Quality analysis of groundwater and surface water bodies around the selected brick kilns in Fatehgarh Sahib and Rupnagar Districts in Punjab, India

Brick production is a business that benefits many people, such as providing building materials, employment, and interest to the business owners. However, it has been associated with many adverse impacts various components of ecosystem.Thepresent studyaimed to determine the impact of isolated brick kilns onthe pollution levelof water bodies in Fatehgarh Sahib and Rupnagar Districts of Punjab, India. Physicochemical and microbiological parameters of water were evaluated. The results revealed that the isolated brick kilns partially impacted the water bodies, as the concentration of heavy metals waspresent in surface water near the study area. Parameters such as electrical conductivity (EC), Turbidity, total dissolved solids (TDS), Chloride (Cl), alkalinity and chemical oxygen demand (COD) estimated for surface water samples showed high contamination levels, except for pH, which was acidic (6.2) for surface water. The groundwater was alkaline with pH estimated to be 7.6. The alkalinity and COD levels of groundwater were 693.3 mg/l and 12.4,respectively, as the peak values, and both values were beyond the permissible limits for drinking water. Total coliforms were present in all samples at low health risk (13/15), except two surface water ponds, which showed a health risk. One-third of groundwater was highly contaminated by Escherichia coli, whereas only one of the twelve samples was contaminated withE.coli. The changes of all estimated water parameters in groundwater with distance did not follow any spatial pattern. They could partially be attributed to the lithology of the soil and prominent agricultural activities in the region. The WQI was highly influenced by heavy metals, notably arsenic (As) from both lithologic and brick kilns' origins and lead (Pb) from burning fuels in the brick kilns.

Transient dynamics of a 2D granular pile

International audienceWe investigate by means of Contact Dynamics simulations the transient dynamics of a 2D granular pile set into motion by applying shear velocity during a short time interval to all particles. The spreading dynamics is directly controlled by the input energy whereas in recent studies of column collapse the dynamics scales with the initial potential energy of the column. As in column collapse, we observe a power-law dependence of the runout distance with respect to the input energy with nontrivial exponents. This suggests that the power-law behavior is a generic feature of granular dynamics, and the values of the exponents reflect the distribution of kinetic energy inside the material. We observe two regimes with different values of the exponents: the low-energy regime reflects the destabilization of the pile by the impact with a runout time independent of the input energy whereas the high-energy regime is governed by the input energy. We show that the evolution of the pile in the high-energy regime can be described by a characteristic decay time and the available energy after the pile is destabilized

Sulfate attack and embedded steel corrosion resistances of volcanic-aggregate concrete with fly ash and silica fume

Construction materials are increasingly on high demand in the developing world. The construction industry has a challenge of discovering, new  alternative construction materials to conventional materials which are locally available materials in environmentally friendly manner. The  experimental tests are conducted on volcanic concrete system to analyze its properties especially corrosion resistance potential for its applicability in construction. The major aim is to investigate its suitability and corrosion resistance potential especially when used in construction of structures with embedded steel. The test results of the material show that volcanic concrete system with 30% fly ash and 10% silica fume cementing materials is an alternative green construction material. Permeability properties are reduced by 8% and 24% with 30% fly ash and 10% silica fume respectively. Tests also indicate that Compressive strength, Corrosion potential and polarization resistance in volcanic concrete system with supplementing  cement materials has more potential to resist sulfate attack when compared with conventional volcanic concrete systems. The supplementary cementing materials (SCM) reduce the pore system and hence decrease the ingress of corrosive ions an  water in concrete. Corrosive ions, moisture and air would initiate corrosion to the embedded steel in concrete leading to reduced service life such structures. Key word: Supplementary Cementing Materials, Sulfate attack, volcanic concrete system, Granite powder, river sand, Corrosion of embedded stee

Le rôle de la leptine dans le métabolisme anormal des ostéoblastes de patients atteints d’ostéoarthrose

L’ostéoarthrose (OA) est une pathologie qui touche les articulations principalement chez les personnes âgées. Il devient capital de mieux cerner cette pathologie à cause des coûts économiques qu’elle engendre mais surtout à cause du vieillissement de la population. Cette maladie se caractérise par une dégradation du cartilage articulaire, une sclérose osseuse, une inflammation de la membrane synoviale ainsi que la présence d’ostéophytes. L’étiologie de cette pathologie est restée nébuleuse car la recherche sur la maladie touchait principalement le cartilage articulaire. Toutefois, le rôle clé de l’os sous-chondral dans l’OA est maintenant reconnu. L’obésité étant un facteur de risque de l’OA, nous avons émis l’hypothèse que la leptine, une adipocytokine clé dans l’obésité, joue un rôle important dans l’OA. En effet, la leptine modifie le phénotype des ostéoblastes (Ob) normaux humain et puisque les Ob OA humains ont un phénotype altéré, notre objectif était de déterminer le rôle potentiel de la leptine dans ces cellules. Pour ce faire, nous avons préparé des cultures primaires d’Ob issus de la plaque sous-chondral du plateau tibial de patients OA et d’individus normaux (N). L’expression de la leptine et de son récepteur actif (OB-Rb) ont été mesurées par RT-PCR en temps réel, et leur production a été mesurée par ELISA et immunobuvardage (IB). La prolifération des Ob OA a été déterminée par incorporation de BrdU. La phosphorylation de p42/44 MAPK dans les Ob OA a été déterminée par IB. Le phénotype des Ob fut déterminé par la mesure de l’activité de la phosphatase alcaline (ALP) et la sécrétion d’ostéocalcine (OC), en présence ou non de leptine. De plus, les effets des ARNs d’interférences (SiRNA) anti-leptine et anti OB-Rb sur le phénotype des Ob OA furent déterminés via leur impact sur l’activité de l’ALP et sur la sécrétion d’OC. L’effet dose-réponse de la leptine sur les expressions d’OB-Rb, du facteur de croissance TGF-1 ou encore sur sa propre expression furent déterminées par RT-PCR en temps réel. Pour terminer, la signalisation de la leptine a été étudiée en évaluant l’effet dose réponse de celle-ci sur la production des protéines JAK2 et STAT3 phosphorylées par IB. Les résultats obtenus ont montrés que les Ob OA expriment et produisent plus de leptine que les Ob N. Au niveau phénotypique, ces Ob OA possèdent une activité de l’ALP ainsi qu’une sécrétion d’OC plus importante que celles observées chez les Ob N. L’ajout d’anticorps inactivant l’interaction leptine et OB-Rb ou d’inhibiteurs chimiques comme tyrphostin ou piceatannol diminuèrent l’activité de l’ALP ainsi que la sécrétion d’OC dans les Ob OA. Par contre, l’ajout de leptine exogène aux Ob OA augmenta l’activité de l’ALP sans pour autant faire varier la sécrétion d’OC. La leptine à des doses de 1ng/ml à 10mg/ml stimula la prolifération des Ob OA ainsi que la phosphorylation de p42/44 MAPK. La leptine exogène diminua l’expression de TFG-1 tandis qu’elle stimula la phosphorylation de JAK2 et STAT3 ou encore sa propre expression de manière dose-dépendante. Cependant, l’expression d’OB-Rb diminua de manière dose-dépendante. Enfin, le traitement des Ob OA avec des Si leptine ou Si OB-Rb diminua l’activité d’ALP, la sécrétion d’OC, l’expression de la leptine, l’expression d’OB-RB ainsi que l’expression du facteur TGF-1. L’ensemble de ces données démontre que la leptine endogène des Ob OA est sous contrôle des facteurs de croissance et qu’elle contribue à maintenir le phénotype anormal de l’os sous-chondral OA. De plus, ceci suggère que la leptine serait un acteur important dans la régulation du remodelage osseux.Osteoarthritis (OA) is a disease which mainly affects the joints in the elderly. It becomes essential to better understand this disease because of the economic costs it brings, but mainly because of population aging. This disease is characterized by a deterioration of cartilage, bone sclerosis, inflammation of the synovial membrane and the presence of osteophytes. The knowledge of its etiology has remained incomplete because research on this disease focused mainly on the articular cartilage. However, the key role of subchondral bone in OA is now recognized. Obesity is a risk factor for OA, then we hypothesized that leptin, a key adipocytokine in obesity plays an important role in OA. Indeed, leptin alters the phenotype of osteoblasts (Ob) and human Ob has altered phenotype in OA patients, our objective was to determine the potential role of leptin in OA Ob. To do this, we prepared primary cultures of Ob from the sub-chondral plate of the tibial plateaus of OA patients and normal individuals (N). The expression of leptin and its receptor active (OB-Rb) were measured by RT-PCR in real time, and their production was measured by ELISA and western blot (WB). The proliferation of Ob OA was determined by BrdU incorporation. The phosphorylation of p42/44 MAPK was evaluated by WB. The phenotype of Ob was determined by measuring the activity of alkaline phosphatase (ALP) and the secretion of osteocalcin (OC), in the presence or absence of leptin. Moreover, the effects of small interference RNAs (siRNAs) anti-leptin and anti OB-Rb on the phenotype of OA Ob were determined through their impact on the activity of the ALP and the secretion of OC. The dose-response effect of 1eptin on its own expression or the expressions of OB-Rb, the growth factor TGF-β1 were determined by RT-PCR in real time. Finally, signalisation of leptin in OA Ob was studied by evaluating the dose-response effect of this on the production of JAK2 and STAT3 protein phosphorylated by WB. The results showed that the OA Ob express and produce more leptin than N. Moreover, these Ob OA have an activity of the ALP and a secretion OC higher than those observed in N Ob. The addition of antibodies inactivating interaction leptin and OB-Rb or chemical inhibitors such as tyrphostin or piceatannol diminished the activity of the ALP and the secretion of OC in OA Ob against by the addition of exogenous leptin to Ob OA increased the activity of the ALP without influencing the secretion of OC. Leptin at doses of 1ng/ml to 10mg/mL stimulated the proliferation of OA Ob and the phosphorylation of p42/44 MAPK. Exogenous leptin decreased the expression of TGF-β1 while it stimulated the phosphorylation of JAK2 and STAT3 and expression of its own in dose-dependent manner. However, the expression of OB-Rb decreased in dose-dependent. Finally, the treatment of OA Ob with Si leptin or Si OB-Rb decreased activity of ALP, the secretion of OC, the leptin expression, expression of OB-Rb and the expression of TGF-β1 factor. All these data show that endogenous leptin Ob OA controls the growth factors and contributes to maintaining the abnormal phenotype of the subchondral bone OA. Moreover, this suggests that leptin is an important player in the regulation of bone remodellin

Parental Family Violence and Mental Health among parents and their offspring in the Southern Province, Rwanda

Background Children who witness violence between parents have an elevated risk of developing mental disorders as well as being victims or perpetrator of family violence (FV) in their future relationships when compared with children from non-violent family. Objectives To assess links between both parental FV and mental disorders, and mental disorders in their offspring. Methods One hundred and thirty eight (138) participants dispatched in two categories: spouses/partners (N: 89; 40 Males) and offspring (N: 49; 20 Males) have been recruited from eight District Police Unities (DPU) of the Rwandan Southern Province to participate in this cross-sectional study during a 7 months period. This study used the student “t” to examine the links between parental FV and mental disorders in offspring. Results Parental FV was linked with PTSD, psychopathic and addiction behavior symptoms in offspring. Parental anxious attachment was linked with anxiety and addiction behavior symptoms in offspring and the risk of being perpetrator or victims of FV.  Parental avoidant attachment was linked with depression symptoms in offspring. Further, both parental low self-esteem and PTSD were linked with depression and PTSD symptoms in offspring. Conclusion The results indicate that FV and mental disorders experienced by parents seem to affect offspring’s mental health and generate specific mental disorders. Therefore, the intervention programs should focus on the treatment of both parental and children mental disorders. Rwanda J Med Health Sci 2020;3(3):291-31

Validation of Anxiety Sensitivity Index (ASI-16) on Nonclinical Sample of Rwandans: A Cross-Sectional Study

The editorial board announced this article has been retracted on January 17, 2019.If you have any further question, please contact us at: [email protected] Article Title: Validation of Anxiety Sensitivity Index (ASI-16) on Nonclinical Sample of Rwandans: A Cross-Sectional StudyAuthor/s: Emmanuel Biracyaza, Jean Mutabaruka, Samuel HabimanaJournal Title: International Journal of Social Science StudiesISSN: 2324-8033; E-ISSN: 2324-8041Volume and Number: Vol. 7, No. 1, 2019Pages: 53-61DOI: https://doi.org/10.11114/ijsss.v7i1.391

Implementation of Universal Primary Education Programme in Uganda and its Influence on Education Performance

This study was an assessment of implementation process of Universal Primary education (UPE) programme in Uganda and how it influences the performance of the programme. The principal whim for undertaking this study was the yearning to assess the quality of UPE in Uganda derived from the view that having reached the year 2015, the year that was set for achieving UPE Millennium Development Goal number 2, and the national commitment to improving quality primary education remains unclear. In order to attain this, a combination of research methods have been conducted particularly the interviews and documentary analysis; where 11interviews were carried out. Further analysis was done on content documents Annual Education Abstracts from the Ministry of education and sports and some reports from NAPE and UWEZO. From the findings, quality implementation framework was not followed, implementation process influences programme performance, and it’s not only implementation that influences performance but also other factors