21 research outputs found
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Cryogenic Characterization of FBK RGB-HD SiPMs
We report on the cryogenic characterization of Red Green Blue - High Density
(RGB-HD) SiPMs developed at Fondazione Bruno Kessler (FBK) as part of the
DarkSide program of dark matter searches with liquid argon time projection
chambers. A dedicated setup was used to measure the primary dark noise, the
correlated noise, and the gain of the SiPMs at varying temperatures. A
custom-made data acquisition system and analysis software were used to
precisely characterize these parameters. We demonstrate that FBK RGB-HD SiPMs
with low quenching resistance (RGB-HD-LR) can be operated from 40 K to 300
K with gains in the range to and noise rates on the order of a
few Hz/mm
Regulatory T Cells in Severe Persistent Asthma in the Era of Monoclonal Antibodies Target Therapies
Asthma is an immunoinflammatory disease characterized by bronchial hyper-reactivity to different external stimuli. New monoclonal target treatments have been developed, but few studies have investigated the role of regulatory T cells in severe asthma and the modulatory effect of biological therapy on regulatory T cell functions. Their dysfunction may contribute to the development and exacerbation of asthma. Here we review the recent literature on the potential immunological role of regulatory T cells in the pathogenesis of severe asthma. The analysis of the role of regulatory T cells was performed in terms of functions and their possible interactions with mechanisms of action of the novel treatment for severe asthma. In an era of biological therapies for severe asthma, little data is available on the potential effects of what could be a new therapy: monoclonal antibody targeting of regulatory T cell numbers and functions