Intermolecular interactions of decamethoxinum and acetylsalicylic acid in systems of various complexity levels

Intermolecular interactions between decamethoxinum (DEC) and acetylsalicylic acid (ASА) have been studied in the phospholipid-containing systems of escalating complexity levels. The host media for these substances were solvents, L-α-dipalmitoylphosphatidylcholine (DPPC) membranes, and samples of human erythrocytes. Peculiar effects caused by DEC-ASА interaction have been observed in each system using appropriate techniques: (a) DEC-ASА non-covalent complexes formation in DPPC-containing systems were revealed by mass spectrometry with electrospray ionization; (b) joint DEC-ASА action on DPPC model membranes led to increasing of membrane melting temperature Tm, whereas individual drugs caused pronounced Tm decreasing, which was demonstrated by differential scanning calorimetry; (c) deceleration of DEC-induced haemolysis of erythrocytes under joint DEC-ASА application was observed by optical microscopy

Arecibo Pulsar Survey Using ALFA. I. Survey Strategy and First Discoveries

We report results from the initial stage of a long-term pulsar survey of the Galactic plane using the Arecibo L-band Feed Array (ALFA), a seven-beam receiver operating at 1.4 GHz with 0.3 GHz bandwidth. The search targets Galactic latitudes |b| < 5 deg in the longitude ranges 32 deg < l < 77 deg and 168 deg < l < 77 deg. Data discussed here were collected over a 100 MHz passband centered on 1.42 GHz using a spectrometer that recorded 256 channels every 64 microsec. In a preliminary, standard period-DM analysis, we have detected 29 previously known pulsars and discovered 11 new ones. One of these, with a period of 69 ms and a low characteristic age of 82 kyr, is a plausible candidate for association with the unidentified EGRET source 3EG J1928+1733. Another is a non-recycled pulsar in a relativistic binary with orbital period of 3.98 hr. We also search the data for isolated dispersed pulses, a technique that yielded discovery of an extremely sporadic radio emitter with a spin period of 1.2 s. Simulations we have carried out indicate that about 1000 new pulsars will be found in the ALFA survey. In addition to providing a large sample for use in population analyses and for probing the magnetoionic interstellar medium, the survey maximizes the chances of finding rapidly spinning millisecond pulsars and pulsars in compact binary systems. Our search algorithms will exploit the multiple data streams from ALFA to discriminate between radio frequency interference and celestial signals, including pulsars and possibly new classes of transient radio sources.Comment: 10 pp, 9 figures, accepted by the Astrophysical Journa

An Eccentric Binary Millisecond Pulsar in the Galactic Plane

Binary pulsar systems are superb probes of stellar and binary evolution and the physics of extreme environments. In a survey with the Arecibo telescope, we have found PSR J1903+0327, a radio pulsar with a rotational period of 2.15 ms in a highly eccentric (e = 0.44) 95-day orbit around a solar mass companion. Infrared observations identify a possible main-sequence companion star. Conventional binary stellar evolution models predict neither large orbital eccentricities nor main-sequence companions around millisecond pulsars. Alternative formation scenarios involve recycling a neutron star in a globular cluster then ejecting it into the Galactic disk or membership in a hierarchical triple system. A relativistic analysis of timing observations of the pulsar finds its mass to be 1.74+/-0.04 Msun, an unusually high value.Comment: 28 pages, 4 figures inc Supplementary On-Line Material. Accepted for publication in Science, published on Science Express: 10.1126/science.115758

PSR J1856+0245: Arecibo Discovery of a Young, Energetic Pulsar Coincident with the TeV Gamma-ray Source HESS J1857+026

We present the discovery of the Vela-like radio pulsar J1856+0245 in the Arecibo PALFA survey. PSR J1856+0245 has a spin period of 81ms, a characteristic age of 21kyr, and a spin-down luminosity Edot = 4.6 x 10^36 ergs/s. It is positionally coincident with the TeV gamma-ray source HESS J1857+026, which has no other known counterparts. Young, energetic pulsars create wind nebulae, and more than a dozen pulsar wind nebulae have been associated with very-high-energy (100GeV-100TeV) gamma-ray sources discovered with the HESS telescope. The gamma-ray emission seen from HESS J1857+026 is potentially produced by a pulsar wind nebula powered by PSR J1856+0245; faint X-ray emission detected by ASCA at the pulsar's position supports this hypothesis. The inferred gamma-ray efficiency is epsilon_gamma = L_gamma/Edot = 3.1% (1-10TeV, for a distance of 9kpc), comparable to that observed in similar associations.Comment: 13 pages, 1 figure, accepted for publication in The Astrophysical Journal Letter

The fitness of African malaria vectors in the presence and limitation of host behaviour

&lt;p&gt;Background Host responses are important sources of selection upon the host species range of ectoparasites and phytophagous insects. However little is known about the role of host responses in defining the host species range of malaria vectors. This study aimed to estimate the relative importance of host behaviour to the feeding success and fitness of African malaria vectors, and assess its ability to predict their known host species preferences in nature.&lt;/p&gt; &lt;p&gt;Methods Paired evaluations of the feeding success and fitness of African vectors Anopheles arabiensis and Anopheles gambiae s.s in the presence and limitation of host behaviour were conducted in a semi-field system (SFS) at Ifakara Health Institute, Tanzania. In one set of trials, mosquitoes were released within the SFS and allowed to forage overnight on a host that was free to exhibit natural behaviour in response to insect biting. In the other, mosquitoes were allowed to feed directly on from the skin surface of immobile hosts. The feeding success and subsequent fitness of vectors under these conditions were investigated on 6 host types (humans, calves, chickens, cows, dogs and goats) to assess whether physical movements of preferred host species (cattle for An. arabiensis, humans for An. gambiae s.s.) were less effective at preventing mosquito bites than those of common alternatives.&lt;/p&gt; &lt;p&gt;Results Anopheles arabiensis generally had greater feeding success when applied directly to host skin than when foraging on unrestricted hosts (in five of six host species). However, An. gambiae s.s obtained blood meals from free and restrained hosts with similar success from most host types (four out of six). Overall, the blood meal size, oviposition rate, fecundity and post-feeding survival of mosquito vectors were significantly higher after feeding on hosts free to exhibit behaviour, than those who were immobilized during feeding trials.&lt;/p&gt; &lt;p&gt;Conclusions Allowing hosts to move freely during exposure to mosquitoes was associated with moderate reductions in mosquito feeding success, but no detrimental impact to the subsequent fitness of mosquitoes that were able to feed upon them. This suggests that physical defensive behaviours exhibited by common host species including humans do not impose substantial fitness costs on African malaria vectors.&lt;/p&gt

PSR J1856+0245: Arecibo discovery of a young energetic pulsar coincident with the TeV g-RAY source HESS J1857+026

We present the discovery of the Vela-like radio pulsar J1856+0245 in the Arecibo PALFA survey. PSR J1856+0245 has a spin period of 81 ms, a characteristic age of 21 kyr, and a spin-down luminosity Ė p 4.6 x 10 36 ergs s-1. It is positionally coincident with the TeV γ-ray source HESS J1857+026, which has no other known counterparts. Young, energetic pulsars create wind nebulae, and more than a dozen pulsar wind nebulae have been associated with very high energy (100 GeV-100 TeV) γ-ray sources discovered with the HESS telescope. The γ-ray emission seen from HESS J1857+026 is potentially produced by a pulsar wind nebula powered by PSR J1856+0245; faint X-ray emission detected by ASCA at the pulsar\u27s position supports this hypothesis. The inferred γ-ray efficiency is εγ p Lγ/Ė p 3.1 % (1-10 TeV, for a distance of 9 kpc), comparable to that observed in similar associations. © 2008. The American Astronomical Society

The young, highly relativistic binary pulsar J1906+0746

We report the discovery of PSR J1906+0746, a young 144-ms pulsar in a highly relativistic 3.98-hr orbit with an eccentricity of 0.085 and expected gravitational wave coalescence time of 300 Myr. The new pulsar was found during precursor survey observations with the Arecibo 1.4-GHz feed array system and retrospectively detected in the Parkes Multibeam plane pulsar survey data. From radio follow-up observations with Arecibo, Jodrell Bank, Green Bank, and Parkes, we have measured the spin-down and binary parameters of the pulsar and its basic spectral and polarization properties. We also present evidence for pulse profile evolution, which is likely due to geodetic precession, a relativistic effect caused by the misalignment of the pulsar spin and total angular momentum vectors. Our measurements show that PSR J1906+0746 is a young object with a characteristic age of 112 kyr. From the measured rate of orbital periastron advance 7.57+/-0.03 deg/yr, we infer a total system mass of 2.61+/-0.02 Msun. While these parameters suggest that the PSR J1906+0746 binary system might be a younger version of the double pulsar system, intensive searches for radio pulses from the companion have so far been unsuccessful. It is therefore not known whether the companion is another neutron star or a massive white dwarf. Regardless of the nature of the companion, a simple calculation suggests that the Galactic birth rate of binaries similar to PSR J1906+0746 is 60/Myr. This implies that PSR J1906+0746 will make a significant contribution to the computed cosmic inspiral rate of compact binary systems.Comment: 19 pages, 3 figures, accepted for publication in Ap

Arecibo pulsar survey using ALPHA: Probing radio pulsar intermittency and transients

We present radio transient search algorithms, results, and statistics from the ongoing Arecibo Pulsar ALFA (PALFA) survey of the Galactic plane. We have discovered seven objects through a search for isolated dispersed pulses. All of these objects are Galactic and have measured periods between 0.4 and 4.7 s. One of the new discoveries has a duty cycle of 0.01%, smaller than that of any other radio pulsar. We discuss the impact of selection effects on the detectability and classification of intermittent sources, and compare the efficiencies of periodicity and single-pulse (SP) searches for various pulsar classes. For some cases we find that the apparent intermittency is likely to be caused by off-axis detection or a short time window that selects only a few bright pulses and favors detection with our SP algorithm. In other cases, the intermittency appears to be intrinsic to the source. No transients were found with DMs large enough to require that they originate from sources outside our Galaxy. Accounting for the on-axis gain of the ALFA system, as well as the low gain but large solid-angle coverage of far-out sidelobes, we use the results of the survey so far to place limits on the amplitudes and event rates of transients of arbitrary origin. © 2009. The American Astronomical Society. All rights reserved.

Arecibo and the ALFA Pulsar Survey

The recently started Arecibo L-band Feed Array (ALFA) pulsar survey aims to find ~1000 new pulsars. Due to its high time and frequency resolution the survey is especially sensitive to millisecond pulsars, which have the potential to test gravitational theories, detect gravitational waves and probe the neutron-star equation of state. Here we report the results of our preliminary analysis: in the first months we have discovered 21 new pulsars. One of these, PSR J1906+0746, is a young 144-ms pulsar in a highly relativistic 3.98-hr low-eccentricity orbit. The 2.61 +- 0.02 solar-mass system is expected to coalesce in ~300 Myr and contributes significantly to the computed cosmic inspiral rate of compact binary systems.Comment: 8 pages, invited review for the Hanas Pulsar Symposium, ChJAA in pres