Performance up gradation of static VAR compensator with thyristor binary switched capacitor and reactor using model reference adaptive controller

There are various static var compensator configurations are available and listed in the literature. Their performances are evaluated based on their voltage support, dynamic response, losses, cost, and additional filter requirement, if any. In this paper, efforts are made to improve the dynamic performance parameter such as rise time, settling time, and peak overshoots. A new topology with an adaptive controller is presented, in which capacitor and reactor banks are divided in their binary values and connected in the shunt. Capacitor and reactor banks are operated by thyristorised switches. Both these banks are operated in closed-loop form as a cascade control. Amongst these, capacitor bank operates as coarse control, and reactor bank acts as fine control. For the performance enhancement, a model reference adaptive controller is used. The system identification toolbox is used to evaluate the mathematical model of the plant with Matlab. The model\u27s performance was analyzed deeply by the adaptive controller with different reference models such as critical, under, and overdamped. The performance parameters such as rise time, settling time, and peak overshoot in the form of reactive power swings, are evaluated and plotted for different adaptive gains using MIT rules

Regulation of RKIP Function by Helicobacter pylori in Gastric Cancer

Helicobacter pylori (H. pylori) is a gram-negative, spiral-shaped bacterium that infects more than half of the world’s population and is a major cause of gastric adenocarcinoma. The mechanisms that link H. pylori infection to gastric carcinogenesis are not well understood. In the present study, we report that the Raf-kinase inhibitor protein (RKIP) has a role in the induction of apoptosis by H. pylori in gastric epithelial cells. Western blot and luciferase transcription reporter assays demonstrate that the pathogenicity island of H. pylori rapidly phosphorylates RKIP, which then localizes to the nucleus where it activates its own transcription and induces apoptosis. Forced overexpression of RKIP enhances apoptosis in H. pylori-infected cells, whereas RKIP RNA inhibition suppresses the induction of apoptosis by H. pylori infection. While inducing the phosphorylation of RKIP, H. pylori simultaneously targets non-phosphorylated RKIP for proteasome-mediated degradation. The increase in RKIP transcription and phosphorylation is abrogated by mutating RKIP serine 153 to valine, demonstrating that regulation of RKIP activity by H. pylori is dependent upon RKIP’s S153 residue. In addition, H. pylori infection increases the expression of Snail, a transcriptional repressor of RKIP. Our results suggest that H. pylori utilizes a tumor suppressor protein, RKIP, to promote apoptosis in gastric cancer cells

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

OVERVIEW OF RENEWABLE ENERGY SOURCES IN THE PERSPECTIVE OF CARBON FOOT PRINTING REDUCTION

A review is done on the different methods to reduce the carbon emission ultimately the carbon footprint in the different sectors in the perceptive of the renewable sources. In method for the Regional energy targeting along with the supply chain synthesis different algorithms are proposed such as Regional Energy Clustering (REC) for the biomass supply chains. Some method as are based on the scheduling the manufacturing processes in process industries so as to reduce the carbon footprint and energy consumption

A PEOPLES VIEW ON SMART CITIES AND ASSOCIATED CARBON FOOT PRINTS.

In last several years, the renewable energy programs have been updated and followed continuously by the government. With the basic cycle adopted in 70’s and in some cases early 80s, a forced of research and development was in main focus on renewable energy for reducing carbon emission. Some of the private energy also has taken part in this self motivated energy. This paper gives an insight what different categories have people needed in the name of the development. Development at the cost of pollution is of great matter. Author in this paper had prepared a questionnaire and also did one to one interaction forreading peoples mind

BENEFITS OF USING RENEWABLE ENERGY SOURCES FOR SMART CITY INITIATIVE IN MAHARASHTRA IN CARBON EMISSION REDUCTION PERSPECTIVE

Considering newly elected state and national government and today’s need for the world there is need of smart city and many other developments which may demand an more electrical power and this may put burden on the all state electricity board for increasing power demand. But the generation is limited due to limited natural resources this calls a need for renewable energy sources and integrating renewable with national grid is another big challenge. Our consent is carbon foot printing related to increased non renewable energy resources. In this paper methodology of carbon foot reduction is explained in great detail. &nbsp

POWER QUALITY IMPROVEMENT BY MITIGATION OF VOLTAGE SAG WITH DVR USING SVPWM TECHNIQUE

In last decade, research hasbeen carried out to address the problems associated with power quality improvement issues.The power quality is affected mainly due to the sensitive loads which results in voltage sag and voltage swells.It is necessary to investigate the suitable methodsformitigation of voltage sags.From the wide range of mitigation methods, the selected one has to be observed for the effect on the characteristics.Authors have carried out the study and implementationof mitigation method to address the stated problem.In this paper, authors have implementedDynamicVoltage Restorer (DVR) based on application of SpaceVector Pulse Width Modulation (SVPWM).The implemented model gives remarkable results and mitigation of voltage sag is achieved

SMES TECHNOLOGY FOR STABILITY IMPROVEMENT OF RENEWABLE ENERGY SYSTEMS

In today’s world it has become avery important that electrical power must be made available to the customer 24 x 7. This fact attracted researchers and it increasedfocus on large scale integration of new renewable energy sources like wind power and solar power introduces the need for energy storage. Superconducting Magnetic Energy Storage (SMES) is a recent and promisingalternative for active power compensation. Having high efficiency, very highresponse time and high power capability it is ideal for smoothingfast fluctuations.Superconducting Magnetic Energy Storage is a promisingtechnology that stores electricity from the grid within the magnetic field of a coil comprised of superconducting wires with near zero loss of energy

Power Quality Improvement By Mitigation Of Voltage Sag With Dvr Using Svpwm Technique

In last decade, research hasbeen carried out to address the problems associated with power quality improvement issues.The power quality is affected mainly due to the sensitive loads which results in voltage sag and voltage swells.It is necessary to investigate the suitable methodsformitigation of voltage sags.From the wide range of mitigation methods, the selected one has to be observed for the effect on the characteristics.Authors have carried out the study and implementationof mitigation method to address the stated problem.In this paper, authors have implementedDynamicVoltage Restorer (DVR) based on application of SpaceVector Pulse Width Modulation (SVPWM).The implemented model gives remarkable results and mitigation of voltage sag is achieved

Smes TECHNOLOGY For Stability Improvement Of Renewable Energy Systems

In today's world it has become avery important that electrical power must be made available to the customer 24 x 7. This fact attracted researchers and it increasedfocus on large scale integration of new renewable energy sources like wind power and solar power introduces the need for energy storage. Superconducting Magnetic Energy Storage (SMES) is a recent and promisingalternative for active power compensation. Having high efficiency, very highresponse time and high power capability it is ideal for smoothingfast fluctuations.Superconducting Magnetic Energy Storage is a promisingtechnology that stores electricity from the grid within the magnetic field of a coil comprised of superconducting wires with near zero loss of energy