Comparison of the Eficacy of Intravenous Magnesium Sulfate and Oral Indomethcin in the Management of Preterm Labor

Abstract: Background & Aims: Preterm labor is often resulted in preterm births and increased rate of neonatal morbidity and mortality. Treatment consists of bedrest, hydration, pharmacologic interventions, and combinations of these. The purpose of this study was to compare the efficacy of intravenous magnesium sulfate (MgSO4) and indomethacin in the treatment of preterm labor pains. Neonatal and maternal side effects of each method were also studied. Methods: A total of 120 women between 26 and 31 weeks’ gestation admitted due to preterm labor were randomized to receive either MgSO4 (n = 60) or oral indomethacin (n = 60). All women received betamethasone and prophylactic antibiotics. Data were analyzed using student t-test and X2. Results: The two groups had no significant difference in mean gestational age and cervical dilation and effacement at enrollment. The gestational age at delivery was similar in both groups (p=0.279). Delivery was delayed for more than 48 hours in 81% of subjects in MgSO4 group and in 87% of subjects in the indomethacin group (P=0.298). Neonatal birth weight, type of delivery, recurrent preterm labor pain and mean time to suppress the contractions were similar in both groups. No serious side effect was seen in the two groups. Conlusion: Acute tocolysis by either IV MgSO4 or oral indomethacin can delay preterm birth for 48 hours, provide the critical period of steroid effect, arrest an episode of preterm labor, and consequently delays delivery and improves neonatal outcomes. It is therefore necessary that all Obstetricians remain up-to-date regarding the efficacy, indications, contraindications, and side effects of all tocolytics. Keywords: Preterm labor, Magnesium sulfate, Indomethacin, Tocolysi

Understanding destination brand love using machine learning and content analysis method

This study aims to apply the concept of brand love in tourist destinations in order to identify the core-elements that could have influential impacts on generating destination brand love. This has been carried out by using a mixed-method of machine learning and content analysis. We have discovered that the topics have been generated for historical landmarks and destinations by analyzing the visitors’ on-line reviews are architecture, historical sites, tradition and shrine places, which could be similar to other tourist historical destinations in different part of the world. However, this study has the potential to be a model for other researches related to different destinations with possible different topics emerged. Our study contributes by providing both researchers and managers a novel method to understand what attributes of destination brand love they need to posit more emphasize to attract more visitors based on the destination type

A new method for critical path method with fuzzy processing time

Critical path method plays an important role on managing medium to large-scale problems. It is often difficult to determine the critical path for different reasons such as the existing uncertainties in processing tasks. One alternative to handle the uncertainty associated with the processing time is to use fuzzy techniques. We present a new method to calculate the critical path method when the processing times follow trapezoidal fuzzy numbers. The proposed model of this paper does not use any defuzzification technique to find the final processing time. The implementation of the proposed model is compared with other techniques using a well-known example from the literature

Group-based pharmacogenetic prediction: is it feasible and do current NHS England ethnic classifications provide appropriate data?

Inter-individual variation of drug metabolising enzymes (DMEs) leads to variable efficacy of many drugs and even adverse drug responses. Consequently, it would be desirable to test variants of many DMEs before drug treatment. Inter-ethnic differences in frequency mean that the choice of SNPs to test may vary across population groups. Here we examine the utility of testing representative groups as a way of assessing what variants might be tested. We show that publicly available population information is potentially useful for determining loci for pre-treatment genetic testing, and for determining the most prevalent risk haplotypes in defined groups. However, we also show that the NHS England classifications have limitations for grouping for these purposes, in particular for people of African descent. We conclude: (1) genotyping of hospital patients and people from the hospital catchment area confers no advantage over using samples from appropriate existing ethnic group collections or publicly available data, (2) given the current NHS England Black African grouping, a decision as to whether to test, would have to apply to all patients of recent Black African ancestry to cover reported risk alleles and (3) the current scarcity of available genome and drug effect data from Africans is a problem for both testing and treatment decisions

A semi-analytical solution of micro polar flow in a porous channel with mass injection by using differential transform method

In this letter, the differential transform method (DTM) was applied to the micro-polar flow in a porous channel with mass injection. Approximate solutions of the governing system of nonlinear ordinary differential equations were calculated in the form of DTM series with easily computable terms. The validity of the series solutions were verified by comparison with numerical results obtained using a fourth order Runge–Kutta method. The computed DTM velocity profiles are shown and the influence of Reynolds number on the velocity component in x-direction is discussed

Palenque de San Basilio in Colombia: genetic data support an oral history of a paternal ancestry in Congo

The Palenque, a black community in rural Colombia, have an oral history of fugitive African slaves founding a free village near Cartagena in the seventeenth century. Recently, linguists have identified some 200 words in regular use that originate in a Kikongo language, with Yombe, mainly spoken in the Congo region, being the most likely source. The non-recombining portion of the Y chromosome (NRY) and mitochondrial DNA were analysed to establish whether there was greater similarity between present-day members of the Palenque and Yombe than between the Palenque and 42 other African groups (for all individuals,n= 2799) from which forced slaves might have been taken. NRY data are consistent with the linguistic evidence that Yombe is the most likely group from which the original male settlers of Palenque came. Mitochondrial DNA data suggested substantial maternal sub-Saharan African ancestry and a strong founder effect but did not associate Palenque with any particular African group. In addition, based on cultural data including inhabitants' claims of linguistic differences, it has been hypothesized that the two districts of the village (Abajo and Arriba) have different origins, with Arriba founded by men originating in Congo and Abajo by those born in Colombia. Although significant genetic structuring distinguished the two from each other, no supporting evidence for this hypothesis was found

Human genetic variation, relationships of peoples of sub- Saharan Africa and implications for healthcare

Sub-Saharan Africa is thought to have the most genetic variation of any continent and to be the place of origin of anatomically modern human. Nevertheless it is the subject of relatively few studies of human genetic variation. This thesis contributes to redressing this imbalance. Sex-specific genetic systems (non-recombining portion of the Y chromosome (NRY) and mitochondrial DNA (mtDNA)) along with functional nuclear loci were characterised in multiple sub-Saharan African populations with large sample sizes to infer relationships of peoples and identify implications for healthcare. This thesis contains four projects which addressed questions in genetic anthropology, human evolution and pharmacogenetics utilising human genetic variation. In chapter 2, NRY analysis shows that a hypothesised paternal Yombe (Congo) ancestry of Palenque (Colombia), based on linguistic and historical evidence, is consistent with genetic data. Chapter 3, based on NRY data, demonstrates that a) multiple waves of migration occurred southwards during the expansion of Bantu-speaking peoples (EBSP), b) the eastern route displayed more recent migrations than the western route and c) the absence of substantial east to west NRY gene flow in sub-Saharan Africa over the past millennium. Chapter 4 suggests an eastern route out of Africa for the CASP12 truncated variant is more likely than a western route. (The stop-codon mutation was also dated to around 120,000 YBP). Chapter 5 demonstrates that a potentially functional CYP1A2 variant which has not been reported outside Africa is present at considerable frequencies in sub-Saharan African population groups and that exons associated with active sites in CYP1A genes are well conserved

Discrete scale invariance, and its logarithmic extension

It is known that discrete scale invariance leads to log-periodic corrections to scaling. We investigate the correlations of a system with discrete scale symmetry, discuss in detail possible extension of this symmetry such as translation and inversion, and find general forms for correlation functions.Comment: 12 pages, LaTe

Synthesis of Single-Phase Anatase TiO2 Nanoparticles by Hydrothermal Treatment

Pure anatase powders of titanium dioxide with a homogeneous nanosized particles distribution were prepared by a facile hydrothermal route using solution of acetic acid and tetraisopropyl orthotitanate as the precursors with a molar ratio of 1:1. The modified hydrolyzed alkoxide was treated at various temperatures under different autogenic pressures. Two different reactors were employed as autoclaves for heating and generation of high pressures during the synthesis and crystallization of TiO2 nanoparticles. The characteristics of TiO2 powders obtained under various synthesis conditions were verified using X-Ray Diffraction (XRD) and Field Emission Scanning Electron Microscopy (FE-SEM). The results indicated that particles size of the formed TiO2 could be finely tuned by varying the experimental parameters of temperature, pressure and the amount of nitric acid in the peptization step. TiO2 nanoparticles with good dispersion and mean size of about 9 nm could be seen in FE-SEM image of sample synthesized under temperature of 160 °C for 12 h using more nitric acid in the peptization step. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3488

Pengaruh Model Pembelajaran Talking Stick terhadap Keaktifan Belajar Siswa

[Title: The Effect of a Talking Stick Learning Model on Student Learning Activities]. A fun learning environment, active and meaningful for students need to be created by applying active learning model for students that learning model talking stick. This type of research is quasi-experimental. This research aimed to know there is or no effect of talking stick learning model toward students learning activeness. This research implemented in class VIII SMP Negeri 5 Mataram in academic year 2015/2016 from March to April 2016. The technique of sample using cluster random sampling, in order to obtain first-class VIII I totalling 30 students as an experimental class and class VIII E totalling 30 students as the control class. The results of this research are students' activeness learning showed by using the instrument is activeness of student learning questionnaire. Based on data analysis showed that t-test was 8.28 and t- table was 2.000 (df = 58). So, t-test > t-table (8.28 > 2.000). This means that there is an effect of talking stick learning model toward students learning activeness