Blasting technique for stabilizing accidentprone slope for sustainable railway route

Konkan Railway has many unstable slopes along the 741 km long route from Roha to Thokur in the states of Maharashtra, Goa and Karnataka in India. Frequent cases of boulder fall, slope failure and landslide used to occur on the track during the rainy season. Such cases have resulted in several severe train accidents, traffic interruptions, loss of lives and assets. Hence the Konkan Railway Corporation deployed several geotechnical measures such as wire-netting, retaining wall, rock bolting and shotcreting for stability enhancement. However, none of these measures proved effective and accidents continued. Finally, the Konkan Railway Corporation decided to redesign the cut-slopes using blasting. Excavation of hard rock for its removal without damaging the existing track (2– 3 m away from the slope) and disrupting the traffic, was a daunting task. An unplanned blast would have resulted in the closure of the route for hours. The present study explains the method in which entire cutting was redesigned by formation of 5 to 2 m wide berms at an interval of 6 m bench height from rail track level using novel direction controlled blasting technique. Further, stability of the cut-slope, before and after exacavation, has been determined using kinematic analysis and 3D numerical modelling. Similar technique can be adopted to widen or stabilize an active transportation route in hills

Permeability of Microporous Carbon Preforms

The permeability of microporous amorphous carbon preforms with varying pore size and pore distributions has been experimentally examined. The porous structures have been characterized by mercury porosimetry and by quantitative metallography of pressure-infiltration-cast metal matrix composites based on the carbon preforms. The permeability shows a linear correlation with the fraction porosity and the square of the pore diameter

Permeability of Microporous Carbon Preforms

The permeability of microporous amorphous carbon preforms with varying pore size and pore distributions has been experimentally examined. The porous structures have been characterized by mercury porosimetry and by quantitative metallography of pressure-infiltration-cast metal matrix composites based on the carbon preforms. The permeability shows a linear correlation with the fraction porosity and the square of the pore diameter

लाख शब्दावली (अंग्रेजी - हिंदी) Technical terms related to Lac

लाख शब्दावली (अंग्रेजी - हिंदी) Technical terms related to La

A Pharmacovigilance Study in Medicine Department of Tertiary Care Hospital in Chhattisgarh (Jagdalpur), India

The aim of the present study was to observe adverse drug reactions (ADRs) with respect to polypharmacy at tertiary care centre at Bastar, Jagdalpur (Government Medical College, Jagdalpur). A prospective, observational evaluation of the ADRs conducted over a period of 6 months in Department of Medicine in Government Medical College, Jagdalpur. During the study period, a total of about 4850 patients visited the OPD and inpatient ward of medicine department, and 154 ADRs events were reported. Out of 154 reports that were identified, a higher percentage of ADRs in females (51.29%) was observed as compared to males (48.7%). Of the 154 ADRs, 76 (49.35%) were found to be mild, 55 moderate (35.71%), and 23 severe (14.93%). A total of 99 (64.28%) ADRs were observed in patients receiving four or more medications concurrently. Conversely 55 (35.71%) ADRs were detected in patients using three or less medicines. The largest number of reports was associated with antimicrobial therapy (28.57%), followed by antihypertensive (24.02%) and antidiabetics (14.28%). Among the affected organ systems, gastrointestinal ADRs constituted a major component (39.61%) followed by skin reactions (28.57%). On causality assessment, nearly 36.36% ADRs were considered as probable, 31.16% possible, and 9.74% could not be categorized and were placed under unassessable. Expected, limited ADR are permissible in normal clinical setting, but the present study focuses on the result showing increased and amplified ADR associated with the polypharmacy practices, which may be curtailed with rational drug prescribing habit

Wear and Friction Behavior of Metal Impregnated Microporous Carbon Composites

Metal-matrix composites have been prepared by pressure-infiltration casting of copper-base alloy melts into microporous carbon preforms. The carbon preforms contained varying proportions of amorphous carbon and graphite. Load dependence of the wear and friction behavior of the composite pins has been examined under ambient conditions against cast-iron plates, using a pin-on-plate reciprocating wear tester. The wear resistance of the composite is significantly improved, as compared with the base alloy. Contrary to the normally expected behavior, the addition of graphite to the amorphous carbon does not reduce the friction coefficient, especially at high loads. The wear and friction behavior of the composites is very sensitive to the size and distribution of the microstructural constituents

Transforming livestock productivity through watershed interventions: A case study of Parasai-Sindh watershed in Bundelkhand region of Central India

CONTEXT: Global experiences reveal the positive impact of watershed-based interventions in improving livelihoods and environmental security. In the drylands, increasing forage resources and improving livestock productivity is a critical challenge. OBJECTIVES: The overarching aim of this paper is to analyse the impact of watershed-based interventions on livestock population, productivity, fodder resources, and biomass availability. The paper describes the interrelationship between land, water, crop, and livestock and how the gap in forage deficit can be bridged through a range of watershed interventions

Inhibition of Glioblastoma Growth by the Thiadiazolidinone Compound TDZD-8

This is an open-access article distributed under the terms of the Creative Commons Attribution License.[Background]: Thiadiazolidinones (TDZD) are small heterocyclic compounds first described as non-ATP competitive inhibitors of glycogen synthase kinase 3 beta (GSK-3 beta). In this study, we analyzed the effects of 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5- dione (TDZD-8), on murine GL261 cells growth in vitro and on the growth of established intracerebral murine gliomas in vivo. [Methodology/Principal Findings]: Our data show that TDZD-8 decreased proliferation and induced apoptosis of GL261 glioblastoma cells in vitro, delayed tumor growth in vivo, and augmented animal survival. These effects were associated with an early activation of extracellular signal-regulated kinase (ERK) pathway and increased expression of EGR-1 and p21 genes. Also, we observed a sustained activation of the ERK pathway, a concomitant phosphorylation and activation of ribosomal S6 kinase (p90RSK) and an inactivation of GSK-3 beta by phosphorylation at Ser 9. Finally, treatment of glioblastoma stem cells with TDZD-8 resulted in an inhibition of proliferation and self-renewal of these cells. [Conclusions/Significance]: Our results suggest that TDZD-8 uses a novel mechanism to target glioblastoma cells, and that malignant progenitor population could be a target of this compound.This work was supported by the Ministerio de Educacion y Ciencia grant SAF2007-62811 (to A.P.-C.). CIBERNED is funded by the Instituto de Salud Carlos III. JA.M.-G. and M.S.-S. are fellows of CIBERNED. D.A.-M. is a fellow of the Consejo Superior de Investigaciones Científicas.Peer reviewe

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto- noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far