Introduction: The difficulty of unbinding Hellenism

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Some Thoughts on the Trails and Travails of Hellenism and Orientalism: An Interview with Gonda Van Steen

No abstract availabl

Introduction: The difficulty of unbinding Hellenism

No abstract (available)

The Multi-slit Approach to Coronal Spectroscopy with the Multi-slit Solar Explorer (MUSE)

The Multi-slit Solar Explorer (MUSE) is a proposed mission aimed at understanding the physical mechanisms driving the heating of the solar corona and the eruptions that are at the foundation of space weather. MUSE contains two instruments, a multi-slit EUV spectrograph and a context imager. It will simultaneously obtain EUV spectra (along 37 slits) and context images with the highest resolution in space (0.33-0.4 arcsec) and time (1-4 s) ever achieved for the transition region and corona. The MUSE science investigation will exploit major advances in numerical modeling, and observe at the spatial and temporal scales on which competing models make testable and distinguishable predictions, thereby leading to a breakthrough in our understanding of coronal heating and the drivers of space weather. By obtaining spectra in 4 bright EUV lines (Fe IX 171A, Fe XV 284A, Fe XIX-XXI 108A) covering a wide range of transition region and coronal temperatures along 37 slits simultaneously, MUSE will be able to "freeze" the evolution of the dynamic coronal plasma. We describe MUSE's multi-slit approach and show that the optimization of the design minimizes the impact of spectral lines from neighboring slits, generally allowing line parameters to be accurately determined. We also describe a Spectral Disambiguation Code to resolve multi-slit ambiguity in locations where secondary lines are bright. We use simulations of the corona and eruptions to perform validation tests and show that the multi-slit disambiguation approach allows accurate determination of MUSE observables in locations where significant multi-slit contamination occurs

Multi-component decomposition of astronomical spectra by compressed sensing

Funding: STFC Ernest Rutherford Fellowship (grant agreement No. ST/R004285/1) (PA).The signal measured by an astronomical spectrometer may be due to radiation from a multi-component mixture of plasmas with a range of physical properties (e.g., temperature, Doppler velocity). Confusion between multiple components may be exacerbated if the spectrometer sensor is illuminated by overlapping spectra dispersed from different slits, with each slit being exposed to radiation from a different portion of an extended astrophysical object. We use a compressed sensing method to robustly retrieve the different components. This method can be adopted for a variety of spectrometer configurations, including single-slit, multi-slit (e.g., the proposed MUlti-slit Solar Explorer mission), and slot spectrometers (which produce overlappograms).Publisher PDFPeer reviewe

S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination

Immunoglobulin class switch recombination is governed by long-range interactions between enhancers and germline transcript promoters to activate transcription and modulate chromatin accessibility to activation-induced cytidine deaminase (AID). However, mechanisms leading to the differential targeting of AID to switch (S) regions but not to constant (CH) regions remain unclear. We show that S and CH regions are dynamically modified with histone marks that are associated with active and repressed chromatin states, respectively. Chromatin accessibility is superimposable with the activating histone modifications, which extend throughout S regions irrespective of length. High density elongating RNA polymerase II (RNAP II) is detected in S regions, suggesting that the transcription machinery has paused and stalling is abolished by deletion of the S region. We propose that RNAP II enrichment facilitates recruitment of histone modifiers to generate accessibility. Thus, the histone methylation pattern produced by transcription localizes accessible chromatin to S regions, thereby focusing AID attack

c-Myc regulates transcriptional pause release

Recruitment of the RNA polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA-binding transcription factors is well recognized as a key regulatory step in gene expression. We report here that promoter-proximal pausing is a general feature of transcription by Pol II in mammalian cells and thus an additional step where regulation of gene expression occurs. This suggests that some transcription factors recruit the transcription apparatus to promoters, whereas others effect promoter-proximal pause release. Indeed, we find that the transcription factor c-Myc, a key regulator of cellular proliferation, plays a major role in Pol II pause release rather than Pol II recruitment at its target genes. We discuss the implications of these results for the role of c-Myc amplification in human cancer.National Institutes of Health (U.S.) (Grant number RO1-HG002668)National Institutes of Health (U.S.) (Grant number RO1-GM34277)National Institutes of Health (U.S.) (Grant number RO1-CA133404)National Cancer Institute (U.S.) (Grant Number PO1- CA42063)National Cancer Institute (U.S.) Cancer Center Support Grant (Grant Number P30-CA14051)National Institutes of Health (U.S.) Postdoctoral Fellowship (5-F32-HD051190