Thermal expansion study of a uvarovite rich garnet

Thermal expansion measurements have been performed on a uvarovite rich garnet sample for the first time and compared with the expansion data on grossular and pyrope-rich garnets reported in the literature. A semiclassical model has been used to analyze the data and to obtain various thermodynamic parameters. Using these parameters, the lattice specific heat and the corresponding entropy have also been calculated. © World Scientific Publishing Company

Amine Containing Analogs of Sulindac for Cancer Prevention

Background: Sulindac belongs to the chemically diverse family of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) that effectively prevent adenomatous colorectal polyps and colon cancer, especially in patients with familial adenomatous polyposis. Sulindac sulfide amide (SSA), an amide analog of sulindac sulfide, shows insignificant COX-related activity and toxicity while enhancing anticancer activity in vitro and demonstrating in vivo xenograft activity. Objective: Develop structure-activity relationships in the sulindac amine series and identify analogs with promising anticancer activities. Method: A series of sulindac amine analogs were designed and synthesized and then further modified in a “libraries from libraries” approach to produce amide, sulfonamide and N,N-disubstituted sulindac amine sub-libraries. All analogs were screened against three cancer cell lines (prostate, colon and breast). Results: Several active compounds were identified viain vitro cancer cell line screening with the most potent compound (26) in the nanomolar range. Conclusion: Compound 26 and analogs showing the most potent inhibitory activity may be considered for further design and optimization efforts as anticancer hit scaffolds

Search for non-Gaussianity in pixel, harmonic and wavelet space: compared and combined

We present a comparison between three approaches to test non-Gaussianity of cosmic microwave background data. The Minkowski functionals, the empirical process method and the skewness of wavelet coefficients are applied to maps generated from non-standard inflationary models and to Gaussian maps with point sources included. We discuss the different power of the pixel, harmonic and wavelet space methods on these simulated almost full-sky data (with Planck like noise). We also suggest a new procedure consisting of a combination of statistics in pixel, harmonic and wavelet space.Comment: Accepted for publication in PR

K-hindered decay of a six-quasiparticle isomer in Hf176

The structure and decay properties of high-K isomers in Hf176 have been studied using beam sweeping techniques and the Gammasphere multidetector array. A new ΔK=8 decay branch, from a Kπ=22⊃-, six-quasiparticle, isomeric (t1/2=43μs) state at 4864 keV to the 20⊃- state of a Kπ=14⊃- band, has been identified. The reduced hindrance factor per degree of K forbiddenness for this decay is measured to be unusually low (fν=3.2), which suggests K mixing in the states involved. The deduced interaction matrix elements are discussed within the context of relevant K-mixing scenarios. The 3266-keV state, previously interpreted as a Kπ=16⊃+ intrinsic state, is reassigned as the Jπ=16⊃+ member of the band based on the Kπ=15⊃+ state at 3080 keV. The systematics of fν values as a function of the degree of forbiddenness is discussed in light of this change

Quark Matter in a Strong Magnetic Background

In this chapter, we discuss several aspects of the theory of strong interactions in presence of a strong magnetic background. In particular, we summarize our results on the effect of the magnetic background on chiral symmetry restoration and deconfinement at finite temperature. Moreover, we compute the magnetic susceptibility of the chiral condensate and the quark polarization at zero temperature. Our theoretical framework is given by chiral models: the Nambu-Jona-Lasinio (NJL), the Polyakov improved NJL (or PNJL) and the Quark-Meson (QM) models. We also compare our results with the ones obtained by other groups.Comment: 34 pages, survey. To appear in Lect. Notes Phys. "Strongly interacting matter in magnetic fields" (Springer), edited by D. Kharzeev, K. Landsteiner, A. Schmitt, H.-U. Ye

Heavy-flavor production and medium properties in high-energy nuclear collisions --What next?

Open and hidden heavy-flavor physics in high-energy nuclear collisions are entering a new and exciting stage towards reaching a clearer understanding of the new experimental results with the possibility to link them directly to the advancement in lattice Quantum Chromo-Dynamics (QCD). Recent results from experiments and theoretical developments regarding open and hidden heavy-flavor dynamics have been debated at the Lorentz Workshop Tomography of the Quark-Gluon Plasma with Heavy Quarks, which was held in October 2016 in Leiden, The Netherlands. In this contribution, we summarize identified common understandings and developed strategies for the upcoming five years, which aim at achieving a profound knowledge of the dynamical properties of the quark-gluon plasma

Search for the Chiral Magnetic Effect in Au+Au collisions at sNN=27\sqrt{s_{_{\rm{NN}}}}=27 GeV with the STAR forward Event Plane Detectors

A decisive experimental test of the Chiral Magnetic Effect (CME) is considered one of the major scientific goals at the Relativistic Heavy-Ion Collider (RHIC) towards understanding the nontrivial topological fluctuations of the Quantum Chromodynamics vacuum. In heavy-ion collisions, the CME is expected to result in a charge separation phenomenon across the reaction plane, whose strength could be strongly energy dependent. The previous CME searches have been focused on top RHIC energy collisions. In this Letter, we present a low energy search for the CME in Au+Au collisions at $\sqrt{s_{_{\rm{NN}}}}=27$ GeV. We measure elliptic flow scaled charge-dependent correlators relative to the event planes that are defined at both mid-rapidity $|\eta|<1.0$ and at forward rapidity $2.1 < |\eta|<5.1$. We compare the results based on the directed flow plane ($\Psi_1$) at forward rapidity and the elliptic flow plane ($\Psi_2$) at both central and forward rapidity. The CME scenario is expected to result in a larger correlation relative to $\Psi_1$ than to $\Psi_2$, while a flow driven background scenario would lead to a consistent result for both event planes[1,2]. In 10-50\% centrality, results using three different event planes are found to be consistent within experimental uncertainties, suggesting a flow driven background scenario dominating the measurement. We obtain an upper limit on the deviation from a flow driven background scenario at the 95\% confidence level. This work opens up a possible road map towards future CME search with the high statistics data from the RHIC Beam Energy Scan Phase-II.Comment: main: 8 pages, 5 figures; supplementary material: 2 pages, 1 figur

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele