Latino Parents' Engagement in their Adolescents' Participation in Youth Programs

This study examines the types of parental support parents demonstrate to their adolescents in youth programs. Therefore, the question of interest is: how are Latino parents engaged in their adolescents’ participation in youth programs? Parents of youth in organized youth programs were recruited for semi-structured interviews. Twenty-three parents were interviewed, 12 of those parents were Latino and 7 (males = 2, females = 5) of them compromise the analytic sample. Semi-structured interviews were conducted with trained interviewers. Interviews were recorded, transcribed, and checked and transcripts were analyzed for parental support. Themes identified were entered into a qualitative data management program, Nvivo 9. Findings indicated that Latino parents showed more indirect support than direct support. Parents who were directly supportive were more likely to be indirectly supportive as well. Common barriers included: work, time constraints, scheduling, and commitment conflicts. Overall, parents provide different kinds of support that can ultimately contribute to youths’ participation in youth programs. The current study provides unique information about Latino parents’ perspectives.Ope

Perspectives from parent-adolescent dyads on parental engagement in their adolescents' out-of-school programs

The current study examines how parent-adolescent dyads perceive parental involvement in adolescents' out-of-school programs. As part of a larger study, semi-structured interviews were conducted with 36 adolescents in youth programs and their parents separately. Youth were 13-18 years old (M = 15.9, SD = 1.2). Also, youth were a diverse sample of 14 Latino/a (38.9%), 9 African American or Black (25.0%), and 13 European American (36.1%) and included 23 female participants (63.9%) and 13 male participants (36.1%). Qualitative methods and approaches, such as open coding, consensus, and the inductive approach were utilized to provide an understanding of how parent-adolescent dyads perceive parental involvement. Two constructs and 7 overarching categories were identified. The first construct is type of parental involvement, which includes three overarching categories: direct parental involvement, indirect parental involvement, and lack of parental involvement. The second construct is level of parental involvement, which includes four overarching categories: good amount of parental involvement, more parental involvement, less parental involvement, and reasons for lack of parental involvement. This study suggests that parent-adolescent dyads perceive parental involvement differently and that there is variation between how parents and youth perceive parental involvement by ethnic group

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

The International Stem Cell Initiative analyzed 125 human embryonic stem (ES) cell lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for genetic changes occurring during culture. Most lines were analyzed at an early and late passage. Single-nucleotide polymorphism (SNP) analysis revealed that they included representatives of most major ethnic groups. Most lines remained karyotypically normal, but there was a progressive tendency to acquire changes on prolonged culture, commonly affecting chromosomes 1, 12, 17 and 20. DNA methylation patterns changed haphazardly with no link to time in culture. Structural variants, determined from the SNP arrays, also appeared sporadically. No common variants related to culture were observed on chromosomes 1, 12 and 17, but a minimal amplicon in chromosome 20q11.21, including three genes expressed in human ES cells, ID1, BCL2L1 and HM13, occurred in >20% of the lines. Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells

Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

Background and purpose: Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods: In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results: The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79–2.03), major bleeding 0.59 (0.40–0.88), myocardial infarction 0.68 (0.40–1.16), and all-cause death 0.86 (0.67–1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76–1.78), myocardial infarction 0.84 (0.48–1.46), major bleeding 0.98 (0.63–1.52) and all-cause death 1.01 (0.79–1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52–1.19), myocardial infarction 0.96 (0.63–1.45), major bleeding 1.54 (1.14–2.08), and all-cause death 0.97 (0.80–1.19). Conclusions: Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration: URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013

Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation. the GLORIA-AF registry

Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007

La perception et la production de l'accent lexical de l'espagnol par des francophones (aspects phonétiques et psycholinguistes)

TOULOUSE2-BUC Mirail (315552102) / SudocSudocFranceF

Première campagne de fouille du tumulus de Saint-Bélec (Leuhan, Finistère)

International audienc

Première campagne de fouille du tumulus de Saint-Bélec (Leuhan, Finistère)

International audienc