6,987 research outputs found
Euclid preparation: XI. Mean redshift determination from galaxy redshift probabilities for cosmic shear tomography
The analysis of weak gravitational lensing in wide-field imaging surveys is considered to be a major cosmological probe of dark energy. Our capacity to constrain the dark energy equation of state relies on an accurate knowledge of the galaxy mean redshift âšzâ©. We investigate the possibility of measuring âšzâ© with an accuracy better than 0.002â(1â
+â
z) in ten tomographic bins spanning the redshift interval 0.2â 99.8%. The zPDF approach can also be successful if the zPDF is de-biased using a spectroscopic training sample. This approach requires deep imaging data but is weakly sensitive to spectroscopic redshift failures in the training sample. We improve the de-biasing method and confirm our finding by applying it to real-world weak-lensing datasets (COSMOS and KiDS+VIKING-450)
The VLT-FLAMES Tarantula Survey X: Evidence for a bimodal distribution of rotational velocities for the single early B-type stars
Aims: Projected rotational velocities (\vsini) have been estimated for 334
targets in the VLT-FLAMES Tarantula survey that do not manifest significant
radial velocity variations and are not supergiants. They have spectral types
from approximately O9.5 to B3. The estimates have been analysed to infer the
underlying rotational velocity distribution, which is critical for
understanding the evolution of massive stars.
Methods: Projected rotational velocities were deduced from the Fourier
transforms of spectral lines, with upper limits also being obtained from
profile fitting. For the narrower lined stars, metal and non-diffuse helium
lines were adopted, and for the broader lined stars, both non-diffuse and
diffuse helium lines; the estimates obtained using the different sets of lines
are in good agreement. The uncertainty in the mean estimates is typically 4%
for most targets. The iterative deconvolution procedure of Lucy has been used
to deduce the probability density distribution of the rotational velocities.
Results: Projected rotational velocities range up to approximately 450 \kms
and show a bi-modal structure. This is also present in the inferred rotational
velocity distribution with 25% of the sample having \ve100\,\kms
and the high velocity component having \ve\,\kms. There is no
evidence from the spatial and radial velocity distributions of the two
components that they represent either field and cluster populations or
different episodes of star formation. Be-type stars have also been identified.
Conclusions: The bi-modal rotational velocity distribution in our sample
resembles that found for late-B and early-A type stars. While magnetic braking
appears to be a possible mechanism for producing the low-velocity component, we
can not rule out alternative explanations.Comment: to be publisged in A&
Fluoroscopy usage in contemporary interventional electrophysiology: Insights from a European registry
Background: Fluoroscopy has been an essential part of every electrophysiological procedure since its inception. However, till now no clear standards regarding acceptable x-ray exposure nor recommendation how to achieve them have been proposed. Hypothesis: Current norms and quality markers required for optimal clinical routine can be identified. Methods: Centers participating in this Europe-wide multicenter, prospective registry were requested to provide characteristics of the center, operators, technical equipment as well as procedural settings of consecutive cases. Results: Twenty-five centers (72% university clinics, with a mean volume of 526 ± 348 procedures yearly) from 14 European countries provided data on 1788 cases [9% diagnostic procedures (DP), 38% atrial fibrillation (AF) ablations, 44% other supraventricular (SVT) ablations, and 9% ventricular ablations (VT)] conducted by 95 operators (89% male, 41 ± 7 years old). Mean dose area product (DAP) and time was 304 ± 608 cGy*cm2, 3.6 ± 4.8 minutes, 1937 ± 608 cGy*cm2, 15.3 ± 15.5 minutes, 805 ± 1442 cGy*cm2, 10.6 ± 10.7 minutes, and 1277 ± 1931 cGy*cm2, 10.4 ± 12.3 minutes for DP, AF, SVT, and VT ablations, respectively. Seven percent of all procedures were conducted without any use of fluoroscopy. Procedures in the lower quartile of DAP were performed more frequently by female operators (OR 1.707, 95%CI 1.257-2.318, P =.001), in higher-volume center (OR 1.001 per one additional procedure, 95%CI 1.000-1.001, P =.002), with the use of 3D-mapping system (OR 2.622, 95%CI 2.053-3.347, P <.001) and monoplane x-ray system (OR 2.945, 95%CI 2.149-4.037, P <.001). Conclusion: Exposure to ionizing radiation varies widely in daily practice for all procedure. Significant opportunities for harmonization of exposure toward the lower range has been identified
Sudemycin E Influences Alternative Splicing and Changes Chromatin Modifications
Sudemycin E is an analog of the pre-messenger RNA splicing modulator FR901464 and its derivative spliceostatin A. Sudemycin E causes the death of cancer cells through an unknown mechanism. We found that similar to spliceostatin A, sudemycin E binds to the U2 small nuclear ribonucleoprotein (snRNP) component SF3B1. Native chromatin immunoprecipitations showed that U2 snRNPs physically interact with nucleosomes. Sudemycin E induces a dissociation of the U2 snRNPs and decreases their interaction with nucleosomes. To determine the effect on gene expression, we performed genome-wide array analysis. Sudemycin E first causes a rapid change in alternative pre-messenger RNA splicing, which is later followed by changes in overall gene expression and arrest in the G2 phase of the cell cycle. The changes in alternative exon usage correlate with a loss of the H3K36me3 modification in chromatin encoding these exons. We propose that sudemycin E interferes with the ability of U2 snRNP to maintain an H3K36me3 modification in actively transcribed genes. Thus, in addition to the reversible changes in alternative splicing, sudemycin E causes changes in chromatin modifications that result in chromatin condensation, which is a likely contributing factor to cancer cell death
The First VLBI Image of the Young, Oxygen-Rich Supernova Remnant in NGC 4449
We report on sensitive 1.4-GHz VLBI radio observations of the unusually
luminous supernova remnant SNR 4449-1 in the galaxy NGC 4449, which gave us the
first well-resolved image of this object. The remnant's radio morphology
consists of two approximately parallel bright ridges, suggesting similarities
to the barrel shape seen for many older Galactic supernova remnants or possibly
to SN 1987A. The angular extent of the remnant is 65 x 40 mas, corresponding to
(3.7 x 2.3) x 10^{18} (D/3.8 Mpc) cm. We also present a new, high
signal-to-noise optical spectrum. By comparing the remnant's linear size to the
maximum velocities measured from optical lines, as well as using constraints
from historical images, we conclude that the supernova explosion occurred
between ~1905 and 1961, likely around 1940. The age of the remnant is therefore
likely ~70 yr. We find that SNR 4449-1's shock wave is likely still interacting
with the circumstellar rather than interstellar medium.Comment: 7 pages, Accepted for publication in MNRA
Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice
SHARPIN (Shank-Associated RH Domain-Interacting Protein) is a component of the linear ubiquitin chain assembly complex (LUBAC), which enhances TNF-induced NF-kappa B activity. SHARPIN-deficient (Sharpin(cpdm/cpdm)) mice display multi-organ inflammation and chronic proliferative dermatitis (cpdm) due to TNF-induced keratinocyte apoptosis. In cells, SHARPIN also inhibits integrins independently of LUBAC, but it has remained enigmatic whether elevated integrin activity levels in the dermis of Sharpin(cpdm/cpdm) mice is due to increased integrin activity or is secondary to inflammation. In addition, the functional contribution of increased integrin activation to the Sharpin(cpdm/cpdm) phenotype has not been investigated. Here, we find increased integrin activity in keratinocytes from Tnfr1(-/-) Sharpin(cpdm/cpdm) double knockout mice, which do not display chronic inflammation or proliferative dermatitis, thus suggesting that SHARPIN indeed acts as an integrin inhibitor in vivo. In addition, we present evidence for a functional contribution of integrin activity to the Sharpin(cpdm/cpdm) skin phenotype. Treatment with an integrin beta 1 function blocking antibody reduced epidermal hyperproliferation and epidermal thickness in Sharpin(cpdm/cpdm) mice. Our data indicate that, while TNF-induced cell death triggers the chronic inflammation and proliferative dermatitis, absence of SHARPIN-dependent integrin inhibition exacerbates the epidermal hyperproliferation in Sharpin(cpdm/cpdm) mice
Young people's uses of celebrity: Class, gender and 'improper' celebrity
This is an Author's Accepted Manuscript of an article published in Discourse: Studies in the Cultural
Politics of Education, 34(1), 2013, copyright Taylor & Francis, available online at:
http://www.tandfonline.com/10.1080/01596306.2012.698865.In this article, we explore the question of how celebrity operates in young people's everyday lives, thus contributing to the urgent need to address celebrity's social function. Drawing on data from three studies in England on young people's perspectives on their educational and work futures, we show how celebrity operates as a classed and gendered discursive device within young people's identity work. We illustrate how young people draw upon class and gender distinctions that circulate within celebrity discourses (proper/improper, deserving/undeserving, talented/talentless and respectable/tacky) as they construct their own identities in relation to notions of work, aspiration and achievement. We argue that these distinctions operate as part of neoliberal demands to produce oneself as a âsubject of valueâ. However, some participants produced readings that show ambivalence and even resistance to these dominant discourses. Young people's responses to celebrity are shown to relate to their own class and gender position.The Arts and Humanities Research Council, the British Academy, the
Economic and Social Research Council, and the UK Resource Centre for
Women in Science Engineering and Technology
Mendelian randomization study of B-type natriuretic peptide and type 2 diabetes: evidence of causal association from population studies
<p>Background: Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP) levels in blood and risk of type 2 diabetes (T2D), but the prospective association of BNP with T2D is uncertain, and it is unclear whether the association is confounded.</p>
<p>Methods and Findings: We analysed the association between levels of the N-terminal fragment of pro-BNP (NT-pro-BNP) in blood and risk of incident T2D in a prospective case-cohort study and genotyped the variant rs198389 within the BNP locus in three T2D case-control studies. We combined our results with existing data in a meta-analysis of 11 case-control studies. Using a Mendelian randomization approach, we compared the observed association between rs198389 and T2D to that expected from the NT-pro-BNP level to T2D association and the NT-pro-BNP difference per C allele of rs198389. In participants of our case-cohort study who were free of T2D and cardiovascular disease at baseline, we observed a 21% (95% CI 3%-36%) decreased risk of incident T2D per one standard deviation (SD) higher log-transformed NT-pro-BNP levels in analysis adjusted for age, sex, body mass index, systolic blood pressure, smoking, family history of T2D, history of hypertension, and levels of triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. The association between rs198389 and T2D observed in case-control studies (odds ratio = 0.94 per C allele, 95% CI 0.91-0.97) was similar to that expected (0.96, 0.93-0.98) based on the pooled estimate for the log-NT-pro-BNP level to T2D association derived from a meta-analysis of our study and published data (hazard ratio = 0.82 per SD, 0.74-0.90) and the difference in NT-pro-BNP levels (0.22 SD, 0.15-0.29) per C allele of rs198389. No significant associations were observed between the rs198389 genotype and potential confounders.</p>
<p>Conclusions: Our results provide evidence for a potential causal role of the BNP system in the aetiology of T2D. Further studies are needed to investigate the mechanisms underlying this association and possibilities for preventive interventions.</p>
Bilayer manganites: polarons in the midst of a metallic breakdown
The exact nature of the low temperature electronic phase of the manganite
materials family, and hence the origin of their colossal magnetoresistant (CMR)
effect, is still under heavy debate. By combining new photoemission and
tunneling data, we show that in La{2-2x}Sr{1+2x}Mn2O7 the polaronic degrees of
freedom win out across the CMR region of the phase diagram. This means that the
generic ground state is that of a system in which strong electron-lattice
interactions result in vanishing coherent quasi-particle spectral weight at the
Fermi level for all locations in k-space. The incoherence of the charge
carriers offers a unifying explanation for the anomalous charge-carrier
dynamics seen in transport, optics and electron spectroscopic data. The
stacking number N is the key factor for true metallic behavior, as an
intergrowth-driven breakdown of the polaronic domination to give a metal
possessing a traditional Fermi surface is seen in the bilayer system.Comment: 7 pages, 2 figures, includes supplementary informatio
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