Farm-wide virtual load monitoring for offshore wind structures via Bayesian neural networks

Offshore wind structures are subject to deterioration mechanisms throughout their operational lifetime. Even if the deterioration evolution of structural elements can be estimated through physics-based deterioration models, the uncertainties involved in the process hurdle the selection of lifecycle management decisions. In this scenario, the collection of relevant information through an efficient monitoring system enables the reduction of uncertainties, ultimately driving more optimal lifecycle decisions. However, a full monitoring instrumentation implemented on all wind turbines in a farm might become unfeasible due to practical and economical constraints. Besides, certain load monitoring systems often become defective after a few years of marine environment exposure. Addressing the aforementioned concerns, a farm-wide virtual load monitoring scheme directed by a fleet-leader wind turbine offers an attractive solution. Fetched with data retrieved from a fully-instrumented wind turbine, a model can be trained and then deployed, thus yielding load predictions of non-fully monitored wind turbines, from which only standard data remains available. In this paper, we propose a virtual load monitoring framework formulated via Bayesian neural networks (BNNs) and we provide relevant implementation details needed for the construction, training, and deployment of BNN data-based virtual monitoring models. As opposed to their deterministic counterparts, BNNs intrinsically announce the uncertainties associated with generated load predictions and allow to detect inaccurate load estimations generated for non-fully monitored wind turbines. The proposed virtual load monitoring is thoroughly tested through an experimental campaign in an operational offshore wind farm and the results demonstrate the effectiveness of BNN models for fleet-leader-based farm-wide virtual monitoring

HUWE1 mutation explains phenotypic severity in a case of familial idiopathic intellectual disability

The advent of next-generation sequencing has proven to be a key force in the identification of new genes associated with intellectual disability. In this study, high-throughput sequencing of the coding regions of the X-chromosome led to the identification of a missense variant in the HUWE1 gene. The same variant has been reported before by Froyen et al. (2008). We compare the phenotypes and demonstrate that, in the present family, the HUWE1 mutation segregates with the more severe ID phenotypes of two out of three brothers. The third brother has a milder form of ID and does not carry the mutation

Spitzer Mid-to-Far-Infrared Flux Densities of Distant Galaxies

We study the infrared (IR) properties of high-redshift galaxies using deep Spitzer 24, 70, and 160 micron data. Our primary interest is to improve the constraints on the total IR luminosities, L(IR), of these galaxies. We combine the Spitzer data in the southern Extended Chandra Deep Field with a K-band-selected galaxy sample and photometric redshifts from the Multiwavelength Survey by Yale-Chile. We used a stacking analysis to measure the average 70 and 160 micron flux densities of 1.5 < z < 2.5 galaxies as a function of 24 micron flux density, X-ray activity, and rest-frame near-IR color. Galaxies with 1.5 < z < 2.5 and S(24)=53-250 micro-Jy have L(IR) derived from their average 24-160 micron flux densities within factors of 2-3 of those derived from the 24 micron flux densities only. However, L(IR) derived from the average 24-160 micron flux densities for galaxies with S(24) > 250 micro-Jy and 1.5 < z < 2.5 are lower than those derived using only the 24 micron flux density by factors of 2-10. Galaxies with S(24) > 250 micro-Jy have S(70)/S(24) flux ratios comparable to sources with X-ray detections or red rest-frame IR colors, suggesting that warm dust possibly heated by AGN may contribute to the high 24 micron emission. Based on the average 24-160 micron flux densities, nearly all 24 micron-selected galaxies at 1.5 < z < 2.5 have L(IR) < 6 x 10^12 solar luminosities, which if attributed to star formation corresponds to < 1000 solar masses per year. This suggests that high redshift galaxies may have similar star formation efficiencies and feedback processes as local analogs. Objects with L(IR) > 6 x 10^12 solar luminosities are quite rare, with a surface density ~ 30 +/- 10 per sq. deg, corresponding to ~ 2 +/- 1 x 10^-6 Mpc^-3 over 1.5 < z < 2.5.Comment: Accepted for Publication in ApJ. AASTeX format. 34 pages, 12 figures. Updated references and other small textual revision

Constraining stellar assembly and AGN feedback at the peak epoch of star formation

We study stellar assembly and feedback from active galactic nuclei (AGN) around the epoch of peak star formation (1<z<2), by comparing hydrodynamic simulations to rest-frame UV-optical galaxy colours from the Wide Field Camera 3 (WFC3) Early-Release Science (ERS) Programme. Our Adaptive Mesh Refinement simulations include metal-dependent radiative cooling, star formation, kinetic outflows due to supernova explosions, and feedback from supermassive black holes. Our model assumes that when gas accretes onto black holes, a fraction of the energy is used to form either thermal winds or sub-relativistic momentum-imparting collimated jets, depending on the accretion rate. We find that the predicted rest-frame UV-optical colours of galaxies in the model that includes AGN feedback is in broad agreement with the observed colours of the WFC3 ERS sample at 1<z<2. The predicted number of massive galaxies also matches well with observations in this redshift range. However, the massive galaxies are predicted to show higher levels of residual star formation activity than the observational estimates, suggesting the need for further suppression of star formation without significantly altering the stellar mass function. We discuss possible improvements, involving faster stellar assembly through enhanced star formation during galaxy mergers while star formation at the peak epoch is still modulated by the AGN feedback.Comment: 6 pages, 4 figures, accepted for publication in MNRAS Letter

Predictions for the Counts of Faint, High-Redshift Galaxies in the Mid-Infrared

Deep mid-infrared (MIR) observations could reveal a population of faint, high-redshift (z>3) dusty starburst galaxies that are the progenitors of present-day spheroids or bulges, and are beyond the reach of current instruments. We utilize a semi-analytic galaxy formation scheme to find an extreme model for the MIR galaxy counts, designed to maximize the number of detectable sources down to a flux level of a few nJy. The model incorporates the formation of heavily dust-enshrouded stellar populations at high redshift, and is consistent with existing observations, including faint counts at 1.6um in the NICMOS Hubble Deep Field, and the upper limit on the extragalactic MIR background from TeV gamma rays. Our models predict upto 0.5 galaxies/sq.arcsec at the threshold of 100 nJy at 6um, with a comparable or larger surface density at longer MIR wavelengths. We conclude that a significant new population of high-redshift galaxies could be detected by the Space Infrared Telescope Facility (SIRTF) and Next Generation Space Telescope (NGST). Such a population would constitute background noise for the Terrestrial Planet Finder (TPF), and could necessitate repeat observations: every {\it TPF} resolution element have a 10 percent chance of being contaminated by a background galaxy.Comment: Submitted to ApJ, 8 emulateapj pages with 6 figure

Probing cosmic dawn with emission lines: predicting infrared and nebular line emission for ALMA and JWST

Infrared and nebular lines provide some of our best probes of the physics regulating the properties of the interstellar medium (ISM) at high-redshift. However, interpreting the physical conditions of high-redshift galaxies directly from emission lines remains complicated due to inhomogeneities in temperature, density, metallicity, ionisation parameter, and spectral hardness. We present a new suite of cosmological, radiation-hydrodynamics simulations, each centred on a massive Lyman-break galaxy that resolves such properties in an inhomogeneous ISM. Many of the simulated systems exhibit transient but well defined gaseous disks that appear as velocity gradients in [CII]~158.6$\mu$m emission. Spatial and spectral offsets between [CII]~158.6$\mu$m and [OIII]~88.33$\mu$m are common, but not ubiquitous, as each line probes a different phase of the ISM. These systems fall on the local [CII]-SFR relation, consistent with newer observations that question previously observed [CII]~158.6$\mu$m deficits. Our galaxies are consistent with the nebular line properties of observed $z\sim2-3$ galaxies and reproduce offsets on the BPT and mass-excitation diagrams compared to local galaxies due to higher star formation rate (SFR), excitation, and specific-SFR, as well as harder spectra from young, metal-poor binaries. We predict that local calibrations between H$\alpha$ and [OII]~3727$\AA$ luminosity and galaxy SFR apply up to $z>10$, as do the local relations between certain strong line diagnostics (R23 and [OIII]~5007$\AA$/H$\beta$) and galaxy metallicity. Our new simulations are well suited to interpret the observations of line emission from current (ALMA and HST) and upcoming facilities (JWST and ngVLA)

New Methods for Identifying Lyman Continuum Leakers and Reionization-Epoch Analogues

Identifying low-redshift galaxies that emit Lyman continuum radiation (LyC leakers) is one of the primary, indirect methods of studying galaxy formation in the epoch of reionization. However, not only has it proved challenging to identify such systems, it also remains uncertain whether the low-redshift LyC leakers are truly ‘analogues’ of the sources that reionized the Universe. Here, we use high-resolution cosmological radiation hydrodynamics simulations to examine whether simulated galaxies in the epoch of reionization share similar emission line properties to observed LyC leakers at z ∼ 3 and z ∼ 0. We find that the simulated galaxies with high LyC escape fractions (fesc) often exhibit high O32 and populate the same regions of the R23–O32 plane as z ∼ 3 LyC leakers. However, we show that viewing angle, metallicity, and ionization parameter can all impact where a galaxy resides on the O32–fesc plane. Based on emission line diagnostics and how they correlate with fesc, lower metallicity LyC leakers at z ∼ 3 appear to be good analogues of reionization-era galaxies. In contrast, local [S II]-deficient galaxies do not overlap with the simulated high-redshift LyC leakers on the S II Baldwin–Phillips–Terlevich (BPT) diagram; however, this diagnostic may still be useful for identifying leakers. We use our simulated galaxies to develop multiple new diagnostics to identify LyC leakers using infrared and nebular emission lines. We show that our model using only [C II]158 μm and [O III]88 μm can identify potential leakers from non-leakers from the local Dwarf Galaxy Survey. Finally, we apply this diagnostic to known high-redshift galaxies and find that MACS 1149_JD1 at z = 9.1 is the most likely galaxy to be actively contributing to the reionization of the Universe

Duplications of the critical Rubinstein-Taybi deletion region on chromosome 16p13.3 cause a novel recognisable syndrome

Background The introduction of molecular karyotyping technologies facilitated the identification of specific genetic disorders associated with imbalances of certain genomic regions. A detailed phenotypic delineation of interstitial 16p13.3 duplications is hampered by the scarcity of such patients. Objectives To delineate the phenotypic spectrum associated with interstitial 16p13.3 duplications, and perform a genotype-phenotype analysis. Results The present report describes the genotypic and phenotypic delineation of nine submicroscopic interstitial 16p13.3 duplications. The critically duplicated region encompasses a single gene, CREBBP, which is mutated or deleted in Rubinstein-Taybi syndrome. In 10 out of the 12 hitherto described probands, the duplication arose de novo. Conclusions Interstitial 16p13.3 duplications have a recognizable phenotype, characterized by normal to moderately retarded mental development, normal growth, mild arthrogryposis, frequently small and proximally implanted thumbs and characteristic facial features. Occasionally, developmental defects of the heart, genitalia, palate or the eyes are observed. The frequent de novo occurrence of 16p13.3 duplications demonstrates the reduced reproductive fitness associated with this genotype. Inheritance of the duplication from a clinically normal parent in two cases indicates that the associated phenotype is incompletely penetrant

Probing Cosmic Dawn: Modelling the Assembly History, SEDs, and Dust Content of Selected z∼9 Galaxies

The presence of spectroscopically confirmed Balmer breaks in galaxy spectral energy distributions (SEDs) at z > 9 provides one of the best probes of the assembly history of the first generations of stars in our Universe. Recent observations of the gravitationally lensed source, MACS 1149_JD1 (JD1), indicate that significant amounts of star formation likely occurred at redshifts as high as z ≃ 15. The inferred stellar mass, dust mass, and assembly history of JD1, or any other galaxy at these redshifts that exhibits a strong Balmer break, can provide a strong test of our best theoretical models from high-resolution cosmological simulations. In this work, we present the results from a cosmological radiation-hydrodynamics simulation of the region surrounding a massive Lyman-break galaxy. For two of our most massive systems, we show that dust preferentially resides in the vicinity of the young stars thereby increasing the strength of the measured Balmer break such that the simulated SEDs are consistent with the photometry of JD1 and two other z > 9 systems (GN-z10-3 and GN-z9-1) that have proposed Balmer breaks at high redshift. We find strong variations in the shape and luminosity of the SEDs of galaxies with nearly identical stellar and halo masses, indicating the importance of morphology, assembly history, and dust distribution in making inferences on the properties of individual galaxies at high redshifts. Our results stress the importance that dust may play in modulating the observable properties of galaxies, even at the extreme redshifts of z > 9

New methods for identifying Lyman continuum leakers and reionization-epoch analogues

Identifying low-redshift galaxies that emit Lyman Continuum radiation (LyC leakers) is one of the primary, indirect methods of studying galaxy formation in the epoch of reionization. However, not only has it proved challenging to identify such systems, it also remains uncertain whether the low-redshift LyC leakers are truly "analogues" of the sources that reionized the Universe. Here, we use high-resolution cosmological radiation hydrodynamics simulations to examine whether simulated galaxies in the epoch of reionization share similar emission line properties to observed LyC leakers at $z\sim3$ and $z\sim0$. We find that the simulated galaxies with high LyC escape fractions ($f_{\rm esc}$) often exhibit high O32 and populate the same regions of the R23-O32 plane as $z\sim3$ LyC leakers. However, we show that viewing angle, metallicity, and ionisation parameter can all impact where a galaxy resides on the O32-$f_{\rm esc}$ plane. Based on emission line diagnostics and how they correlate with $f_{\rm esc}$, lower-metallicity LyC leakers at $z\sim3$ appear to be good analogues of reionization-era galaxies. In contrast, local [SII]-deficient galaxies do not overlap with the simulated high-redshift LyC leakers on the SII-BPT diagram; however, this diagnostic may still be useful for identifying leakers. We use our simulated galaxies to develop multiple new diagnostics to identify LyC leakers using IR and nebular emission lines. We show that our model using only [CII]$_{\rm 158\mu m}$ and [OIII]$_{\rm 88\mu m}$ can identify potential leakers from non-leakers from the local Dwarf Galaxy Survey. Finally, we apply this diagnostic to known high-redshift galaxies and find that MACS1149_JD1 at $z=9.1$ is the most likely galaxy to be actively contributing to the reionization of the Universe