4,584 research outputs found
The large N limit of M2-branes on Lens spaces
We study the matrix model for N M2-branes wrapping a Lens space L(p,1) =
S^3/Z_p. This arises from localization of the partition function of the ABJM
theory, and has some novel features compared with the case of a three-sphere,
including a sum over flat connections and a potential that depends
non-trivially on p. We study the matrix model both numerically and analytically
in the large N limit, finding that a certain family of p flat connections give
an equal dominant contribution. At large N we find the same eigenvalue
distribution for all p, and show that the free energy is simply 1/p times the
free energy on a three-sphere, in agreement with gravity dual expectations.Comment: 28 pages, 4 figure
TeV Scale Implications of Non Commutative Space time in Laboratory Frame with Polarized Beams
We analyze , and processes within the
Seiberg-Witten expanded noncommutative scenario using polarized beams. With
unpolarized beams the leading order effects of non commutativity starts from
second order in non commutative(NC) parameter i.e. , while with
polarized beams these corrections appear at first order () in cross
section. The corrections in Compton case can probe the magnetic
component() while in Pair production and Pair annihilation
probe the electric component() of NC parameter. We include the
effects of earth rotation in our analysis. This study is done by investigating
the effects of non commutativity on different time averaged cross section
observables. The results which also depends on the position of the collider,
can provide clear and distinct signatures of the model testable at the
International Linear Collider(ILC).Comment: 22 pages, 19 figures, new comments and references added, few typos
corrected, Published in JHE
Lattice QCD and the Schwarz alternating procedure
A numerical simulation algorithm for lattice QCD is described, in which the
short- and long-distance effects of the sea quarks are treated separately. The
algorithm can be regarded, to some extent, as an implementation at the quantum
level of the classical Schwarz alternating procedure for the solution of
elliptic partial differential equations. No numerical tests are reported here,
but theoretical arguments suggest that the algorithm should work well also at
small quark masses.Comment: Plain TeX source, 20 pages, figures include
On the linear fractional self-attracting diffusion
In this paper, we introduce the linear fractional self-attracting diffusion
driven by a fractional Brownian motion with Hurst index 1/2<H<1, which is
analogous to the linear self-attracting diffusion. For 1-dimensional process we
study its convergence and the corresponding weighted local time. For
2-dimensional process, as a related problem, we show that the renormalized
self-intersection local time exists in L^2 if .Comment: 14 Pages. To appear in Journal of Theoretical Probabilit
Towards strange metallic holography
We initiate a holographic model building approach to `strange metallic'
phenomenology. Our model couples a neutral Lifshitz-invariant quantum critical
theory, dual to a bulk gravitational background, to a finite density of gapped
probe charge carriers, dually described by D-branes. In the physical regime of
temperature much lower than the charge density and gap, we exhibit anomalous
scalings of the temperature and frequency dependent conductivity. Choosing the
dynamical critical exponent appropriately we can match the non-Fermi liquid
scalings, such as linear resistivity, observed in strange metal regimes. As
part of our investigation we outline three distinct string theory realizations
of Lifshitz geometries: from F theory, from polarised branes, and from a
gravitating charged Fermi gas. We also identify general features of
renormalisation group flow in Lifshitz theories, such as the appearance of
relevant charge-charge interactions when . We outline a program to
extend this model building approach to other anomalous observables of interest
such as the Hall conductivity.Comment: 71 pages, 8 figure
Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes
Objective: The greatest genetic effect reported for systemic sclerosis (SSc) lies in the major histocompatibility complex (MHC) locus. Leveraging the largest SSc genome-wide association study, we aimed to fine-map this region to identify novel human leucocyte antigen (HLA) genetic variants associated with SSc susceptibility and its main clinical and serological subtypes. Methods: 9095 patients with SSc and 17 584 controls genome-wide genotyped were used to impute and test single-nucleotide polymorphisms (SNPs) across the MHC, classical HLA alleles and their composite amino acid residues. Additionally, patients were stratified according to their clinical and serological status, namely, limited cutaneous systemic sclerosis (lcSSc), diffuse cutaneous systemic sclerosis (dcSSc), anticentromere (ACA), antitopoisomerase (ATA) and anti-RNApolIII autoantibodies (ARA). Results: Sequential conditional analyses showed nine SNPs, nine classical alleles and seven amino acids that modelled the observed associations with SSc. This confirmed previously reported associations with HLA-DRB1∗11:04 and HLA-DPB1∗13:01, and revealed a novel association of HLA-B∗08:01. Stratified analyses showed specific associations of HLA-DQA1∗02:01 with lcSSc, and an exclusive association of HLA-DQA1∗05:01 with dcSSc. Similarly, private associations were detected in HLA-DRB1∗08:01 and confirmed the previously reported association of HLA-DRB1∗07:01 with ACA-positive patients, as opposed to the HLA-DPA1∗02:01 and HLA-DQB1∗03:01 alleles associated with ATA presentation. Conclusions: This study confirms the contribution of HLA class II and reveals a novel association of HLA class I with SSc, suggesting novel pathways of disease pathogenesis. Furthermore, we describe specific HLA associations with SSc clinical and serological subtypes that could serve as biomarkers of disease severity and progression
Ethanol reversal of tolerance to the respiratory depressant effects of morphine
Opioids are the most common drugs associated with unintentional drug overdose. Death results from respiratory depression. Prolonged use of opioids results in the development of tolerance but the degree of tolerance is thought to vary between different effects of the drugs. Many opioid addicts regularly consume alcohol (ethanol), and post-mortem analyses of opioid overdose deaths have revealed an inverse correlation between blood morphine and ethanol levels. In the present study, we determined whether ethanol reduced tolerance to the respiratory depressant effects of opioids. Mice were treated with opioids (morphine, methadone, or buprenorphine) for up to 6 days. Respiration was measured in freely moving animals breathing 5% CO(2) in air in plethysmograph chambers. Antinociception (analgesia) was measured as the latency to remove the tail from a thermal stimulus. Opioid tolerance was assessed by measuring the response to a challenge dose of morphine (10 mg/kg i.p.). Tolerance developed to the respiratory depressant effect of morphine but at a slower rate than tolerance to its antinociceptive effect. A low dose of ethanol (0.3 mg/kg) alone did not depress respiration but in prolonged morphine-treated animals respiratory depression was observed when ethanol was co-administered with the morphine challenge. Ethanol did not alter the brain levels of morphine. In contrast, in methadone- or buprenorphine-treated animals no respiratory depression was observed when ethanol was co-administered along with the morphine challenge. As heroin is converted to morphine in man, selective reversal of morphine tolerance by ethanol may be a contributory factor in heroin overdose deaths
The Cyprinodon variegatus genome reveals gene expression changes underlying differences in skull morphology among closely related species
Genes in durophage intersection set at 15 dpf. This is a comma separated table of the genes in the 15 dpf durophage intersection set. Given are edgeR results for each pairwise comparison. Columns indicating whether a gene is included in the intersection set at a threshold of 1.5 or 2 fold are provided. (CSV 13Â kb
Mass-Matching in Higgsless
Modern extra-dimensional Higgsless scenarios rely on a mass-matching between
fermionic and bosonic KK resonances to evade constraints from precision
electroweak measurements. After analyzing all of the Tevatron and LEP bounds on
these so-called Cured Higgsless scenarios, we study their LHC signatures and
explore how to identify the mass-matching mechanism, the key to their
viability. We find singly and pair produced fermionic resonances show up as
clean signals with 2 or 4 leptons and 2 hard jets, while neutral and charged
bosonic resonances are visible in the dilepton and leptonic WZ channels,
respectively. A measurement of the resonance masses from these channels shows
the matching necessary to achieve . Moreover, a large single
production of KK-fermion resonances is a clear indication of compositeness of
SM quarks. Discovery reach is below 10 fb of luminosity for resonances
in the 700 GeV range.Comment: 28 pages, 18 figure
Quantum Gravity in Everyday Life: General Relativity as an Effective Field Theory
This article is meant as a summary and introduction to the ideas of effective
field theory as applied to gravitational systems.
Contents:
1. Introduction
2. Effective Field Theories
3. Low-Energy Quantum Gravity
4. Explicit Quantum Calculations
5. ConclusionsComment: 56 pages, 2 figures, JHEP style, Invited review to appear in Living
Reviews of Relativit
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