The Ayurvedic management for Tinea Versicolor by Virechana Karma

Tinea versicolor is a common skin rash caused by over growth of yeast over skin surface resulting in uneven skin colour and scaling which is harmless, asymptomatic and non-contagious.[1] In this case generally medication used are antifungal i.e. Ketaconazoles systemic and tropically which may lead to many side effects and re-occurrence. In Ayurveda there is no detail explanation but somehow correlated with Sidma Kusta, which is one among the Maha Kusta. Which can be treated by Vamana Karma, Virechana Karma or Rakthamokshana.[2] By this we can say Ayurvedic treatment modalities are utilized according to presentation of disease

CGMap Ongoing Research in Africa Projects Summary

This summary looks at the number of projects entered in the map, countries where projects are reported to be working and the research area that the projects focus on. Data was extracted on July 06, 2010

Effects of Single and Integrated Water, Sanitation, Handwashing, and Nutrition Interventions on Child Soil-Transmitted Helminth and Giardia infections: A Cluster-Randomized Controlled Trial in Rural Kenya

Helminth and protozoan infections affect more than 1 billion children globally. Improving water quality, sanitation, handwashing, and nutrition could be more sustainable control strategies for parasite infections than mass drug administration, while providing other quality of life benefits

A Review on Bio-Based Control of Post-Harvest Diseases

Bacillus subtilis non-pathogenic beneficial bacteria, promotes plant growth, disease resistance and tolerance to abiotic stresses. It produces bioactive substances with antibiotic properties and induces physiological features in plant metabolism without adverse effects on the environment or human health. Bacillus subtilis has been used to treat various postharvest diseases during handling, transportation and storage of various fresh fruits and vegetables. It is the first microorganism patented as a postharvest bio control agent for Brown rot of stone fruits, improving the post-harvest physiology of various fruit/vegetables. Bacillus strains AG1 and H110 have been shown to be effective against Vine wood fungal pathogens and post-harvest pathogens. They have been shown to reduce symptoms of Anthracnose in fruit caused by fungal pathogens Colletotrichum gloeosporioides and C. acutatum and White rot caused by Botryosphaeria dothidea. Endophytic Bacillus strains have been developed that can colonize plant tissues and live in the same ecological niches as pathogens, thus preventing post-harvest diseases and improving preservation during storage. Bacillus strains induce auxins, cytokinins, gibberellins, ABA, JA and SA in plants, which can stimulate plant growth under stressful conditions. Endophytic bacteria can induce ISR against pathogens and abiotic stressors, extending the shelf life of stored fruits and vegetables. Microbial antagonists can be applied after harvest to control fruit and vegetable diseases, but a single microbial strain cannot prevent all fruits/vegetables from decaying during storage. Combining diverse antagonistic microorganisms with diverse microbial activity and combining various bio-controlling characteristics can prevent post-harvest decay on fruits/vegetables

Climate Change Impact on Horticultural Crops: A Review

Our civilization is fundamentally based on agriculture, which provides resources and food to an expanding population. But because of rising temperatures, altered rainfall patterns, and a rise in the frequency and severity of extreme weather events, climate change is endangering this industry. Our study aims to fill a significant gap in the existing literature by focusing on the effects of climate change on vegetable crops. It also highlights the need to address climate change in a differentiated manner, taking into account the unique characteristics of each agricultural sector. By using the Web of Science and Scopus databases, 219 publications were carefully examined to see which ones fully addressed how climate change is affecting vegetable crops. Only 53 of the 219 publications that were reviewed were solely concerned with how climate change is affecting vegetable crops. This suggests that more specialised research is needed in this field, especially considering the complex issues that climate change raises regarding yield, non-trivial quality, and food safety. Future research in this area is therefore encouraged. Crop-based adaptation techniques are required, taking into account the crop's characteristics, degree of sensitivity, and agro-ecological zone. In addition, monitoring the ability of various horticulture crops to absorb carbon dioxide in comparison to annual field crops can help create a blueprint for addressing climate change-related problems

Spatial Variability of Escherichia coli in Rivers of Northern Coastal Ecuador

The use of contaminated surface water continues to be a pressing issue in areas of the world where people lack improved drinking water sources. In northern coastal Ecuador, many communities rely on untreated surface water as their primary source of drinking water. We undertook a study to explore how microscale river hydrodynamics affect microbial water quality at community water collection locations at three rivers with varying stream velocity and turbidity profiles. To examine how the distance from river shore and physiochemical water quality variables affect microbial contamination levels in the rivers; we collected a total of 355 water samples within six villages on three rivers; and tested for Escherichia coli concentrations using the IDEXX Quanti-tray method. We found that log10 E. coli concentrations decreased with increasing distance from shore (? = ?0.017; p = 0.003). Water in the main channel had E. coli concentrations on average 0.12 log10 lower than within eddies along the river shore and 0.27 log10 lower between the sample closest to shore and any sample >6 m from the shore. Higher E. coli concentrations were also significantly associated with increased turbidity (? = 0.003; p < 0.0001) and decreased dissolved oxygen levels (? = ?0.310; p < 0.0001). The results of this study can help inform community members about the safest locations to collect drinking water and also provide information on watershed scale transport of microbial contaminants between village

Performance of Gluconate and Lactate Based Formulations on Plant Growth and Yield Attributes in Maize (Zea mays L.)

Aim: To check the efficacy of gluconate and lactate based formulations on plant growth and yield characteristics of maize. Place and Duration of Study: School of Agricultural Sciences, Malla Reddy University, Hyderabad, spring 2021. Methodology: The experiment was laid-out in Randomized Block Design (RBD), with Maize hybrid (DHM-117) spacing adopted (60 x 20 cm) with 4 replications. The treatments viz; T1: Control (No fertilizer), T2:100% RDF, T3: 75% RDF + 25% Sahasra Organic Formulations (SOF), T4:50% RDF + 50% SOF, T5: 25% RDF + 75% SOF, T6: 100% SOF. The RDF (N:72-80; P:24; K:20 kg/acre). Results: The yield attributes were recorded intermittently and maximum grain yield (7,649.8 kg &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ha-1) and Stover yield (8,859.87 kg ha-1) were recorded with T2 (100% RDF), followed by T3 (75% RDF + 25% Sahasra Organic Formulations). Similarly gross returns (₹ 123606.5 ha-1), net returns (₹ 87116.49 ha-1) and B: C (3.4) ratio was also recorded highest in T2 followed by T3 (75% RDF + 25 % SOF), while the lowest were recorded with T1 (control). Conclusion: Adoption of gluconate and lactate based formulations enhanced soil fertility, soil organic carbon and yield in Maize crop. The study concluded that the integrated approach i.e., T3 (75% RDF + 25% SOF) has realized the highest net returns (₹ 82466.8 ha-1) and B: C ratio (3.4) in comparison to the 100% RDF treatment thus reducing the cost of fertilizers and benefiting the net returns to the farmers

Design, synthesis and characterization of novel paracetamol derivatives to target breast cancer

1257-1272Most breast cancers are Estrogen Receptor-positive type. In the mammary epithelial, estrogen controls many cellular activities such as proliferation, differentiation and migration. There are two genetically distinct and functional estrogen receptors (ERs), ERα and ERβ, belonging to the superfamily of nuclear receptors for steroid/thyroid harmones. Estrogenexert its functions in different tissues by binding with its receptors, including alpha and beta (ERα and ERβ). Estrogen Receptor alpha (ERα) controls breast tissue development and progression of breast cancer. Paracetamol is one of the most widely used medicines. A recent experimental study suggests that paracetamol may have several pharmacological effects other than its well known analgesic/antipyretic properties. The docking study was performed on different paracetamol derivatives using Schrodinger 2015 (maestro 10.1) on Human Estrogen Receptor Alpha Ligand-Binding Domain (1XP6) and Endothelial nitric oxide synthase (3NLE). The in silico studies indicate that N-(4-((1H-1,2,3-triazol-4-yl)methoxy)phenyl) acetamide derivatives exhibit comparable docking score and good hydrogen bond interactions at Ligand binding domain of ERα and 3NLE. Based on the docking studies, a new series of N-(4-((1H-1,2,3-triazol-4-yl)methoxy)phenyl) acetamide derivatives have been synthesized by employing click chemistry approach. Nine compounds have been evaluated for their cytotoxicity in MCF-7 cell line and anti oxidant activity. Many of the synthesized compounds exhibit potent cytotoxic and anti oxidant activity. In particular 5c, 5g, and 5b compounds show most potent cytotoxicity with IC50 value of 19.83, 20.57, 20.83 µg/mL respectively and 5e and 5f show most potent anti oxidant activity with IC50 value of 0.4, 0.5 µg/mL respectively

Association between Malaria Infection and Early Childhood Development Mediated by Anemia in Rural Kenya.

Malaria is a leading cause of morbidity and mortality among children under five years of age, with most cases occurring in Sub-Saharan Africa. Children in this age group in Africa are at greatest risk worldwide for developmental deficits. There are research gaps in quantifying the risks of mild malaria cases, understanding the pathways linking malaria infection and poor child development, and evaluating the impact of malaria on the development of children under five years. We analyzed the association between malaria infection and gross motor, communication, and personal social development in 592 children age 24 months in rural, western Kenya as part of the WASH Benefits environmental enteric dysfunction sub-study. Eighteen percent of children had malaria, 20% were at risk for gross motor delay, 21% were at risk for communication delay, and 23% were at risk for personal social delay. Having a positive malaria test was associated with increased risk for gross motor, communication, and personal social delay while adjusting for child characteristics, household demographics, study cluster, and intervention treatment arm. Mediation analyses suggested that anemia was a significant mediator in the pathway between malaria infection and risk for gross motor, communication, and personal social development delays. The proportion of the total effect of malaria on the risk of developmental delay that is mediated by anemia across the subscales was small (ranging from 9% of the effect on gross motor development to 16% of the effect on communication development mediated by anemia). Overall, malaria may be associated with short-term developmental delays during a vulnerable period of early life. Therefore, preventative malaria measures and immediate treatment are imperative for children's optimal development, particularly in light of projections of continued high malaria transmission in Kenya and Africa