301 research outputs found
On the density matrix for the kink ground state of higher spin XXZ chain
The exact expression for the density matrix of the kink ground state of
higher spin XXZ chain is obtained
Formation of Carbon Nanostructures with Ge and SiC Nanoparticles Prepared by Direct Current and Radio Frequency Hybrid Arc Discharge
Case Studies of Energy Information Systems and Related Technology: Operational Practices, Costs, and Benefits
Energy Information Systems (EIS), which can
monitor and analyze building energy consumption
and related data throughout the Internet, have been
increasing in use over the last decade. Though EIS
developers describe the capabilities, costs, and
benefits of EIS, many of these descriptions are
idealized and often insufficient for potential users to
evaluate cost, benefit and operational usefulness.
LBNL has conducted a series of case studies of
existing EIS and related technology installations.
This study explored the following questions: 1) How is the EIS used in day-to-day operation? 2) What are the costs and benefits of an EIS? 3) Where do the energy savings come from? This paper reviews the process of these technologies
from installation through energy management
practice. The study is based on interviews with
operators and energy managers who use EIS.
Analysis of energy data trended by EIS and utility
bills was also conducted to measure the benefit. This
paper explores common uses and findings to identify
energy savings attributable to EIS, and discusses nonenergy
benefits as well. This paper also addresses
technologies related to EIS that have been
demonstrated and evaluated by LBNL
On the problem of calculation of correlation functions in the six-vertex model with domain wall boundary conditions
The problem of calculation of correlation functions in the six-vertex model
with domain wall boundary conditions is addressed by considering a particular
nonlocal correlation function, called row configuration probability. This
correlation function can be used as building block for computing various (both
local and nonlocal) correlation functions in the model. The row configuration
probability is calculated using the quantum inverse scattering method; the
final result is given in terms of a multiple integral. The connection with the
emptiness formation probability, another nonlocal correlation function which
was computed elsewhere using similar methods, is also discussed.Comment: 15 pages, 2 figure
Introduction to Commercial Building Control Strategies and Techniques for Demand Response -- Appendices
There are 3 appendices listed: (A) DR strategies for HVAC systems; (B) Summary of DR strategies; and (C) Case study of advanced demand response
Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency.
BACKGROUND AND OBJECTIVE: The exacerbation-prone phenotype of COPD is particularly important, as exacerbations lead to poor quality of life and disease progression. We previously found that COPD patients who lack Siglec-14, a myeloid cell protein that recognizes bacteria and triggers inflammatory responses, are less prone to exacerbation. We hypothesized that the variations in other SIGLEC genes could also influence COPD exacerbation frequency, and investigated the association between SIGLEC9 polymorphisms and the exacerbation-prone phenotype of COPD. METHODS: We examined whether SIGLEC9 polymorphisms affect the frequency of COPD exacerbation in 135 subjects within our study population, and also analysed the correlation between the genotypes and the severity of airflow obstruction and emphysema in 362 Japanese smokers including 244 COPD patients. The association between these single nucleotide polymorphisms (SNPs) and COPD phenotypes were also assessed in a Caucasian population of ECLIPSE study. The effects of these coding SNPs (cSNPs) on Siglec-9 protein functions were analysed using in vitro assays. RESULTS: The G allele of rs2075803 and rs2075803 G/rs2258983 A(GA) haplotype in SIGLEC9 was associated with higher frequency of exacerbations and the extent of emphysema in COPD. These results did not replicate in the ECLIPSE study. A myeloid cell line expressing the Siglec-9 variant corresponding to GA haplotype produced more TNF-α than the one expressing the variant corresponding to the other major haplotype. CONCLUSION: The SIGLEC9 rs2075803 G/rs2258983 A haplotype, which corresponds to a Siglec-9 variant that is less effective at suppressing inflammatory response, may be a risk factor for the development of emphysema
Multi-component assessment of chronic obstructive pulmonary disease: an evaluation of the ADO and DOSE indices and the global obstructive lung disease categories in international primary care data sets
Acknowledgements We thank Sian Williams of the International Primary Care Respiratory Group for her help and encouragement with the project. The OPCRD database was made available courtesy of the Respiratory Effectiveness Group and RIRL and the data were kindly prepared for analysis by Julie von Ziegenweidt. Funding The International Primary Care Respiratory Group (IPCRG) provided funding for this research project as an UNLOCK group study for which the funding was obtained through an unrestricted grant by Novartis AG, Basel, Switzerland. The latter funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Database access for the OPCRD was provided by the Respiratory Effectiveness Group (REG) and Research in Real Life; the OPCRD statistical analysis was funded by REG. The Bocholtz Study was funded by PICASSO for COPD, an initiative of Boehringer Ingelheim, Pfizer and the Caphri Research Institute, Maastricht University, The Netherlands.Peer reviewedPublisher PD
Importance of individual events in temporal networks
Records of time-stamped social interactions between pairs of individuals
(e.g., face-to-face conversations, e-mail exchanges, and phone calls)
constitute a so-called temporal network. A remarkable difference between
temporal networks and conventional static networks is that time-stamped events
rather than links are the unit elements generating the collective behavior of
nodes. We propose an importance measure for single interaction events. By
generalizing the concept of the advance of event proposed by [Kossinets G,
Kleinberg J, and Watts D J (2008) Proceeding of the 14th ACM SIGKDD
International conference on knowledge discovery and data mining, p 435], we
propose that an event is central when it carries new information about others
to the two nodes involved in the event. We find that the proposed measure
properly quantifies the importance of events in connecting nodes along
time-ordered paths. Because of strong heterogeneity in the importance of events
present in real data, a small fraction of highly important events is necessary
and sufficient to sustain the connectivity of temporal networks. Nevertheless,
in contrast to the behavior of scale-free networks against link removal, this
property mainly results from bursty activity patterns and not heterogeneous
degree distributions.Comment: 36 pages, 13 figures, 2 table
Controlling transmembrane protein concentration and orientation in supported lipid bilayers
The trans-membrane protein – proteorhodopsin (pR) has been incorporated into supported lipid bilayers (SLB). In-plane electric fields have been used to manipulate the orientation and concentration of these proteins, within the SLB, through electrophoresis leading to a 25-fold increase concentration of pR
Spt2p Defines a New Transcription-Dependent Gross Chromosomal Rearrangement Pathway
Large numbers of gross chromosomal rearrangements (GCRs) are frequently observed in many cancers. High mobility group 1 (HMG1) protein is a non-histone DNA-binding protein and is highly expressed in different types of tumors. The high expression of HMG1 could alter DNA structure resulting in GCRs. Spt2p is a non-histone DNA binding protein in Saccharomyces cerevisiae and shares homology with mammalian HMG1 protein. We found that Spt2p overexpression enhances GCRs dependent on proteins for transcription elongation and polyadenylation. Excess Spt2p increases the number of cells in S phase and the amount of single-stranded DNA (ssDNA) that might be susceptible to cause DNA damage and GCR. Consistently, RNase H expression, which reduces levels of ssDNA, decreased GCRs in cells expressing high level of Spt2p. Lastly, high transcription in the chromosome V, the location at which GCR is monitored, also enhanced GCR formation. We propose a new pathway for GCR where DNA intermediates formed during transcription can lead to genomic instability
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