Ana Enriqueta Terán o el corazón del águila

Apuntes y congojas de una decadencia novelada en tres muertes (2014) de Doña Ana Enriqueta Terán, primera incursión novelística publicada por la Fundación Editorial El perro y la rana, nos obsequió una experiencia inigualable y harto placentera: El discurso narrativo excede la historia del clan familiar e incluso la reivindicación de la voz femenina; su tersa y franca urdimbre está enclavada en la celebración conmovedora del habla de la infancia y el lenguaje poético que construye túneles de amor y memori

Neoplasias cutâneas mais comuns

A pele é o principal local de aparecimento de neoplasias no cão, e o segundo no gato (Scott et al., 2001). Sendo o maior órgão do corpo e sendo também facilmente observado, é natural que quaisquer alterações que aí surjam sejam mais facilmente detectadas, aumentando as possibilidades de um diagnóstico precoce e um melhor prognóstico Pretende-se alertar o Enfermeiro Veterinário para as principais neoplasias cutâneas em animais de companhia, abordando as suas principais características e eventuais predisposições, de modo a habilitar este profissional com conhecimentos que lhe permitam contribuir para a melhoria dos cuidados de saúde em oncologia veterinária. Os tumores da pele e dos tecidos subcutâneos representam aproximadamente um terço dos tumores em cães, e cerca de um quarto dos tumores em gatos. Em cães, estas neoplasias são na sua maioria de carácter benigno (70-80%), mas em gatos, cerca de 50-65% destas neoplasias são de carácter maligno (Blackwood, 2011). Trabalhar numa equipa de oncologia veterinária, implica estar correctamente informado sobre as neoplasias (cutâneas), para melhor informar. É função do Enfermeiro Veterinário estar alerta para qualquer alteração que surja, e esclarecer proprietários para que procurem ajuda da equipa de saúde veterinária sempre que necessário. Desta forma, e em conjunto com médicos veterinários e proprietários de animais de companhia, estarão a contribuir para um diagnóstico precoce e um melhor prognóstico

Severe Invasive Streptococcal Disease - Emerging Disease?

Introdução: A incidência da doença estreptocócica invasiva (DSI) tem vindo a aumentar na Europa e América do Norte desde o final dos anos 1980, provavelmente relacionada com a emergência de estirpes mais virulentas. Em oito meses foram internados no nosso hospital seis casos desta entidade rara. Objectivos: Descrever as características da doença estreptocócica invasiva grave. Métodos: Estudo descritivo, de Dezembro de 2007 a Julho de 2008. Analisaram-se parâmetros demográficos, factores de risco, clínica, terapêutica, complicações e evolução. Resultados: Identificaram-se seis casos com mediana de idade de 2,5 anos: síndrome de choque tóxico estreptocócico (STSS) (2), fasceíte necrotizante (2), bacteriémia (1) e infecção estreptocócica grave (1). Cinco casos ocorreram entre Dezembro e Fevereiro. Em quatro doentes registaram-se eventuais factores de risco (infecções virais e anti-inflamatórios não esteroides). Duas crianças necessitaram de cirurgia e três de tratamento em cuidados intensivos. Todas as estirpes eram susceptíveis à penicilina e clindamicina. Ocorreram complicações em 5/6 doentes: choque séptico (3), coagulação intravascular disseminada (2), insuficiência renal (2), abcesso de tecidos moles (2), sobreinfecção bacteriana (2), síndrome de dificuldade respiratória do adulto (1), osteomielite /artrite séptica (1) e pneumonia/derrame pleural (1). Não se registaram óbitos. Comentários: Seis casos de DSI num curto espaço de tempo podem indiciar a emergência de estirpes de Streptococcus grupo A (GAS) de maior virulência no nosso país, pelo que a realização de estudos moleculares será fundamental na identificação de clones invasivos. Apesar da susceptibilidade à penicilina, a DSI cursa com morbilidade elevada, pelo que, o importante parece ser procurar novas formas de tratar o doente e não o agente

Altered cogs of the clock: Insights into the embryonic etiology of spondylocostal dysostosis

Spondylocostal dysostosis (SCDO) is a rare heritable congenital condition, characterized by multiple severe malformations of the vertebrae and ribs. Great advances were made in the last decades at the clinical level, by identifying the genetic mutations underlying the different forms of the disease. These were matched by extraordinary findings in the Developmental Biology field, which elucidated the cellular and molecular mechanisms involved in embryo body segmentation into the precursors of the axial skeleton. Of particular relevance was the discovery of the somitogenesis molecular clock that controls the progression of somite boundary formation over time. An overview of these concepts is presented, including the evidence obtained from animal models on the embryonic origins of the mutant-dependent disease. Evidence of an environmental contribution to the severity of the disease is discussed. Finally, a brief reference is made to emerging in vitro models of human somitogenesis which are being employed to model the molecular and cellular events occurring in SCDO. These represent great promise for understanding this and other human diseases and for the development of more efficient therapeutic approaches.PTDC/BEX-BID/5410/2014, SFRH/BD/146043/2019, UID/BIM/04773/2019info:eu-repo/semantics/publishedVersio

Verification and validation of openInjMoldSim, an open-source solver to model the filling stage of thermoplastic injection molding

In the present study, the simulation of the three-dimensional (3D) non-isothermal, non-Newtonian fluid flow of polymer melts is investigated. In particular, the filling stage of thermoplastic injection molding is numerically studied with a solver implemented in the open-source computational library O p e n F O A M ® . The numerical method is based on a compressible two-phase flow model, developed following a cell-centered unstructured finite volume discretization scheme, combined with a volume-of-fluid (VOF) technique for the interface capturing. Additionally, the Cross-WLF (Williams–Landel–Ferry) model is used to characterize the rheological behavior of the polymer melts, and the modified Tait equation is used as the equation of state. To verify the numerical implementation, the code predictions are first compared with analytical solutions, for a Newtonian fluid flowing through a cylindrical channel. Subsequently, the melt filling process of a non-Newtonian fluid (Cross-WLF) in a rectangular cavity with a cylindrical insert and in a tensile test specimen are studied. The predicted melt flow front interface and fields (pressure, velocity, and temperature) contours are found to be in good agreement with the reference solutions, obtained with the proprietary software M o l d e x 3 D ® . Additionally, the computational effort, measured by the elapsed wall-time of the simulations, is analyzed for both the open-source and proprietary software, and both are found to be similar for the same level of accuracy, when the parallelization capabilities of O p e n F O A M ® are employed.This work is funded by FEDER funds through the COMPETE 2020 Programme and National Funds through FCT (Portuguese Foundation for Science and Technology) under the projects UID-B/05256/2020, UID-P/05256/2020, MOLDPRO-Aproximações multi-escala para moldação por injeção de materiais plásticos (POCI-01-0145-FEDER-016665), and FAMEST-Footwear, Advanced Materials, Equipment’s and Software Technologies (POCI-01-0247-FEDER-024529)

Development of the drag coefficient of a sphere translating through a viscoelastic fluid

Presentation at 15th OpenFOAM Workshop, June 22-25, 2020, Arlington, VA, USA

Using computational modelling to study extensional rheometry tests for inelastic fluids

The present work focuses on the extensional rheometry test, performed with the Sentmanat extensional rheometer (SER) device, and its main objectives are: (i) to establish the modelling requirements, such as the geometry of the computational domain, initial and boundary conditions, appropriate case setup, and (ii) to investigate the effect of self-induced errors, namely on the sample dimensions and test temperature, on the extensional viscosity obtained through the extensional rheometry tests. The definition of the modelling setup also comprised the selection of the appropriate mesh refinement level to model the process and the conclusion that gravity can be neglected without affecting the numerical predictions. The subsequent study allowed us to conclude that the errors on the sample dimensions have similar effects, originating differences on the extensional viscosity proportional to the induced variations. On the other hand, errors of a similar order of magnitude on the test temperature promote a significant difference in the predicted extensional viscosity.This work was funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT-Portuguese Foundation for Science and Technology under the projects UIDB/05256/2020/, UIDP/05256/2020, CPCA/A2/6202/2020, CPCA_A2_6231_2020, NORTE-08-5369- FSE-000034, under program IMPULSE-Polímeros e Compósitos: Drivers da Inovação Tecnológica e da Competitividade Industrial

Different ventilatory responses to progressive maximal exercise test performed with either the arms or legs

OBJECTIVE: This study aimed to compare respiratory responses, focusing on the time-domain variability of ventilatory components during progressive cardiopulmonary exercise tests performed on cycle or arm ergometers. METHODS: The cardiopulmonary exercise tests were conducted on twelve healthy volunteers on either a cycle ergometer or an arm ergometer following a ramp protocol. The time-domain variabilities (the standard deviations and root mean squares of the successive differences) of the minute ventilation, tidal volume and respiratory rate were calculated and normalized to the number of breaths. RESULTS: There were no significant differences in the timing of breathing throughout the exercise when the cycle and arm ergometer measurements were compared. However, the arm exercise time-domain variabilities for the minute ventilation, tidal volume and respiratory rate were significantly greater than the equivalent values obtained during leg exercise. CONCLUSION: Although the type of exercise does not influence the timing of breathing when dynamic arm and leg exercises are compared, it does influence time-domain ventilatory variability of young, healthy individuals. The mechanisms that influence ventilatory variability during exercise remain to be studied