Syndrome de Garcin révélant un lymphome malin non hodgkinien

INTRODUCTION: R Garcin described progressive unilateral cranial nerve palsy in 1926. Garcin syndrome is characterized by progressive involvement of the cranial nerves culminating in total unilateral paralysis of all cranial nerves. Carcinoma of the skull base or ENT regions is the most common etiology. CASE REPORT: A 74-year-old man developed signs involving the left Vth (V2 and V3) cranial nerve then the VIth, VIIth and VIIIth cranial nerves and finally the IXth and Xth. MRI showed involvement of these cranial nerves with gadolinium uptake and involvement of the pons at the terminal phase. Careful ENT explorations failed to reveal a cause. The lymphocyte count was elevated in the cerebrospinal fluid. The patient died one year after diagnosis and the general autopsy was normal. The neuropathological studies led to the post-mortem diagnosis of type B non-Hodgkin lymphoma. CONCLUSION: In patients with Garcin syndrome, lymphoma is a possible diagnosis when carcinoma of the ENT regions or of the skull bases are not present

The mass-loss rates of red supergiants and the de Jager prescription

Mass loss of red supergiants (RSG) is important for the evolution of massive stars, but is not fully explained. Several empirical prescriptions have been proposed, trying to express the mass-loss rate (Mdot) as a function of fundamental stellar parameters (mass, luminosity, effective temperature). Our goal is to test whether the de Jager et al. (1988) prescription, used in some stellar evolution models, is still valid in view of more recent mass-loss determinations. By considering 40 Galactic RSGs presenting an infrared excess and an IRAS 60-mu flux larger than 2 Jy, and assuming a gas-to-dust mass ratio of 200, it is found that the de Jager rate agrees within a factor 4 with most Mdot estimates based on the 60-mu signal. It is also in agreement with 6 of the only 8 Galactic RSGs for which Mdot can be measured more directly through observations of the circumstellar gas. The two objects that do not follow the de Jager prescription (by an order of magnitude) are mu Cep and NML Cyg. We have also considered the RSGs of the Magellanic Clouds. Thanks to the works of Groenewegen et al. (2009) and Bonanos et al. (2010), we find that the RSGs of the SMC have Mdots consistent with the de Jager rate scaled by (Z/Zsun)**(alpha), where Z is the metallicity and alpha is 0.7. The situation is less clear for the LMC RSGs. In particular, for luminosties larger than 1.6E+05 Lsun, one finds numerous RSGs (except WOH-G64) having Mdot significantly smaller than the de Jager rate, and indicating that Mdot would no longer increase with L. Before this odd situation is confirmed through further analysis of LMC RSGs, we suggest to keep the de Jager prescription unchanged at solar metallicity in the stellar evolutionary models and to apply a (Z/Zsun)**0.7 dependence.Comment: 13 pages, 9 figures. Accepted by Astronomy and Astrophysic

Quantification of Dendritic Cells and Osteoclasts in the Bone Marrow of Patients with Monoclonal Gammopathy

The purpose of this study was to find histological clues for reliable differentiation between monoclonal gammopathy of undetermined significance (MGUS) and myeloma when clinical parameters are controversial. Differential appearance of dendritic cells and osteoclasts, two cell types developing from the monocytic lineage upon distinct cytokine activation profile, might be a useful approach. Bone and bone-marrow biopsies performed in 105 patients were studied using histomorphometry after identification of osteoclasts (by histochemical identification of tartrate resistant acid phosphatase) and dendritic cells (by immunohistochemical detection of the S-100 protein). Patients were classified by the World Health Organization criteria but histopathological criteria were more adapted to identify MGUS (53 cases), myeloma (46), B-cell lymphoma (six) since six myeloma were not correctly classified. Histomorphometry was compared to 15 control cases. The number of marrow dendritic cell was significantly increased with B-cell lymphoma >MGUS >myeloma > controls. Dendritic cell were often mixed with lymphoma cells. Myeloma had increased bone resorption with a high osteoclast number and moderate increase in dendritic cells. B-cell lymphomas had a considerable increase in dendritic cell but presented mononucleated osteoclasts. These findings can help in the classification of MGUS in the early stages of the disease and could help to propose preventive treatments

Late-Type Red Supergiants: Too Cool for the Magellanic Clouds?

We have identified seven red supergiants (RSGs) in the Large Magellanic Cloud (LMC) and four RSGs in the Small Magellanic Cloud (SMC), all of which have spectral types that are considerably later than the average type observed in their parent galaxy. Using moderate-resolution optical spectrophotometry and the MARCS stellar atmosphere models, we determine their physical properties and place them on the H-R diagram for comparison with the predictions of current stellar evolutionary tracks. The radial velocities of these stars suggest that they are likely all members of the Clouds rather than foreground dwarfs or halo giants. Their locations in the H-R diagram also show us that those stars are cooler than the current evolutionary tracks allow, appearing to the right of the Hayashi limit, a region in which stars are no longer in hydrodynamic equilibrium. These stars exhibit considerable variability in their V magnitudes, and three of these stars also show changes in their effective temperatures (and spectral types) on the time-scales of months. One of these stars, [M2002] SMC 055188, was caught in an M4.5 I state, as late as that seen in HV 11423 at its recent extreme: considerable later, and cooler, than any other supergiant in the SMC. In addition, we find evidence of variable extinction due to circumstellar dust and changes in the stars' luminosities, also consistent with our recent findings for HV 11423 - when these stars are hotter they are also dustier and more luminous. We suggest that these stars have unusual properties because they are in an unstable (and short-lived) evolutionary phase.Comment: 26 pages, 6 figures; submitted to the Astrophysical Journa

Stress response function of a two-dimensional ordered packing of frictional beads

We study the stress profile of an ordered two-dimensional packing of beads in response to the application of a vertical overload localized at its top surface. Disorder is introduced through the Coulombic friction between the grains which gives some indeterminacy and allows the choice of one constrained random number per grain in the calculation of the contact forces. The so-called `multi-agent' technique we use, lets us deal with systems as large as $1000\times1000$ grains. We show that the average response profile has a double peaked structure. At large depth $z$, the position of these peaks grows with $cz$, while their widths scales like $\sqrt{Dz}$. $c$ and $D$ are analogous to `propagation' and `diffusion' coefficients. Their values depend on that of the friction coefficient $\mu$. At small $\mu$, we get $c_0-c \propto \mu$ and $D \propto \mu^\beta$, with $\beta \sim 2.5$, which means that the peaks get closer and wider as the disorder gets larger. This behavior is qualitatively what was predicted in a model where a stochastic relation between the stress components is assumed.Comment: 7 pages, 7 figures, accepted version to Europhys. Let

Systematic trend of water vapour absorption in red giant atmospheres revealed by high resolution TEXES 12 micron spectra

The structures of the outer atmospheres of red giants are very complex. The notion of large optically thick molecular spheres around the stars (MOLspheres) has been invoked in order to explain e.g. spectro-interferometric observations. However, high-resolution spectra in the mid-IR do not easily fit into this picture. They rule out any large sphere of water vapour in LTE surrounding red giants. Our aim here is to investigate high-resolution, mid-infrared spectra for a range of red giants, from early-K to mid M. We have recorded 12 microns spectra of 10 well-studied bright red giants, with TEXES on the IRTF. We find that all giants in our study cooler than 4300 K, spanning a range of effective temperatures, show water absorption lines stronger than expected. The strengths of the lines vary smoothly with spectral type. We identify several spectral features in the wavelength region that undoubtedly are formed in the photosphere. From a study of water-line ratios of the stars, we find that the excitation temperatures, in the line-forming regions, are several hundred Kelvin lower than expected from a classical photospheric model. This could either be due to an actually lower temperature structure in the outer regions of the photospheres caused by, for example, extra cooling, or due to non-LTE level populations, affecting the source function and line opacities. We have demonstrated that these diagnostically interesting water lines are a general feature of red giants across spectral types, and we argue for a general explanation of their formation rather than explanations requiring specific properties. Since the water lines are neither weak (filled in by emission) nor appear in emission, as predicted by LTE MOLsphere models in their simplest forms, the evidence for the existence of such large optically-thick, molecular spheres enshrouding the stars is weakened. (abbreviated)Comment: Accepted for publication in A&

The massive expanding molecular torus in the planetary nebula NGC 6302

We measure the mass and kinematics of the massive molecular torus in the planetary nebula NGC 6302. The nebula is the proto-typical butterfly nebula. The origin of the wing-like morphology is disputed: determining the mass-loss history of the confining torus is an important step in understanding the formation of this structure. We performed submillimeter observations with JCMT and the SMA interferometer. The continuum emission as well as the J=2-1 and 3-2 transitions of 12CO and 13CO are analysed at arcsecond resolution. The CO emission indicates a mass of the torus of ~ 2Msun +/- 1Msun. The 12CO and 13CO emission matches the dark lane seen in absorption in the Halpha image of the object. The CO torus is expanding with a velocity of ~ 8 km/s, centred at Vlsr=-31.5 km/s. The size and expansion velocity of the torus indicates that the torus was ejected from ~ 7500 yr to 2900 yr ago, with a mass-loss rate of 5x10^{-4}Msun/yr. We also see a ballistic component in the CO images with a velocity gradient of 140 km/s/pc. The derived mass-loss history of the torus favours binary interaction as the cause of the ejection of the torus. We predict the existence of a companion with an orbital period P < 1 month.Comment: 13 pages, 10 figures, accepted for publication in A&

Enhanced statistical stability in coherent interferometric imaging

http://iopscience.iop.org/0266-5611/International audienc

The Shapes of AGB Envelopes as Probes of Binary Companions

We describe how the large scale geometry of the circumstellar envelopes of asymptotic giant branch stars can be used to probe the presence of unseen stellar companions. A nearby companion modifies the mass loss by gravitationally focusing the wind towards the orbital plane, and thereby determines the shape of the envelope at large distances from the star. Using available simulations, we develop a prescription for the observed shapes of envelopes in terms of the binary parameters, envelope orientation, and type of observation. The prescription provides a tool for the analysis of envelope images at optical, infrared, and millimetre wavelengths, which can be used to constrain the presence of companions in well observed cases. We illustrate this approach by examining the possible role of binary companions in triggering the onset of axi-symmetry in planetary nebula formation. If interaction with the primary leads to axi-symmetry, the spherical halos widely seen around newly formed nebulae set limits on the companion mass. Only low mass objects may orbit close to the primary without observable shaping effects: they remain invisible until the interaction causes a sudden change in the mass loss geometry.Comment: 11 pages, 7 figures, to appear in MNRA