The clustering coefficient of a scale-free random graph

We consider a random graph process in which, at each time step, a new vertex is added with m out-neighbours, chosen with probabilities proportional to their degree plus a strictly positive constant. We show that the expectation of the clustering coefficient of the graph process is asymptotically proportional to (log n)/n. Bollobas and Riordan have previously shown that when the constant is zero, the same expectation is asymptotically proportional to ((log n)^2)/n

Improved bounds for the number of forests and acyclic orientations in the square lattice

In a recent paper Merino and Welsh (1999) studied several counting problems on the square lattice $L_n$. The authors gave the following bounds for the asymptotics of $f(n)$, the number of forests of $L_n$, and $\alpha(n)$, the number of acyclic orientations of $L_n$: $3.209912 \leq \lim_{n\rightarrow\infty} f(n)^{1/n^2} \leq 3.84161$ and $22/7 \leq \lim_{n\rightarrow\infty} \alpha(n) \leq 3.70925$. In this paper we improve these bounds as follows: $3.64497 \leq \lim_{n\rightarrow\infty} f(n)^{1/n^2} \leq 3.74101$ and $3.41358 \leq \lim_{n\rightarrow\infty} \alpha(n) \leq 3.55449$. We obtain this by developing a method for computing the Tutte polynomial of the square lattice and other related graphs based on transfer matrices

Knowledge-based vision and simple visual machines

The vast majority of work in machine vision emphasizes the representation of perceived objects and events: it is these internal representations that incorporate the 'knowledge' in knowledge-based vision or form the 'models' in model-based vision. In this paper, we discuss simple machine vision systems developed by artificial evolution rather than traditional engineering design techniques, and note that the task of identifying internal representations within such systems is made difficult by the lack of an operational definition of representation at the causal mechanistic level. Consequently, we question the nature and indeed the existence of representations posited to be used within natural vision systems (i.e. animals). We conclude that representations argued for on a priori grounds by external observers of a particular vision system may well be illusory, and are at best place-holders for yet-to-be-identified causal mechanistic interactions. That is, applying the knowledge-based vision approach in the understanding of evolved systems (machines or animals) may well lead to theories and models that are internally consistent, computationally plausible, and entirely wrong

Poultry Farming in the Coastal Agro Ecosystem of Kerala

The potential for development of the coastal agro eco system through supplementary occupation has not yet been fully realized. The people living the coastal areas are among the poorest in the world. Poor water and soil quality, diseases and social backwardness are the other reasons for unsuccessful development. Though aquaculture has got great scope for generation of wealth and enhanced per capita income, consistent results are not obtained due to fish diseases and inappropriate management at farm level

Enhanced hippocampal long-term potentiation and spatial learning in aged 11ß-hydroxysteroid dehydrogenase type 1 knock-out mice

Glucocorticoids are pivotal in the maintenance of memory and cognitive functions as well as other essential physiological processes including energy metabolism, stress responses, and cell proliferation. Normal aging in both rodents and humans is often characterized by elevated glucocorticoid levels that correlate with hippocampus-dependent memory impairments. 11ß-Hydroxysteroid dehydrogenase type 1 (11ß-HSD1) amplifies local intracellular ("intracrine") glucocorticoid action; in the brain it is highly expressed in the hippocampus. We investigated whether the impact of 11ß-HSD1 deficiency in knock-out mice (congenic on C57BL/6J strain) on cognitive function with aging reflects direct CNS or indirect effects of altered peripheral insulin-glucose metabolism. Spatial learning and memory was enhanced in 12 month "middle-aged" and 24 month "aged" 11ß-HSD1<sup>–/–</sup> mice compared with age-matched congenic controls. These effects were not caused by alterations in other cognitive (working memory in a spontaneous alternation task) or affective domains (anxiety-related behaviors), to changes in plasma corticosterone or glucose levels, or to altered age-related pathologies in 11ß-HSD1<sup>–/–</sup> mice. Young 11ß-HSD1<sup>–/–</sup> mice showed significantly increased newborn cell proliferation in the dentate gyrus, but this was not maintained into aging. Long-term potentiation was significantly enhanced in subfield CA1 of hippocampal slices from aged 11ß-HSD1<sup>–/–</sup> mice. These data suggest that 11ß-HSD1 deficiency enhances synaptic potentiation in the aged hippocampus and this may underlie the better maintenance of learning and memory with aging, which occurs in the absence of increased neurogenesis

A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.

Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress. Here, we identify a chromatin-based system required for inducible aneuploidy in a human pathogen. Candida albicans utilizes chromosome missegregation to acquire tolerance to antifungal drugs and for nonmeiotic ploidy reduction after mating. We discovered that the ancestor of C. albicans and 2 related pathogens evolved a variant of histone 2A (H2A) that lacks the conserved phosphorylation site for kinetochore-associated Bub1 kinase, a key regulator of chromosome segregation. Using engineered strains, we show that the relative gene dosage of this variant versus canonical H2A controls the fidelity of chromosome segregation and the rate of acquisition of tolerance to antifungal drugs via aneuploidy. Furthermore, whole-genome chromatin precipitation analysis reveals that Centromere Protein A/ Centromeric Histone H3-like Protein (CENP-A/Cse4), a centromeric histone H3 variant that forms the platform of the eukaryotic kinetochore, is depleted from tetraploid-mating products relative to diploid parents and is virtually eliminated from cells exposed to aneuploidy-promoting cues. We conclude that genetically programmed and environmentally induced changes in chromatin can confer the capacity for enhanced evolvability via chromosome missegregation

Institution village linkage programme Coastal Agro Ecosystem & Interventions

Agriculture, animal husbandry and fisheries provide maximum employment in the primary sector and form the major source of income and livelihood security of about 70 percent of the population in India. After the introduction of the liberalisation policy and giving thrust for the adoption of improved technologies, there has been a spectacular increase in production in all these segments and the country has witnessed a rapid structural change. Massive adoption of scientific inventions and technological interventions witnessed revolutionary changes in all sectors of development and quality of life of people. Achieving self-sufficiency on food front has been one of the finest Indian successes of the post independence era. The food grain production increased four times (from 50.8 million tonnes during 1950-51 to 198.7 million tonnes during 2000-01) since independence as compared to the three-fold increase in population. Further significant advances have also been made in the production of milk, fish, oilseeds, fruits and vegetables. In fisheries, the country has ushered in the blue revolution with gross production reaching 5.6 million metric tonnes offish and edible invertebrates during 2000- 2001. India is the second largest Asian country in terms of culture fisheries and the third largest in terms of capture fisheries (NAAS, 2001). Due to concerted efforts on strategic research and production technology in oilseeds sector, the country witnessed yellow revolution with the production reaching 25 million tonnes per annum. This was possible as a result of strong agricultural research support provided by the National Agricultural Research System (NARS)

Systematic characterisation of the Herschel SPIRE Fourier Transform Spectrometer

A systematic programme of calibration observations was carried out to monitor the performance of the SPIRE FTS instrument on board the Herschel Space Observatory. Observations of planets (including the prime point-source calibrator, Uranus), asteroids, line sources, dark sky, and cross-calibration sources were made in order to monitor repeatability and sensitivity, and to improve FTS calibration. We present a complete analysis of the full set of calibration observations and use them to assess the performance of the FTS. Particular care is taken to understand and separate out the effect of pointing uncertainties, including the position of the internal beam steering mirror for sparse observations in the early part of the mission. The repeatability of spectral line centre positions is <5km/s, for lines with signal-to-noise ratios >40, corresponding to <0.5-2.0% of a resolution element. For spectral line flux, the repeatability is better than 6%, which improves to 1-2% for spectra corrected for pointing offsets. The continuum repeatability is 4.4% for the SLW band and 13.6% for the SSW band, which reduces to ~1% once the data have been corrected for pointing offsets. Observations of dark sky were used to assess the sensitivity and the systematic offset in the continuum, both of which were found to be consistent across the FTS detector arrays. The average point-source calibrated sensitivity for the centre detectors is 0.20 and 0.21 Jy [1 sigma; 1 hour], for SLW and SSW. The average continuum offset is 0.40 Jy for the SLW band and 0.28 Jy for the SSW band.Comment: 41 pages, 37 figures, 32 tables. Accepted for publication in MNRA

The place of strategic environmental assessment in the privatised electricity industry

The private sector has given relatively little attention to the emergence of strategic environmental assessment (SEA); even recently privatised utilities, where SEA might be deemed particularly appropriate, and whose activities are likely to fall within the scope of the European Union SEA Directive, have shown less interest than might be expected. However, the global trend towards the privatisation of state-owned enterprises makes the adaptation of SEA towards these industries all the more pressing. This paper addresses the place that SEA might take within the electricity sector, taking the privatised UK electricity industry as an example. Particular challenges are posed by the radical restructuring of the industry, designed to introduce competitive behaviour, making the development of comprehensive SEA processes problematic, and requiring SEA to be placed in the context of corporate environmental policy and objectives.</p