Conservative Outpatient Physical Therapy Management of Patient with Atraumatic Anterior Sternoclavicular Joint Subluxation: A Case Report

Introduction: Atraumatic Anterior Subluxations of the Sternoclavicular Joint (SCJ) are a rare upper extremity injury that may cause range of motion (ROM) and strength deficits to the shoulder joint due to pain and feelings of instability. There are a variety of approaches for management as with SCJ subluxations, but atraumatic anterior displacements respond mostly to conservative management or masterly neglect. Case Description: The patient was a 63-year-old female with an atraumatic anterior subluxation of her right side. The patient did not qualify for surgical or physician intervention and was referred to physical therapy for conservative treatment and pain management. Interventions: The therapy provided emphasized general strengthening of the shoulder complex and passive treatments utilizing hot pack and Kinesiotape. The interventions were performed to improve upper extremity strength, ROM, and pain. Outcomes: Over the course of treatment, the patient was able to decrease best and worst pain, increase strength of the upper extremity, and functional mobility. Discussion: The patient responded well to treatment allowing her to return to work without limitations. There was only one goal that was not met by discharge that was caused by various reasons. More research is needed to further distinguish the best treatment for managing atraumatic anterior subluxations of the SCJ

Instruction in Functional Assessment

By Marcie Desrochers, Moira Fallon, College at Brockport faculty members. Instruction in Functional Assessment introduces learners to functional assessment (FA), which includes a variety of assessment approaches (indirect, observational, and experimental) for identifying the cause of an individual\u27s challenging behavior for the purpose of designing effective treatments. FA is mandated by federal law and is a recognized empirically based approach to treatment of individuals with challenging behaviors (e.g., disruptive, self-injurious, and aggressive behaviors). Instruction in FA is essential for students who will one day enter professions as educators, psychologists, social workers, counselors, or mental health professionals. The purpose of this textbook is to provide instruction in FA skills for pre-professionals in the fields of education and psychology. This supplemental resource provides the context, background, and knowledge to facilitate students\u27 acquisition of the methods, decision-making, and skills involved in conducting FA. Each chapter begins with focus questions designed to promote reflective thinking and ends with discussion questions. To promote application of FA in diverse situations and teach important lessons, case studies of individuals with challenging behaviors, interactive activities, and opportunities for practice are embedded in the chapters. Moreover, the text includes the ingredients to facilitate students\u27 role play and rehearsal of appropriate FA skills while working in cooperative groups and using performance-based traininghttps://digitalcommons.brockport.edu/bookshelf/1362/thumbnail.jp

Data to support observation of late and ultra-late latency components of cortical laser evoked potentials

open access articleData are provided to document the presence of late and ultra-late latency components of cortical laser evoked potentials (LEPs) following noxious laser stimulus in Stancak et al. (2015) [3]. The latency components, labeled provisionally as N4, N5, and N6, were observed in 16 healthy human participants who were asked to fully attend their painful and non-painful sensations occurring in association with noxious laser stimulus. Individual laser evoked potential waveforms are provided in support of this observation. Data provided demonstrate the cortical sources of the late and ultra-late laser evoked potentials. The cortical sources of LEPs were reconstructed using the standardized Low Resolution Electromagnetic Tomography (sLORETA) method

Evidence-Based Leadership Preparation Program Practices: From the Perceptions of Georgia Rural School Leaders

Phenomenological analysis was used to explore Georgia rural school principals’ lived experiences of effective school leadership preparedness. Four overarching themes were found: productive/favorable leadership preparation program culture, bridge theory and practice in educational leadership preparation program, multicultural competencies for practice, and recommendations for effective principal preparation. The findings revealed that school leaders need increased experiential learning opportunities, increased assignments applicable to daily leader tasks, and increased cultural awareness and diversity training in their preparation programs. Principal preparation programs should work with school districts to provide purposeful, collaborative, and sustainable professional learning to prepare competent school leaders. Further research includes recruiting more rural school principals to share their experiences and perceptions with principal preparation program providers in an effort to advance aspiring principal training. Implications for practice include equipping aspiring principals with the knowledge and skills to lead for equity to continue to have a pipeline of effective school leaders to serve in Georgia’s traditionally underserved areas

School Leadership Support: Understanding the Experiences of Elementary-Level Teachers During a Global Health Pandemic

The purpose of this study was to better understand how the current COVID-19 global health pandemic has professionally and emotionally impacted elementary-level teachers. Teachers experienced diverse challenges during this unprecedented time with a rapid shift from in-person to online learning. Two overarching themes emerged based on participant experiences: abandoning best practices and increased stress and emotional pain. Implications for practice included the need for school leaders to evaluate the current level of support being provided to teachers and assess areas of need to support professional and emotional growth with the backdrop of the pandemic. We encourage future research with all educators to better understand how they are experiencing this health pandemic including the school leaders themselves

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

Loss of the E3 ubiquitin ligase Parkin causes early onset Parkinson's disease, a neurodegenerative disorder of unknown etiology. Parkin has been linked to multiple cellular processes including protein degradation, mitochondrial homeostasis, and autophagy; however, its precise role in pathogenesis is unclear. Recent evidence suggests that Parkin is recruited to damaged mitochondria, possibly affecting mitochondrial fission and/or fusion, to mediate their autophagic turnover. The precise mechanism of recruitment and the ubiquitination target are unclear. Here we show in Drosophila cells that PINK1 is required to recruit Parkin to dysfunctional mitochondria and promote their degradation. Furthermore, PINK1 and Parkin mediate the ubiquitination of the profusion factor Mfn on the outer surface of mitochondria. Loss of Drosophila PINK1 or parkin causes an increase in Mfn abundance in vivo and concomitant elongation of mitochondria. These findings provide a molecular mechanism by which the PINK1/Parkin pathway affects mitochondrial fission/fusion as suggested by previous genetic interaction studies. We hypothesize that Mfn ubiquitination may provide a mechanism by which terminally damaged mitochondria are labeled and sequestered for degradation by autophagy

Identification of the Synthetic Cannabinoid R()WIN55,212-2 as a Novel Regulator of IFN Regulatory Factor 3 Activation and IFN- Expression

Beta Interferons (IFN-βs) represent one of the first line treatments for relapsing remitting multiple sclerosis (RRMS), slowing disease progression whilst reducing the frequency of relapses. Despite this, more effective, well tolerated therapeutic strategies are needed. Cannabinoids palliate experimental autoimmune encephalomyelitis (EAE) symptoms and have therapeutic potential in MS patients although the precise molecular mechanism for these effects is not understood. Toll-like receptor (TLR) signaling controls innate immune responses and TLRs are implicated in MS. Here we demonstrate that the synthetic cannabinoid R(+)WIN55,212-2 is a novel regulator of TLR3 and TLR4 signaling by inhibiting the pro-inflammatory signaling axis triggered by TLR3 and TLR4 whilst selectively augmenting TLR3-induced activation of IFN regulatory factor 3 (IRF3) and expression of IFN-β. We present evidence that R(+)WIN55,212-2 strongly promotes the nuclear localization of IRF3. The potentiation of IFN-β expression by R(+)WIN55,212-2 is critical for manifesting its protective effects in the murine MS model EAE as evidenced by its reduced therapeutic efficacy in the presence of an anti-IFN-β antibody. R(+)WIN55,212-2 also induces IFN-β expression in MS patient peripheral blood mononuclear cells (PBMCs), whilst downregulating inflammatory signaling in these cells. These findings identify R(+)WIN55,212-2 as a novel regulator of TLR3 signaling to IRF3 activation and IFN-β expression and highlights a new mechanism that may be open to exploitation in the development of new therapeutics for the treatment of MS

Elastic and efficient LiDAR reconstruction for large-scale exploration tasks

We present an efficient, elastic 3D LiDAR reconstruction framework which can reconstruct up to maximum LiDAR ranges (60 m) at multiple frames per second, thus enabling robot exploration in large-scale environments. Our approach only requires a CPU. We focus on three main challenges of large-scale reconstruction: integration of long-range LiDAR scans at high frequency, the capacity to deform the reconstruction after loop closures are detected, and scalability for long-duration exploration. Our system extends upon a state-of-the-art efficient RGB-D volumetric reconstruction technique, called supereight, to support LiDAR scans and a newly developed submapping technique to allow for dynamic correction of the 3D reconstruction. We then introduce a novel pose graph sparsification and submap fusion feature to make our system more scalable for large environments. We evaluate the performance using a published dataset captured by a handheld mapping device scanning a set of buildings, and with a mobile robot exploring an underground room network. Experimental results demonstrate that our system can reconstruct at 3 Hz with 60 m sensor range and ~5 cm resolution, while state-of-the-art approaches can only reconstruct to 25 cm resolution or 20 m range at the same frequency

Identification of the Synthetic Cannabinoid R()WIN55,212-2 as a Novel Regulator of IFN Regulatory Factor 3 Activation and IFN- Expression

Beta Interferons (IFN-βs) represent one of the first line treatments for relapsing remitting multiple sclerosis (RRMS), slowing disease progression whilst reducing the frequency of relapses. Despite this, more effective, well tolerated therapeutic strategies are needed. Cannabinoids palliate experimental autoimmune encephalomyelitis (EAE) symptoms and have therapeutic potential in MS patients although the precise molecular mechanism for these effects is not understood. Toll-like receptor (TLR) signaling controls innate immune responses and TLRs are implicated in MS. Here we demonstrate that the synthetic cannabinoid R(+)WIN55,212-2 is a novel regulator of TLR3 and TLR4 signaling by inhibiting the pro-inflammatory signaling axis triggered by TLR3 and TLR4 whilst selectively augmenting TLR3-induced activation of IFN regulatory factor 3 (IRF3) and expression of IFN-β. We present evidence that R(+)WIN55,212-2 strongly promotes the nuclear localization of IRF3. The potentiation of IFN-β expression by R(+)WIN55,212-2 is critical for manifesting its protective effects in the murine MS model EAE as evidenced by its reduced therapeutic efficacy in the presence of an anti-IFN-β antibody. R(+)WIN55,212-2 also induces IFN-β expression in MS patient peripheral blood mononuclear cells (PBMCs), whilst downregulating inflammatory signaling in these cells. These findings identify R(+)WIN55,212-2 as a novel regulator of TLR3 signaling to IRF3 activation and IFN-β expression and highlights a new mechanism that may be open to exploitation in the development of new therapeutics for the treatment of MS