93 research outputs found
Determination of Leptoquark Properties in Polarized Collisions
We study leptoquark production using polarized colliders for the
center of mass energies ~GeV and 1~TeV. We show that using
polarization asymmetries the ten different types of leptoquarks listed by
Buchm\"uller, R\"uckl and Wyler can be distinquished from one another for
leptoquark masses essentially up to the kinematic limit of the respective
colliders. Thus, if a leptoquark were discovered an collider could
play a crucial role in determining its origins.Comment: 10 pages (plus 10 postscript figures submitted separately), OCIP/C
94-
Resolved Photon Contributions to Leptoquark Production in and Collision
We calculate the resolved photon contribution to leptoquark production at
colliders for the center of mass energies ~GeV and
1~TeV. We also calculate the resolved photon contribution to leptoquark
production at colliders for the center of mass energies ~and~2~TeV. In both cases we find that these contributions are considerably
larger than the standard contributions considered in the literature.Comment: 9 pages (5 postscript figures in separate uuencoded file), OCIP/C
93-1
Spread of a SARS-CoV-2 variant through Europe in the summer of 2020.
Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3â5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variantâs success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes. © 2021, The Author(s), under exclusive licence to Springer Nature Limited
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
Mouse Chromosome 11
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46996/1/335_2004_Article_BF00648429.pd
Mouse Chromosome 3
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46995/1/335_2004_Article_BF00648421.pd
FRET between CdSe quantum dots in lipid vesicles and water- and lipid-soluble dyes
Because of the coatings needed to solubilize and passivate quantum dots for biological applications, their use
in fluorescent resonance energy transfer (FRET) has been limited. However, hydrophobic particles without
polymer coatings may be embedded into lipid membranes, as demonstrated here with biomimetic vesicles.
FRET is seen to a lipid-soluble dye (DiD) and a water-soluble dye (Cy3.5) in which the vesicles are suspended.
The degree of energy transfer to each dye suggests that most of the QDs are located deep within the lipid, as
confirmed by electron microscopy of whole mounts and thin sections of vesicles. Energy transfer is also seen
to a voltage-sensitive, lipid-soluble dye (di-4-ANEPPS) only when the potassium ionophore valinomycin is
present in the membrane. The effect is dependent upon potassium ion concentration rather than absolute
membrane potential
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