63 research outputs found
Contribution to the fauna and bionomics of entomophagous insects feeding on the small spruce bark beetle Ips amitinus (Eichh.) (Coleoptera, Curculionidae: Scolytinae) in West Siberia
A total of 29 species of entomophagous insects from 15 families of 4 orders were found for the fi rst time in the galleries of the small spruce bark beetle Ips amitinus within its invasive range in West Siberia; 26 species were predators of Ips amitinus, including 11 species of obligate and 15 species of facultative zoophages. The most abundant obligate predators were Thanasimus femoralis (Zett.) (Coleoptera, Cleridae) and Medetera fasciata Frey (Diptera, Dolichopodidae); the most abundant facultative predator was Placusa complanata Er. (Coleoptera, Staphylinidae). The larval ectoparasitoids Dinotiscus eupterus (Walk.) and Rhopalicus tutela (Walk.) (Pteromalidae) and the endoparasitoid of adults Ropalophorus clavicornis (Wesm.) (Braconidae) develop on I. amitinus both in its native range and in the secondary ranges. Widespread representatives of the local fauna that have established new trophic links with I. amitinus absolutely predominate among its entomophages in West Siberia. The European species Phloeonomus sjoebergi A. Strand (Staphylinidae) and Epuraea dolosa Kir. (Nitidulidae) were found for the fi rst time in Siberia. Ips amitinus has been included in the prey spectrum of Medetera penicillata Neg., which is an obligate predator of Polygraphus proximus Blandf., another invasive bark beetle of Far Eastern origin
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ Π°ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΡΡ ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅Π°ΡΠΎΠ² ΠΊΡΠΎΠ²ΠΈ Π½Π° ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΡ ΠΏΡΠΈ ΡΡΡΠΎΠΌΠ°Π»ΡΠ½ΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡΡ ΡΠΎΠ³ΠΎΠ²ΠΈΡΡ Π² ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ΅
In experiment in vivo laws of regeneration of damages of a cornea on background intrastromal introductions of autologus mononuclear blood are studied. It is proved, that local application of mononuclear cells significantly reduces the duration and expressiveness of inflammatory process and as consequence, is accelerated process of regeneration of the damaged corneal tissue.Π ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ΅ in vivo ΠΈΠ·ΡΡΠ΅Π½Ρ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΡΠΎΠ³ΠΎΠ²ΠΈΡΡ Π½Π° ΡΠΎΠ½Π΅ ΠΈΠ½ΡΡΠ°ΡΡΡΠΎΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Π°ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΡΡ
ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅Π°ΡΠΎΠ² ΠΊΡΠΎΠ²ΠΈ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅Π°ΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠΌΠ΅Π½ΡΡΠ°Π΅Ρ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΈ, ΠΊΠ°ΠΊ ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅, ΡΡΠΊΠΎΡΡΠ΅Ρ ΠΏΡΠΎΡΠ΅ΡΡ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½Π½ΠΎΠΉ ΡΠΎΠ³ΠΎΠ²ΠΈΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ
ΠΠ°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ ΠΊΠΎΠ½ΡΡΠ½ΠΊΡΠΈΠ²Ρ ΠΈ ΡΠΊΠ»Π΅ΡΡ ΠΏΠΎΡΠ»Π΅ ΠΈΠ½ΡΡΠ°ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΠΏΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠ° ΡΠΈΠΊΠ»ΠΎΡΠΏΠΎΡΠΈΠ½Π° Π Ρ ΠΊΡΠΎΠ»ΠΈΠΊΠΎΠ² ΡΠΎ ΡΡΠ΅ΡΠΎΠΈΠ΄Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΡΡ Π³Π»Π°ΡΠΊΠΎΠΌΡ
Β Aim. In an in vivo experiment, to study the effect of local intraoperative application of 0.05% cyclosporin A solution on the conjunctival and scleral regeneration after surgery on the rabbit eyes with steroid-inducedΒ glaucoma.Materials and methods. At the first stage of the experiment, a model of steroid-induced glaucoma was reproduced for 29 male Californian rabbits by injecting 0.5 ml of a 0.4% solution of dexamethasone subconjunctivally in both eyes once a week for 3 months (12 subconjunctival injections for each rabbit). At the second stage of the experiment, after the development ofΒ steroid glaucoma, the rabbits were divided into the main group, consistingΒ of the subgroup Β«aΒ» (n = 8) and the subgroup Β«bΒ» (n = 8), and the comparison group (n = 8). All animals were performed a penetrating incision of the conjunctiva and a non-penetrating incision of the sclera of one of the eyes. A hemostatic sponge impregnated with 0.05% cyclosporin Π solution was applied to the intervention area in the main group, in the subgroup Β«aΒ» β for 3 minutes, in the subgroup Β«bΒ» β for 6 minutes. In the comparison group, the cytostatic was not used.Results. The use of 0.05% cyclosporin Π solution led to a decrease in theΒ infiltration of fibroblasts and inflammatory cells into the area of surgicalΒ injury. On the 4th day after the surgery, cell density in the intervention areaΒ in the subgroup Β«aΒ» with 3-minute application of cytostatic-antimetabolite solution was 2.7 times lower (p = 0.043) than in the comparison group, while exceeding the values in the subgroup Β«bΒ» by 3.2 times (p = 0.036). The number of fibroblasts in the subgroups Β«aΒ» and Β«bΒ» was 3.6 (p = 0.043) and 12.8 times (p = 0.031) less than in the comparison group, and a shift in the cellular composition of the infiltrate towards the fibroblastic population occurred only on the 14th day after the surgery.Conclusion. Intraoperative application of 0.05% cyclosporin Π solution significantly slows down the course of regeneration, reducing infiltrative inflammation in the intervention area, which prevents excessive scarring.Β Β Π¦Π΅Π»Ρ. Π ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ΅ in vivo ΠΈΠ·ΡΡΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠ΅ΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΡΠ°ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΠΏΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠΈ 0,05%-Π³ΠΎ ΡΠ°ΡΡΠ²ΠΎΡΠ° (Ρ-ΡΠ°) ΡΠΈΠΊΠ»ΠΎΡΠΏΠΎΡΠΈΠ½Π° Π Π½Π° ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΡ ΠΊΠΎΠ½ΡΡΠ½ΠΊΡΠΈΠ²Ρ ΠΈ ΡΠΊΠ»Π΅ΡΡΒ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ Π½Π° Π³Π»Π°Π·Π°Ρ
ΠΊΡΠΎΠ»ΠΈΠΊΠΎΠ² ΡΠΎ ΡΡΠ΅ΡΠΎΠΈΠ΄Π½ΠΎΠΉΒ Π³Π»Π°ΡΠΊΠΎΠΌΠΎΠΉ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ° I ΡΡΠ°ΠΏΠ΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ° 29 ΡΠ°ΠΌΡΠ°ΠΌΒ ΠΊΡΠΎΠ»ΠΈΠΊΠΎΠ² ΠΊΠ°Π»ΠΈΡΠΎΡΠ½ΠΈΠΉΡΠΊΠΎΠΉ ΠΏΠΎΡΠΎΠ΄Ρ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π»ΠΈΒ ΡΡΠ΅ΡΠΎΠΈΠ΄Π½ΡΡ Π³Π»Π°ΡΠΊΠΎΠΌΡ ΠΏΡΡΠ΅ΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΠΎΠ΄ ΠΊΠΎΠ½ΡΡΠ½ΠΊΡΠΈΠ²ΡΒ ΠΎΠ±ΠΎΠΈΡ
Π³Π»Π°Π· 0,5 ΠΌΠ» 0,4%-Π³ΠΎ Ρ-ΡΠ° Π΄Π΅ΠΊΡΠ°ΠΌΠ΅ΡΠ°Π·ΠΎΠ½Π° 1 ΡΠ°Π· Π² Π½Π΅Π΄ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 3 ΠΌΠ΅Ρ (12 ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ). ΠΠ° II ΡΡΠ°ΠΏΠ΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°, ΠΏΠΎΡΠ»Π΅ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΡΠ΅ΡΠΎΠΈΠ΄Π½ΠΎΠΉ Π³Π»Π°ΡΠΊΠΎΠΌΡ, ΠΊΡΠΎΠ»ΠΈΠΊΠΎΠ² ΡΠ°Π·Π΄Π΅Π»ΠΈΠ»ΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π½ΡΡ Π³ΡΡΠΏΠΏΡ, ΡΠΎΡΡΠΎΡΡΡΡ ΠΈΠ· ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏΡ Β«aΒ» (n = 8) ΠΈ ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏΡ Β«bΒ» (n = 8), ΠΈ Π³ΡΡΠΏΠΏΡ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ (n = 8). ΠΡΠ΅ΠΌ ΠΆΠΈΠ²ΠΎΡΠ½ΡΠΌ Π²ΡΠΏΠΎΠ»Π½ΡΠ»ΠΈ ΡΠΊΠ²ΠΎΠ·Π½ΠΎΠΉ ΡΠ°Π·ΡΠ΅Π· ΠΊΠΎΠ½ΡΡΠ½ΠΊΡΠΈΠ²Ρ ΠΈ Π½Π΅ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡΠΈΠΉ Π½Π°Π΄ΡΠ΅Π· ΡΠΊΠ»Π΅ΡΡ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· Π³Π»Π°Π·. ΠΠ° ΠΎΠ±Π»Π°ΡΡΡ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° Π² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ Π½Π°ΠΊΠ»Π°Π΄ΡΠ²Π°Π»ΠΈ Π³Π΅ΠΌΠΎΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΡΡ Π³ΡΠ±ΠΊΡ, ΠΏΡΠΎΠΏΠΈΡΠ°Π½Π½ΡΡ 0,05%-ΠΌ Ρ-ΡΠΎΠΌ ΡΠΈΠΊΠ»ΠΎΡΠΏΠΎΡΠΈΠ½Π° Π, Π² ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏΠ΅ Β«Π°Β» Π½Π° 3 ΠΌΠΈΠ½, Π² ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏΠ΅ Β«bΒ» β Π½Π° 6 ΠΌΠΈΠ½. Π Π³ΡΡΠΏΠΏΠ΅ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΈΡΠΎΡΡΠ°ΡΠΈΠΊ Π½Π΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ 0,05%-Π³ΠΎ Ρ-ΡΠ° ΡΠΈΠΊΠ»ΠΎΡΠΏΠΎΡΠΈΠ½Π° ΠΒ ΠΏΡΠΈΠ²Π΅Π»ΠΎ ΠΊ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ ΠΈΠ½ΡΠΈΠ»ΡΡΡΠ°ΡΠΈΠΈ Π·ΠΎΠ½Ρ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉΒ ΡΡΠ°Π²ΠΌΡ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ ΠΈ ΡΠΈΠ±ΡΠΎΠ±Π»Π°ΡΡΠ°ΠΌΠΈ. ΠΠ° 4- Π΅ ΡΡΡ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½Π°Ρ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ Π² ΠΎΠ±Π»Π°ΡΡΠΈ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° Π² ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏΠ΅ Β«Π°Β» ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ Ρ ΡΡΠ΅Ρ
ΠΌΠΈΠ½ΡΡΠ½ΠΎΠΉ Π°ΠΏΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠ΅ΠΉ Ρ-ΡΠ° ΡΠΈΡΠΎΡΡΠ°ΡΠΈΠΊΠ°-Π°Π½ΡΠΈΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ° Π±ΡΠ»Π° Π² 2,7 ΡΠ°Π·Π° ΠΌΠ΅Π½ΡΡΠ΅ (p = 0,043), ΡΠ΅ΠΌ Π²Β Π³ΡΡΠΏΠΏΠ΅ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ, ΠΏΡΠ΅Π²ΡΡΠ°Ρ ΠΏΡΠΈ ΡΡΠΎΠΌ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏΡ Β«bΒ» Π² 3,2 ΡΠ°Π·Π° (p = 0,036). Π§ΠΈΡΠ»Π΅Π½Π½ΠΎΡΡΡΒ ΡΠΈΠ±ΡΠΎΠ±Π»Π°ΡΡΠΎΠ² Π² ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏΠ°Ρ
Β«Π°Β» ΠΈ Β«bΒ» Π±ΡΠ»Π° Π² 3,6 (p = 0,043) ΠΈ 12,8 ΡΠ°Π·Π° (p = 0,031) Π½ΠΈΠΆΠ΅, ΡΠ΅ΠΌ Π² Π³ΡΡΠΏΠΏΠ΅ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ. ΠΡΠΈΒ ΡΡΠΎΠΌ ΡΠ΄Π²ΠΈΠ³ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° ΠΈΠ½ΡΠΈΠ»ΡΡΡΠ°ΡΠ° Π² ΡΡΠΎΡΠΎΠ½ΡΒ ΡΠΈΠ±ΡΠΎΠ±Π»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ ΠΏΡΠΎΠΈΠ·ΠΎΡΠ΅Π» ΡΠΎΠ»ΡΠΊΠΎ Π½Π° 14-Π΅Β ΡΡΡ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ.Β ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ½ΡΡΠ°ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ Π°ΠΏΠΏΠ»ΠΈΠΊΠ°ΡΠΈΡ 0,05%-Π³ΠΎ Ρ- ΡΠ° ΡΠΈΠΊΠ»ΠΎΡΠΏΠΎΡΠΈΠ½Π° Π ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π·Π°ΠΌΠ΅Π΄Π»ΡΠ΅Ρ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅Β Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎ-ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ, ΡΠΌΠ΅Π½ΡΡΠ°ΡΒ ΠΈΠ½ΡΠΈΠ»ΡΡΡΠ°ΡΠΈΠ²Π½ΠΎΠ΅ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅ Π² Π·ΠΎΠ½Π΅ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π°, ΡΡΠΎΒ ΠΏΡΠ΅Π΄ΠΎΡΠ²ΡΠ°ΡΠ°Π΅Ρ ΠΈΠ·Π»ΠΈΡΠ½Π΅Π΅ ΡΡΠ±ΡΠ΅Π²Π°Π½ΠΈΠ΅.
Numerical simulation of the fractures of anisotropic materials characterized by the high degree of anisotropy of elongation at break
The failure criteria of anisotropic materials, the criteria being expressed via deformations, are rarely applied in practice, and are usually used for low-ductility materials. Another situation involves the simulation of failures in materials with the high anisotropy of mechanical properties and that suffer elastic-brittle fracture. For such materials the failure criteria are formulated using ultimate strains and strain tensor invariants. For simulating the fractures of materials that are characterized by the anisotropy of strength properties, the failure criteria are applied with the critical values of stresses and strains, as well as their intensities. Using the value of cumulative plastic strain as a failure criterion does reflect the anisotropy of elastic and plastic properties of a material, but it does not reflect that of the strength properties. The application of this method allows accounting the total plastic strain induced by tension and compression in the conditions of the wave strain of targets during their impact loading
ΠΠΈΠ½Π°ΠΌΠΈΠΊΠ° Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎ-ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΎΡΠ½ΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΏΡΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ·Π²Π΅ ΡΠΎΠ³ΠΎΠ²ΠΈΡΡ Π½Π° ΡΠΎΠ½Π΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π°ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΡΡ ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅Π°ΡΠΎΠ² ΠΊΡΠΎΠ²ΠΈ
In the experiment in vivo the mechanisms of the development of inflammatory regenerative processes with corneal ulcer against the background of the instillations of blood autologous mononuclear leukocyte and traditional pharmacotherapy are studied. It is determined that against the background of the use of blood autologous mononuclear leukocyte the duration and the intensity of inflammation reduce and the clearance of ulcer defect from necrotic mass accelerates. The instillations of blood autologous mononuclear leukocyte against the background of traditional pharmacotherapy of experimental corneal ulcer stimulate fast change of cell phases in the inflammation center and activate the process of regeneration of damaged cornea structures.Π ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ΅ in vivo ΠΈΠ·ΡΡΠ΅Π½Ρ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎ-ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΏΡΠΈ ΡΠ·Π²Π΅ ΡΠΎΠ³ΠΎΠ²ΠΈΡΡ Π½Π° ΡΠΎΠ½Π΅ ΠΈΠ½ΡΡΠΈΠ»Π»ΡΡΠΈΠΉ Π°ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΡΡ
ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅Π°ΡΠΎΠ² ΠΊΡΠΎΠ²ΠΈ ΠΈ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π½Π° ΡΠΎΠ½Π΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π°ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΡΡ
ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅Π°ΡΠΎΠ² ΠΊΡΠΎΠ²ΠΈ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠΌΠ΅Π½ΡΡΠ°Π΅ΡΡΡ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΡΠΊΠΎΡΡΠ΅ΡΡΡ ΠΎΡΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠ·Π²Π΅Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΡΠ΅ΠΊΡΠ° ΠΎΡ Π½Π΅ΠΊΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΡ. ΠΠ½ΡΡΠΈΠ»Π»ΡΡΠΈΠΈ Π°ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΡΡ
ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅Π°ΡΠΎΠ² ΠΊΡΠΎΠ²ΠΈ Π½Π° ΡΠΎΠ½Π΅ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ·Π²Ρ ΡΠΎΠ³ΠΎΠ²ΠΈΡΡ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΡΡ Π±ΡΡΡΡΠΎΠΉ ΡΠΌΠ΅Π½Π΅ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΡΠ°Π· Π² ΠΎΡΠ°Π³Π΅ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΡ ΠΈ Π°ΠΊΡΠΈΠ²ΠΈΠ·ΠΈΡΡΡΡ ΠΏΡΠΎΡΠ΅ΡΡ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½Π½ΡΡ
ΡΠΎΠ³ΠΎΠ²ΠΈΡΠ½ΡΡ
ΡΡΡΡΠΊΡΡΡ
ΠΠ°ΡΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ ΠΊΠΎΠ½ΡΡΠ½ΠΊΡΠΈΠ²Ρ ΠΈ ΡΠΊΠ»Π΅ΡΡ Π½Π° ΡΠΎΠ½Π΅ ΠΈΠ½ΡΡΠ°ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΠΏΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠ° ΡΠΈΠΊΠ»ΠΎΡΠΏΠΎΡΠΈΠ½Π° Π
Purpose. In experiment in vivo to study the features of regeneration of the conjunctiva and sclera of rats after surgery with intraoperative application of a 0.05% Ciclosporin A.Materials and methods. Πxperimental animals (rats) (n = 48) were divided into the main group, including the subgroups a (n = 16) and b (n = 16) and the comparison group (n = 16). Performed a through cut of the conjunctiva and damage to the surface layers of the sclera one of the eyes of all animals. Further on the surgical trauma zone in the main group, the intraoperative application of the cytostatic was performed. In the subgroup a with a duration of 3 minutes, in the subgroup b β 6 minutes. In the comparison group a hemostatic sponge without a cytostatic was used intraoperatively.Results. In the comparison group postoperative period proceeds with a stereotyped dynamics of cell phase changes in damaged tissues. In the end the development of dense conjunctival-scleral fusion in the area of surgical trauma was noted. Intraoperative application of 0.05% Cyclosporine A leads to a slowing of regeneration, preventing formation of rough conjunctival-scleral scar.Conclusions. Intraoperative applications of 0.05% Cyclosporin A change the stereotyped dynamics of the inflammatory-reparative regeneration in the surgical intervention zone, inhibiting the migration of cells almost in 3 times and significantly (in 2 times) prolonging the duration of the macrophage phase. This causes a slowdown of reparative regeneration, prevents excessive scarring in the operating area.Β Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ: Π² ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ΅ in vivo ΠΈΠ·ΡΡΠΈΡΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ ΠΊΠΎΠ½ΡΡΠ½ΠΊΡΠΈΠ²Ρ ΠΈ ΡΠΊΠ»Π΅ΡΡ ΠΊΡΡΡ ΠΏΠΎΡΠ»Π΅ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° ΠΈ ΠΈΠ½ΡΡΠ°ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΠΏΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠΈ 0,05%-Π³ΠΎ ΡΠ°ΡΡΠ²ΠΎΡΠ° ΡΠΈΠΊΠ»ΠΎΡΠΏΠΎΡΠΈΠ½Π° Π.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΆΠΈΠ²ΠΎΡΠ½ΡΠ΅ (ΡΠ°ΠΌΡΡ ΠΊΡΡΡ, n = 48) Π±ΡΠ»ΠΈ ΡΠ°Π·Π΄Π΅Π»Π΅Π½Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Π½ΡΡ Π³ΡΡΠΏΠΏΡ, Π²ΠΊΠ»ΡΡΠ°ΡΡΡΡ ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏΡ Π° (n = 16) ΠΈ b (n = 16), ΠΈ Π³ΡΡΠΏΠΏΡ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ (n = 16). ΠΡΠ΅ΠΌ ΠΆΠΈΠ²ΠΎΡΠ½ΡΠΌ Π²ΡΠΏΠΎΠ»Π½ΡΠ»ΠΈ ΡΠΊΠ²ΠΎΠ·Π½ΠΎΠΉ ΡΠ°Π·ΡΠ΅Π· ΠΊΠΎΠ½ΡΡΠ½ΠΊΡΠΈΠ²Ρ ΠΈ Π½Π΅ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡΠΈΠΉ Π½Π°Π΄ΡΠ΅Π· ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΡ
ΡΠ»ΠΎΠ΅Π² ΡΠΊΠ»Π΅ΡΡ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· Π³Π»Π°Π·. ΠΠ° ΠΎΠ±Π»Π°ΡΡΡ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠ°Π²ΠΌΡ Π² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ Π½Π°ΠΊΠ»Π°Π΄ΡΠ²Π°Π»Π°ΡΡ Π³Π΅ΠΌΠΎΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π³ΡΠ±ΠΊΠ°, ΠΏΡΠΎΠΏΠΈΡΠ°Π½Π½Π°Ρ 0,05%-ΠΌ ΡΠ°ΡΡΠ²ΠΎΡΠΎΠΌ ΡΠΈΠΊΠ»ΠΎΡΠΏΠΎΡΠΈΠ½Π° Π: Π² ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏΠ΅ Π° Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ 3 ΠΌΠΈΠ½, Π² ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏΠ΅ b β 6 ΠΌΠΈΠ½. Π Π³ΡΡΠΏΠΏΠ΅ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΠΈΠ½ΡΡΠ°ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎ Π½Π°ΠΊΠ»Π°Π΄ΡΠ²Π°Π»Π°ΡΡ Π³Π΅ΠΌΠΎΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π³ΡΠ±ΠΊΠ° Π±Π΅Π· ΡΠΈΡΠΎΡΡΠ°ΡΠΈΠΊΠ°.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π³ΡΡΠΏΠΏΡ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΉ ΠΏΠ΅ΡΠΈΠΎΠ΄ ΠΏΡΠΎΡΠ΅ΠΊΠ°Π» ΡΠΎ ΡΡΠ΅ΡΠ΅ΠΎΡΠΈΠΏΠ½ΠΎΠΉ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΎΠΉ ΡΠΌΠ΅Π½Ρ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΡΠ°Π· Π² ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½Π½ΡΡ
ΡΠΊΠ°Π½ΡΡ
. Π ΠΈΡΡ
ΠΎΠ΄Π΅ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΏΠ»ΠΎΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠ½ΠΊΡΠΈΠ²Π°Π»ΡΠ½ΠΎ-ΡΠΊΠ»Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΡΠ΅Π½ΠΈΡ Π² Π·ΠΎΠ½Π΅ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠ°Π²ΠΌΡ. ΠΠ½ΡΡΠ°ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ Π°ΠΏΠΏΠ»ΠΈΠΊΠ°ΡΠΈΡ 0,05%-ΠΌ ΡΠ°ΡΡΠ²ΠΎΡΠΎΠΌ ΡΠΈΠΊΠ»ΠΎΡΠΏΠΎΡΠΈΠ½Π° Π ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΠ»Π° ΠΊ Π·Π°ΠΌΠ΅Π΄Π»Π΅Π½ΠΈΡ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ, ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΠΎΠ²Π°Π»Π° ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π³ΡΡΠ±ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠ½ΠΊΡΠΈΠ²Π°Π»ΡΠ½ΠΎ-ΡΠΊΠ»Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ±ΡΠ°.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ½ΡΡΠ°ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ Π°ΠΏΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠΈ 0,05%-Π³ΠΎ ΡΠ°ΡΡΠ²ΠΎΡΠ° ΡΠΈΠΊΠ»ΠΎΡΠΏΠΎΡΠΈΠ½Π° Π ΠΌΠ΅Π½ΡΡΡ ΡΡΠ΅ΡΠ΅ΠΎΡΠΈΠΏΠ½ΡΡ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎ-ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ Π² Π·ΠΎΠ½Π΅ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π°, ΠΏΠΎΠ΄Π°Π²Π»ΡΡ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π² ΡΡΠΈ ΡΠ°Π·Π° ΠΌΠΈΠ³ΡΠ°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ, ΠΈ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ (Π² Π΄Π²Π° ΡΠ°Π·Π°) ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Ρ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΌΠ°ΠΊΡΠΎΡΠ°Π³Π°Π»ΡΠ½ΠΎΠΉ ΡΠ°Π·Ρ. ΠΡΠΎ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»ΠΈΠ²Π°Π΅Ρ Π·Π°ΠΌΠ΅Π΄Π»Π΅Π½ΠΈΠ΅ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ, ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΡΡΡΠ΅Π΅ ΠΈΠ·Π±ΡΡΠΎΡΠ½ΠΎΠΌΡ ΡΡΠ±ΡΠ΅Π²Π°Π½ΠΈΡ Π² ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π·ΠΎΠ½Π΅.
Limits on the Majorana neutrino mass in the 0.1 eV range
The Heidelberg-Moscow experiment gives the most stringent limit on the
Majorana neutrino mass. After 24 kg yr of data with pulse shape measurements,
we set a lower limit on the half-life of the neutrinoless double beta decay in
76Ge of T_1/2 > 5.7 * 10^{25} yr at 90% C.L., thus excluding an effective
Majorana neutrino mass greater than 0.2 eV. This allows to set strong
constraints on degenerate neutrino mass models.Comment: 6 pages (latex) including 3 postscript figures and 2 table
Modelling of the ultraviolet and visual SED variability in the hot magnetic Ap star CU Vir
The spectral energy distribution (SED) in chemically peculiar stars may be
significantly affected by their abundance anomalies. The observed SED
variations are usually assumed to be a result of inhomogeneous surface
distribution of chemical elements, flux redistribution and stellar rotation.
However, the direct evidence for this is still only scarce. We aim to identify
the processes that determine the SED and its variability in the UV and visual
spectral domains of the helium-weak star CU Vir. We used the model atmospheres
to obtain the emergent flux and predict the rotationally modulated flux
variability of the star. We show that most of the light variations in the vby
filters of the Stromgren photometric system are a result of the uneven surface
distribution of silicon, chromium, and iron. Our models are only able to
explain a part of the variability in the u filter, however. The observed UV
flux distribution is very well reproduced, and the models are able to explain
most of the observed features in the UV light curve. The variability observed
in the visible is merely a faint gleam of that in the UV. While the amplitude
of the light curves reaches only several hundredths of magnitude in the visual
domain, it reaches about 1 mag in the UV. The visual and UV light variability
of CU Vir is caused by the flux redistribution from the far UV to near UV and
visible regions, inhomogeneous distribution of the elements and stellar
rotation. Bound-free transitions of silicon and bound-bound transitions of iron
and chromium contribute the most to the flux redistribution. This mechanism can
explain most of the rotationally modulated light variations in the filters
centred on the Paschen continuum and on the UV continuum of the star CU Vir.
However, another mechanism(s) has to be invoked to fully explain the observed
light variations in the u filter and in the region 2000-2500 A.Comment: 14 pages, 13 figures, accepted for publication in Astronomy and
Astrophysic
Direct Search for Dark Matter - Striking the Balance - and the Future
Weakly Interacting Massive Particles (WIMPs) are among the main candidates
for the relic dark matter (DM). The idea of the direct DM detection relies on
elastic spin-dependent (SD) and spin-independent (SI) interaction of WIMPs with
target nuclei. In this review paper the relevant formulae for WIMP event rate
calculations are collected. For estimations of the WIMP-proton and WIMP-neutron
SD and SI cross sections the effective low-energy minimal supersymmetric
standard model is used. The traditional one-coupling-dominance approach for
evaluation of the exclusion curves is described. Further, the mixed spin-scalar
coupling approach is discussed. It is demonstrated, taking the high-spin Ge-73
dark matter experiment HDMS as an example, how one can drastically improve the
sensitivity of the exclusion curves within the mixed spin-scalar coupling
approach, as well as due to a new procedure of background subtraction from the
measured spectrum. A general discussion on the information obtained from
exclusion curves is given. The necessity of clear WIMP direct detection
signatures for a solution of the dark matter problem, is pointed out.Comment: LaTeX, 49 pages, 14 figures, 185 reference
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