Decoding the ocean's microbiological secrets for marine enzyme biodiscovery

A global census of marine microbial life has been underway over the past several decades. During this period, there have been scientific breakthroughs in estimating microbial diversity and understanding microbial functioning and ecology. It is estimated that the ocean, covering 71% of the earth's surface with its estimated volume of about 2 x 10(18) m(3) and an average depth of 3800 m, hosts the largest population of microbes on Earth. More than 2 million eukaryotic and prokaryotic species are thought to thrive both in the ocean and on its surface. Prokaryotic cell abundances can reach densities of up to 10(12) cells per millilitre, exceeding eukaryotic densities of around 10(6) cells per millilitre of seawater. Besides their large numbers and abundance, marine microbial assemblages and their organic catalysts (enzymes) have a largely underestimated value for their use in the development of industrial products and processes. In this perspective article, we identified critical gaps in knowledge and technology to fast-track this development. We provided a general overview of the presumptive microbial assemblages in oceans, and an estimation of what is known and the enzymes that have been currently retrieved. We also discussed recent advances made in this area by the collaborative European Horizon 2020 project 'INMARE'

El Derecho Argentino frente a la pandemia y post-pandemia COVID-19. TOMO I

La Facultad de Derecho de la Universidad Nacional de Córdoba no podía permanecer indolente frente a la conmoción que, durante este año 2020, ha provocado en el mundo la pandemia de COVID-19. Como comunidad educativa advertíamos que la prioridad máxima era lograr la continuidad de la labor de nuestra Casa de Estudios, para garantizar a nuestros alumnos del grado y del posgrado, el ejercicio de su derecho a estudiar, continuando y en algunos casos iniciando sus estudios, a pesar de las condiciones adversas que se vivían. Con esa finalidad convocamos a los profesores titulares de todas las cátedras y eméritos y consultos que quisieran hacerlo, a sumarse con sus aportes a esta construcción colectiva, que aborda los temas que nos ocupan desde las diversas perspectivas de las distintas áreas del mundo jurídico. Y la desinteresada respuesta positiva no se hizo esperar. Prueba de ello es este libro cuyas dimensiones, tanto en lo cuantitativo como en lo cualitativo, superaron las expectativas iniciales. La jerarquía de los autores que generosamente han participado con sus contribuciones, en algunos casos en forma individual y en otros acompañados por sus equipos de colaboradores, permiten prever que esta obra ha de brindar elementos de juicio de gran utilidad para continuar construyendo el mundo jurídico, dentro de la pandemia y después de ella.ÍNDICE GENERAL. TOMO I. "Pandemia, postpandemia y derecho" por Guillermo Eduardo Barrera Buteler. UNIVERSIDAD Y PANDEMIA: "Desafíos y estrategias de la Universidad Nacional de Córdoba en tiempos de COVID-19. Enseñanza y aprendizaje pospandemia" por Ramón Pedro Yanzi Ferreira. HISTORIA. HISTORIA DEL DERECHO. DERECHO ROMANO: "De las pestes en la antigua Roma" por Edgardo García Chiple, Juan B. Fernández, Marisa Domínguez y Laura Salomón. Adscriptos: Carla Pedrón, Julieta Dalin, Lorena Sánchez, Eduardo Villafañe Molina y Rodrigo López. "Los cuerpos heridos. Las epidemias en la historia" por Marcela Aspell. DERECHO PRIVADO: "Los principios generales del Derecho Privado como instrumentos de solución de conflictos derivados de la pandemia del coronavirus" por Juan Carlos Palmero. "COVID-19 y contrato" por Juan Manuel Aparicio. "Saliendo de la crisis (Una mirada a la preconcursalidad privada para la actividad empresarial: nada nuevo, solo ideas o actitudes nuevas)" por Efraín Hugo Richard. "Responsabilidad de administradores en la emergencia" por Horacio Roitman, Alejandro Vergara, Marcos Broglio Michelli y María Victoria Marengo. "Alteración de las circunstancias por efecto de la pandemia de Covid 19 y exigibilidad contractual" por Alejandro E. Freytes. "Daños causados por contagio por coronavirus. La cuestión de la causalidad" por José Fernando Márquez. "El ejercicio de los derechos personalísimos en tiempos de pandemia y post pandemia" por Beatriz Junyent de Sandoval, Patricia Stein y Gabriel Eugenio Tavip. "Panorama sobre la normativa de emergencia COVID-19 en la publicidad registral de los derechos reales sobre inmuebles provincia de Córdoba" por Raquel Virginia Moyano y Gabriela Sosa.Fil: Barrera Buteler, Guillermo Eduardo. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Yanzi Ferreira, Ramón Pedro. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: García Chiple, Edgardo. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Fernández, Juan B. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Domínguez, Marisa. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Salomón, Laura. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Pedrón, Carla. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Dalin, Julieta. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Sánchez, Lorena. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Villafañe Molina, Eduardo. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: López, Rodrigo. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Aspell, Marcela. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Palmero, Juan Carlos. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Aparicio, Juan Manuel. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Richard, Efraín Hugo. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Roitman, Horacio. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Vergara, Alejandro. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Broglio Michelli, Marcos. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Marengo, María Victoria. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Freytes, Alejandro E. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Márquez, José Fernando. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Junyent de Sandoval, Beatriz. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Stein, Patricia. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Tavip, Gabriel Eugenio. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Moyano, Raquel Virginia. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina.Fil: Sosa, Gabriela. Universidad Nacional de Córdoba. Facultad de Derecho; Argentina

Female homicides and femicides in Ecuador: a nationwide ecological analysis from 2001 to 2017

Background: gender–based violence is a major public health concern arising from the structural discrimination of women and girls. In 2014, Ecuador criminalized acts of femicide in response to a growing crisis across the region. As no epidemiological studies on the state of female homicides and femicides have been published, we estimated patterns of female homicides and femicides nationally and the burden through economic cost per years of life lost, between 2001 and 2017.Methods: using aggregated data from the National Institute of Census and Statistics and police records we estimated the annual mortality rates, cumulative incidence and prevalence odds ratios for female homicides and femicides, from 2001 to 2017. The impact of aggressions, assaults and violence on years of life lost due to premature mortality was estimated using the Human Capital method.Results: over the period, at least 3236 cases of female homicides and femicides were reported. The highest murder rate occurred in the province of Sucumbíos (6.5 per 100,000) and in the Putumayo canton (12.5 per 100,000). The most common way to murder their victims was using firearms (38%). The highest odds ratio was estimated for women aged between 25 and 29, at 4.5 (3.9–5.1), of primary school attainment at 17.2 (14.6–20.3) and of Afro-Ecuadoran descent 18.1 (10.5–30.9). Female homicide-related costs reached, on average, $35 million per year and more than$500 million lost from 2001 to 2017.Conclusions: the high rates, distribution and cost indicate that investments are urgently needed to address the structural causes and reduce the impact of female homicides and femicides in Ecuador; thereby protecting the livelihood and well-being of their women and girls

Mycobiota in Chilean Chili Capsicum annuum L. used for production of Merkén

info:eu-repo/semantics/publishedVersio

Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study

Published by Elsevier Ltd.Background: Differences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally. Methods: In this observational study, we derived individual-level data on adults (aged 18-99 years) with rheumatic disease and a confirmed status of their highest COVID-19 severity level from the COVID-19 Global Rheumatology Alliance (GRA) registry, collected between March 12, 2020, and Aug 27, 2021. Environmental and societal factors were obtained from publicly available sources. The primary endpoint was mortality attributed to COVID-19. We used a multivariable logistic regression to evaluate independent associations between environmental and societal factors and death, after controlling for individual-level risk factors. We used a series of nested mixed-effects models to establish whether environmental and societal factors sufficiently explained country-level variations in death. Findings: 14 044 patients from 23 countries were included in the analyses. 10 178 (72·5%) individuals were female and 3866 (27·5%) were male, with a mean age of 54·4 years (SD 15·6). Air pollution (odds ratio 1·10 per 10 μg/m3 [95% CI 1·01-1·17]; p=0·0105), proportion of the population aged 65 years or older (1·19 per 1% increase [1·10-1·30]; p<0·0001), and population mobility (1·03 per 1% increase in number of visits to grocery and pharmacy stores [1·02-1·05]; p<0·0001 and 1·02 per 1% increase in number of visits to workplaces [1·00-1·03]; p=0·032) were independently associated with higher odds of mortality. Number of hospital beds (0·94 per 1-unit increase per 1000 people [0·88-1·00]; p=0·046), human development index (0·65 per 0·1-unit increase [0·44-0·96]; p=0·032), government response stringency (0·83 per 10-unit increase in containment index [0·74-0·93]; p=0·0018), as well as follow-up time (0·78 per month [0·69-0·88]; p<0·0001) were independently associated with lower odds of mortality. These factors sufficiently explained country-level variations in death attributable to COVID-19 (intraclass correlation coefficient 1·2% [0·1-9·5]; p=0·14). Interpretation: Our findings highlight the importance of environmental and societal factors as potential explanations of the observed regional disparities in COVID-19 outcomes among people with rheumatic disease and lay foundation for a new research agenda to address these disparities.MAG is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (grant numbers K01 AR070585 and K24 AR074534 [JY]). KDW is supported by the Department of Veterans Affairs and the Rheumatology Research Foundation Scientist Development award. JAS is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (grant numbers K23 AR069688, R03 AR075886, L30 AR066953, P30 AR070253, and P30 AR072577), the Rheumatology Research Foundation (K Supplement Award and R Bridge Award), the Brigham Research Institute, and the R. Bruce and Joan M. Mickey Research Scholar Fund. NJP is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (T32-AR-007258). AD-G is supported by grants from the Centers for Disease Control and Prevention and the Rheumatology Research Foundation. RH was supported by the Justus-Liebig University Giessen Clinician Scientist Program in Biomedical Research to work on this registry. JY is supported by grants from the National Institutes of Health (K24 AR074534 and P30 AR070155).info:eu-repo/semantics/publishedVersio

Appropriateness of antiplatelet therapy for primary and secondary cardio- and cerebrovascular prevention in acutely hospitalized older people

Aims: Antiplatelet therapy is recommended for the secondary prevention of cardio- and cerebrovascular disease, but for primary prevention it is advised only in patients at very high risk. With this background, this study aims to assess the appropriateness of antiplatelet therapy in acutely hospitalized older people according to their risk profile. Methods: Data were obtained from the REPOSI register held in Italian and Spanish internal medicine and geriatric wards in 2012 and 2014. Hospitalized patients aged 6565 assessable at discharge were selected. Appropriateness of the antiplatelet therapy was evaluated according to their primary or secondary cardiovascular prevention profiles. Results: Of 2535 enrolled patients, 2199 were assessable at discharge. Overall 959 (43.6%, 95% CI 41.5\u201345.7) were prescribed an antiplatelet drug, aspirin being the most frequently chosen. Among patients prescribed for primary prevention, just over half were inappropriately prescribed (52.1%), being mainly overprescribed (155/209 patients, 74.2%). On the other hand, there was also a high rate of inappropriate underprescription in the context of secondary prevention (222/726 patients, 30.6%, 95% CI 27.3\u201334.0%). Conclusions: This study carried out in acutely hospitalized older people shows a high degree of inappropriate prescription among patients prescribed with antiplatelets for primary prevention, mainly due to overprescription. Further, a large proportion of patients who had had overt cardio- or cerebrovascular disease were underprescribed, in spite of the established benefits of antiplatelet drugs in the context of secondary prevention

Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study an international prospective cohort study

We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care. We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care