Soundness of Unravelings for Conditional Term Rewriting Systems via Ultra-Properties Related to Linearity

Unravelings are transformations from a conditional term rewriting system (CTRS, for short) over an original signature into an unconditional term rewriting systems (TRS, for short) over an extended signature. They are not sound w.r.t. reduction for every CTRS, while they are complete w.r.t. reduction. Here, soundness w.r.t. reduction means that every reduction sequence of the corresponding unraveled TRS, of which the initial and end terms are over the original signature, can be simulated by the reduction of the original CTRS. In this paper, we show that an optimized variant of Ohlebusch's unraveling for a deterministic CTRS is sound w.r.t. reduction if the corresponding unraveled TRS is left-linear or both right-linear and non-erasing. We also show that soundness of the variant implies that of Ohlebusch's unraveling. Finally, we show that soundness of Ohlebusch's unraveling is the weakest in soundness of the other unravelings and a transformation, proposed by Serbanuta and Rosu, for (normal) deterministic CTRSs, i.e., soundness of them respectively implies that of Ohlebusch's unraveling.Comment: 49 pages, 1 table, publication in Special Issue: Selected papers of the "22nd International Conference on Rewriting Techniques and Applications (RTA'11)

Family based association analyses between the Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Neuroticism, Anxiety and Depression

We studied the association between the short/long promotor-based length polymorphism of the serotonin transporter gene (5-HTTLPR) and neuroticism, anxiety and depression. Subjects included twins, their siblings and parents from the Netherlands Twin Register (559 parents and 1,245 offspring). Subjects had participated between one and five times in a survey study measuring neuroticism, anxiety and depression. Offspring of these families were also approached to participate in a psychiatric interview diagnosing DSM-IV major depression. Within-family and total association between 5-HTTLPR and these traits were tested. Only three of the 36 tests showed a significant effect of 5-HTTLPR (P < 0.05). These effects were in opposite directions, i.e. both negative and positive regression coefficients were found for the s allele. No additive effect of the s allele was found for DSM-IV depression. Our results strongly suggest that there is no straightforward association between 5-HTTLPR and neuroticism, anxiety and depression

Progress of the ALIFE2 study : a dynamic road towards more evidence

Investigator-initiated studies are invaluable, especially in fields that are not particularly of interest for the pharmaceutical industry because they are either less profitable or concern special patient groups such as pregnant women. However, designing, conducting, and completing an investigator-initiated randomised controlled trial is challenging. Patients and physicians' preferences, ethics requirements, (international) legislation and funding are all areas where such challenges are encountered. The Anticoagulants for LIving FEtuses (ALIFE)2 study (NTR3361) is an example of an investigator initiated international multicenter trial that progresses slowly, at least initially, as many challenges had to be overcome. Here, we discuss the challenges we faced during the course of the ALIFE2 study up till now and we explain how some of these challenges can be tackled or even avoided

A Reduction-Preserving Completion for Proving Confluence of Non-Terminating Term Rewriting Systems

We give a method to prove confluence of term rewriting systems that contain non-terminating rewrite rules such as commutativity and associativity. Usually, confluence of term rewriting systems containing such rules is proved by treating them as equational term rewriting systems and considering E-critical pairs and/or termination modulo E. In contrast, our method is based solely on usual critical pairs and it also (partially) works even if the system is not terminating modulo E. We first present confluence criteria for term rewriting systems whose rewrite rules can be partitioned into a terminating part and a possibly non-terminating part. We then give a reduction-preserving completion procedure so that the applicability of the criteria is enhanced. In contrast to the well-known Knuth-Bendix completion procedure which preserves the equivalence relation of the system, our completion procedure preserves the reduction relation of the system, by which confluence of the original system is inferred from that of the completed system

Confluence Competition 2018

We report on the 2018 edition of the Confluence Competition, a competition of software tools that aim to (dis)prove confluence and related properties of rewrite systems automatically

Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph

Using EpiLymph case-control data, we found that chronic lymphocytic leukemia patients were more likely to have abnormal reactive serological patterns to Epstein Barr virus than controls. Here, we aimed to assess whether this association is modified by genetic variants. We examined 1,305 Single Nucleotide Polymorphisms from 300 selected genes related to various pathways in 240 cases and 513 controls from five European centers. In a recessive model, patients positive to aberrant antibody pattern and homozygous for rare genotypes in rs8113877T>G or rs17576A>G of the MMP9 gene were at highest risk of chronic lymphocytic leukemia. In a dominant model, TP73 showed the highest risk in patients positive to aberrant antibody pattern and homozygous for the wild-type genotype in rs1885859G>C or rs3765701A>T. All interactions were additive and no main effect was observed. The strong interactions observed may be indicative of a specific pathway in cancer genesis. Confirmation of these results is warranted

Homeomorphic Embedding for Online Termination of Symbolic Methods

Well-quasi orders in general, and homeomorphic embedding in particular, have gained popularity to ensure the termination of techniques for program analysis, specialisation, transformation, and verification. In this paper we survey and discuss this use of homeomorphic embedding and clarify the advantages of such an approach over one using well-founded orders. We also discuss various extensions of the homeomorphic embedding relation. We conclude with a study of homeomorphic embedding in the context of metaprogramming, presenting some new (positive and negative) results and open problems

Automatically Proving and Disproving Feasibility Conditions

[EN] In the realm of term rewriting, given terms s and t, a reachability condition s>>t is called feasible if there is a substitution O such that O(s) rewrites into O(t) in zero or more steps; otherwise, it is called infeasible. Checking infeasibility of (sequences of) reachability conditions is important in the analysis of computational properties of rewrite systems like confluence or (operational) termination. In this paper, we generalize this notion of feasibility to arbitrary n-ary relations on terms defined by first-order theories. In this way, properties of computational systems whose operational semantics can be given as a first-order theory can be investigated. We introduce a framework for proving feasibility/infeasibility, and a new tool, infChecker, which implements it.Supported by EU (FEDER), and projects RTI2018-094403-B-C32, PROMETEO/2019/098, and SP20180225. Also by INCIBE program "Ayudas para la excelencia de los equipos de investigación avanzada en ciberseguridad" (Raul Gutiérrez).Gutiérrez Gil, R.; Lucas Alba, S. (2020). Automatically Proving and Disproving Feasibility Conditions. Springer Nature. 416-435. https://doi.org/10.1007/978-3-030-51054-1_27S416435Andrianarivelo, N., Réty, P.: Over-approximating terms reachable by context-sensitive rewriting. In: Bojańczyk, M., Lasota, S., Potapov, I. (eds.) RP 2015. LNCS, vol. 9328, pp. 128–139. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24537-9_12Dershowitz, N.: Termination of rewriting. J. Symb. Comput. 3(1/2), 69–116 (1987). https://doi.org/10.1016/S0747-7171(87)80022-6Giesl, J., Thiemann, R., Schneider-Kamp, P., Falke, S.: Mechanizing and improving dependency pairs. J. Autom. Reasoning 37(3), 155–203 (2006). https://doi.org/10.1007/s10817-006-9057-7Goguen, J.A., Meseguer, J.: Models and equality for logical programming. In: Ehrig, H., Kowalski, R., Levi, G., Montanari, U. (eds.) TAPSOFT 1987. LNCS, vol. 250, pp. 1–22. Springer, Heidelberg (1987). https://doi.org/10.1007/BFb0014969Gutiérrez, R., Lucas, S.: Automatic generation of logical models with AGES. In: Fontaine, P. (ed.) CADE 2019. LNCS (LNAI), vol. 11716, pp. 287–299. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-29436-6_17Kojima, Y., Sakai, M.: Innermost reachability and context sensitive reachability properties are decidable for linear right-shallow term rewriting systems. In: Voronkov, A. (ed.) RTA 2008. LNCS, vol. 5117, pp. 187–201. Springer, Heidelberg (2008). https://doi.org/10.1007/978-3-540-70590-1_13Kojima, Y., Sakai, M., Nishida, N., Kusakari, K., Sakabe, T.: Context-sensitive innermost reachability is decidable for linear right-shallow term rewriting systems. Inf. Media Technol. 4(4), 802–814 (2009)Kojima, Y., Sakai, M., Nishida, N., Kusakari, K., Sakabe, T.: Decidability of reachability for right-shallow context-sensitive term rewriting systems. IPSJ Online Trans. 4, 192–216 (2011)Lucas, S.: Analysis of rewriting-based systems as first-order theories. In: Fioravanti, F., Gallagher, J.P. (eds.) LOPSTR 2017. LNCS, vol. 10855, pp. 180–197. Springer, Cham (2018). https://doi.org/10.1007/978-3-319-94460-9_11Lucas, S.: Context-sensitive computations in functional and functional logic programs. J. Funct. Logic Program. 1998(1) (1998). http://danae.uni-muenster.de/lehre/kuchen/JFLP/articles/1998/A98-01/A98-01.htmlLucas, S.: Proving semantic properties as first-order satisfiability. Artif. Intell. 277 (2019). https://doi.org/10.1016/j.artint.2019.103174Lucas, S.: Using well-founded relations for proving operational termination. J. Autom. Reasoning 64(2), 167–195 (2019). https://doi.org/10.1007/s10817-019-09514-2Lucas, S., Gutiérrez, R.: Use of logical models for proving infeasibility in term rewriting. Inf. Process. Lett. 136, 90–95 (2018). https://doi.org/10.1016/j.ipl.2018.04.002Lucas, S., Marché, C., Meseguer, J.: Operational termination of conditional term rewriting systems. Inf. Process. Lett. 95(4), 446–453 (2005). https://doi.org/10.1016/j.ipl.2005.05.002Lucas, S., Meseguer, J.: Proving operational termination of declarative programs in general logics. In: Chitil, O., King, A., Danvy, O. (eds.) Proceedings of the 16th International Symposium on Principles and Practice of Declarative Programming, Kent, Canterbury, United Kingdom, 8–10 September 2014, pp. 111–122. ACM (2014). https://doi.org/10.1145/2643135.2643152Lucas, S., Meseguer, J., Gutiérrez, R.: The 2D dependency pair framework for conditional rewrite systems. Part I: definition and basic processors. J. Comput. Syst. Sci. 96, 74–106 (2018). https://doi.org/10.1016/j.jcss.2018.04.002Lucas, S., Meseguer, J., Gutiérrez, R.: The 2D dependency pair framework for conditional rewrite systems—Part II: advanced processors and implementation techniques. J. Autom. Reasoning (2020, in press)McCune, W.: Prover9 and Mace4. https://www.cs.unm.edu/~mccune/mace4/Meßner, F., Sternagel, C.: nonreach – a tool for nonreachability analysis. In: Vojnar, T., Zhang, L. (eds.) TACAS 2019. LNCS, vol. 11427, pp. 337–343. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-17462-0_19Middeldorp, A., Nagele, J., Shintani, K.: Confluence competition 2019. In: Beyer, D., Huisman, M., Kordon, F., Steffen, B. (eds.) TACAS 2019. LNCS, vol. 11429, pp. 25–40. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-17502-3_2Nishida, N., Maeda, Y.: Narrowing trees for syntactically deterministic conditional term rewriting systems. In: Kirchner, H. (ed.) Proceedings of the 3rd International Conference on Formal Structures for Computation and Deduction. FSCD 2018. Leibniz International Proceedings in Informatics (LIPIcs), vol. 108, pp. 26:1–26:20. Schloss Dagstuhl-Leibniz-Zentrum fuer Informatik (2018). https://doi.org/10.4230/LIPIcs.FSCD.2018.26Ohlebusch, E.: Advanced Topics in Term Rewriting. Springer, Heidelberg (2002). http://www.springer.com/computer/swe/book/978-0-387-95250-5Prawitz, D.: Natural Deduction: A Proof-Theoretical Study. Dover, New York (2006)Sternagel, C., Sternagel, T., Middeldorp, A.: CoCo 2018 Participant: ConCon 1.5. In: Felgenhauer, B., Simonsen, J. (eds.) Proceedings of the 7th International Workshop on Confluence. IWC 2018, p. 66 (2018). http://cl-informatik.uibk.ac.at/events/iwc-2018/Sternagel, C., Yamada, A.: Reachability analysis for termination and confluence of rewriting. In: Vojnar, T., Zhang, L. (eds.) TACAS 2019. LNCS, vol. 11427, pp. 262–278. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-17462-0_15Winkler, S., Moser, G.: MædMax: a maximal ordered completion tool. In: Galmiche, D., Schulz, S., Sebastiani, R. (eds.) IJCAR 2018. LNCS (LNAI), vol. 10900, pp. 472–480. Springer, Cham (2018). https://doi.org/10.1007/978-3-319-94205-6_3