Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis

<p>Abstract</p> <p>Background</p> <p>Plants have long been investigated as a source of antibiotics and other bioactives for the treatment of human disease. New Zealand contains a diverse and unique flora, however, few of its endemic plants have been used to treat tuberculosis. One plant, <it>Laurelia novae-zelandiae</it>, was reportedly used by indigenous Maori for the treatment of tubercular lesions.</p> <p>Methods</p> <p><it>Laurelia novae-zelandiae </it>and 44 other native plants were tested for direct anti-bacterial activity. Plants were extracted with different solvents and extracts screened for inhibition of the surrogate species, <it>Mycobacterium smegmatis</it>. Active plant samples were then tested for bacteriostatic activity towards <it>M. tuberculosis </it>and other clinically-important species.</p> <p>Results</p> <p>Extracts of six native plants were active against <it>M. smegmatis</it>. Many of these were also inhibitory towards <it>M. tuberculosis </it>including <it>Laurelia novae-zelandiae </it>(Pukatea). <it>M. excelsa </it>(Pohutukawa) was the only plant extract tested that was active against <it>Staphylococcus aureus</it>.</p> <p>Conclusions</p> <p>Our data provide support for the traditional use of Pukatea in treating tuberculosis. In addition, our analyses indicate that other native plant species possess antibiotic activity.</p

'Show me the evidence' : mobilisation, citizenship and risk in Indian asbestos issues

This paper examines asbestos issues, mobilisation and citizenship in India. It shows how asbestos has been considered as a tool for Indian economic growth and modernisation and explores the scientific debates around its ‘safe’ use. In seeking to locate experiences of citizenship within a globalised context, this research has focused on anti-asbestos mobilisation and protest in cosmopolitan cities as well as more decentralised contexts. It argues that the state’s narrow definition of asbestos diseases enables it to officially document the lack of asbestos diseases experienced by Indian workers. This process, which defines sufferers as politically invisible and inconsequential, accompanied by the 30 year delay between exposure and the onset of disease, hinders anti-asbestos organisations as there is no constituency to be mobilised. Parallel (and partially interrelated) grassroots asbestos movements which are more worker-orientated are, however, marginalised from the transnational protests. The paper argues that mobilisation around identity issues thus creates different contexts in India, in which activists are simultaneously both intimately connected and enormously distant to different aspects of the mobilisation process. In addition, while geographic and political differences are compressed through transnational mobilisation; class, regional and educational differences are expanded. Keywords: asbestos; mobilisation; citizenship; anti-asbestos mobilisation; India; asbestos diseases

Rapid assessment of facilitators and barriers related to the acceptance, challenges and community perception of daily regimen for treating tuberculosis in India

Introduction: The Revised National Tuberculosis Control Program (RNTCP) is the largest tuberculosis (TB) control program in the world based on Directly Observed Treatment Short-Course (DOTS) strategy. Globally, most countries have been using a daily regimen and in India a shift towards a daily regimen for TB treatment has already begun. The daily strategy is known to improve program coverage along with compliance. Such strategic shifts have both management and operational implications. We undertook a rapid assessment to understand the facilitators and barriers in adopting the daily regimen for TB treatment in three Indian states. Methods: In-depth interviews were planned across six districts of three purposively selected states of Maharashtra, Bihar and Sikkim, among health system personnel at various levels to identify their perspectives on adoption of a daily regimen for TB. These districts were sampled on the basis of TB notification rates. Thematic analysis of the qualitative data was undertaken. Results: 62 respondents were interviewed from these 6 districts. During the analysis, it was observed that an easily accessible, patient-centred and personalized outreach is an enabling factor for adherence to treatment. Lack of transportation facilities, out-of-pocket expenses and loss of wages for accessing DOTS at institutions are major identified barriers for treatment adherence at individual level. At program level, lack of trained service providers, poor administration of treatment protocols and inadequate supervision by health care providers and program managers are key factors that influence program outcomes. Conclusion: A major observation that emerged from the interviews is that the key to achieve a relapse-free cure is ensuring that a patient receives all doses of the prescribed treatment regimen. However, switching to a daily regimen makes adherence difficult and thus new strategies are needed for its implementation at patient and health provider levels. Most stakeholders appreciate the reasons for switching to a daily regimen. The stakeholders recognised the efforts of the Ministry of Health & Family Welfare (MoHFW) in spearheading the program. Strategies like the 99 DOTS call-centre approach may also further ensure treatment adherence

Microbiological, Chemical and Physicochemical Surveys of the Paddy Field Soil

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Effects of compost application on growth and nodulation of kidney bean, soybean and alfalfa under salt stress

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スギ ラクヨウ ノ ブンカイ カテイ ムキ チッソ タイシャ オ チュウシン トシテ

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