Exploiting tightly-coupled cores

This is the published manuscript. It was first published by Springer in the Journal of Signal Processing Systems here: http://link.springer.com/article/10.1007%2Fs11265-014-0944-6.The individual processors of a chip-multiprocessor traditionally have rigid boundaries. Inter-core communication is only possible via memory and control over a core’s resources is localised. Specialisation necessary to meet today’s challenging energy targets is typically provided through the provision of a range of processor types and accelerators. An alternative approach is to permit specialisation by tailoring the way a large number of homogeneous cores are used. The approach here is to relax processor boundaries, create a richer mix of intercore communication mechanisms and provide finer-grain control over, and access to, the resources of each core. We evaluate one such design, called Loki, that aims to support specialisation in software on a homogeneous many-core architecture. We focus on the design of a single 8-core tile, conceived as the building block for a larger many-core system. We explore the tile’s ability to support a range of parallelisation opportunities and detail the control and communication mechanisms needed to exploit each core’s resources in a flexible manner. Performance and a detailed breakdown of energy usage is provided for a range of benchmarks and configurations.This work was supported by EPSRC grant EP/G033110/1

Revisiting Embeddings for Graph Neural Networks

Current graph representation learning techniques use Graph Neural Networks (GNNs) to extract features from dataset embeddings. In this work, we examine the quality of these embeddings and assess how changing them can affect the accuracy of GNNs. We explore different embedding extraction techniques for both images and texts; and find that the performance of different GNN architectures is dependent on the embedding style used. We see a prevalence of bag of words (BoW) embeddings and text classification tasks in available graph datasets. Given the impact embeddings has on GNN performance. this leads to a phenomenon that GNNs being optimised for BoW vectors

WH2 and proline-rich domains of WASP-family proteins collaborate to accelerate actin filament elongation.

WASP-family proteins are known to promote assembly of branched actin networks by stimulating the filament-nucleating activity of the Arp2/3 complex. Here, we show that WASP-family proteins also function as polymerases that accelerate elongation of uncapped actin filaments. When clustered on a surface, WASP-family proteins can drive branched actin networks to grow much faster than they could by direct incorporation of soluble monomers. This polymerase activity arises from the coordinated action of two regulatory sequences: (i) a WASP homology 2 (WH2) domain that binds actin, and (ii) a proline-rich sequence that binds profilin-actin complexes. In the absence of profilin, WH2 domains are sufficient to accelerate filament elongation, but in the presence of profilin, proline-rich sequences are required to support polymerase activity by (i) bringing polymerization-competent actin monomers in proximity to growing filament ends, and (ii) promoting shuttling of actin monomers from profilin-actin complexes onto nearby WH2 domains. Unoccupied WH2 domains transiently associate with free filament ends, preventing their growth and dynamically tethering the branched actin network to the WASP-family proteins that create it. Collaboration between WH2 and proline-rich sequences thus strikes a balance between filament growth and tethering. Our work expands the number of critical roles that WASP-family proteins play in the assembly of branched actin networks to at least three: (i) promoting dendritic nucleation; (ii) linking actin networks to membranes; and (iii) accelerating filament elongation

Mopra CO Observations of the Bubble HII Region RCW120

We use the Mopra radio telescope to test for expansion of the molecular gas associated with the bubble HII region RCW120. A ring, or bubble, morphology is common for Galactic HII regions, but the three-dimensional geometry of such objects is still unclear. Detected near- and far-side expansion of the associated molecular material would be consistent with a three-dimensional spherical object. We map the $J = 1\rightarrow 0$ transitions of $^{12}$CO, $^{13}$CO, C$^{18}$O, and C$^{17}$O, and detect emission from all isotopologues. We do not detect the $0_0\rightarrow 1_{-1} E$ masing lines of CH$_3$OH at 108.8939 GHz. The strongest CO emission is from the photodissociation region (PDR), and there is a deficit of emission toward the bubble interior. We find no evidence for expansion of the molecular material associated with RCW120 and therefore can make no claims about its geometry. The lack of detected expansion is roughly in agreement with models for the time-evolution of an HII region like RCW120, and is consistent with an expansion speed of $< 1.5\, {\rm km\, s^{-1}}$. Single-position CO spectra show signatures of expansion, which underscores the importance of mapped spectra for such work. Dust temperature enhancements outside the PDR of RCW120 coincide with a deficit of emission in CO, confirming that these temperature enhancements are due to holes in the RCW120 PDR. H$\alpha$ emission shows that RCW120 is leaking $\sim5\%$ of the ionizing photons into the interstellar medium (ISM) through PDR holes at the locations of the temperature enhancements. H-alpha emission also shows a diffuse "halo" from leaked photons not associated with discrete holes in the PDR. Overall $25\pm10\%$ of all ionizing photons are leaking into the nearby ISM.Comment: 35 pages, 14 figures. Accepted to Ap

Changing shapes in the nanoworld

What are the mechanisms leading to the shape relaxation of three dimensional crystallites ? Kinetic Monte Carlo simulations of fcc clusters show that the usual theories of equilibration, via atomic surface diffusion driven by curvature, are verified only at high temperatures. Below the roughening temperature, the relaxation is much slower, kinetics being governed by the nucleation of a critical germ on a facet. We show that the energy barrier for this step linearly increases with the size of the crystallite, leading to an exponential dependence of the relaxation time.Comment: 4 pages, 5 figures. Accepted by Phys Rev Let

The Effects of the Transition from Pre-nursing to Nursing on Mental Health

Mental health is an ever-growing crisis among adolescents and young adults, with suicide as second leading cause of death and the number of those negatively affected continually on the rise. Transitions are one of the major stressors prevalent among these age groups, placing individuals at risk for mental health deficits. This quantitative voluntary response comparative study assesses the transitional mental health of pre-nursing students and students in the nursing program at East Tennessee State University. Emailed to all with a declared major of pre-nursing or nursing, this study measured mental health using evidenced based assessment tools. The PHQ-9 for depression and the GAD-7 for anxiety, along with additional demographic information and mental health service usage questions, was sent to and completed by participants. A total of n = 173 responses were received. Of these responses n = 99 or 57.2 percent were nursing students, a participation rate of 9.6 percent, and n = 74 or 42.8 percent were pre-nursing students. The research revealed that depression and anxiety scores were above the cutoff for moderate depression and anxiety in both groups, as well as identified a deficit in availability of mental health resources, with over 10 percent of students unable to access counseling or psychiatric services. Contraindicatory to literature, which predicted improving mental health in the progression through university studies, this study reveals a variable and even worsening trajectory of mental health as students transition into the nursing program and progressed through college