746 research outputs found
Distinctive correspondence between separable visual attention functions and intrinsic brain networks
Separable visual attention functions are assumed to rely on distinct but interacting neural mechanisms. Bundesen's “theory of visual attention” (TVA) allows the mathematical estimation of independent parameters that characterize individuals' visual attentional capacity (i.e., visual processing speed and visual short-term memory storage capacity) and selectivity functions (i.e., top-down control and spatial laterality). However, it is unclear whether these parameters distinctively map onto different brain networks obtained from intrinsic functional connectivity, which organizes slowly fluctuating ongoing brain activity. In our study, 31 demographically homogeneous healthy young participants performed whole- and partial-report tasks and underwent resting-state functional magnetic resonance imaging (rs-fMRI). Report accuracy was modeled using TVA to estimate, individually, the four TVA parameters. Networks encompassing cortical areas relevant for visual attention were derived from independent component analysis of rs-fMRI data: visual, executive control, right and left frontoparietal, and ventral and dorsal attention networks. Two TVA parameters were mapped on particular functional networks. First, participants with higher (vs. lower) visual processing speed showed lower functional connectivity within the ventral attention network. Second, participants with more (vs. less) efficient top-down control showed higher functional connectivity within the dorsal attention network and lower functional connectivity within the visual network. Additionally, higher performance was associated with higher functional connectivity between networks: specifically, between the ventral attention and right frontoparietal networks for visual processing speed, and between the visual and executive control networks for top-down control. The higher inter-network functional connectivity was related to lower intra-network connectivity. These results demonstrate that separable visual attention parameters that are assumed to constitute relatively stable traits correspond distinctly to the functional connectivity both within and between particular functional networks. This implies that individual differences in basic attention functions are represented by differences in the coherence of slowly fluctuating brain activity
Methodological Approach For The Compilation Of A Water Distribution Network Model Using QGIS And EPANET
ArticleThis paper presents the development of a methodological approach based on the integration of free-of-charge open-source software, e.g. QGIS and EPANET, and engineering practices applicable to water distribution network design. The use of QGIS and EPANET, as well as the integration thereof with sound engineering practices and judgement, proved to be both viable and practical to enable practitioners to create a water distribution network model of an existing network in smaller developments or towns. Typically, in the latter smaller developments or towns, the professional cost associated with the additional time required when commercial licensed software is used, could be lower than the actual cost associated with the procurement of the licensed software itself. Hence, the developed process flow diagrams will not only potentially save time and money in comparison to a traditional, manual approach in EPANET, but will also provide guidance to practitioners and assist smaller municipalities in southern Africa facing challenges in terms of outdated records and budget constraints. It is envisaged that the implementation of the overall methodology will contribute to improved water infrastructure planning, design and management, especially in the southern African context where water resources are scarce and service delivery remains a pressing issue
Theory of visual attention's thalamic model for visual short-term memory capacity and top-down control: evidence from a thalamo-cortical structural connectivity analysis
In the theory of visual attention (TVA), it is suggested that objects in a visual scene compete for representation in a visual short-term memory (vSTM) store. The race towards the store is assumed to be biased by top-down controlled weighting of the objects according to their task relevance. Only objects that reach the store before its capacity limitation is reached are represented consciously in a given instant. TVA-based computational modeling of participants' performance in whole- and partial-report tasks permits independent parameters of individual efficiency of top-down control α and vSTM storage capacity K to be extracted. The neural interpretation of the TVA proposes recurrent loops between the posterior thalamus and posterior visual cortices to be relevant for generating attentional weights for competing objects and for maintaining selected objects in vSTM. Accordingly, we tested whether structural connectivity between posterior thalamus and occipital cortices (PT-OC) is associated with estimates of top-down control and vSTM capacity. We applied whole- and partial-report tasks and probabilistic tractography in a sample of 37 healthy adults. We found vSTM capacity K to be associated with left PT-OC structural connectivity and a trend-wise relation between top-down control α and right PT-OC structural connectivity. These findings support the assumption of the relevance of thalamic structures and their connections to visual cortex for top-down control and vSTM capacity
Auxin-Binding Protein 1 is a negative regulator of the SCF(TIR1/AFB) pathway
International audienceAuxin is a major plant hormone that controls most aspects of plant growth and development. Auxin is perceived by two distinct classes of receptors: transport inhibitor response 1 (TIR1, or auxin-related F-box (AFB)) and auxin/indole-3-acetic acid (AUX/IAA) coreceptors, that control transcriptional responses to auxin, and the auxin-binding protein 1 (ABP1), that controls a wide variety of growth and developmental processes. To date, the mode of action of ABP1 is still poorly understood and its functional interaction with TIR1/AFB-AUX/IAA coreceptors remains elusive. Here we combine genetic and biochemical approaches to gain insight into the integration of these two pathways. We find that ABP1 is genetically upstream of TIR1/AFBs; ABP1 knockdown leads to an enhanced degradation of AUX/IAA repressors, independently of its effects on endocytosis, through the SCF TIR1/AFB E3 ubiquitin ligase pathway. Combining positive and negative regulation of SCF ubiquitin-dependent pathways might be a common mechanism conferring tight control of hormone-mediated responses
Spin dynamics of an ultra-small nanoscale molecular magnet
We present mathematical transformations which allow us to calculate the spin dynamics of an ultra-small nanoscale molecular magnet consisting of a dimer system of classical (high) Heisenberg spins. We derive exact analytic expressions (in integral form) for the time-dependent spin autocorrelation function and several other quantities. The properties of the time-dependent spin autocorrelation function in terms of various coupling parameters and temperature are discussed in detail
ac Josephson effect in the resonant tunneling through mesoscopic superconducting junctions
We investigate ac Josephson effect in the resonant tunneling through
mesoscopic superconducting junctions. In the presence of microwave irradiation,
we show that the trajectory of multiple Andreev reflections can be closed by
emitting or absorbing photons. Consequently, photon-assisted Andreev states are
formed and play the role of carrying supercurrent. On the Shapiro steps, dc
component appears when the resonant level is near a series of positions with
spacing of half of the microwave frequency. Analytical result is derived in the
limit of infinite superconducting gap, based on which new features of ac
Josephson effect are revealed.Comment: 11 pages, 3 figure
The temporal dynamics of Arc expression regulate cognitive flexibility
YesNeuronal activity regulates the transcription and
translation of the immediate-early gene Arc/Arg3.1,
a key mediator of synaptic plasticity. Proteasomedependent
degradation of Arc tightly limits its
temporal expression, yet the significance of this
regulation remains unknown. We disrupted the temporal
control of Arc degradation by creating an Arc
knockin mouse (ArcKR) where the predominant Arc
ubiquitination sites were mutated. ArcKR mice had
intact spatial learning but showed specific deficits
in selecting an optimal strategy during reversal
learning. This cognitive inflexibility was coupled to
changes in Arc mRNA and protein expression resulting
in a reduced threshold to induce mGluR-LTD and
enhanced mGluR-LTD amplitude. These findings
show that the abnormal persistence of Arc protein
limits the dynamic range of Arc signaling pathways
specifically during reversal learning. Our work
illuminates how the precise temporal control of activity-dependent
molecules, such as Arc, regulates synaptic
plasticity and is crucial for cognition.Open access funded by Biotechnology and Biological Sciences Research Counci
Manifestation of ageing in the low temperature conductance of disordered insulators
We are interested in the out of equilibrium phenomena observed in the
electrical conductance of disordered insulators at low temperature, which may
be signatures of the electron coulomb glass state. The present work is devoted
to the occurrence of ageing, a benchmark phenomenon for the glassy state. It is
the fact that the dynamical properties of a glass depend on its age, i.e. on
the time elapsed since it was quench-cooled. We first critically analyse
previous studies on disordered insulators and question their interpretation in
terms of ageing. We then present new measurements on insulating granular
aluminium thin films which demonstrate that the dynamics is indeed age
dependent. We also show that the results of different relaxation protocols are
related by a superposition principle. The implications of our findings for the
mechanism of the conductance slow relaxations are then discussed
Decreased cingulo-opercular network functional connectivity mediates the impact of aging on visual processing speed
The neural factors that account for the visual processing speed reduction in aging are incompletely understood. Based on previous reports of age-related decreases in the intrinsic functional connectivity (iFC) within the cingulo-opercular network and its relevance for processing speed, we hypothesized that these decreases are associated with age-related reductions in visual processing speed. We used a whole-report task and modeling based on Bundesen's `theory of visual attention' to parameterize visual processing speed in 91 healthy participants aged from 20 to 77 years. iFC was estimated using independent component analysis of resting-state functional magnetic resonance imaging data. From the clusters within the cingulo-opercular network exhibiting age-related decreased iFC, we found a cluster in the left insula to be particularly associated with visual processing speed and to mediate the age effect on visual speed. This mediation was not observed for age-related decreased iFC in other networks or for other attentional parameters. Our results point to the iFC in the cingulo-opercular network, represented by the left insula, as being a relevant marker for visual processing speed changes in aging
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