50 research outputs found
Power, norms and institutional change in the European Union: the protection of the free movement of goods
How do institutions of the European Union change? Using an institutionalist approach, this article highlights the interplay between power, cognitive limits, and the normative order that underpins institutional settings and assesses their impact upon the process of institutional change. Empirical evidence from recent attempts to reinforce the protection of the free movement of goods in the EU suggests that, under conditions of uncertainty, actors with ambiguous preferences assess attempts at institutional change on the basis of the historically defined normative order which holds a given institutional structure together. Hence, path dependent and incremental change occurs even when more ambitious and functionally superior proposals are on offer
Orbit Determination of Close Binary Systems using Lucky Imaging
We present relative positions of visual binaries observed during 2009 with
the FastCam "lucky-imaging" camera at the 1.5-m Carlos Sanchez Telescope (TCS)
at the Observatorio del Teide. We obtained 424 CCD observations (averaged in
198 mean relative positions) of 157 binaries with angular separations in the
range 0.14-15.40", with a median separation of 0.51". For a given system, each
CCD image represents the sum of the best 10-25% images from 1000-5000
short-exposure frames. Derived internal errors were 7 mas in r and 1.2^{\circ}
(9 mas) in q. When comparing to systems with very well-known orbits, we find
that the rms deviation in r residuals is 23 mas, while the rms deviation in q
residuals is 0.73 deg/r. We confirmed 18 Hipparcos binaries and we report new
companions to BVD 36 A and J 621 B. For binaries with preliminary orbital
parameters, the relative radial velocity was estimated as well. We also present
four new revised orbits computed for LDS 873, BU 627 A-BC, BU 628 and HO 197
AB. This work is the first results on visual binaries using the FastCam
lucky-imaging camera.Comment: 23 pages, 10 figures, 14 tables, accepted August 18th, 2011, to be
published in MNRA
The C313Y Piedmontese mutation decreases myostatin covalent dimerisation and stability
<p>Abstract</p> <p>Background</p> <p>Myostatin is a key negative regulator of muscle growth and development, whose activity has important implications for the treatment of muscle wastage disorders. Piedmontese cattle display a double-muscled phenotype associated with the expression of C313Y mutant myostatin. <it>In vivo</it>, C313Y myostatin is proteolytically processed, exported and circulated extracellularly but fails to correctly regulate muscle growth. The C313Y mutation removes the C313-containing disulphide bond, an integral part of the characteristic TGF-β cystine-knot structural motif.</p> <p>Results</p> <p>Here we present <it>in vitro </it>analysis of the structure and stability of the C313Y myostatin protein that reveals significantly decreased covalent dimerisation for C313Y myostatin accompanied by a loss of structural stability compared to wild type. The C313Y myostatin growth factor, processed from full length precursor protein, fails to inhibit C2C12 myoblast proliferation in contrast to wild type myostatin. Although structural modeling shows the substitution of tyrosine causes structural perturbation, biochemical analysis of additional disulphide mutants, C313A and C374A, indicates that an intact cystine-knot motif is a major determinant in myostatin growth factor stability and covalent dimerisation.</p> <p>Conclusions</p> <p>This research shows that the cystine-knot structure is important for myostatin dimerisation and stability, and that disruption of this structural motif perturbs myostatin signaling.</p
Fermi Large Area Telescope View of the Core of the Radio Galaxy Centaurus A
We present gamma-ray observations with the LAT on board the Fermi Gamma-Ray
Telescope of the nearby radio galaxy Centaurus~A. The previous EGRET detection
is confirmed, and the localization is improved using data from the first 10
months of Fermi science operation. In previous work, we presented the detection
of the lobes by the LAT; in this work, we concentrate on the gamma-ray core of
Cen~A. Flux levels as seen by the LAT are not significantly different from that
found by EGRET, nor is the extremely soft LAT spectrum
(\G=2.67\pm0.10_{stat}\pm0.08_{sys} where the photon flux is \Phi\propto
E^{-\G}). The LAT core spectrum, extrapolated to higher energies, is
marginally consistent with the non-simultaneous HESS spectrum of the source.
The LAT observations are complemented by simultaneous observations from Suzaku,
the Swift Burst Alert Telescope and X-ray Telescope, and radio observations
with the Tracking Active Galactic Nuclei with Austral Milliarcsecond
Interferometry (TANAMI) program, along with a variety of non-simultaneous
archival data from a variety of instruments and wavelengths to produce a
spectral energy distribution (SED). We fit this broadband data set with a
single-zone synchrotron/synchrotron self-Compton model, which describes the
radio through GeV emission well, but fails to account for the non-simultaneous
higher energy TeV emission observed by HESS from 2004-2008. The fit requires a
low Doppler factor, in contrast to BL Lacs which generally require larger
values to fit their broadband SEDs. This indicates the \g-ray emission
originates from a slower region than that from BL Lacs, consistent with
previous modeling results from Cen~A. This slower region could be a slower
moving layer around a fast spine, or a slower region farther out from the black
hole in a decelerating flow.Comment: Accepted by ApJ. 32 pages, 5 figures, 2 tables. J. Finke and Y.
Fukazawa corresponding author