Comparative West Nile virus detection in organs of naturally infected American Crows (Corvus brachyrhynchos).

Widespread deaths of American Crows (Corvus brachyrhynchos)were associated with the 1999 outbreak of West Nile (WN) virus in the New York City region. We compared six organs from 20 crow carcasses as targets for WN virus detection. Half the carcasses had at least one positive test result for WN virus infection. The brain was the most sensitive test organ; it was the only positive organ for three of the positive crows. The sensitivity of crow organs as targets for WN virus detection makes crow death useful for WN virus surveillance

Subamorphous thermal conductivity of crystalline half-Heusler superlattices

En publicar-se l'article, l'autor Emigdio Chávez treballa a l'Institut Català de Nanociència i NanotecnologiaThe quest to improve the thermoelectric figure of merit has mainly followed the roadmap of lowering the thermal conductivity while keeping unaltered the power factor of the material. Ideally an electron-crystal phonon-glass system is desired. In this work, we report an extraordinary reduction of the cross-plane thermal conductivity in crystalline (TiNiSn):(HfNiSn) half-Heusler superlattices (SLs). We create SLs with thermal conductivities below the effective amorphous limit, which is kept in a large temperature range (120-300 K). We measured thermal conductivity at room temperature values as low as 0.75 W m⁻¹ K⁻¹, the lowest thermal conductivity value reported so far for half-Heusler compounds. By changing the deposition conditions, we also demonstrate that the thermal conductivity is highly impacted by the way the single segments of the SL grow. These findings show a huge potential for thermoelectric generators where an extraordinary reduction of the thermal conductivity is required but without losing the crystal quality of the syste

Quantum Time and Spatial Localization: An Analysis of the Hegerfeldt Paradox

Two related problems in relativistic quantum mechanics, the apparent superluminal propagation of initially localized particles and dependence of spatial localization on the motion of the observer, are analyzed in the context of Dirac's theory of constraints. A parametrization invariant formulation is obtained by introducing time and energy operators for the relativistic particle and then treating the Klein-Gordon equation as a constraint. The standard, physical Hilbert space is recovered, via integration over proper time, from an augmented Hilbert space wherein time and energy are dynamical variables. It is shown that the Newton-Wigner position operator, being in this description a constant of motion, acts on states in the augmented space. States with strictly positive energy are non-local in time; consequently, position measurements receive contributions from states representing the particle's position at many times. Apparent superluminal propagation is explained by noting that, as the particle is potentially in the past (or future) of the assumed initial place and time of localization, it has time to propagate to distant regions without exceeding the speed of light. An inequality is proven showing the Hegerfeldt paradox to be completely accounted for by the hypotheses of subluminal propagation from a set of initial space-time points determined by the quantum time distribution arising from the positivity of the system's energy. Spatial localization can nevertheless occur through quantum interference between states representing the particle at different times. The non-locality of the same system to a moving observer is due to Lorentz rotation of spatial axes out of the interference minimum.Comment: This paper is identical to the version appearing in J. Math. Phys. 41; 6093 (Sept. 2000). The published version will be found at http://ojps.aip.org/jmp/. The paper (40 page PDF file) has been completely revised since the last posting to this archiv

A Climate Index Optimized for Longshore Sediment Transport Reveals Interannual and Multidecadal Littoral Cell Rotations

A recent 35-year endpoint shoreline change analysis revealed significant counterclockwiserotations occurring in north-central Oregon, USA, littoral cells that extend 10s of kilometers in length.While the potential for severe El Niños to contribute to littoral cell rotations at seasonal to interannual scalewas previously recognized, the dynamics resulting in persistent (multidecadal) rotation were unknown,largely due to a lack of historical wave conditions extending back multiple decades and the difficulty ofseparating the timescales of shoreline variability in a high energy region. This study addresses this questionby (1) developing a statistical downscaling framework to characterize wave conditions relevant for longshoresediment transport during data-poor decades and (2) applying a one-line shoreline change model toquantitatively assess the potential for such large embayed beaches to rotate. A climateINdex was optimizedto capture variability in longshore wave power as a proxy for potentialLOngshore Sediment Transport(LOST_IN), and a procedure was developed to simulate many realizations of potential wave conditions fromthe index. Waves were transformed dynamically with Simulating Waves Nearshore to the nearshore asinputs to a one-line model that revealed shoreline rotations of embayed beaches at multiple time and spatialscales not previously discernible from infrequent observations. Model results indicate that littoral cellsrespond to both interannual and multidecadal oscillations, producing comparable shoreline excursions toextreme El Niño winters. The technique quantitatively relates morphodynamic forcing to specific climatepatterns and has the potential to better identify and quantify coastal variability on timescales relevant to achanging climate.This work would not have been possible without funding from the NSF Graduate Research Fellowship Program (GRFP) through NSF grant DGE-1314109, the Coastal and Ocean Climate Applications (COCA) program through NOAA grant NA15OAR4310243, NOAA’s Regional Integrated Sciences and Assessments Program (RISA), under NOAA grant NA15OAR4310145, and the Spanish Ministerio de Educación Cultura y Deporte FPU (Formación del Profesorado Universitario) studentship BOE-A-2013-12235. Beach survey data collection undertaken on the Oregon coast was made possible by the Northwest Association of Networked Ocean Observing Systems (NANOOS) through NOAA grant NA16NOS0120019

Aurintricarboxylic Acid is a Canonical Disruptor of the TAZ-TEAD Transcriptional Complex

Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we report that the pharmacologically active small molecule aurintricarboxylic acid (ATA) acts as a disruptor of the TAZ-TEAD complex. ATA was identified in a high-throughput screen using a TAZ-TEAD AlphaLISA assay that was tailored to identify disruptors of this transcriptional complex. We further used fluorescence polarization assays both to confirm disruption of the TAZ-TEAD complex and to demonstrate that ATA binds to interface 3. We have previously shown that cell-based models that express the oncogenic TAZ-CAMTA1 (TC) fusion protein display enhanced TEAD transcriptional activity because TC functions as an activated form of TAZ. Utilizing cell-based studies and our TC model system, we performed TC/TEAD reporter, RNA-Seq, and qPCR assays and found that ATA inhibits TC/TEAD transcriptional activity. Further, disruption of TC/TEAD and TAZ/TEAD interaction by ATA abrogated anchorage-independent growth, the phenotype most closely linked to dysregulated TAZ/TEAD activity. Therefore, this study demonstrates that ATA is a novel small molecule that has the ability to disrupt the undruggable TAZ-TEAD interface

Diet induced modifications of fatty-acid composition in mealworm larvae (Tenebrio molitor)

The diet of Western human societies is characterized by an excess of saturated fatty acids (FAs) and a high concentration of ω-6 relative to ω-3 polyunsaturated FA (PUFA). These unbalanced diets are suspected to trigger diseases and disorders. To alleviate this public health concern, the production of healthier meat with more PUFAs of higher ω-3 concentration could potentially be achieved by modifying livestock diets. The high nutritional value and limited breeding costs of edible insects have brought insect feed into the discussion as a promising fat source for animal and human diets. In this study, we sought to increase the amount of ω-3 PUFAs in mealworm (Tenebrio molitor) larvae. We investigated the effects of diets varying in ω-3/ω-6 ratio and FA concentration but similar in PUFA proportion on larva FA composition. Mealworm larvae showed significant plasticity in lipid composition. High dietary ω-3/ω-6 ratios induced an increase in the proportion of ω-3 and a decrease in ω-6, which resulted in higher larval ω-3/ω-6 ratios, but also in higher larval PUFA proportion. Increasing FA concentrations in larva diets also favored the accumulation of PUFAs to the detriment of monounsaturated and saturated FAs. Providing ω-3-rich seeds to mealworm larvae could allow the production of economical animal fat with healthier PUFA percentages (> 60%) and ω-3/ω-6 ratios (>0.5)

Holography in asymptotically flat space-times and the BMS group

In a previous paper (hep-th/0306142) we have started to explore the holographic principle in the case of asymptotically flat space-times and analyzed in particular different aspects of the Bondi-Metzner-Sachs (BMS) group, namely the asymptotic symmetry group of any asymptotically flat space-time. We continue this investigation in this paper. Having in mind a S-matrix approach with future and past null infinity playing the role of holographic screens on which the BMS group acts, we connect the IR sectors of the gravitational field with the representation theory of the BMS group. We analyze the (complicated) mapping between bulk and boundary symmetries pointing out differences with respect to the AdS/CFT set up. Finally we construct a BMS phase space and a free hamiltonian for fields transforming w.r.t BMS representations. The last step is supposed to be an explorative investigation of the boundary data living on the degenerate null manifold at infinity.Comment: 31 pages, several changes in section 3 and 7 and references update

Relativistic conservation laws and integral constraints for large cosmological perturbations

For every mapping of a perturbed spacetime onto a background and with any vector field $\xi$ we construct a conserved covariant vector density $I(\xi)$, which is the divergence of a covariant antisymmetric tensor density, a "superpotential". $I(\xi)$ is linear in the energy-momentum tensor perturbations of matter, which may be large; $I(\xi)$ does not contain the second order derivatives of the perturbed metric. The superpotential is identically zero when perturbations are absent. By integrating conserved vectors over a part \Si of a hypersurface $S$ of the background, which spans a two-surface \di\Si, we obtain integral relations between, on the one hand, initial data of the perturbed metric components and the energy-momentum perturbations on \Si and, on the other hand, the boundary values on \di\Si. We show that there are as many such integral relations as there are different mappings, $\xi$'s, \Si's and \di\Si's. For given boundary values on \di\Si, the integral relations may be interpreted as integral constraints (e.g., those of Traschen) on local initial data including the energy-momentum perturbations. Conservation laws expressed in terms of Killing fields \Bar\xi of the background become "physical" conservation laws. In cosmology, to each mapping of the time axis of a Robertson-Walker space on a de Sitter space with the same spatial topology there correspond ten conservation laws. The conformal mapping leads to a straightforward generalization of conservation laws in flat spacetimes. Other mappings are also considered. ...Comment: This paper, published 7 years ago, was found useful by some researchers but originally was not put on the gr-qc website. Now it has been retyped with very minor changes: few wordings have been modified and several misprints occurring in the printed version correcte

Five Dimensional Rotating Black Hole in a Uniform Magnetic Field. The Gyromagnetic Ratio

In four dimensional general relativity, the fact that a Killing vector in a vacuum spacetime serves as a vector potential for a test Maxwell field provides one with an elegant way of describing the behaviour of electromagnetic fields near a rotating Kerr black hole immersed in a uniform magnetic field. We use a similar approach to examine the case of a five dimensional rotating black hole placed in a uniform magnetic field of configuration with bi-azimuthal symmetry, that is aligned with the angular momenta of the Myers-Perry spacetime. Assuming that the black hole may also possess a small electric charge we construct the 5-vector potential of the electromagnetic field in the Myers-Perry metric using its three commuting Killing vector fields. We show that, like its four dimensional counterparts, the five dimensional Myers-Perry black hole rotating in a uniform magnetic field produces an inductive potential difference between the event horizon and an infinitely distant surface. This potential difference is determined by a superposition of two independent Coulomb fields consistent with the two angular momenta of the black hole and two nonvanishing components of the magnetic field. We also show that a weakly charged rotating black hole in five dimensions possesses two independent magnetic dipole moments specified in terms of its electric charge, mass, and angular momentum parameters. We prove that a five dimensional weakly charged Myers-Perry black hole must have the value of the gyromagnetic ratio g=3.Comment: 23 pages, REVTEX, v2: Minor changes, v3: Minor change

Защитные покрытия на основе порошковых эпокси-полиэфирных красок, содержащих ускорители отверждения

As a result of the study, the effect of curing accelerators (heterocyclic amine and zinc-containing accelerator) on the structure, physico-mechanical and protective properties of coatings based on powder epoxy-polyester compositions was established. The introduction of accelerators into the compositions affects the depth and speed of the curing process of film formers and provides the possibility to reduce the curing temperature. It has been established that the use of heterocyclic amine accelerator is more effective than a zinc-containing catalyst. For compositions containing heterocyclic amine, a decrease in gel time and an increase in the complex of physico-mechanical and protective characteristics of the coatings are observed, which were evaluated for the resistance of the coatings to the static action of a 3 % solution of sodium chloride. It is shown that changes in the protective properties of coatings, depending on the composition, correlate with the structural parameters of the polymer film and are due to the formation of the spatial structure of the polymer with different cross-link density. The use of mixtures of the investigated curing accelerators leads to an increase in the density of the polymer spatial network. This provides high protective properties of coatings to the action of aggressive electrolytes by reducing the permeability of corrosive media into the coating material. For 5000 hours of testing there are no pockets of corrosion under a film and no significant disruption of the continuity of the coatings (bubbles, peeling, wrinkling and cracking) in comparison with the basic compositions that do not contain accelerators.В результате исследования установлен характер влияния ускорителей отверждения (гетероциклический амин и цинксодержащий ускоритель) на структуру, физико-механические и защитные свойства покрытий на основе порошковых эпокси-полиэфирных композиций. Введение ускорителей в состав композиций влияет на глубину и скорость процесса отверждения пленкообразователей и обеспечивает возможность снижения температуры отверждения. Установлено, что применение гетероциклического аминного ускорителя более эффективно, чем цинксодержащего ускорителя. Для композиций, содержащих гетероциклический амин, наблюдается снижение времени гелеобразования и повышение комплекса физико-механических и защитных характеристик покрытий, которые оценивались по стойкости покрытий к статическому воздействию 3 %-ного раствора хлорида натрия. Показано, что изменения защитных свойств покрытий в зависимости от состава коррелируют со структурными параметрами полимерной пленки и обусловлены формированием пространственной структуры полимера с различной плотностью поперечных связей. Применение смесей исследованных ускорителей отверждения приводит к росту плотности пространственной сетки полимера, что обеспечивает высокие защитные свойства покрытий к действию агрессивных электролитов за счет снижения проницаемости агрессивных сред в материал покрытий. За 5000 ч испытаний не наблюдается очагов подпленочной коррозии и нарушения сплошности покрытий (пузыри, отслаивание, сморщивание, растрескивание) в сравнении с базовыми составами, не содержащими ускорители