Deep Neural Network-Based Detector for Single-Carrier Index Modulation NOMA

In this paper, a deep neural network (DNN)-based detector for an uplink single-carrier index modulation nonorthogonal multiple access (SC-IM-NOMA) system is proposed, where SC-IM-NOMA allows users to use the same set of subcarriers for transmitting their data modulated by the sub-carrier index modulation technique. More particularly, users of SC-IMNOMA simultaneously transmit their SC-IM data at different power levels which are then exploited by their receivers to perform successive interference cancellation (SIC) multi-user detection. The existing detectors designed for SC-IM-NOMA, such as the joint maximum-likelihood (JML) detector and the maximum likelihood SIC-based (ML-SIC) detector, suffer from high computational complexity. To address this issue, we propose a DNN-based detector whose structure relies on the model-based SIC for jointly detecting both M-ary symbols and index bits of all users after trained with sufficient simulated data. The simulation results demonstrate that the proposed DNN-based detector attains near-optimal error performance and significantly reduced runtime complexity in comparison with the existing hand-crafted detectors

Deep Learning-Based Signal Detection for Dual-Mode Index Modulation 3D-OFDM

In this paper, we propose a deep learning-based signal detector called DuaIM-3DNet for dual-mode index modulation-based three-dimensional (3D) orthogonal frequency division multiplexing (DM-IM-3D-OFDM). Herein, DM-IM-3D- OFDM is a subcarrier index modulation scheme which conveys data bits via both dual-mode 3D constellation symbols and indices of active subcarriers. Thus, this scheme obtains better error performance than the existing IM schemes when using the conventional maximum likelihood (ML) detector, which, however, suffers from high computational complexity, especially when the system parameters increase. In order to address this fundamental issue, we propose the usage of a deep neural network (DNN) at the receiver to jointly and reliably detect both symbols and index bits of DM-IM-3D-OFDM under Rayleigh fading channels in a data-driven manner. Simulation results demonstrate that our proposed DNN detector achieves near-optimal performance at significantly lower runtime complexity compared to the ML detector

GEOTOURISM CURRENT STATE AND FUTURE PROSPECTS: A CASE STUDY IN THE CAO BANG UNESCO GLOBAL GEOPARK, VIETNAM

Cao Bang Geopark is one of three UNESCO heritage sites in Vietnam, with unique geological, landscape and cultural properties of high value to tourism. This study aims to provide a better understanding of the potential for geotourism development in Cao Bang Global Geopark, thereby proposing reasonable development strategies in the future. The research using the multicriteria assessment and SWOT analysis tool found that Cao Bang Global Geopark has a high ability to attract tourists and exploit large tourism resources globally. However, the infrastructure, technical facilities, human resources and investment capital for geotourism are still limited and need to be improved. The research results can be considered useful references for academia and managers in finding strategies and solutions for sustainable geotourism development at Cao Bang Geopark in the future

SECURE PERFORMANCE ANALYSIS OF ADAPTIVE ENERGY HARVESTING ENABLED RELAYING NETWORKS

In this paper, the impact of the jamming signal on the secrecy performance of Energy Harvesting (EH) enabled dual-hop amplify-and-forward relaying network is investigated. First, the security outage probability analysis is studied for conventional networks under a single passive eavesdropper attack. Then, the outage performance analysis in two cases regarding energy harvesting is investigated. Moreover, the proposed work enhances Physical Layer (PHY) security performance of two-hop relaying model using Cooperative Jamming Dual-Hop Techniques (CJDH). For this purpose, new closed-form expressions are derived for the outage probability of CJDH model in the presence of interference over Rayleigh fading channels. A power allocation optimization problem for energy harvesting protocol is formulated and solved for enhancing the system security. The derived analytical formulas herein are supported by numerical and simulation results to clarify the main contributions of the paper

Short Tandem Repeats Used in Preimplantation Genetic Testing of Î’-Thalassemia: Genetic Polymorphisms For 15 Linked Loci in the Vietnamese Population

BACKGROUND: β-thalassemia is one of the most common monogenic diseases worldwide. Preimplantation genetic testing (PGT) of β-thalassemia is performed to avoid affected pregnancies has become increasingly popular worldwide. In which, the indirect analysis using short tandem repeat (STRs) linking with HBB gene to detect different β-globin (HBB) gene mutation is a simple, accurate, economical and also provides additional control of contamination and allele-drop-out ADO. AIM: This study established microsatellite markers for PGT of Vietnamese β-thalassemia patient. METHODS: Fifteen (15) STRs gathered from 5 populations were identified by in silico tools within 1 Mb flanking the HBB gene. The multiplex PCR reaction was optimized and performed on 106 DNA samples from at-risk families. RESULTS: After estimating, PIC values were ≥ 0.7 for all markers, with expected heterozygosity and observed heterozygosity values ranged from 0.81 to 0.92 and 0.53 to 0.86, respectively. One hundred percent of individuals had at least seven heterozygous markers and were found to be heterozygous for at least two markers on either side of the HBB gene. The STRs panel was successfully performed on one at-risk family. CONCLUSION: In general, a pentadecaplex marker (all < 1 Mb from the HBB gene) assay was constituted for β-thalassemia PGT on Vietnamese population

Epidemiology, Clinical Manifestations, and Outcomes of Streptococcus suis Infection in Humans

Streptococcus suis, a bacterium that affects pigs, is a neglected pathogen that causes systemic disease in humans. We conducted a systematic review and meta-analysis to summarize global estimates of the epidemiology, clinical characteristics, and outcomes of this zoonosis. We searched main literature databases for all studies through December 2012 using the search term "streptococcus suis." The prevalence of S. suis infection is highest in Asia; the primary risk factors are occupational exposure and eating of contaminated food. The pooled proportions of case-patients with pig-related occupations and history of eating high-risk food were 38.1% and 37.3%, respectively. The main clinical syndrome was meningitis (pooled rate 68.0%), followed by sepsis, arthritis, endocarditis, and endophthalmitis. The pooled case-fatality rate was 12.8%. Sequelae included hearing loss (39.1%) and vestibular dysfunction (22.7%). Our analysis identified gaps in the literature, particularly in assessing risk factors and sequelae of this infection

An Outbreak of Severe Infections with Community-Acquired MRSA Carrying the Panton-Valentine Leukocidin Following Vaccination

Background: Infections with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) are emerging worldwide. We investigated an outbreak of severe CA-MRSA infections in children following out-patient vaccination. Methods and Findings: We carried out a field investigation after adverse events following immunization (AEFI) were reported. We reviewed the clinical data from all cases. S. aureus recovered from skin infections and from nasal and throat swabs were analyzed by pulse-field gel electrophoresis, multi locus sequence typing, PCR and microarray. In May 2006, nine children presented with AEFI, ranging from fatal toxic shock syndrome, necrotizing soft tissue infection, purulent abscesses, to fever with rash. All had received a vaccination injection in different health centres in one District of Ho Chi Minh City. Eight children had been vaccinated by the same health care worker (HCW). Deficiencies in vaccine quality, storage practices, or preparation and delivery were not found. Infection control practices were insufficient. CA-MRSA was cultured in four children and from nasal and throat swabs from the HCW. Strains from children and HCW were indistinguishable. All carried the Panton-Valentine leukocidine (PVL), the staphylococcal enterotoxin B gene, the gene complex for staphylococcal-cassette-chromosome mec type V, and were sequence type 59. Strain HCM3A is epidemiologically unrelated to a strain of ST59 prevalent in the USA, althoughthey belong to the same lineage. Conclusions. We describe an outbreak of infections with CA-MRSA in children, transmitted by an asymptomatic colonized HCW during immunization injection. Consistent adherence to injection practice guidelines is needed to prevent CA-MRSA transmission in both in- and outpatient settings

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke