Linha de vida como recurso narrativo para a formação sócio emocional em estudantes de pedagogia

Se presentan resultados de experiencias en uso de líneas de vida en educación superior. Las líneas de vida son un recurso autobiográfico para la construcción social de la identidad en la formación inicial docente. Así mismo, éstas posibilitan la reflexión sobre el proceso formativo en un contexto intersubjetivo. La metodología es cualitativa, y se analizan las experiencias sobre la elaboración y socialización de líneas de vida. Los participantes fueron 60 estudiantes de Pedagogía en Educación Especial de la Universidad Católica de Temuco, Chile. Los resultados muestran un eje narrativo que determina significados y sentimientos durante el proceso de elaboración de las líneas de vida. Como conclusión, la línea de vida es un recurso que permite reconocerse a sí mismo y a los otros. Esto contribuye al desarrollo de habilidades reflexivas y socioemocionales. La dimensión colectiva de la línea de vida facilita el desarrollo de empatía como competencia necesaria para la formación docente

Línea de vida como recurso narrativo para la formación socioemocional en estudiantes de pedagogía / Lifeline as a narrative resource for socio-emotional formation in students of pedagogy

Results of experiences in the use of lifelines in higher education are presented. It is an autobiographical resource for the social construction of identity in initial teacher training. Likewise, it makes possible the reflection on the formative process in an intersubjective context. The methodology is qualitative, and experiences are analyzed on the elaboration and socialization of the lifeline. The participants were 60 students of Pedagogy in Special Education of the Catholic University of Temuco, Chile. The results show a narrative axis that articulates meanings and feelings during the elaboration process of lifeline. It is concluded that the lifeline is a resource for the recognition of oneself and others. This contributes to the development of reflective and socio-emotional skills. The collective dimension of the lifeline facilitates the emergence of empathy as a necessary competence for teacher training. Se presentan resultados de experiencias en uso de líneas de vida en educación superior. Las líneas de vida son un recurso autobiográfico para la construcción social de la identidad en la formación inicial docente. Así mismo, éstas posibilitan la reflexión sobre el proceso formativo en un contexto intersubjetivo. La metodología es cualitativa, y se analizan las experiencias sobre la elaboración y socialización de líneas de vida. Los participantes fueron 60 estudiantes de Pedagogía en Educación Especial de la Universidad Católica de Temuco, Chile. Los resultados muestran un eje narrativo que determina significados y sentimientos durante el proceso de elaboración de las líneas de vida. Como conclusión, la línea de vida es un recurso que permite reconocerse a sí mismo y a los otros. Esto contribuye al desarrollo de habilidades reflexivas y socioemocionales. La dimensión colectiva de la línea de vida facilita el desarrollo de empatía como competencia necesaria para la formación docente

Manual Orientador, estrategias Socioemocionales en Aulas Universitarias

De este manual queremos destacar algunas ideas que nos parecen particularmente dignas de mención. Por una parte, la contextualización de la propuesta a partir de los antecedentes de la educación socioemocional en la formación universitaria. Por otra, las fases para la puesta en práctica: motivación, reflexión, diseño, aplicación y evaluación. En tercer lugar, las estrategias para la puesta en práctica. También merecen mención la aportación de un glosario, las oportunas referencias bibliográficas y los anexos que aportan recursos útiles para la implementación

Morphological changes of gel-type functional polymers after intermatrix synthesis of polymer stabilized silver nanoparticles

This paper reports the results of intermatrix synthesis (IMS) of silver metal nanoparticles (Ag-MNPs) in Purolite C100E sulfonic ion exchange polymer of the gel-type structure. It has been shown that the surface morphology of the initial MNP-free polymer is absolutely smooth, but it dramatically changes after the kinetic loading of Ag on the polymer and then IMS of Ag-MNPs. These morphological changes can be explained by the interaction of Ag-NPs with the polymer chains, leading to a sort of additional cross-linking of the polymer. As a result, the modification of the gel-type matrix with Ag-MNPs leads to the increase of the matrix cross-linking, which results in the increase of its surface area and the appearance of nanoporosity in the polymer gel. Ag-MNPs are located near the polymer surface and do not form any visible agglomerations. All these features of the nanocomposites obtained are important for their practical applications in catalysis, sensor applications, and bactericide water treatment

Formación socioemocional: percepciones de académicos de la Universidad Católica de Temuco, Chile

Objective: Teacher education has been characterized by its focus on conceptual knowledge, however, current guidelines reveal the need to incorporate socio-emotional education in initial teacher training curricula. The objective of the study is to know the perceptions of trainers of trainers regarding the socio-emotional dimension in the university context. Methods: The authoress rely on a qualitative approach, following a case study design. Ten academics from various majors from the Faculty of Education of the Catholic University of Temuco in Chile participated. Semi-structured interviews were applied. Results: The findings show there are two categories. The first, the need to modify training programs to incorporate a socio-emotional approach. The second includes the tensions to consider when implementing a socio-emotional approach. Conclusions: The authoress arrived at the conclusions that incorporating a socio-emotional approach in an explicit and transversal way would strengthen preservice teacher education. The lack of socio-emotional strategies makes the training of academics necessary. The incorporation of the approach will allow academics and future teachers to experience, value and strengthen socio-emotional education from their own educational practices. Resulting in a comprehensive training, as well as personal well-being and professional development.Objetivo: La formación del profesorado se ha caracterizado por un fuerte énfasis en saberes conceptuales, sin embargo, las actuales directrices revelan la necesidad de incorporar la educación socioemocional en los currículos de formación inicial docente. El objetivo del estudio es conocer las percepciones de formadores de formadores respecto de la dimensión socioemocional en el contexto universitario. Método:  Los autores asumieron un enfoque cualitativo, con diseño de estudio de caso. Participaron diez académicos de diversas carreras de la Facultad de Educación de la Universidad Católica de Temuco en Chile. Se aplicaron entrevistas semiestructuradas. Resultados: La pesquisa produjo el hallazgo de dos categorías. La primera, la necesidad de modificar programas de formación para incorporar un enfoque socioemocional. La segunda, recoge las tensiones a considerar al implementar un enfoque socioemocional. Conclusiones: Se concluye que incorporar un enfoque socioemocional de manera explícita y transversal, fortalecería la formación inicial del profesorado. La falta de estrategias socioemocionales hace necesario la formación de los académicos. La incorporación del enfoque permitirá a académicos y a futuros docentes vivenciar, valorar y fortalecer la educación socioemocional desde sus propias prácticas educativas. De esta manera, se responde a la formación integral, así como, al bienestar personal y al desarrollo profesional

Effects of oral prednisone administration on serum cystatin C in dogs

ANTECEDENTES La administración oral de glucocorticoides altera la concentración sérica de cistatina C (sCysC) en humanos. OBJETIVO Determinar si la administración oral de prednisona altera la sCysC en perros sin enfermedad renal preexistente. Los animales Se incluyeron cuarenta y seis perros: 10 perros diagnosticados con meningitis arterial esteroide sensible (SRMA; grupo A), 20 perros diagnosticados de hiperadrenocorticismo hipofisario-dependiente (PDH; grupo B) y 16 perros control sanos (grupo C). Metodos Estudio observacional retrospectivo. A los perros diagnosticados con SRMA se les administró prednisona 4 mg / kg / 24 h PO 7 días, reduciendo la dosis a 2 mg / kg / 24 h 7 días antes del retiro de la medicación. En el grupo A, el muestreo se realizó en los días 0, 7, 14 y un control final en el día 21. Se recogieron muestras de sangre y orina en los 3 grupos, y en el grupo A, el muestreo se realizó en todos los puntos de tiempo (días 1, 7). , 14, y 21). RESULTADOS En el grupo A, sCysC fue significativamente mayor en el día 7 en comparación con el grupo de control (0,4 ± 0,04 mg / l vs. 0,18 ± 0,03 mg / l medio ± SEM respectivamente P 0.05). Los perros con PDH incluidos en el grupo B no tuvieron diferencias significativas en sCysC (0.22 ± 0.03 mg / L) en comparación con el control (P> 0.05). CONCLUSIONES Y IMPORTANCIA CLÍNICA La administración oral de prednisona, a diferencia de la producción alterada de glucocorticoides endógenos, aumenta la sCysC en perros de una manera dependiente de la dosis.BACKGROUND Oral administration of glucocorticoid alters serum cystatin C (sCysC) concentration in humans. OBJECTIVE To determine if oral administration of prednisone alters sCysC in dogs without pre‐existing renal disease. ANIMALS Forty six dogs were included: 10 dogs diagnosed with steroid responsive meningitis arteritis (SRMA; group A), 20 dogs diagnosed of pituitary‐dependent hyperadrenocorticism (PDH; group B), and 16 healthy control dogs (group C). METHODS Retrospective observational study. SRMA diagnosed dogs were administered prednisone 4 mg/kg/24 h PO 7 days, reducing the dose to 2 mg/kg/24 h 7 days before medication withdrawal. In group A, sampling was performed at days 0, 7, 14 and a final control at day 21. Blood and urine samples were collected in the 3 groups, and in group A, sampling was performed at all time points (days 1, 7, 14, and 21). RESULTS In group A, sCysC was significantly higher at day 7 compared to the control group (0.4 ± 0.04 mg/L vs. 0.18 ± 0.03 mg/L mean ± SEM respectively P 0.05). Dogs with PDH included in group B did not have significant differences in sCysC (0.22 ± 0.03 mg/L) compared to control (P > 0.05). CONCLUSIONS AND CLINICAL IMPORTANCE Oral administration of prednisone unlike altered endogenous glucocorticoid production, increases sCysC in dogs in a dose‐dependent fashion.• Ministerio de Economía y Competitividad. Beca Juan de la Cierva IJCI-2014-19428, para Beatriz Macías GarcíapeerReviewe

Molecular Processing of Tau Protein in Progressive Supranuclear Palsy : Neuronal and Glial Degeneration

ACKNOWLEDGMENTS This work was supported by Fondo Nacional de Ciencia y Tecnologia, FONDOCyT, from the Ministry of Higher Education, Science and Technology, Dominican Republic (2015-3A2-127 to MP-H) and (2018-2019-2A3-208 to JL-M and MP-H). The authors want to express their gratitude to the following: Dr. P. Davies† (Albert Einstein College of Medicine, Bronx, NY, USA) and Lester I. Binder† (North Western, Chicago, IL, USA) for the generous gift of mAbs TG–3 and Alz–50, and Tau–1, Tau–5 and Tau–7, respectively; Tec. Amparo Viramontes Pintos for the handling of the brain tissue; support in the confocal microscopy unit of CIIDIR Durango, Instituto Politecnico Nacional; Union Medica Uni- A. Mart´ınez-Maldonado et al. / Molecular Processing of Tau Protein in Progressive Supranuclear Palsy 1529 versity Clinic, Dominican Republic, for their support and collaboration in the development of this research project. We also want to express our gratitude to the Mexican families who have donated the brain of their loved ones affected with Alzheimer’s disease and made our research possible. This work is dedicated to the memory of Professor Dr. Jose Ra ´ ul Mena L ´ opez ´ †. †Deceased. Authors’ disclosures available online (https:// www.j-alz.com/manuscript-disclosures/20-1139r2).Peer reviewedPublisher PD

Depletion of thiols leads to redox deregulation, production of 4-hydroxinonenal and sperm senescence: a possible role for GSH regulation in spermatozoa

[EN] We hypothesized that thiols and particularly glutathione (GSH) are essential for the regulation of stallion sperm functionality. To test this hypothesis, we initially investigated the relationship between sperm function and GSH content, revealing highly significant correlations between GSH, sperm viability, motility, and velocity parameters (P < 0.001). Furthermore, the deleterious effects of GSH depletion using menadione and 1,3 dimethoxy 1,4, naphtoquinone (DMNQ) were able to be prevented by the addition of cysteine, but no other antioxidant. Pre-incubation with cysteine prevented menadione and DMNQ induced damage to sperm membranes after 1 h (P < 0.001; P < 0.05) and after 3 h of incubation (P < 0.001, P < 0.05). Pre-incubation with cysteine ameliorated both the menadione- and DMNQ-induced increase in 4-hydroxynonenal (P < 0.001). As cysteine is a precursor of GSH, we hypothesized that stallion spermatozoa are able to synthesize this tripeptide using exogenous cysteine. To test this hypothesis, we investigated the presence of two enzymes required to synthesize GSH (GSH and GCLC) and using western blotting and immunocytochemistry we detected both enzymes in stallion spermatozoa. The inhibition of GCLC reduced the recovery of GSH by addition of cysteine after depletion, suggesting that stallion spermatozoa may use exogenous cysteine to regulate GSH. Other findings supporting this hypothesis were changes in sperm functionality after BSO treatment and changes in GSH and GSSG validated using HPLC-MS, showing that BSO prevented the increase in GSH in the presence of cysteine, although important stallion to stallion variability occurred and suggested differences in expression of glutamate cysteine ligase. Mean concentration of GSH in stallion spermatozoa was 8.2 ± 2.1 μM/109 spermatozoa, well above the nanomolar ranges per billion spermatozoa reported for other mammals.SIThe authors received financial support for this study from the Ministerio de Economía y Competitividad-FEDER, Madrid, Spain, grants AGL2013-43211-R, AGL2017-83149-R Junta de Extremadura-FEDER (European Regional Development Fund) (GR 18008 and IB16030). PMM is supported by a pre-doctoral grant from the Ministerio de Educación, Cultura y Deporte, Madrid Spain FPU13/03991. COF is supported by a post-doctoral grant from the Ministerio de Economía y Competitividad “Juan de la Cierva” IJCI-2014-21671, JMO-R holds a PhD grant from Valhondo Calaaf Foundation, Cáceres Spain

Envejecimiento de la población

&bull;Actividades b&aacute;sicas de la vida diaria en personas mayores y factores asociados &bull;Asociaci&oacute;n entre depresi&oacute;n y posesi&oacute;n de mascotas en personas mayores &bull;Calidad de vida en adultos mayores de Santiago aplicando el instrumento WHOQOL-BREF &bull;Calidad de vida en usuarios con enfermedad de Parkinson, demencia y sus cuidadores, comuna de Vitacura &bull;Caracterizaci&oacute;n de egresos hospitalarios de adultos mayores en Puerto Natales (2007-2009) &bull;Comportamiento de las patolog&iacute;as incluidas como GES para el adulto mayor atendido en un Cesfam &bull;Contribuci&oacute;n de vitaminas y minerales a las ingestas recomendadas diarias en ancianos institucionalizados de Madrid &bull;Estado de salud oral del paciente inscrito en el Programa de Visita Domiciliaria &bull;Evaluaci&oacute;n del programa de discapacidad severa en Casablanca con la matriz de marco l&oacute;gico &bull;Factores asociados a satisfacci&oacute;n vital en una cohorte de adultos mayores de Santiago, Chile &bull;Pauta instrumental para la identificaci&oacute;n de riesgos para el adulto mayor autovalente, en su vivienda &bull;Perfil farmacol&oacute;gico del paciente geri&aacute;trico institucionalizado y posibles consecuencias en el deterioro cognitivo &bull;Programa de cuidados paliativos y alivio del dolor en Puerto Natales &bull;Rehabilitaci&oacute;n mandibular implantoprot&eacute;sica: efecto en calidad de vida relacionada con salud bucal en adultos mayores &bull;Salud bucodental en adultos mayores autovalentes de la Regi&oacute;n de Valpara&iacute;so &bull;Transici&oacute;n epidemiol&oacute;gica y el estudio de carga de enfermedad en Brasi

Anti-Spike antibodies 3 months after SARS-CoV-2 mRNA vaccine booster dose in patients on hemodialysis: the prospective SENCOVAC study

Background: Patients on hemodialysis are at high-risk for complications derived from coronavirus disease 2019 (COVID-19). The present analysis evaluated the impact of a booster vaccine dose and breakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on humoral immunity 3 months after the booster dose. Methods: This is a multicentric and prospective study assessing immunoglobulin G anti-Spike antibodies 6 and 9 months after initial SARS-CoV-2 vaccination in patients on hemodialysis that had also received a booster dose before the 6-month assessment (early booster) or between the 6- and 9-month assessments (late booster). The impact of breakthrough infections, type of vaccine, time from the booster and clinical variables were assessed. Results: A total of 711 patients [67% male, median age (range) 67 (20-89) years] were included. Of these, 545 (77%) received an early booster and the rest a late booster. At 6 months, 64 (9%) patients had negative anti-Spike antibody titers (3% of early booster and 29% of late booster patients, P =. 001). At 9 months, 91% of patients with 6-month negative response had seroconverted and there were no differences in residual prevalence of negative humoral response between early and late booster patients (0.9% vs 0.6%, P =. 693). During follow-up, 35 patients (5%) developed breakthrough SARS-CoV-2 infection. Antibody titers at 9 months were independently associated with mRNA-1273 booster (P =. 001), lower time from booster (P =. 043) and past breakthrough SARS-CoV-2 infection (P <. 001). Conclusions: In hemodialysis patients, higher titers of anti-Spike antibodies at 9 months were associated with mRNA-1273 booster, lower time from booster and past breakthrough SARS-CoV-2 infectionThe present project has been supported by Fresenius Medical Care, Diaverum, Vifor Pharma, Vircell, Fundación Renal Iñigo Álvarez de Toledo and ISCIII FEDER funds RICORS2040 (RD21/0005