National Food Consumption Survey prevalence of
underweight classified in three low weight-for-age categories
was compared with standard growth charts to estimate
population-attributable fractions for mortality and morbidity
outcomes, based on increased risk for each category and
applied to revised burden of disease estimates for South Africa
in 2000. Maternal underweight, leading to an increased risk of
intra-uterine growth retardation and further risk of low birth
weight (LBW), was also assessed using the approach adopted
by the global assessment. Monte Carlo simulation-modelling
techniques were used for the uncertainty analysis.
Setting. South Africa.
Subjects. Children under 5 years of age and pregnant women.
Outcome measures. Mortality and disability-adjusted life years
(DALYs) from protein- energy malnutrition and a fraction of
those from diarrhoeal disease, pneumonia, malaria, other non-
HIV/AIDS infectious and parasitic conditions in children aged
0 - 4 years, and LBW.
Results. Among children under 5 years, 11.8% were
underweight. In the same age group, 11 808 deaths (95%
uncertainty interval 11 100 - 12 642) or 12.3% (95% uncertainty
interval 11.5 - 13.1%) were attributable to being underweight.
Protein-energy malnutrition contributed 44.7% and diarrhoeal
disease 29.6% of the total attributable burden. Childhood and
maternal underweight accounted for 2.7% (95% uncertainty
interval 2.6 - 2.9%) of all DALYs in South Africa in 2000 and
10.8% (95% uncertainty interval 10.2 - 11.5%) of DALYs in
children under 5.
Conclusions. The study shows that reduction of the occurrence
of underweight would have a substantial impact on child
mortality, and also highlights the need to monitor this
important indicator of child health. South African Medical Journal Vol. 97 (8) Part 2 2007: pp. 733-73
Together, yet still not equal? Sex integration in equestrian sport
Sex segregation is a core organising principle of most modern sports and is a key element in the marginalisation and subordination of girls and women in sport and beyond. In this article I explore the only Olympic-level sport which is not organised around sex segregation â equestrian sport â in order to consider the implications of sex integration for female participants. I draw on a study conducted on elite riders that found that although sex integration in equestrian sport does not lead to female participants being excluded from high-level competition, men continue to perform disproportionately well. This suggests that although sex integration may be an important step towards breaking down gender hierarchies in sport, without accompanying wider changes in gender norms and expectations, sex integration alone will not be enough to achieve greater gender equality in equestrian sport
Diversity and impact of rare variants in genes encoding the platelet G protein-coupled receptors
Platelet responses to activating agonists are influenced by common
population variants within or near G protein-coupled receptor (GPCR)
genes that affect receptor activity. However, the impact of rare GPCR
gene variants is unknown. We describe the rare single nucleotide variants
(SNVs) in the coding and splice regions of 18 GPCR genes in
7,595 exomes from the 1,000-genomes and Exome Sequencing
Project databases and in 31 cases with inherited platelet function disorders
(IPFDs). In the population databases, the GPCR gene target
regions contained 740 SNVs (318 synonymous, 410 missense, 7 stop
gain and 6 splice region) of which 70 % had global minor allele frequency
(MAF) < 0.05 %. Functional annotation using six computational
algorithms, experimental evidence and structural data identified
156/740 (21 %) SNVs as potentially damaging to GPCR function, most
commonly in regions encoding the transmembrane and C-terminal intracellular
receptor domains. In 31 index cases with IPFDs (Gi-pathway
defect n=15; secretion defect n=11; thromboxane pathway defect
n=3 and complex defect n=2) there were 256 SNVs in the target
regions of 15 stimulatory platelet GPCRs (34 unique; 12 with
MAF< 1 % and 22 with MAFâ„ 1 %). These included rare variants predicting
R122H, P258T and V207A substitutions in the P2Y12 receptor
that were annotated as potentially damaging, but only partially explained
the platelet function defects in each case. Our data highlight
that potentially damaging variants in platelet GPCR genes have low
individual frequencies, but are collectively abundant in the population.
Potentially damaging variants are also present in pedigrees with IPFDs
and may contribute to complex laboratory phenotypes
Potentiation rather than distraction in a trace fear conditioning procedure
Trace conditioning procedures are defined by the introduction of a trace interval between conditioned stimulus (CS, e.g. noise or light) offset and unconditioned stimulus (US, e.g. footshock). The introduction of an additional stimulus as a distractor has been suggested to increase the attentional demands of the task and to extend the usefulness of the behavioural model. In Experiment 1, the CS was noise and the distractor was provided by an intermittent light. In Experiment 2, the CS was light and the distractor was provided by an intermittent noise. In both experiments, the introduction of a 10s trace interval weakened associative learning compared with that seen in a 0s delay conditioned group. However, there was no consistent evidence of distraction. On the contrary, in Experiment 1, associative learning was stronger (in both trace and delay conditioned groups) for rats conditioned also in the presence of the intermittent light. In Experiment 2, there was no such effect when the roles of the stimuli were reversed. The results of Experiment 2 did however confirm the particular salience of the noise stimulus. The finding of increased associative learning dependent on salience is consistent with arousal-mediated effects on associative learning
Deterministically Driven Avalanche Models of Solar Flares
We develop and discuss the properties of a new class of lattice-based
avalanche models of solar flares. These models are readily amenable to a
relatively unambiguous physical interpretation in terms of slow twisting of a
coronal loop. They share similarities with other avalanche models, such as the
classical stick--slip self-organized critical model of earthquakes, in that
they are driven globally by a fully deterministic energy loading process. The
model design leads to a systematic deficit of small scale avalanches. In some
portions of model space, mid-size and large avalanching behavior is scale-free,
being characterized by event size distributions that have the form of
power-laws with index values, which, in some parameter regimes, compare
favorably to those inferred from solar EUV and X-ray flare data. For models
using conservative or near-conservative redistribution rules, a population of
large, quasiperiodic avalanches can also appear. Although without direct
counterparts in the observational global statistics of flare energy release,
this latter behavior may be relevant to recurrent flaring in individual coronal
loops. This class of models could provide a basis for the prediction of large
solar flares.Comment: 24 pages, 11 figures, 2 tables, accepted for publication in Solar
Physic
The use of toxicokinetics and exposure studies to show that carprofen in cattle tissue could lead to secondary toxicity and death in wild vultures
Veterinary medicines can be extremely damaging to the environment, as seen with the catastrophic declines in Gyps vulture in South Asia due to their secondary exposure to diclofenac in their primary food source. Not surprisingly, concern has been raised over other similar drugs. In this study, we evaluate the toxicity of carprofen to the Gyps vulture clade through plasma pharmacokinetics evaluations in Bos taurus cattle (their food source) and Gyps africanus (a validated model species); tissue residues in cattle; and the effect of carprofen as a secondary toxicant as both tissue-bound residue or pure drug at levels expected in cattle tissues. Carprofen residues were highest in cattle kidney (7.72 ± 2.38 mg/kg) and injection site muscle (289.05 ± 98.96 mg/kg of dimension of 5 à 5 à 5 cm). Vultures exposed to carprofen as residues in the kidney tissue or pure drug equivalents showed no toxic signs. When exposed to average injection site concentrations (64 mg/kg) one of two birds died with evidence of severe renal and liver damage. Toxicokinetic analysis revealed a prolonged drug half-life of 37.75 h in the dead bird as opposed to 13.99 ± 5.61 h from healthy birds dosed intravenously at 5 mg/kg. While carprofen may generally be harmless to Gyps vultures, its high levels at the injection site in treated cattle can result in lethal exposure in foraging vultures, due to relative small area of tissue it is found therein. We thus suggest that carprofen not be used in domesticated ungulates in areas where carcasses are accessible or provided to vultures at supplementary feeding sites.The Royal Society for the Protection of Birds and the Chester Zoo.http://www.elsevier.com/locate/chemosphere2019-01-01hj2018Paraclinical Science
Radiation Hydrodynamical Instabilities in Cosmological and Galactic Ionization Fronts
Ionization fronts, the sharp radiation fronts behind which H/He ionizing
photons from massive stars and galaxies propagate through space, were
ubiquitous in the universe from its earliest times. The cosmic dark ages ended
with the formation of the first primeval stars and galaxies a few hundred Myr
after the Big Bang. Numerical simulations suggest that stars in this era were
very massive, 25 - 500 solar masses, with H II regions of up to 30,000
light-years in diameter. We present three-dimensional radiation hydrodynamical
calculations that reveal that the I-fronts of the first stars and galaxies were
prone to violent instabilities, enhancing the escape of UV photons into the
early intergalactic medium (IGM) and forming clumpy media in which supernovae
later exploded. The enrichment of such clumps with metals by the first
supernovae may have led to the prompt formation of a second generation of
low-mass stars, profoundly transforming the nature of the first protogalaxies.
Cosmological radiation hydrodynamics is unique because ionizing photons coupled
strongly to both gas flows and primordial chemistry at early epochs,
introducing a hierarchy of disparate characteristic timescales whose relative
magnitudes can vary greatly throughout a given calculation. We describe the
adaptive multistep integration scheme we have developed for the self-consistent
transport of both cosmological and galactic ionization fronts.Comment: 6 pages, 4 figures, accepted for proceedings of HEDLA2010, Caltech,
March 15 - 18, 201
Sum rules and energy scales in the high-temperature superconductor YBa2Cu3O6+x
The Ferrell-Glover-Tinkham (FGT) sum rule has been applied to the temperature
dependence of the in-plane optical conductivity of optimally-doped
YBa_2Cu_3O_{6.95} and underdoped YBa_2Cu_3O_{6.60}. Within the accuracy of the
experiment, the sum rule is obeyed in both materials. However, the energy scale
\omega_c required to recover the full strength of the superfluid \rho_s in the
two materials is dramatically different; \omega_c \simeq 800 cm^{-1} in the
optimally doped system (close to twice the maximum of the superconducting gap,
2\Delta_0), but \omega_c \gtrsim 5000 cm^{-1} in the underdoped system. In both
materials, the normal-state scattering rate close to the critical temperature
is small, \Gamma < 2\Delta_0, so that the materials are not in the dirty limit
and the relevant energy scale for \rho_s in a BCS material should be twice the
energy gap. The FGT sum rule in the optimally-doped material suggests that the
majority of the spectral weight of the condensate comes from energies below
2\Delta_0, which is consistent with a BCS material in which the condensate
originates from a Fermi liquid normal state. In the underdoped material the
larger energy scale may be a result of the non-Fermi liquid nature of the
normal state. The dramatically different energy scales suggest that the nature
of the normal state creates specific conditions for observing the different
aspects of what is presumably a central mechanism for superconductivity in
these materials.Comment: RevTeX 4 file, 9 pages with 7 embedded eps figure
High Speed Solution of Spacecraft Trajectory Problems Using Taylor Series Integration
Taylor series integration is implemented in a spacecraft trajectory analysis code-the Spacecraft N-body Analysis Program (SNAP) - and compared with the code s existing eighth-order Runge-Kutta Fehlberg time integration scheme. Nine trajectory problems, including near Earth, lunar, Mars and Europa missions, are analyzed. Head-to-head comparison at five different error tolerances shows that, on average, Taylor series is faster than Runge-Kutta Fehlberg by a factor of 15.8. Results further show that Taylor series has superior convergence properties. Taylor series integration proves that it can provide rapid, highly accurate solutions to spacecraft trajectory problems
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