A destressing "deafness" in French?

French is a language in which accent is mandatory on the last syllable of every content word. In contrast, Spanish uses accent to distinguish different lexical items (e.g., b'ebe vs beb'e). Two population of subjects were tested on the same materials to study whether such linguistic differences have an impact on the perceptual capacities of listeners. In Experiment 1, using an ABX paradigm, we find that French Subjects have a surprising deficit compared to Spanish Subjects in making accent distinctions. In Experiment 2, we find that Spanish subjects cannot ignore irrelevant differences in accent in a phoneme-based ABX task, whereas French Subjects have no difficulty at all. In Experiment 3, we replicate the basic French finding, and find that Spanish subjects benefit from redundant accent information even when phonemic information alone is sufficient to perform the task. In our final Experiment 4, we show that French subjects can hear the acoustic correlates of accent; their problem seem to arise at the level of short term memory. Implications for language-specific processing and acquisition are discussed

Growth hormone secretion during space flight and evaluation of the physiological responses of animals held in the research animal holding facility

The spaceflight of the Research Animal Holding Facility (RAHF) on the Space Laboratory 3 (SL 3) provided the opportunity to evaluate the suitability of the RAHF for housing and maintaining experimental animals during spaceflight, and to determine changes in the secretion of growth hormone during spaceflight. Using ground-based studies the following were investigated: the optimum conditions for creating gravitational force on space flight animals; neural pathways that may play a role in the space flight syndrome; and the time course of muscle atrophy due to hypodynamia and hypokenesia in hindlimb-suspended animals and the role of growth hormone in these processes

Near-infrared spectroscopy for functional studies of brain activity in human infants: promise, prospects, and challenges

A recent workshop brought together a mix of researchers with expertise in optical physics, cerebral hemodynamics, cognitive neuroscience, and developmental psychology to review the potential utility of near-IR spectroscopy (NIRS) for studies of brain activity underlying cognitive processing in human infants. We summarize the key findings that emerged from this workshop and outline the pros and cons of NIRS for studying the brain correlates of perceptual, cognitive, and language development in human infants

Words, rules, and mechanisms of language acquisition

We review recent artificial language learning studies, especially those following Endress and Bonatti (2007), suggesting that humans can deploy a variety of learning mechanisms to acquire artificial languages. Several experiments provide evidence for multiple learning mechanisms that can be deployed in fluent speech: one mechanism encodes the positions of syllables within words and can be used to extract generalization, while the other registers co-occurrence statistics of syllables and can be used to break a continuum into its components. We review dissociations between these mechanisms and their potential role in language acquisition. We then turn to recent criticisms of the multiple mechanisms hypothesis and show that they are inconsistent with the available data. Our results suggest that artificial and natural language learning is best understood by dissecting the underlying specialized learning abilities, and that these data provide a rare opportunity to link important language phenomena to basic psychological mechanisms

Augmented Reality als Entscheidungshilfe beim Möbelkauf

Diese Studie untersucht den Einfluss von Augmented Reality (AR) auf den Kaufentscheidungsprozess beim Möbelkauf. Ziel der Studie waren konkrete, handlungsleitende und wissenschaftlich fundierte Erkenntnisse für die Praxis im Umgang mit der digitalen Transformation. Dafür wurde der Einfluss einer AR-App in der Möbelbranche untersucht. Es konnte gezeigt werden, dass die AR-App ihren Nutzern eine wertvolle Unterstützung im Kaufentscheidungsprozess bietet. Die App funktioniert jedoch nicht als eigenständiger Kanal, sondern entfaltet ihren Nutzen nur im Zusammenspiel mit den bisherigen Kanälen und Hilfsmitteln. Insbesondere der Austausch mit Dritten bietet deutliches Entwicklungspotenzial und Chancen, die Customer Experience weiter zu verbessern. Einen klaren Kundenmehrwert würde eine händlerübergreifende AR-App bieten. Weiterer Forschungsbedarf ergibt sich aus den Rückkoppelungseffekten zwischen veränderter Kundeninteraktion und Technologieentwicklung

Prokineticin-1 (PROK1) modulates interleukin (IL)-11 expression via prokineticin receptor 1 (PROKR1) and the calcineurin/NFAT signalling pathway

Prokineticin-1 (PROK1) is a multifunctional secreted protein which signals via the G-protein coupled receptor, PROKR1. Previous data from our laboratory using a human genome survey microarray showed that PROK1–prokineticin receptor 1 (PROKR1) signalling regulates numerous genes important for establishment of early pregnancy, including the cytokine interleukin (IL)-11. Here, we have shown that PROK1–PROKR1 induces the expression of IL-11 in PROKR1 Ishikawa cells and first trimester decidua via the calcium–calcineurin signalling pathway in a guanine nucleotide-binding protein (Gq/11), extracellular signal-regulated kinases, Ca2+ and calcineurin–nuclear factor of activated T cells dependent manner. Conversely, treatment of human decidua with a lentiviral miRNA to abolish endogenous PROK1 expression results in a significant reduction in IL-11 expression and secretion. Importantly, we have also shown a regulatory role for the regulator of calcineurin 1 isoform 4 (RCAN1-4). Overexpression of RCAN1-4 in PROKR1 Ishikawa cells using an adenovirus leads to a reduction in PROK1 induced IL-11 indicating that RCAN1-4 is a negative regulator in the calcineurin-mediated signalling to IL-11. Finally, we have shown the potential for both autocrine and paracrine signalling in the human endometrium by co-localizing IL-11, IL-11Rα and PROKR1 within the stromal and glandular epithelial cells of non-pregnant endometrium and first trimester decidua. Overall we have identified and characterized the signalling components of a novel PROK1–PROKR1 signalling pathway regulating IL-11

Esophageal cancer in a young woman with bulimia nervosa: a case report

Adenocarcinoma of the esophagus has increased dramatically within the United States and continues to have a poor prognosis despite aggressive treatment. Identifying potential risk factors is critical for the early detection and treatment of this disease. The present case report describes a very young woman who developed adenocarcinoma of the esophagus after only a brief history of bulimia. These findings suggest that even in very young patients, bulimia may represent a risk factor for adenocarcinoma of the esophagus